New antibody drug could reduce infusions for nerve disorder
NCT ID NCT05225675
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial tests an experimental drug called ARGX-117 in 54 adults with multifocal motor neuropathy (MMN), a condition that causes muscle weakness. Participants receive either ARGX-117 or a placebo by IV, and researchers check if the drug can safely delay the need for standard IVIg treatments. The goal is to see if ARGX-117 can help control the disease with fewer infusions.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ARGX-117 (an experimental antibody given intravenously)
What this could lead to
If it works, this could point toward a new treatment that reduces the need for regular IVIg infusions in people with multifocal motor neuropathy.
What could go wrong
This is a small, early-phase trial with only 54 participants. The drug may not work better than placebo, and side effects are still being studied.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for MULTIFOCAL MOTOR NEUROPATHY are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
AZ Sint-Lucas
Ghent, 9000, Belgium
-
Amsterdam UMC location AMC, Dep of Neurology
Amsterdam, 1105 AZ, Netherlands
-
Austin Neuromuscular Center
Austin, Texas, 78756, United States
-
Azienda Ospedaliera Sant'Andrea-UOS Malattie Neuromuscolari
Rome, 00189, Italy
-
Azienda Ospedaliero Univeritaria Pisana-UOS Neurologia
Pisa, 56126, Italy
-
CHRU de Lille-Hopital Roger Salengro
Lille, 59037, France
-
CHU de Bordeaux-Hopital Pellegrin
Bordeaux, 33076, France
-
CHU de Nice-Hopital Pasteur 2
Nice, 06001, France
-
California Pacific Medical Center-Forbes Norris MDA/ALS Research Center
San Francisco, California, 94109, United States
-
Cleveland Clinic
Cleveland, Ohio, 44195, United States
-
Genge Partners Montreal
Québec, H4A 3TA, Canada
-
George Washington Medical Faculty Associates
Washington D.C., District of Columbia, 20037, United States
-
HonorHealth Research Institute-Neuroscience Research
Scottsdate, Arizona, 85251, United States
-
HonorHealth Research Institute-Neuroscience Research
Maitland, Florida, 32751, United States
-
Hopital Pitie Salpetriere
Paris, 75651, France
-
Hospital Universitari I Politecnic La Fe de Valencia-Servicio Neurologia
Valencia, 46026, Spain
-
Hospital Universitario Vall d'Herbon
Barcelona, 08035, Spain
-
Hospital de la Santa Creu I Santa Pau -Sevicio Neurologia
Barcelona, 08041, Spain
-
IRCCS Ospedale San Raffaele
Milan, 20132, Italy
-
Instituto Clinico Humanitas (IRCCS)
Rozzano, 20089, Italy
-
Katholisches Klinikum Bochum
Bochum, 44791, Germany
-
Medizinische Hochschule Hannover Klinik Fur Neurologie
Hanover, 30625, Germany
-
Medizinische Universitat Wien Universitatsklienik fur Neurologie
Vienna, 1090, Austria
-
Michalscy I Partnerzy Lekarze Spolka Partnerska
Krakow, 31-426, Poland
-
NorthShore University HealthSystem
Glenview, Illinois, 60026, United States
-
Oxford University Hospitals NHS Trust-Jonh Radcliffe Hospital
Oxford, OX3 9DU, United Kingdom
-
Perelman Center for Advanced Medicine-University of Penssylvania
Philadelphia, Pennsylvania, 19104, United States
-
Queen Elisabeth University Hospital
Glasgow, G51 4TF, United Kingdom
-
Toronto General Hospital
Toronto, M5G 2C4, Canada
-
Universitatsklinikum Essen
Essen, 45147, Germany
-
Universitatsklinikum Munster
Münster, 48419, Germany
-
Universitatsmedzin Gottingen, Klinik fur Neurologie
Göttingen, 37075, Germany
-
University College London Hospital
London, ZC1N 3BG, United Kingdom
-
University Medical Centre Utrecht
Utrecht, 3584 CX, Netherlands
-
University of Kansas Medical Center
Kansas City, Kansas, 66160, United States
-
University of Minnesota Delware Clinic Research Unit
Minneapolis, Minnesota, 55414, United States
-
University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, 27514, United States
-
University of South Florida Carol and Frank Morsani Center for Advanced Healthcare
Tampa, Florida, 33612, United States
-
Uniwersyteckie centrum kliniczne Warszawskiego
Warsaw, 02-097, Poland
-
West Virginia University Medicine
Morgantown, West Virginia, 26506, United States