New drug aims to save hearts in duchenne muscular dystrophy

NCT ID NCT03340675

Completed Disease control Sponsor: Cumberland Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested an oral drug called ifetroban in 46 males aged 7 and older with Duchenne muscular dystrophy (DMD). The goal was to see if the drug is safe and can help prevent or treat heart problems, which are a leading cause of death in DMD. Participants received either ifetroban or a placebo daily, and researchers monitored side effects and drug levels in the blood.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ifetroban (oral drug)
What this could lead to: If it works, this could point toward a treatment to protect the heart in Duchenne muscular dystrophy, potentially extending life.
What could go wrong: This is a small Phase 2 trial with only 46 participants, so results may not be conclusive. The drug may not improve heart function or could cause side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for CARDIOMYOPATHY, DILATED are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

dilated cardiomyopathy dilated cardiomyopathy 3B Duchenne muscular dystrophy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIOMYOPATHY, DILATED DUCHENNE MUSCULAR DYSTROPHY CARDIOMYOPATHY

Contacts and locations

Locations

Arkansas Children's Hospital

Little Rock, Arkansas, 72202, United States
Children's Healthcare of Atlanta

Atlanta, Georgia, 30341, United States
Children's National Hospital

Washington D.C., District of Columbia, 20010, United States
Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, 45229, United States
Kennedy Krieger Institute

Baltimore, Maryland, 21205, United States
Lurie Children's Hospital

Chicago, Illinois, 60611, United States
Mattel Children's Hospital

Los Angeles, California, 90095, United States
Monroe Carrell Jr. Children's Hospital at Vanderbilt

Nashville, Tennessee, 37232, United States
Riley Children's Hospital

Indianapolis, Indiana, 46202, United States
Saint. Louis Children's Hospital

St Louis, Missouri, 63110, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.