Neurological pain disorder

This study compares atogepant and topiramate, two daily pills used to prevent migraines, to see which one people tolerate better. About 545 adults with frequent migraines (at least 4 per month) will take one of the two drugs for 24 weeks, then all eligible participants will recei…

This study tested a wearable device called Nerivio that delivers mild electrical pulses to the arm to help prevent migraines. 150 people with chronic migraine used the device for 3 months. Researchers tracked changes in monthly migraine days, attack duration, and patient-reported…

This study tests whether fremanezumab, a monthly injection, can prevent episodic migraine in children aged 6 to 17. Participants receive either the drug or a placebo for 12 weeks, and researchers track changes in monthly migraine days. The goal is to see if fremanezumab is safe a…

This study looks at people who received a total lumbar disc prosthesis (Baguera®L) for lower back pain or sciatica caused by disc degeneration or herniation. The goal is to see how many return to their original job five years after surgery. Unlike spinal fusion, which often limit…

This phase 3 trial tested whether adding the oral drug atogepant (QULIPTA) to standard Botox injections can safely and effectively prevent chronic migraine in adults. 75 participants took atogepant daily for 24 weeks alongside their regular Botox. Researchers monitored side effec…

This study looked at how well eptinezumab works and is tolerated for preventing migraines. It included 130 adults with episodic or chronic migraine. Researchers tracked changes in monthly migraine days over 3 to 12 months of treatment.

This study tested whether a daily oral medication called atogepant (brand name Qulipta) can prevent migraines in Japanese adults who have 4 to 14 migraine days per month. Over 500 participants were randomly assigned to receive one of three doses of atogepant or a placebo for 12 w…

This study tested whether adding Dermabond (a medical glue) to stitches helps keep spinal cord stimulator leads from moving after placement. 57 adults with chronic pain had their leads secured either with stitches alone or with stitches plus glue. The main goal was to measure how…

This completed phase 4 study tested whether rimegepant, a dissolvable tablet taken every other day, can prevent migraines in adults who did not get enough relief from other oral preventive medications. Over 960 participants were enrolled. The main goal was to see if rimegepant re…

This study looked at whether medical cannabis can help people with chronic pain reduce their use of opioid painkillers. 29 patients who wanted to lower their opioid dose but couldn't afford medical cannabis were given access to it. Over 5 months, doctors tracked their pain levels…

This study tested whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) works better than standard medications (Cymbalta or Lyrica) for fibromyalgia triggered by emotional trauma. 48 adults completed the trial, and researchers measured symptom improve…

This study tested two tools to help older adults (65+) on long-term opioid therapy use painkillers more safely. The PainTracker tool helps doctors focus on improving daily function and mental health, while the Opioid Misuse Measure screens for risky opioid use. Researchers studie…

This study tested two ways to help primary care doctors prescribe opioids more safely for patients with chronic pain, depression, or anxiety. One approach used an electronic tool that reminded doctors about risk checks and guidelines. The other added a team of a pharmacist, a soc…

This study tested a 12-month telephone-based nurse care program for 805 adults with depression and signs of opioid use disorder. Participants were randomly assigned to receive nurse support or usual care. The goal was to see if the program could improve treatment for opioid use a…

This study tested whether giving adults with chronic pain discounted vouchers for medical cannabis soft-gel capsules could help them reduce their opioid painkiller use. 270 participants were randomly assigned to receive vouchers for placebo or cannabis capsules with different THC…

This study tested whether a drug that blocks TNF-alpha, a protein involved in inflammation and scar formation, can reduce sciatica pain in people who developed spinal scar tissue after back surgery. 38 adults with persistent pain after discectomy received either the drug or a pla…

This study tested the long-term safety of a monthly injection called fremanezumab to prevent migraines in children aged 6 to 17. Over 500 participants received the shot for up to 84 months. Researchers tracked side effects, changes in migraine days, and overall safety to see if t…

This study tested whether adding eptinezumab to a brief educational program helps adults with both migraine and medication overuse headache. Over 600 participants received either eptinezumab or a placebo. The goal was to see if the drug could reduce the number of migraine days an…

This study tested whether an ultrasound-guided nerve block, using a steroid and local anesthetic, could better control pain from shingles and prevent postherpetic neuralgia (long-term nerve pain). 100 adults with acute shingles and moderate to severe pain were randomly assigned t…

This study tested whether the drug rimegepant can help prevent migraines in Chinese adults. 787 participants took either rimegepant or a placebo every other day for 12 weeks. The main goal was to see if rimegepant reduced the number of migraine days per month compared to placebo.…

This study looked at the long-term safety of eptinezumab, a drug given by IV infusion to prevent migraines. It included 160 Japanese patients who had already completed a previous study. The main goal was to see if the drug is safe and tolerable over 60 weeks of treatment.

This pilot study tested whether rimegepant (Nurtec ODT), a drug already used for migraines, could help prevent cluster headaches. Twenty adults with recurrent cluster headaches took the drug every other day for a week. Researchers measured changes in weekly attack frequency and p…

This completed study tested whether reducing loneliness through group therapy could lower opioid misuse in 102 adults on long-term opioids for chronic pain. Participants received either cognitive behavior therapy or social navigation in weekly sessions. Researchers measured chang…

This completed Phase 4 trial tested the drug rimegepant as a preventive treatment for people with episodic migraines (4–14 migraine days per month). Over 1,400 participants were randomly assigned to take rimegepant daily, every other day, or a placebo for 12 weeks. The main goal …

This study looked at a rare type of daily headache in children and teens called NDPH. Researchers used standard headache medicines and measured certain proteins in the blood to see if they change with treatment. The goal was to better understand the condition and see how well the…

This study tested a drug called fremanezumab, given as a shot under the skin, to prevent migraines in 365 Chinese adults. Participants received either monthly or quarterly injections or a placebo for 12 weeks, followed by an open-label period. The main goal was to see if the drug…

This study tested a wearable device that tracks eye movements during dizzy spells to help doctors tell apart three common inner-ear conditions: Ménière's disease, vestibular migraine, and BPPV. Four adults wore the device for 30 days to capture data. The goal was to develop a com…

This study tested 776 people with chronic pain of unknown cause to see if they had Fabry disease, a rare inherited disorder that can cause pain, kidney, heart, and nerve problems. Researchers used enzyme tests in men and genetic tests in women to find cases. The goal was to see h…

This study tested whether a diode laser can act as a biomarker to measure neuropathic pain in people with peripheral neuropathy. Researchers compared pain responses to a lidocaine patch versus a placebo patch in 75 participants. The goal was to see if the laser test could disting…

This study tested whether a special infrared (FLIR) camera can help measure pain and disease severity in people newly diagnosed with Complex Regional Pain Syndrome (CRPS). Thirty adults with CRPS in one limb had a thermal picture taken of their foot and answered pain questionnair…

This study tested whether videonystagmography (VNG) with caloric testing, a standard balance exam, can distinguish people with vestibular migraine from those with other migraines and healthy individuals. Researchers compared eye movement patterns in 173 participants across three …

This study tested whether measuring the optic nerve sheath with ultrasound can predict postdural puncture headache (PDPH) after spinal anesthesia. 176 adults having knee replacement surgery were scanned before and after the procedure. The goal was to see if changes in nerve sheat…

This study tested whether taking vitamin C before and after planned upper limb surgery could prevent complex regional pain syndrome (CRPS), a chronic pain condition. Nearly 1,000 adults participated, receiving either vitamin C or a placebo. The goal was to see if vitamin C reduce…

This clinical trial tested a new drug called Lu AG09222 to prevent migraines in 874 adults who had already tried 1 to 4 other preventive medications without success. The study compared different doses of the drug against a placebo to find the best dose. The main goal was to see i…

This pilot study tested whether giving vitamin D shortly after a burn injury could prevent chronic pain. Forty adults with burns took either vitamin D or a placebo and were followed for six months. Researchers also studied how vitamin D affects the immune system after a burn. The…

This study looked at whether taking vitamin C can prevent Complex Regional Pain Syndrome (CRPS), a painful condition that can develop after a wrist fracture. Researchers enrolled 220 adults with specific types of wrist fractures and gave them vitamin C to see if it reduced their …

This study tested a drug called eptinezumab to see if it can prevent migraines in people with chronic migraine (15 or more headache days per month). About 981 adults took part, receiving either the drug or a placebo. The main goal was to see if the drug reduced the number of mont…

This study tested the long-term safety of a daily pill called atogepant for preventing migraines in adults with chronic or episodic migraine. Over 156 weeks, 596 participants took 60 mg of atogepant each day. Researchers tracked side effects and lab results to see if the drug rem…

This study looks at whether taking omega-3 supplements (fish oil) for 12 weeks can reduce migraine pain and improve quality of life in children aged 10 to 17. Half of the 58 participants will receive omega-3 oil, and the other half will receive a placebo (coconut oil). Researcher…

This trial investigates whether a multidisciplinary day hospital program can improve quality of life for adults with chronic regional pain syndrome (CRPS), a painful condition that affects movement and daily function. Participants receive coordinated care from a team of specialis…

This completed pilot study tested whether shining a low-level laser into the blood (intravenous laser therapy) can improve sleep and reduce pain in people with chronic sciatica. Sixty-six adults with sciatica and poor sleep received either electroacupuncture alone or electroacupu…

This study tests four virtual coaching sessions to help veterans with chronic pain use their own cannabis products more effectively. Participants will learn strategies to manage pain and related symptoms. The goal is to see if this coaching improves pain relief and satisfaction.

This study investigates whether adding focal muscle vibration to shoulder exercises can improve how the brain processes sensory and movement signals in people with chronic subacromial impingement syndrome. Participants will receive 12 sessions of either vibration-assisted exercis…

This study looks at how well the migraine drug ubrogepant works in everyday life for Canadian adults. About 178 participants will take the drug as prescribed and report their ability to function normally after a migraine attack. The goal is to see if ubrogepant helps people get b…

This small pilot study tested a mindfulness-based therapy designed for older Black adults (age 50+) who have both chronic pain and early memory decline. The goal was to see if the program could improve quality of life and reduce how much pain interferes with daily activities. Nin…

This study tested whether adding a steroid called dexamethasone to a standard occipital nerve block (using numbing medicines) provides extra headache relief. 120 adults with various headache types received injections at the back of the head. Researchers tracked changes in headach…

This study tested a 16-session web-based resistance training program for people with fibromyalgia. Researchers measured balance, muscle performance, and symptoms in 13 adults. The goal was to see if a home-based exercise program could improve physical function and ease fibromyalg…

This study tested two different methods for placing a spinal cord stimulator (SCS) lead in people with chronic back pain. One method uses the patient's sensation of tingling (paresthesia) to guide placement, while the other uses the spine's natural midline as a guide. Sixty adult…

This study tested a 24-session program for 100 adults with fibromyalgia. The program brings together nurses, doctors, physiotherapists, nutritionists, and mental health experts to teach self-management skills. Researchers measured quality of life, pain impact, and mood over 12 mo…

This study tests whether high-intensity laser therapy (HILT) can reduce pain during intercourse for women with provoked vestibulodynia, a condition causing severe pain at the vaginal opening. About 145 women with moderate to severe pain will receive either real or sham laser trea…

This study tested a web-based tool called MigraineManager for teens with migraines. The tool helps teens, their parents, and doctors track headaches and manage symptoms. The goal was to see if it could reduce how often headaches happen. 40 teens with frequent migraines took part.

This study looked at whether adding immersive virtual reality (VR) to standard rehab helps people with long-term arm pain (Complex Regional Pain Syndrome) use their arm better. 13 adults took part, using VR during occupational therapy sessions. The goal was to see if VR could imp…

This study tested whether a 12-week lifestyle-based physical activity program before intensive rehabilitation helps people with chronic low back pain. Twenty-four adults were split into two groups: one did the preparatory program followed by intensive rehab, the other did only th…

This study tested a new pain self-management program called COPES against standard cognitive behavioral therapy for chronic pain in 764 veterans. The goal was to see if COPES could better reduce how much pain interferes with daily life. Participants had chronic musculoskeletal pa…

This completed study compared two minimally invasive surgeries for herniated discs: full endoscopic lumbar discectomy (FELD) and microdiscectomy (MD). Researchers enrolled 200 adults aged 18-85 with single-level disc herniation and sciatica. The goal was to see which technique pr…

This study tested two virtual, 8-week programs (Active Brains 1 and 2) in 267 older adults with chronic pain and early cognitive decline. Both programs taught skills like relaxation, cognitive training, and positive psychology to help manage symptoms. Researchers measured changes…

This pilot study tested whether a TENS device, placed on the forehead, is safe and practical for treating chronic eye pain in 39 veterans. Participants used the device at home for 6 months. The goal was to see if it reduces pain and to prepare for a larger trial.

This study tested two treatments for chronic tailbone pain (coccygodynia) in 100 adults. One group received osteopathic manual therapy—gentle hands-on techniques to mobilize the tailbone and relax muscles—over 6 weeks. The other group got a nerve block injection guided by X-ray. …

This study looked at whether adding a gentle electrical nerve stimulation (TENS) to cognitive behavior therapy (CBT) and standard medicines could reduce pain and improve quality of life in 60 postmenopausal women with fibromyalgia. Participants were split into three groups: one r…

This study tested whether sound therapy using weighted tuning forks, combined with relaxation, could reduce pain in women with fibromyalgia. Forty women aged 30 to 60 took part, attending three weekly sessions. Researchers compared pain levels before and after sessions between th…

This pilot study tested whether an 8-week group therapy program delivered over Zoom could help adults with both chronic pain and opioid use disorder. The therapy, called Emotional Awareness and Expression Therapy (EAET), teaches people to understand and express their emotions as …

This pilot study tested whether a mindfulness program could help veterans with chronic pain and thoughts of suicide. 76 veterans took part to see if the program was acceptable and could reduce pain, depression, and suicide risk. The goal was to improve quality of life and daily f…

This study tested a phone-based counseling program called SBIRT-PM for veterans with chronic pain who were also at risk for substance misuse. Over 1,100 veterans participated, receiving up to four phone calls over 12 weeks to help them engage in non-drug pain treatments and reduc…

This study tested whether a treatment called radiofrequency, combined with a special massage, can reduce pain during sex that starts after having a baby. 80 women who had pain 4 to 12 months after giving birth took part. The goal was to see if this approach could lower pain and i…

This study looked at how satisfied people with migraines were using Sumavel DosePro, a needle-free injector for migraine medication. 246 adults who already used triptan drugs took part. The goal was to see if they liked this new method better than their usual treatment.

This study looked at whether adding TENS (a device that sends mild electrical pulses through the skin) and exercise to usual migraine medication can reduce pain and disability in women with migraine. Thirty-eight women participated, all continuing their prescribed meds. The goal …

This study tested a program called PRIME for older women with chronic pain and depression who also have physical disabilities. Nine women took part in nurse-led goal-setting visits and group therapy sessions focused on acceptance and commitment. The goal was to see if this combin…

This study tested whether taking gabapentin along with oxcarbazepine works better than oxcarbazepine alone for trigeminal neuralgia, a condition causing severe facial pain. 44 adults were split into two groups and had their pain measured over 2 months. The goal was to see which a…

This study tested a device that sends mild electrical pulses to a nerve in the ear (trigeminal nerve) to see if it helps people with migraine. 102 adults with episodic migraine received either real or sham stimulation three times a week for 12 weeks. Researchers measured headache…

This study looked at how the brain processes pain in people with fibromyalgia compared to healthy individuals. Researchers tested whether a non-invasive procedure called transcranial magnetic stimulation (TMS), which uses magnetic pulses to stimulate the brain, could reduce pain …

This completed study tested a laser device (BTL-043) on 31 adults with temporomandibular joint (TMJ) pain. Participants received four 20-minute laser sessions over a few weeks. Researchers measured pain levels, jaw movement, and daily function at 1 and 3 months after treatment to…

This study tested a non-invasive ear-clip device that gently stimulates the vagus nerve to see if it can reduce pain in people with diabetic peripheral neuropathy. 185 adults with type 2 diabetes and chronic nerve pain used the device or a sham version twice daily for 12 weeks. T…

This completed trial tested whether a Whole Health Team (WHT) approach helps veterans with chronic pain improve their daily functioning and quality of life compared to group education or usual care. Over 790 veterans from six VA sites participated, with follow-up lasting 12 month…

This completed study looked at whether giving a continuous nerve block along with intensive physical and occupational therapy can improve recovery in people with Complex Regional Pain Syndrome type 1 (CRPS 1). The study enrolled 30 patients and followed them for up to a year. The…

This study tested a program called RESET, led by community health workers, to improve physical and mental well-being in older adults. Over 450 African American adults aged 50+ with symptoms like depression, anxiety, or chronic pain took part. The program included weekly group pho…

This study tested whether tailoring magnetic brain stimulation to each person's brain signals can better relieve chronic pain. Researchers measured brain activity before treatment to customize the stimulation. 90 adults with chronic pain took part. The goal was to see if this per…

This study tested how well two approved migraine medications, ubrogepant (for acute attacks) and atogepant (for prevention), work together in real-world settings. 391 adults with migraine used both drugs as prescribed by their doctor for 30 days. The goal was to see if the combin…

This study tested whether draining some fluid from the spine (a lumbar puncture) can help relieve severe headaches that often follow a brain aneurysm rupture. The trial involved 74 patients with mild to moderate brain bleeds. Half received a real lumbar puncture, and half receive…

This study tested a telehealth program (CBT-TS) to help 300 veterans on long-term opioids for chronic pain feel more willing to try non-drug treatments like therapy or exercise. The goal was to reduce pain and reliance on opioids. Results will show if changing beliefs about these…

This study looked at whether a single educational phone call from a nurse, before a doctor's appointment, could help people with medication overuse headaches. 88 adults with frequent migraines took part. The goal was to see if the call reduced the number of headache days in the m…

This study looked at whether hypnosis or a placebo pill (given honestly, without deception) can reduce chronic nerve pain and improve how the brain handles pain. Seventy-two adults with long-term nerve pain were randomly assigned to hypnosis, open-label placebo, or usual care. Th…

This completed trial tested a program called REDOCVR for 174 adults with chronic pain. The program combines group education, emotional support, and virtual reality experiences to help people reduce their pain medications. Researchers measured changes in medication use, mental wel…

This study tested whether adding virtual reality to motor imagery exercises (mentally practicing movements) can better reduce pain and disability in people with post-stroke shoulder hand syndrome. Forty adults aged 40-70 who had a stroke at least 3 months ago took part. The main …

This study tested whether a spinal cord stimulation device can reduce chronic leg pain caused by diabetic neuropathy. Twenty-eight people with diabetes received the implant and reported their pain relief and overall improvement over 12 months. The goal was to see if this device c…

This pilot study tested whether adding virtual reality (VR) to a standard educational program helps people with chronic pain and central sensitization. 128 participants completed eight weekly sessions that combined pain education, mindfulness, and VR activities. The study measure…

This study tested a resilience coaching program (PRISM) for 260 teens aged 12-17 with chronic musculoskeletal pain. The goal was to see if coaching improves daily function, reduces distress, and lessens pain compared to usual care. Participants completed surveys and coaching sess…

This study tested two drugs, zonisamide and topiramate, to see which works better for preventing migraines. About 600 people with migraines took one of the medicines for three months. Researchers measured how much their monthly migraine days dropped and how many people had at lea…

This study tested whether a nasal spray called zavegepant can safely and effectively treat migraine attacks in Asian adults. Over 1,400 participants took either the drug or a placebo when they had a moderate or severe migraine. The main goals were to see if the spray could stop p…

This study tested whether a non-invasive, FDA-approved device called cranial electrical stimulation (CES) can reduce chronic pain in veterans with fibromyalgia. Fifty veterans received either real CES or a placebo treatment for several weeks. Researchers used brain scans and pain…

This study tested whether doing exercise in a virtual reality headset can improve quality of life, thinking, and mood in people with fibromyalgia. Thirty adults with fibromyalgia took part in a crossover trial where everyone tried both virtual reality exercise and regular exercis…

This study tested a 7-week program to help older adults with both chronic pain and mild memory problems manage their pain better. Participants received weekly phone coaching and watched educational videos. The goal was to see if the program was practical and could reduce how much…

This study looked at whether classical massage can reduce pain and improve daily function in people with myofascial pain syndrome, a condition that causes muscle knots and radiating pain. Sixty adults aged 30–50 with active trigger points in the upper back took part. Researchers …

This study tested whether a wearable device that delivers gentle vibrations through the skull can improve balance and reduce motion sickness in people with vestibular migraine. Fifty-one participants wore the device while sitting in a rotating chair and answered questions about t…

This study tested new non-drug treatments to reduce nerve pain in the feet and legs of people with HIV. 161 adults with HIV-related nerve pain tried these approaches to see if they could ease pain and improve quality of life. The goal was to find better ways to manage this common…

This study looked at whether aerobic dance exercises can improve symptoms and quality of life in women with fibromyalgia. Forty-four women were split into two groups: one did aerobic dance sessions led by a physiotherapist, and the other did standard postural exercises. Researche…

This study tested whether an ultrasound-guided injection of sugar water around the sciatic nerve could safely reduce sciatica pain in the emergency department. Researchers enrolled 69 adults with acute sciatica and followed up 72 hours later. The goal was to see if the procedure …

This study compared telemedicine follow-ups to standard in-person clinic visits for cancer patients with chronic pain. Researchers measured how much pain interfered with daily activities using a standard questionnaire. The goal was to see if remote care could be as effective and …

This study looked at whether adding progressive muscle relaxation to aerobic exercise helps people with migraine more than exercise alone. 44 adults with migraine were split into two groups: one did both exercise and relaxation, the other did only exercise. Researchers measured p…

This early-stage study tested a new drug called 4ET1103 in 40 healthy volunteers to see if it is safe and how the body processes it. Each person received a single dose of either the drug or a placebo. The goal was to check for side effects and measure drug levels, not to treat pa…

This study tested whether a device that delivers pulsed electromagnetic fields (I-ONE) could help people with complex regional pain syndrome (CRPS) of the foot or ankle. Twenty-eight participants received the device therapy plus standard rehabilitation. Researchers measured pain,…

This study tested whether a daily probiotic supplement could reduce pain, fatigue, and cognitive issues in women with fibromyalgia. 97 participants took either a multi-strain probiotic or a placebo for 12 weeks. Researchers measured changes in pain, sleep, mood, and quality of li…

This pilot study tested a simple procedure called a sphenopalatine ganglion block (SPGB) — applying numbing medicine (lidocaine) inside the nose — against standard care (bed rest and extra fluids) for people who developed a severe headache after an accidental spinal needle punctu…

This pilot study tested whether acupuncture can help headaches in women going through IVF egg stimulation. 37 women received a 30-minute acupuncture session. Researchers measured headache intensity, stress, and emotional distress before and after treatment. The study is small and…

This study looked at whether playing music of a patient's choice during lumbar interventional procedures (like epidural steroid injections) could reduce pain and anxiety in people with chronic back pain. Thirty adults were randomly assigned to hear music or no music during their …

This study tested whether applying antibiotics directly into the tooth socket after wisdom tooth removal works as well as taking antibiotic pills. 90 adults having their lower wisdom teeth taken out were split into two groups: one got antibiotic gel at the surgery site, the other…

This study tested whether stimulating a nerve in the ear (taVNS) can help people with fibromyalgia feel better and exercise more. 90 adults with fibromyalgia were split into three groups: one-sided stimulation, both ears, or just a home exercise program. Over two weeks, researche…

This study tested whether a digital sleep therapy program called Sleepio can improve quality of life, sleep, and thinking in people with fibromyalgia. 80 participants were randomly assigned to use Sleepio or receive standard sleep advice. Researchers measured changes in symptoms …

This study tested whether treating the greater occipital nerve on one side or both sides of the head with pulsed radiofrequency provides better migraine relief. 217 adults with episodic or chronic migraine who did not respond well to preventive medications received the procedure …

This study tested whether remote monitoring through the Neurosphere app could improve pain relief and lower healthcare costs for people with chronic pain using spinal cord stimulators. Thirty-two adults were split into two groups: one had in-person clinic visits, the other used r…

This study tested whether injecting a local anesthetic (bupivacaine) into nerves at the back of the head could reduce menstrual migraine pain. Forty-eight women with menstrual migraines received either the active drug or a placebo (salt water) twice a month for three months. The …

This study tested whether a single 2-hour infusion of ketamine combined with magnesium sulfate can reduce the number of daily attacks in people with refractory chronic cluster headache—a rare and severe headache disorder. 93 adults who had at least 2 attacks per day and did not r…

This study compared two methods of pain relief after hip replacement surgery: a newer technique called erector spinae plane block (ESPB) and the standard epidural. 60 adults having hip replacement took part. Researchers measured pain levels, opioid use, muscle strength, and walki…

This study tested whether adding functional electrical stimulation (FES)-assisted cycling to standard rehab helps stroke survivors with Complex Regional Pain Syndrome (CRPS). Forty participants either received FES cycling plus conventional therapy or conventional therapy alone fo…

This study tested two non-drug treatments for piriformis syndrome, a condition where a muscle in the buttock presses on a nerve, causing pain. Seventy adults received either low-level laser therapy or radial shockwave therapy, both combined with exercise, over four weeks. Researc…

This study looked at whether injecting a dextrose (sugar) solution into the ligaments around the tailbone can reduce pain and improve daily function in people with long-lasting coccydynia (tailbone pain). Researchers reviewed records of 50 adults who received 3-6 injections over …

This study tested a one-day educational workshop for people with chronic non-cancer pain who take high doses of opioids. The workshop, led by a team of doctors, psychologists, and pharmacists, provided information on opioid risks and taught coping strategies. Researchers wanted t…

This study tested whether community health workers (CHWs) can teach older adults with chronic pain how to manage their symptoms using a 7-week program called STEPS. The program included phone sessions with a CHW, online videos, and a wearable activity tracker. Researchers enrolle…

This study looked at whether adding dexmedetomidine to standard spinal anesthesia could lower the chance of acute neuropathic pain after a leg amputation. Thirty adults having elective lower limb amputation were split into two groups: one got the standard anesthetic plus a placeb…

This study tested a non-invasive treatment called radial pressure wave therapy for people with mild to moderate carpal tunnel syndrome. 60 adults received three weekly sessions of either a constant or modulated dose of the therapy. Researchers measured pain, hand function, and ne…

This study tested whether NT 201 injections can reduce pain in adults with long-term nerve pain caused by shingles or a nerve injury. 123 people received either NT 201 or a placebo shot, and researchers tracked their pain levels over 20 weeks. The goal was to see if the treatment…

This study tested a web-based program that combines cognitive behavioral therapy and pain self-management for people being treated for opioid use disorder who also have chronic pain. The program includes online lessons and daily text surveys to track pain and activity. Researcher…

This pilot study tested a 6-week group program for adults with chronic non-cancer pain. The program combined pain education, personalized exercises, and healthy lifestyle tips. Researchers measured quality of life, pain levels, and other factors in 12 participants before, after, …

This study tested whether a short motivational interview combined with self-management techniques could help Hungarian teens aged 12-18 who have had chronic pain for at least 3 months. The program included a 30-minute in-person session plus two follow-up phone calls. Researchers …

This study tested a program that teaches people with chronic muscle and joint pain how to actively cope with their condition using education, gentle movement, and behavioral strategies. 169 adults took part, comparing the program to usual care. The goal was to see if it could red…

This completed study tested two versions of a cooled radiofrequency procedure to relieve chronic knee pain from osteoarthritis. Ten adults with moderate to severe pain received either the standard or a revised nerve-targeting technique. Researchers measured pain, knee function, q…

This study tested a new drug called SR750 in 138 people with trigeminal neuralgia, a condition that causes sudden, severe facial pain. Participants took either SR750 or a placebo for 6 weeks and recorded their daily pain levels. The goal was to see if SR750 reduces pain better th…

This study looked at different rehabilitation programs for 90 adults who had back surgery for degenerative lumbar disease. The goal was to see which rehab approach best reduces nerve pain, helps patients regain function, and improves quality of life. Participants were randomly as…

This pilot study tested whether a non-invasive vagus nerve stimulator can help people with post-COVID syndrome who suffer from fatigue and headaches. Eighteen participants used the device, and researchers measured changes in their functional status and fatigue levels. The goal is…

This study tested whether rimegepant, a dissolvable tablet, can relieve migraine pain in adults who cannot take triptans due to side effects, lack of effectiveness, or heart problems. Over 800 participants took either rimegepant or a placebo during a migraine attack. The main goa…

This study tested whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) could reduce pain and improve quality of life in people with fibromyalgia, compared to standard medications like Cymbalta or Lyrica. Seventy-six adults with fibromyalgia and a his…

This completed study tested a 7-week, peer-led program for adults with spinal cord injury and chronic pain. The program combined education about pain neuroscience with body-based tools like red light therapy, massage, and guided movement. Twelve participants attended group sessio…

This study from Harvard University tested whether mindfully noticing changes in pain throughout the day can help people with chronic pain feel more in control and reduce pain intensity. 300 adults with chronic pain for at least six months were split into groups that either paid c…

This study looked at whether two common drugs, memantine and dextromethorphan, can help maintain or improve pain relief after a ketamine treatment in people with long-term nerve pain. Seven adults with chronic neuropathic pain who had already responded to ketamine took part. The …

This study tested the DOZE app, a digital self-management program designed to improve sleep in young adults aged 18-25 with chronic pain and insomnia. Forty participants used the app and a sleep diary for 10 weeks. The goal was to see if the app is easy to use and helps with pain…

This completed study tested whether hyperbaric oxygen therapy (HBOT) combined with creative art psychotherapy can help women with fibromyalgia who have a history of psychological trauma. Thirty women received 60 sessions of HBOT plus psychotherapy. Researchers measured pain sensi…

This study tested whether ethosuximide, a drug already used for epilepsy, can reduce pain in people with nerve damage. 114 adults with peripheral neuropathic pain took either the drug or a placebo for 42 days. Researchers measured pain levels and quality of life to see if the dru…

This completed Phase 2 trial tested whether blood thinners (rivaroxaban) or antiplatelet drugs (aspirin, clopidogrel) work better than standard migraine medication (metoprolol) for people with both migraine and a small heart hole called PFO. 1,000 participants took one of the fou…

This study compared two hands-on treatments—post-facilitation stretch and active release technique—for piriformis syndrome in 40 women aged 25 to 45. Researchers measured pain, disability, quality of life, and hip movement over six weeks. The goal was to see which approach offers…

This completed study compared two treatments for piriformis syndrome, a condition causing buttock and leg pain. Forty adults whose pain lasted at least three months were randomly assigned to receive either five sessions of focused sound wave therapy or a single steroid injection.…

This study tested whether personalized health coaching can improve daily life for Veterans suffering from long-term pain and related symptoms. Researchers enrolled 260 Veterans with chronic multisymptom illness (like fibromyalgia) and measured changes in pain and disability. The …

This study tested a smartphone app and website called iCanCope with Pain, designed to help teens and young adults (ages 15-25) manage chronic pain. The app lets users track pain, sleep, mood, and activity, set goals, and learn coping strategies. The goal was to see if the program…

This study tested whether slowly reducing prescribed opioids (tapering) can help people with long-term chronic pain use fewer painkillers without worsening their pain or quality of life. 140 adults on daily opioids for chronic non-cancer pain were randomly assigned to start taper…

This study tested whether inhaling isopropyl alcohol (rubbing alcohol) vapor can reduce nausea during a migraine attack, compared to inhaling eucalyptus scent. Twenty-one adults with frequent migraines took part. Participants inhaled the assigned scent at home when nausea started…

This study tested a new online program that teaches mindfulness and coping skills to people recovering from surgery. The goal was to see if patients find it helpful and easy to use compared to a workshop led by a psychologist. 68 adults who had surgery and were referred to a pain…

This study tested whether mirror therapy can reduce pain and improve movement in stroke patients who also have complex regional pain syndrome (CRPS). Forty adults who had a stroke within the past year and were diagnosed with CRPS took part. They received either real mirror therap…

This study compared a capsaicin patch (Qutenza) to a standard nerve pain medication (amitriptyline) in 13 head and neck cancer survivors with long-term nerve pain. The goal was to see if the patch could reduce pain and improve quality of life. Participants received either the pat…

This study tested whether two combinations of migraine medications can reduce the impact of moderate-to-severe tinnitus. 78 adults were randomly assigned to receive either nortriptyline plus topiramate, verapamil plus paroxetine, or a placebo. The main goal was to see if these dr…

This study tested two exercise techniques—dynamic stretching and nerve gliding—in 72 adults with lumbar radiculopathy (nerve-related back pain). Both groups also received standard physiotherapy. The goal was to see which approach better reduced pain and improved daily function ov…

This completed study looked at how well radiofrequency ablation (a procedure that uses heat to calm pain nerves) works for people with chronic pain. 298 participants were treated with a Boston Scientific device and then rated their improvement. The goal was to see real-world resu…

This study tested whether foot reflexology massage could reduce pain, improve sleep, and boost quality of life in women with migraines. Twenty-two women were split into two groups: one received 10 sessions of foot reflexology over 5 weeks, and the other served as a control. Resea…

This study tested whether a mild electrical stimulation (40 kHz) applied through the skin can safely reduce nerve pain in people with spinal cord injury. Thirty adults with paraplegia and chronic nerve pain received either real or placebo stimulation alongside their usual treatme…

This study tested whether attending weekly group mindfulness sessions could improve function and reduce pain for people with chronic low back pain. Over 450 adults took part, comparing group mindfulness with usual one-on-one care. The goal was to see if this approach helps people…

This study tested two physical therapy techniques—nerve gliding exercises and manual muscle release—to see which better relieves sciatica pain. 48 adults with long-term sciatica took part. Researchers measured pain, leg movement, and daily function to find the most effective appr…

This study compared using 3 points versus 1 point to fix a lightweight mesh during laparoscopic hernia repair (TAPP) in 351 adults with a first-time inguinal hernia. The goal was to see which method leads to less pain, fewer complications like seroma or infection, and lower recur…

This study tested a group breathwork program for people with chronic musculoskeletal pain. 35 adults participated to see if the program was feasible, acceptable, and could help reduce pain. The goal was to develop a simple, group-based breathing technique that might ease symptoms…

This pilot study tested whether adding cognitive behavioral therapy and mindfulness meditation to ketamine infusions could make pain relief last longer for people with chronic nerve pain. Thirty adults with moderate-to-severe neuropathic pain were randomly assigned to receive ket…

This study looked at how well a wearable device called REN works for treating migraines in US veterans. The device uses mild electrical pulses to reduce headache pain. Researchers tracked whether veterans needed extra medication after using the device. The goal was to see if this…

This study looked at whether progressive relaxation exercises can help people with type 2 diabetes who have nerve pain, fatigue, and poor sleep. 88 adults took part. The goal was to see if these simple exercises could improve their symptoms and quality of life.

This study followed 226 adults in Israel who were prescribed ubrogepant or atogepant for their migraines. Researchers wanted to see how satisfied people were with these drugs in real-world settings, not just in a lab. Participants used an app to track their experience over 90 day…

This study tested whether a slow, gentle back massage can help women with fibromyalgia feel less pain and fatigue. 48 women took part, receiving 30-minute massages three times a week. The goal was to see if this simple, drug-free approach could improve daily comfort.

This study tested the drug erenumab in 512 adults who have frequent migraines (7 to 14 headache days per month) and had already tried at least one other preventive treatment that didn't work. The main goal was to see if erenumab could reduce the number of hours they spent with mo…

This study tested two types of magnetic brain stimulation (TMS) to see if they can reduce nerve pain in people with spinal cord injury. 26 adults with long-term nerve pain that didn't respond to medication took part. The goal was to measure changes in pain severity, daily functio…

This study looked at whether adding electrical dry needling to therapeutic exercise helps people with long-term neck pain more than exercise alone. 90 adults with chronic neck pain took part. The goal was to see if the combined treatment improves daily function and reduces pain b…

This study tested a new drug called ST-01, given as a shot into the spermatic cord every 28 days, to see if it safely reduces chronic scrotal pain better than standard lidocaine. 63 men with pain lasting over 3 months took part. The main goal was to measure pain changes using a 0…

This study tested whether prazosin, a drug used for high blood pressure and PTSD nightmares, can reduce headaches in veterans and service members who had a mild traumatic brain injury. 89 participants received either prazosin or a placebo for 12 weeks. Researchers tracked headach…

This study tested whether a type of compassion meditation could help Veterans with chronic pain who also have depression or PTSD. 142 Veterans were randomly assigned to either compassion meditation training or a health education group. The goal was to see if meditation could redu…

This study tested a mobile app designed to help people with chronic pain better manage their symptoms and reduce how much pain interferes with daily life. The app uses proven therapy techniques like Acceptance and Commitment Therapy and Cognitive Behavioral Therapy, plus tools to…

This study tested whether adding virtual reality (VR) exercises to standard home balance training helps people with vestibular migraine, a condition causing dizziness and balance problems. Forty adults with the condition were split into two groups: one did only home exercises, th…

This study tested whether combining two manual therapy techniques—fascial manipulation and perineal massage—can improve quality of life for women with dyspareunia (pain during vaginal penetration). Fifty Portuguese women with pelvic floor muscle spasms were split into two groups:…

This study tested a device that delivers pain medicine directly to the spinal cord for cancer patients with severe pain not controlled by oral opioids. Researchers compared the pump to standard medical management in 30 adults. The goal was to see if the pump reduces pain intensit…

This completed study tested two multimodal programs in 70 adults with non-specific chronic low back pain. Both programs combined exercise, behaviour change, education, and mindfulness; one also added functional resistance training. The goal was to see if these approaches improve …

This study tested whether repeated injections of a numbing drug (bupivacaine) into the back of the head could help people with chronic migraine or chronic tension-type headache. 290 adults received either the drug or a placebo (salt water) injection over three months. The main go…

This study tested two at-home digital programs for chronic pain: a virtual reality (VR) program and a self-guided online course. 330 adults with chronic pain used one of the programs for 8 weeks. Researchers measured changes in pain intensity and how pain affected daily life. The…

This study tested whether a type of mindfulness training called Acceptance and Commitment Therapy (ACT) could help women with frequent migraines. 75 women aged 18-65 with 4-14 migraine days per month took part. The main goal was to see if a larger study was possible, but research…

This pilot study tested whether adding exercise and pain-focused therapy to residential drug treatment is practical and helpful. 63 adults with opioid use disorder and pain took part. The goal was to see if they would stick with the program and if it could reduce pain, cravings, …

This study looked at whether indoor physical activity can improve symptoms in people with both fibromyalgia and irritable bowel syndrome (IBS). Researchers measured changes in gut and pain symptoms, intestinal health, and psychological well-being in 165 participants. The goal was…

This study tested a 10-week education program designed to help Korean Americans with chronic pain. The program taught coping strategies and pain management skills in group sessions held at community centers. Researchers wanted to see if the program was feasible and acceptable, an…

This study looked at whether doing hip abductor strengthening exercises could help people with piriformis syndrome feel less pain and move better. 48 adults with the condition took part. The exercises focused on strengthening muscles that move the leg away from the body. The goal…

This study tested two procedures—cryoablation (freezing nerves) and endoscopic denervation (cutting nerves)—to treat chronic sacroiliac joint pain. 51 adults with confirmed pain from the joint were included. The goal was to see which method better reduces pain and improves daily …

This completed Phase 3 trial tested whether brivaracetam, a drug used for seizures, can reduce chronic nerve pain in people with spinal cord injury. 44 adults with persistent pain took part. The study compared brivaracetam to a placebo and measured changes in pain intensity and d…

This study tested whether adding augmented reality mirror therapy (ARMT) to standard physical and occupational therapy helps people with complex regional pain syndrome (CRPS) of the upper limb. Seven participants received both conventional therapy and ARMT sessions over a month. …

This early-stage study tested whether an experimental pill called PIPE-791 is safe and can lower pain in adults with long-term osteoarthritis knee pain or chronic low back pain. 43 participants stopped their usual pain meds, then took either the study drug or a placebo daily for …

This study tested two ways to give steroid injections for mild-to-moderate carpal tunnel syndrome: one guided by ultrasound into the wrist, and one into the buttock muscle. 63 adults with symptoms like numbness and pain were followed to see which method improved pain, hand functi…

This study tested a minimally invasive procedure called pulsed radiofrequency on a nerve bundle in the face (the sphenopalatine ganglion) to see if it could reduce pain in 55 people with chronic headaches or facial pain who hadn't gotten relief from medication. The procedure uses…

This study tested two treatments for vestibulodynia, a chronic pain condition affecting the vulvar area. 209 women received either a lidocaine/estradiol cream, the antidepressant nortriptyline, both, or a placebo. The goal was to see which approach best reduces pain and improves …

This study looked at whether Tai Chi, a gentle mind-body exercise, can help adults over 45 living with both HIV and chronic pain. Researchers tested the program with 36 participants to see if it was practical and liked by patients. The goal was to find a non-drug way to reduce pa…

This study compared cognitive functional therapy (CFT) to conventional therapy for adults with chronic neck pain lasting over 3 months. Sixty participants were randomly assigned to one of the two treatments. CFT combines physical exercises with psychological strategies to help pa…

This study tested two different doses of lidocaine given through an IV to women who had nerve pain after mastectomy for breast cancer. Thirty women took part, and researchers measured how the pain felt (like burning or stinging) using a special scale. The goal was to see if lidoc…

This study tested whether a non-invasive magnetic brain stimulation technique called rTMS can reduce chronic low back pain. Thirty adults with long-lasting pain received multiple sessions of rTMS over the brain's motor cortex. Researchers measured pain changes using a standard pa…

This study tested a 12-week telehealth program for people with migraines, combining online modules, phone sessions, and a headache diary app. Twenty adults from a headache center in New York participated. The goal was to see if the program was feasible and acceptable, not yet to …

This study tested whether the drug acetazolamide can improve sleep-disordered breathing in 39 adults with chronic pain who use opioids. Participants took either the drug or a placebo for one week each. The goal was to see if the pill could reduce sleep apnea events as an alternat…

This study tested a brief, three-session program for people with chronic pain and a history of stressful or traumatic experiences. The goal was to see if the program was practical and helpful. Fifty adults participated, and the study focused on whether people would join, complete…

This study tested a phone-based version of the Walk With Ease program for 267 adults with arthritis, gout, fibromyalgia, rheumatoid arthritis, osteoarthritis, or lupus. Participants followed a 6-week walking program delivered by phone, and researchers measured changes in pain, ph…

This study tested whether a nerve block placed near the breastbone after heart surgery can reduce the need for opioid painkillers. 340 adults having heart surgery through a standard chest incision were randomly assigned to receive either the numbing drug ropivacaine or a saltwate…

This study compared two physical therapy techniques—neurodynamic mobilization and Mulligan SNAGs—for people with chronic sciatica caused by a disc problem. 66 participants completed the trial at Cairo University. Researchers measured pain intensity, pressure pain threshold, and l…

This study tested whether foot reflexology—a type of focused foot massage—could help people with migraines feel less pain and fatigue and have a better quality of life. 78 adults with migraines took part; half received 10 reflexology sessions over 5 weeks, while the other half co…

This study tested different treatment sequences for chronic low back pain in 749 adults. Participants first received either physical therapy or cognitive behavioral therapy. Those who didn't improve were switched to the other therapy or added mindfulness. The goal was to find whi…

This study tested a procedure called pulsed radiofrequency treatment on the greater occipital nerve at the C2 level in 25 people with cervicogenic headache who had not responded to other treatments. The goal was to see if it could reduce headache severity and frequency. The treat…

This study tested a non-invasive brain stimulation technique as an add-on to standard detox therapy for people with chronic migraine and medication overuse. Researchers wanted to see if it could reduce headache days and identify who might benefit most. The trial involved 60 parti…

This study looked at whether people with chronic pain and opioid use disorder would do art on their own at home, and if it helped their pain and mood. 31 adults tried self-directed artmaking up to four times. Researchers measured how many people stuck with it and whether anxiety,…

This study looked at whether a type of physical therapy called Maitland mobilization, combined with exercises, can help people with tailbone pain after a colonoscopy. 42 adults with this condition were split into two groups: one received standard care (heat and stretches), and th…

This study tested a gentle hands-on technique called Primal Reflex Release for people with tailbone pain after a colonoscopy. 46 adults received either the reflex technique or standard physiotherapy. Researchers measured pain, movement, and quality of life to see if the new appro…

This study tested a nerve block called a stellate ganglion block for people with chronic migraine that didn't get better with other treatments. 42 patients received the injection under ultrasound guidance. Researchers tracked changes in monthly headache days and pain scores over …

This study tested whether combining a gentle electrical nerve stimulation device (tVNS) with stress reduction training can ease migraine. Researchers measured brain activity and inflammation in 193 adults with migraine before and after 8 weeks of treatment. The goal was to see if…

This study tested whether adding a gentle manual therapy called strain counterstrain to standard physiotherapy helps women with fibromyalgia feel better. 105 women were split into three groups: one got standard care, another got standard care plus the therapy, and a control group…

This study tested two online self-management programs for 163 adults with chronic non-cancer pain who were on a waiting list for specialist care. One program was a series of educational videos about pain, and the other was an online session teaching skills to manage pain. The goa…

This study tested an experimental drug called BHV-2100 for quickly stopping migraine pain and related symptoms like nausea or sensitivity to light. About 647 people with migraines took either the drug or a placebo. The goal was to see if the drug could provide pain relief within …

This study tested two different ways to treat long-lasting tailbone pain using heat from a needle (radiofrequency ablation). Fifty adults who had not gotten better with standard treatments were randomly assigned to one of two procedures. The goal was to see which method provided …

This study looked at whether prayer can help people with migraines feel less pain and improve anxiety and depression. About 100 adults, half with migraines and half without, took part. They compared the effects of prayer versus reading a neutral text on pain sensitivity and emoti…

This completed study compared an 8-week online yoga program to a conventional exercise routine in 52 women with endometriosis. The goal was to see if yoga could better reduce pain and improve quality of life. Participants practiced meditation, breathing, and gentle poses, while t…

This study tested a personalized psychological intervention for 5 adolescents aged 12-18 with recurrent headaches. Researchers used smartphone surveys to track each teen's unique headache triggers and coping patterns, then delivered 4-5 weekly online therapy sessions based on tha…

This study tested whether adding pulsed electromagnetic field (PEMF) therapy to standard physical therapy could reduce nerve pain and disability in people with a slipped disc in the lower back. Forty-six patients completed the trial, receiving either real or fake PEMF alongside u…

This study tested whether adding Kinesio Taping (a special elastic tape) to posture correction exercises helps university students with tension-type headaches. Fifty-two students aged 18-25 were split into two groups: one did posture exercises alone, the other added Kinesio Tapin…

This study tested a new program called Mindful Action for Pain (MAP) in 126 veterans with chronic pain. MAP combines mindfulness meditation with techniques from acceptance and commitment therapy to help people better manage pain and improve daily function. The goal was to see if …

This study tested whether combining posture correction exercises with a gentle neck mobilization technique called SNAGs could reduce migraine severity, disability, and improve quality of life. Forty-four adults with episodic migraine participated. The approach is non-drug and foc…

This study tested an experimental drug called LX9211 in 79 adults with postherpetic neuralgia, a type of nerve pain that can last for months after a shingles rash heals. The goal was to see if the drug reduces pain and helps with sleep compared to a placebo over 11 weeks. Partici…

This study tested a device called SinuSonic that combines sound vibrations with gentle pressure to help people with Eustachian tube dysfunction (ETD) and facial pain. Thirty adults used the device twice a day for six weeks. Researchers measured changes in symptoms like ear pressu…

This study looked at whether adding a muscle relaxation technique (integrated neuromuscular inhibition) to a standard set of strengthening exercises (McGill program) helps people with piriformis syndrome more than the exercises alone. Fifty-six adults with chronic buttock pain fr…

This study compared two types of needle therapy—pharmacopuncture (injecting herbal extracts) and standard acupuncture—for people with chronic neck pain lasting over three months. A total of 128 adults took part, and the main goal was to see which approach reduced pain more after …

This pilot study tested a small device that stimulates nerves in the ear to help people with cyclic vomiting syndrome, a condition causing repeated bouts of severe nausea and vomiting. Forty-seven children and adults used the device either during an episode or daily for six weeks…

This study tested whether injecting lidocaine plus platelet-rich plasma into a nerve cluster in the neck works better than lidocaine alone for chronic migraine. 200 adults with frequent migraines took part. The main goal was to see if the combo reduced monthly headache days more …

This study tested whether adding acceptance and commitment therapy (ACT) to standard migraine treatment could reduce monthly headache days in people with high-frequency episodic migraine (9-14 headache days per month). Sixty-four adults were randomly assigned to either standard c…

This study tested an 8-week online mindfulness-based stress reduction program in 94 adults with fibromyalgia. Participants were randomly assigned to the online program or usual care. The goal was to see if the program could reduce pain catastrophizing and improve daily function.

This study tested a device called Mi-Helper that cools the inside of the nose to treat migraine headaches at home. 156 adults with migraines used either the real device or a fake one. The goal was to see if the device could safely relieve pain and other bothersome symptoms within…

This study tested a self-management program for jaw muscle pain in 107 adults with fibromyalgia. The program included online sessions on pain education, jaw exercises, and self-massage. Researchers measured changes in quality of life, pain, and fear of movement over 12 months. Th…

This study tested whether different types of sounds (natural, city, broadband, or silence) can help improve mood, stress, and anxiety in people with fibromyalgia. 72 adults with fibromyalgia listened to each sound for 20 minutes during four weekly visits. Researchers measured cha…

This study looked at how well the migraine medication Rimegepant works in real-world settings. Researchers followed 173 adults with migraines who took the drug as needed for acute attacks or long-term prevention. Participants recorded pain levels at several time points after dosi…

This study looked at how intravenous lidocaine affects sleep and quality of life in 51 people with fibromyalgia who still had pain and sleep problems despite other treatments. Researchers measured pain, sleep quality, and overall impact of the condition. The goal was to see if th…

This study looked at whether giving children with migraine an IV of salt water (a common fluid) in the emergency room can help reduce their headache pain. 46 children took part. The goal was to see if the fluid alone, without any other medicine, could make them feel better.

This study looked at whether an 8-week foot exercise program could help people with fibromyalgia who have foot pain. 27 adults with fibromyalgia took part. The program focused on strengthening the small muscles in the feet. Researchers measured changes in foot pain, function, and…

This study tested a drug that blocks a pain-signaling protein (CGRP) in 26 adults with trigeminal or glossopharyngeal nerve pain caused by small fiber neuropathy or fibromyalgia. The goal was to see if it reduces pain and the need for other pain medications, while checking for si…

This study tested a 12-week virtual program called RAMP that teaches mind-body skills to help rural veterans manage chronic pain. Forty veterans participated in weekly group sessions and coaching via video. The goal was to see if the program is feasible and acceptable, not yet to…

This study tested a walking program for veterans with opioid use disorder and chronic pain. Sixty veterans receiving medication for opioid addiction took part. The program included pain education and a step-by-step walking plan using a pedometer. The goal was to see if this appro…

This study looked at whether a mobile cognitive behavioral therapy (CBT) program, combined with a gentle brain stimulation technique called tDCS, could help teens who survived bone cancer manage chronic pain. Researchers first adapted the program for Black and Hispanic teens, the…

This study tested a device that uses muscle sensors and a phone app to teach people how to relax tense muscles. It included 330 adults with chronic low back pain, recent breast surgery pain, or migraines. Half used the device plus usual care; the other half had only usual care. T…

This study looked at whether working with a care manager (patient navigator) and using an online pain coping program can help people with chronic pain improve how they manage their pain and daily activities. The study included 32 adults who had daily pain for at least 3 months an…

This study tested whether a virtual yoga program could help people with chronic pain. 94 participants with pain lasting over 6 months took part in 8 weeks of remote yoga classes and daily 30-minute video-guided practice. Researchers measured how feasible the program was and wheth…

This Phase 3 trial tested a single dose of AXS-07, a combination of meloxicam and rizatriptan, for treating migraines in adults. 302 participants took either the drug or a placebo at the first sign of migraine pain. The study measured how many were pain-free and free of their mos…

This completed pilot study tested whether a smartphone app teaching mindfulness could help people with fibromyalgia. Fifty-four adults used the app daily for pain tracking and weekly for mindfulness lessons, while a control group only tracked symptoms. The goal was to see if the …

This study tested whether wearing prism goggles during pointing exercises can reduce pain in people with Complex Regional Pain Syndrome (CRPS) type I. Fifty-four patients with CRPS after a wrist fracture or surgery were split into two groups: one used real prism goggles, the othe…

This study tested whether a 10-week mind-body walking program (GetActive-Fitbit) is feasible for adults with chronic musculoskeletal pain. 92 participants were randomly assigned to either the walking program or a health education group. The goal was to see if people would join, s…

This study tested whether low-level laser therapy, combined with a self-care program, could help people with jaw joint pain (TMJ disorders). 66 adults with recent jaw muscle pain received the treatment. Researchers measured pain levels, jaw movement, and tender spots to see if th…

This study tested a device called the Human Regenerator Jet, which emits cold atmospheric plasma, to see if it can improve quality of life in adults with chronic stress, fatigue, pain, or Long COVID. Forty participants received 10 sessions of either the plasma or plain air, and r…

This study tested a new program to help older adults manage chronic pain using educational podcasts and support from a community health worker. 40 people aged 50 and older with long-lasting pain took part. The program aimed to teach pain self-management skills and help participan…

This study looked at whether an antidepressant, physical therapy, or a combination of both can help people with chronic low back pain who also struggle with negative feelings. About 308 adults aged 18-75 with pain lasting over 6 months took part. The goal was to see if these trea…

This study tested two treatments for people with chronic neck pain that lasts at least 3 months. One group received a treatment called percutaneous neuromodulation, which uses tiny needles to stimulate nerves. The other group did only therapeutic exercises. The goal was to see wh…

This study tested whether adding home-based posture exercises to regular medication could improve pain and mobility in 55 adults with fibromyalgia. Participants did exercises at home while continuing their usual drugs. Researchers measured pain threshold, spinal flexibility, anxi…

This study tested two types of telehealth programs for people with chronic pain: an online self-guided program and live sessions led by a health coach via phone or video. Over 2,300 adults from four healthcare systems took part. The goal was to see if these programs could help re…

This study looked at how well and how safely lasmiditan works for treating migraine attacks. One hundred adults with migraine took lasmiditan tablets (50, 100, or 200 mg) when they had an attack. Researchers measured how many people were pain-free after 2 hours and tracked any si…

This study tested whether the drug erenumab can help prevent migraines in children (ages 6 to 12) and teenagers (ages 12 to 18) who have chronic migraines. About 284 participants received either the drug or a placebo. The main goal was to see if the drug reduced the number of mig…

This study tested a smartphone app designed to help people with fibromyalgia manage their condition. Researchers wanted to see if the app was easy to use and helpful. The study included 36 adults with fibromyalgia who used the app to track their symptoms and learn coping strategi…

This study tested a non-invasive device that sends mild electrical pulses to the ear to stimulate the vagus nerve, which helps control pain and stress. Thirty adults with fibromyalgia received either real or sham stimulation for 30 minutes daily, five days a week, over four weeks…

This study tested whether an ultrasound-guided nerve block injection (stellate ganglion block) could help people with fibromyalgia who still have symptoms despite taking duloxetine. 68 adults received either the active injection or a sham (fake) injection, and researchers measure…

This study tested two different modes of transcutaneous electrical nerve stimulation (TENS) to relieve chronic pelvic pain in 60 men who had prostate surgery. Participants received TENS sessions three times a week for three months. The goal was to see which mode works better for …

This pilot study tested an oral cannabinoid oil (CBD with a small amount of THC) in 51 adults with chronic pain. The goal was to see if it's practical to run a larger trial and to gather early data on pain relief and safety. Participants took the oil daily for up to 12 weeks, and…

This study tested whether a non-invasive brain stimulation method called tDCS can help relieve chronic pelvic pain in women with endometriosis. Thirty women who were already on hormone therapy and had daily pain scores above 4 out of 10 took part. They received multiple tDCS sess…

This study tested a non-drug approach to help people with phantom limb pain—pain felt in a missing limb. Twenty adults with arm or leg amputations learned to change their brain responses using real-time feedback. The goal was to retrain the brain to reduce pain and improve qualit…

This study tested if an app that teaches better sleep habits could help people with long-term pain and insomnia. 105 adults in a 4-week rehab program either got the app or standard care. The goal was to see if the app improved sleep quality more than rehab alone.

This study tested whether a non-invasive brain stimulation technique called tDCS can reduce pain in women with fibromyalgia. 100 women received either real or sham (fake) stimulation to see if the placebo effect plays a role. The goal is to find out who might benefit most from th…

This study tested whether adding a painless magnetic stimulation treatment to standard manual therapy (like massage and stretching) helps people with sciatica caused by a herniated disc. Forty adults were split into two groups: one got manual therapy alone, the other got manual t…

This study tested whether mirror therapy—a technique using visual feedback from a mirror to trick the brain—works better than routine physical therapy for people with Complex Regional Pain Syndrome (CRPS), a chronic pain condition often after injury. Fifty-two adults aged 40-65 w…

This pilot study tested a mindfulness-based cognitive therapy program, called Quiet Focus, in 12 older Black adults with chronic pain and mild depression. The goal was to see if the program is acceptable and helpful, and to gather information for a larger future study. Participan…

This study tested a procedure called endovascular plug embolization to treat chronic pelvic pain caused by Pelvic Congestion Syndrome (PCS), a condition where veins in the pelvis become enlarged and painful. 44 women with PCS took part. The procedure uses a small plug to block th…

This completed study tested whether botulinum toxin type-A injections relieve pain from myofascial pain syndrome better than a standard local anesthetic (prilocaine). Thirty-eight adults with long-term muscle pain were randomly assigned to receive either botulinum toxin or priloc…

This study tested whether taking a pill called tizanidine before spinal anesthesia (levobupivacaine) improves pain control during and after lower leg surgery. Sixty-four adults scheduled for elective leg surgery were randomly assigned to receive either the standard spinal injecti…

This completed study tested whether a non-invasive brain stimulation technique called tDCS can reduce pain and improve daily function in 100 women with fibromyalgia. Researchers also looked at how a person's tendency to respond to placebo might affect results. Participants receiv…

This study tested a web app called Rose that provides hypnosis audio recordings for people with chronic pain. 100 adults with chronic low back pain or other chronic pain used the app for 8 weeks. The researchers measured how often people used it, their satisfaction, and changes i…

This study tested whether injecting lidocaine into the GB20 acupoint (at the back of the neck) can reduce migraine attacks. Thirty adults with migraines received either weekly lidocaine injections for four weeks or daily propranolol pills. Researchers tracked headache frequency, …

This completed trial tested whether electroacupuncture (acupuncture with a mild electric current) can reduce pain in people with postherpetic neuralgia, a lingering nerve pain after shingles. 448 adults aged 45-75 with moderate-to-severe pain were randomly assigned to real or sha…

This study looked at whether teaching patients about pain before a planned hysterectomy (removal of the uterus) could help lower their anxiety, stress, and pain after surgery. 62 adults took part and received either standard care or extra education about pain. The goal was to see…

This study looked at whether 8 weeks of strength training could improve balance, muscle performance, and symptoms in 57 adults with fibromyalgia. Participants did 16 sessions of 50-minute strength exercises twice a week. Researchers measured balance, jumping ability, and upper bo…

This study tested whether a combination of nucleotides and B vitamins (Nucleo CMP and Neurorubine) could provide better and longer-lasting pain relief than the standard drug carbamazepine for people with trigeminal neuralgia, a severe facial pain condition. 38 adults with classic…

This study looked at a voluntary program to help people with chronic pain slowly lower their opioid medications. 51 adults who wanted to reduce their opioid dose worked with their doctor over 4 months using a personalized tapering plan and a self-help book. The main goal was to s…

This study tested a fractional carbon dioxide laser treatment for women with vaginal and urinary symptoms like dryness, burning, pain during sex, and incontinence. One hundred women received three laser sessions about six weeks apart. The main goal was to see if symptoms improved…

This study tested whether using smartphone surveys to map each person's unique pain patterns could help therapists choose the best treatment focus. Twelve adults with long-term pain answered questions six times a day for three weeks to create a personal 'pain network.' Therapists…

This study tested whether a monthly injection of fremanezumab can prevent chronic migraines in children aged 6 to 17. About 292 participants received either the drug or a placebo. The main goal was to see if the drug reduced the number of migraine days per month over 12 weeks. Th…

This study tested a digital program called 'Empowered Relief: On-Demand' to see if it could help people with chronic pain who misuse prescription opioids. 234 adults with chronic pain and opioid misuse were randomly assigned to either the digital pain relief program or a health e…

This study tested a non-invasive brain stimulation method called tDCS to see if it can reduce chronic nerve pain. Researchers compared real stimulation to a placebo in 24 healthy volunteers and patients with long-term nerve pain. The goal was to measure changes in pain levels and…

This completed study tested two types of telehealth cognitive behavioral therapy (CBT) in 48 veterans with chronic pain who also felt lonely. One therapy focused on loneliness, the other on coping with pain. Researchers measured changes in loneliness, social interactions, and pai…

This study tested whether a toolkit called Pain at Work (PAW) can help employees with chronic pain manage their symptoms and stay productive. Around 380 workers from different workplaces in England took part, with some using the toolkit plus support calls and others receiving usu…

This completed study tested whether repetitive transcranial magnetic stimulation (rTMS) can relieve pain, headaches, depression, and other symptoms in 204 veterans with Gulf War Illness. Participants received rTMS, a non-invasive brain stimulation, and reported changes in pain, m…

This study tested three types of non-invasive brain or spinal stimulation (tDCS, rTMS, and tsDCS) to see which best reduces pain in people with algoneurodystrophy, a chronic pain condition. 36 adults who had pain for over a year and didn't respond to drugs took part. The goal was…

This study tested whether adding a gentle brain stimulation technique called rTMS to standard exercise therapy could reduce pain in people with fibromyalgia. Forty-two adults with long-term pain took part, receiving either real or fake rTMS alongside exercise for 14 weeks. Resear…

This study tested surgery to treat Complex Regional Pain Syndrome (CRPS) in the upper limb. 74 adults with CRPS who had not improved with other treatments received either nerve decompression or correction of a specific structural problem. Pain levels were measured before surgery,…

This study looked at whether a targeted ultrasound-guided nerve block (SPSIPB) can reduce pain in people with postherpetic neuralgia, a chronic pain condition that can linger after shingles. Researchers reviewed records of 34 adults who received this injection and measured pain l…

This study tested a 4-week mental imagery training program in 34 adults (17 with chronic neck pain, 17 healthy). The training involved imagining neck movements to retrain the brain. Researchers measured pain, movement accuracy, fear of movement, and brain activity before and afte…

This study tested whether combining a gentle brain stimulation technique called tDCS with aerobic exercise could improve the body's natural pain control system in people with fibromyalgia. 116 adults with fibromyalgia received either active or sham tDCS along with exercise or a c…

This study tested two common treatments for carpal tunnel syndrome: over-the-counter ibuprofen pills and a nerve exercise called neural mobilization. 123 adults with carpal tunnel took part. The goal was to see if these treatments reduce pain and improve hand and arm function bet…

This study tested a T-shirt printed with ceramic particles that claim to use body heat to emit far infrared radiation, potentially reducing inflammation and muscle pain. Fifty adults with chronic neck or lower back pain wore the shirt for 8 hours. Researchers measured changes in …

This study looked at whether very low-level electrical stimulation of nerves near the spine can reduce chronic pain more than a sham (inactive) device. Twenty adults who already have a nerve stimulator implant took part. Each person received both the real low-level stimulation an…

This study tested whether Erickson hypnosis can reduce chronic pain in people with Parkinson's disease. 33 participants were split into two groups: one received weekly hypnosis sessions for 2 months, the other got usual care. The main goal was to see if pain intensity changed fro…

This early-stage study tested a new nasal spray called PRT-064040 in 80 healthy Chinese adults to see if it is safe and how the body processes it. Participants received either a single dose or seven daily doses of the spray or a placebo. The study does not yet test if the spray h…

This study tested whether manually mobilizing the sacroiliac joint (a joint in the lower back) can reduce tension and pain in the piriformis muscle, a deep hip muscle that often cramps. Researchers used physical therapy techniques on 40 adults with lower back or hip pain and musc…

This study tested a new drug called AXS-07, which combines meloxicam and rizatriptan, for treating migraine attacks in adults. The 100 participants had previously not gotten enough relief from oral CGRP inhibitors. The goal was to see if the drug could relieve headache pain and o…

This study tested whether a mindfulness-based group therapy program, originally developed in Canada, could work for French teenagers aged 12-17 with chronic pain. The main goal was to see if teens would attend at least 6 out of 8 sessions. Researchers also looked at effects on pa…

This pilot study tested a new behavioral treatment called Emotional Awareness and Expression Therapy (EAET) for people with migraines. Thirty adults with frequent migraines were randomly assigned to either EAET or a control group. The therapy involved 8 weekly online sessions whe…

This study tested whether Pilates or core stability exercises better ease fibromyalgia symptoms like pain and balance. Thirty women aged 35-65 with fibromyalgia took part. Researchers used objective tests (pain sensitivity, balance) instead of just questionnaires to compare the t…

This study tested two stretching techniques—Post-Isometric Relaxation and Post-Facilitation Stretching—in 36 adults with piriformis syndrome, a condition that causes buttock pain and limits hip movement. Participants did the exercises three times a week for four weeks. Researcher…

This early-phase study tested whether cannabidiol (CBD) could safely help people with both opioid use disorder and chronic pain. Seven adults on methadone or buprenorphine received single doses of CBD (400, 800, or 1200 mg) or a placebo in a crossover design. Researchers measured…

This study looked at whether kinesio taping (a special stretchy tape) plus dry needling (thin needles into tight muscle spots) can help people with shoulder-hand syndrome after a stroke. 84 patients were split into three groups: taping alone, needling alone, or both together, all…

This study tested different ways to help people on medication for opioid use disorder do more yoga to manage their chronic pain. 192 adults who had been in treatment for at least 3 months took part. The goal was to see which combination of support methods helped them practice yog…

This study looks at whether measuring the optic nerve sheath diameter—the lining around the nerve that connects the eye to the brain—using ultrasound can help doctors know if a treatment for spontaneous intracranial hypotension (a condition where low spinal fluid causes severe he…

This study aims to understand why people experience pain differently and whether the body's natural ability to manage pain can be improved through training, similar to athletic performance. Researchers will enroll 180 adults, including those with widespread muscle pain and those …

This study follows adults with migraine who have been prescribed rimegepant (a dissolving tablet) for acute attacks. Researchers want to see how consistently the drug provides meaningful pain relief across multiple attacks and how satisfied people are with it. The study also look…

This study tested whether doctors can use simple decision guides to better manage opioid misuse behaviors in patients on long-term opioid therapy for chronic pain. Researchers worked with 49 clinicians at community clinics to see if the guides were easy to use and helpful. The go…

This study looked at how three psychological treatments—cognitive therapy, mindfulness meditation, and behavioral activation—might help adults with chronic pain reduce their use of opioid medications. Researchers enrolled 91 people with chronic pain who were at risk of opioid mis…

This study tracked 582 children aged 6 to 18 who had surgery to see how many still had pain 3 months later. Researchers used a pain questionnaire to measure pain levels and identify risk factors. The goal was to better understand chronic post-operative pain in kids, not to test a…

This study looked at how acupuncture affects the brain in people with migraine without aura. Forty adults received either real acupuncture or a sham (fake) version, and their brains were scanned with MRI before and after treatment. The goal was to see if real acupuncture causes d…

This study looked at nearly 2,000 people from the community to understand how depression, anxiety, and migraine are passed down through families. Researchers interviewed family members of all ages, including children as young as 8, to track patterns of these conditions over time.…

This study looked at 20 people with hard-to-treat chronic cluster headache who were already receiving occipital nerve stimulation. Researchers used brain scans to see how the stimulation changes brain activity. The goal was to understand how the treatment works, not to test if it…

This study compared 80 women with and without fibromyalgia to measure muscle strength, muscle thickness, vitamin D levels, and sleep quality. Researchers used advanced tools like isokinetic dynamometers and ultrasound to find differences between the groups. The goal was to better…

This completed study looked at how often hospitalized patients with cirrhosis experience pain. Researchers asked 30 patients about their pain, its location, intensity, and whether it was chronic. The goal was to highlight an often-overlooked issue and encourage better pain care f…

This study looked for substances in the blood that could signal chronic pain after a spinal cord injury. Researchers compared blood samples from 120 people with and without pain, including those with recent and long-term injuries. The goal was to find early warning signs that cou…

This completed study aimed to find biological markers that could predict which migraine patients respond best to a new class of drugs called CGRP monoclonal antibodies. Researchers studied 243 adults with severe migraine, using genetic, brain imaging, and other tests. The goal is…

This study aimed to develop and test two new questionnaires for people with recurrent urinary tract infections (UTIs). The Recurrent UTI Symptom Scale measures symptom severity, while the Recurrent UTI Impact Questionnaire looks at how the condition affects daily life, work, and …

This study tested whether wearable devices can be used to monitor activity in older adults with chronic low back pain. 30 participants wore ankle sensors to track movement and reported on their pain and mobility. The goal was to see if this approach is practical and acceptable fo…

This study looked at 98 women who had a blood patch to treat severe headaches caused by an accidental spinal fluid leak during labor. Researchers wanted to see if certain factors during the blood patch procedure were linked to headaches that last 1 to 6 months. The goal is to bet…

This study follows 87 women who had chronic low back pain 13 years ago to see how their pain, daily activities, and ability to work have changed. Researchers are looking for patterns that might predict who will improve or worsen over time. The goal is to better understand the lon…

This study talked to 50 adults with long-term (non-cancer) pain and their healthcare providers to learn about their experiences managing pain in primary care. The goal was to use this information to create a decision aid tool that helps patients and doctors make informed choices …

This study tested a new way to treat chronic pain without surgery or drugs. Researchers used low-intensity focused ultrasound (sound waves) to temporarily change brain activity in 61 adults with chronic pain. Participants had brain scans and then received mild heat pulses on thei…

This completed registry study followed 120 migraine patients in the Guangdong-Hong Kong-Macao Greater Bay Area who were prescribed rimegepant by their doctors. The goal was to see how the drug affects their quality of life, daily functioning, work productivity, and overall satisf…

This study tested a Portuguese version of the DIVA questionnaire to see if it reliably measures how vaginal aging symptoms (like dryness, itching, or pain) affect daily activities, sex life, emotions, and body image. 300 women with at least one symptom of vulvovaginal atrophy too…

This study looked at 202 Polish adults with chronic low back pain to find out how severe their anxiety symptoms are. Participants filled out a questionnaire called GAD-7, which scores anxiety from none to severe. The goal was simply to measure the problem, not to test any treatme…

This study tested whether offering tai chi classes online is a practical way to help veterans with PTSD and chronic pain. Researchers worked with 42 veterans to see if they would attend sessions and find the program satisfactory. The goal was to gather information needed to desig…

This study looked at symptoms children experience after a migraine attack (called the postdrome phase). Researchers asked 45 children with migraine about their symptoms and how they differ by age and gender. The goal was to better understand this often-overlooked phase of migrain…

This study gathered information from 73 adults with chronic pain who were already using or planning to use an approved medical device (like a spinal cord stimulator) for their pain. Researchers asked participants to report their pain levels on a 0-10 scale and other outcomes duri…

This completed study looked at 393 adults aged 65 and older with chronic pain to see how frailty relates to the type and location of pain, as well as nutritional risk. Researchers measured frailty using standard criteria and assessed pain intensity and type. The goal is to help d…

This study tested whether adding an AI-generated summary to brain MRI reports helps people understand the results. Over 2700 adults read six fictional reports and answered questions about what they found. The goal was to see if the simple summary improved understanding compared t…

This study looked at whether the weekly performance of a favorite NFL team affects chronic pain in avid football fans. Thirty-two adults with chronic pain completed weekly surveys during the football season, rating their pain, mood, and pain-related thoughts. The goal was to see …

This pilot study tested a program called STEPPT to see if it could reduce ethnic disparities in physical therapy referrals and attendance for spine pain. The program included educating clinic staff, updating electronic health records to automate referrals, and providing patient n…

This study looked at how osteopathic manual therapy (OMT) changes the brain in people with migraines, tension, or cluster headaches. Researchers used MRI scans to see if OMT affects brain structure and activity. The goal was to understand how OMT reduces pain and disability, not …

This study tested a school program called SocLaLola that uses a comic book to teach children aged 8-11 about pain. The goal was to see if it improves kids' understanding of pain and reduces their fear of moving. Eighty-two students from two primary schools took part. The program …

This study tested whether wearable devices like the Apple Watch and Oura Ring, along with digital surveys, can predict outcomes for chronic pain patients receiving spinal cord stimulation. Twenty-eight adults with long-term pain were implanted with Abbott's spinal cord stimulator…

This study looked at 24 people with Complex Regional Pain Syndrome (CRPS) type I in their legs who already use a device that stimulates nerves near the spine (dorsal root ganglion stimulation) to control pain. Researchers used special wearable sensors to track things like heart r…

This completed pilot study looked at how lifestyle factors like diet, physical activity, sleep, stress, smoking, and alcohol use relate to pain sensitivity in 20 women with fibromyalgia. Participants wore a Fitbit, logged food, completed questionnaires, and had pain sensitivity t…

This early-stage study tested a single inhaled dose of prochlorperazine in 54 healthy adults to see if it is safe and how the body processes it. The goal was to gather information for future migraine treatments. No treatment benefit was measured, as participants were healthy volu…

This study looked at how pain influences opioid cravings in 89 adults with opioid use disorder and chronic pain. Participants attended a brief education session and then had their pain response and cravings measured. The goal was to better understand the connection between pain a…

This study used ultrasound to measure the thickness of certain hip muscles in 60 adults with hip pain on one side (Greater Trochanteric Pain Syndrome) and compared them to healthy people. The goal was to see if muscle thickness differs between the groups and to check for related …

This study looked at 56 women with endometriosis to see if severe pain during sex is linked to a condition called central sensitization, where the nervous system becomes overly sensitive to pain. Researchers used pain-pressure tests and daily surveys over 6 weeks to measure pain …

This study looked at how migraine patients and healthcare providers in Thailand experience eptinezumab, a preventive migraine infusion given every 3 months. Researchers interviewed 30 participants to find out what makes it easier or harder to use this treatment in a real-world ho…

This study looked at whether levels of certain minerals (like selenium, magnesium, and zinc) in the blood are different in women with fibromyalgia compared to healthy women. It also checked if those mineral levels are linked to how severe the disease is, or to anxiety and depress…

This completed study examined whether fibromyalgia, a condition causing widespread pain, is linked to changes in eye blood vessels. Researchers compared 80 people with and without fibromyalgia using eye scans and symptom questionnaires. The goal was to see if nerve system problem…

This study used a special ultrasound technique to measure stiffness in pelvic floor muscles of 94 women — some healthy and some with pudendal neuralgia, a chronic nerve pain condition. Researchers compared the muscle stiffness between the two groups to see if differences exist. T…

This study looked at how having fibromyalgia changes body measurements and sleep patterns in people with obstructive sleep apnea. Researchers measured neck, waist, and hip sizes, and used sleep tests and ultrasound to compare 77 participants. The goal was to better understand the…

This study looked at 264 people with chronic lower back and leg pain caused by a pinched nerve. Researchers wanted to see if routine blood test results could predict who would get good pain relief from a combination of two treatments: a nerve block and a short electrical pulse to…

This study looked at how to better diagnose chronic pain in 100 torture survivors. Researchers tested a simple pain questionnaire to see if it could find pain that standard methods miss. They also interviewed survivors about pain treatments and tested whether a digital program co…

This study looked at 65 people with fibromyalgia to figure out what kind of pain they have—nerve pain, tissue pain, or a mixed type. Researchers used a special checklist and simple tests like brushing the skin or pressing with a tool. The goal is to help doctors choose better tre…

This study looked at how spinal cord stimulation (SCS) affects pain processing in 34 people with chronic pain. Participants already had an SCS device as part of their care. Researchers tested different stimulation patterns (burst, kHz, tonic, and sham) to see how they changed the…

This study looked at whether people with fibromyalgia have early, hidden changes in heart function. Researchers used a special ultrasound technique called Global Longitudinal Strain (GLS) to measure heart muscle movement in 59 fibromyalgia patients and 59 healthy volunteers. The …

This completed study looked at 204 patients who had a kidney removed (nephrectomy) to find out what factors might lead to chronic pain lasting months or years after surgery. Researchers measured pain levels at 1 hour, 3 months, and 1 year after the operation using a simple 0-to-1…

This study looked at how galcanezumab, a newer migraine prevention drug, affects the brain. Researchers used MRI scans to see if the drug changes brain structure in people with chronic migraine. The goal was to learn more about where the drug works, not to test if it helps sympto…

This study looked at whether genetic testing can help doctors choose better medicines for depression, acute pain, and chronic pain. Over 4,000 people were screened to join one of three trials. The goal was to see if matching drugs to a person's genes improves outcomes compared to…

This study looked at 420 people aged 80 and older to find out how many have fibromyalgia, a condition that causes widespread pain and fatigue. Researchers used standard medical criteria to diagnose fibromyalgia and also checked participants' memory, thinking, and overall health. …

This study tested an online tool designed to help doctors decide which patients with chronic pain are good candidates for spinal cord stimulation. About 80 adults with conditions like failed back surgery syndrome or complex regional pain syndrome took part. The tool's recommendat…

This study tested a French version of a questionnaire that measures how people with chronic pain think about their condition. Researchers compared it to another questionnaire about pain self-confidence. The goal was to see if the new scale adds useful information beyond existing …

This study looked at 77 adults with long-term nerve pain after shingles (postherpetic neuralgia) to see if a spinal nerve stimulation device works better for certain types of pain. Researchers grouped patients by their pain features and measured pain levels, quality of life, and …

This study looked at 158 adults to find out if certain traits or risk factors can predict who will develop chronic pain after lower back surgery. Researchers measured pain severity, disability, and other health factors using questionnaires. The goal was to better understand why s…

This study created a questionnaire to measure health beliefs in people with vestibular migraine, a condition causing dizziness and imbalance. 213 patients completed the scale and received a single educational session about their condition. The goal was to see if the scale is reli…

This study looked at 84 adults with chronic neck pain to see how central sensitization (a condition where the nervous system becomes overly sensitive) relates to pain intensity, thinking patterns, sleep quality, and jaw function. Researchers used questionnaires to measure these f…

This small study looked at how occipital nerve stimulation (ONS) changes the way people with chronic migraine or cluster headache feel pain. Researchers used special tests and questionnaires to measure pain markers before and after ONS, and compared results to people having non-p…

This study used ultrasound to measure the thickness of the piriformis muscle and sciatic nerve in 19 people with piriformis syndrome, comparing the painful side to the pain-free side. The goal was to see if ultrasound can help tell whether the pain comes more from muscle or nerve…

This completed study looked at how psychological resilience and body image relate to pain in people with rheumatoid arthritis or fibromyalgia, compared to healthy volunteers. Researchers measured these factors using questionnaires in 124 adults. The goal was to better understand …

This study looks at people who still have chronic back or leg pain after back surgery, a condition called Failed Back Surgery Syndrome (FBSS). Researchers want to better understand what causes this pain and how to diagnose it faster. They will collect detailed information from 20…

This completed study looked at 128 women to see if those with fibromyalgia also have more chronic pelvic pain and pelvic floor problems. Researchers used pain questionnaires to compare the two groups. The goal was to better understand how these conditions might be related, not to…

This study looked at whether a 12-week walking program could change brain structure in 22 overweight adults who also had headaches. Participants either followed a diet plus walking or diet alone. Researchers measured brain gray and white matter volumes with MRI scans before and a…

This study surveyed 803 people diagnosed with New Daily Persistent Headache (NDPH) to learn about their headache patterns and what treatments they have tried. The goal was to gather information on this poorly understood condition. The survey is now complete, and the results may h…

This study looked at whether gradually lowering opioid doses over time affects pain, quality of life, and mood in people with chronic non-cancer pain. 18 adults on stable opioid therapy were followed to compare slow tapering versus staying on their current dose. The goal was to s…

This study surveyed 2,487 people diagnosed with cluster headache about how well their current treatments work and what they think about new treatment options. Participants filled out a single online questionnaire. The goal was to gather patient views, not to test any new drug or …

This study used special brain scans to look for signs of inflammation in the brains and spinal cords of 60 people with chronic low back pain. Researchers also tested whether a short course of the antibiotic minocycline could reduce both inflammation and pain. The goal was to bett…

This study looked at 150 patients who had surgery for trigeminal neuralgia, a condition causing severe facial pain. Surgeons used a Teflon implant to cushion a blood vessel pressing on a nerve. The study compared two ways of placing the Teflon—either directly against the nerve or…

This study looked at health records of nearly 69,000 adults aged 40 and older to see if those who develop lasting nerve pain after shingles (postherpetic neuralgia) have a higher chance of getting dementia later. Researchers compared people with and without this nerve pain, match…

This study looked at 39 people having lower back surgery for a herniated disc or spinal stenosis. Researchers checked for nerve pain before surgery and again 1, 3, 6, and 12 months after using a simple questionnaire. The goal was to see how common nerve pain is after surgery and …

This completed study looked at blood samples from 66 women to find differences in small molecules (metabolites) between those with fibromyalgia, those with both fibromyalgia and possible sarcopenia (muscle loss), and healthy women. The goal was to identify potential biomarkers th…

This study tested whether a small device that collects blood from the arm (instead of a needle in the vein) works as well for measuring levels of the drug zavegepant. Fourteen healthy adults took the nasal spray and gave blood samples using both methods. The goal was to see if th…

This completed study from Turkey examined vitamin B12 and folic acid levels in 104 fibromyalgia patients before and after they started antiepileptic treatment. Researchers wanted to see if these drugs, already known to lower B12 and folate in epilepsy patients, have the same effe…

This study reviewed medical records of 60 adults who had radiofrequency treatment for intercostal neuralgia, a type of nerve pain in the chest wall. The goal was to find out which patient or clinical factors are linked to better pain relief after the procedure. Researchers measur…

This study tested a seven-session pain school program for 82 adults with chronic non-cancer pain. The program included teaching, group discussions, and exercises led by a team of pain specialists. The goal was to see if patients found the program helpful and relevant to their nee…

This completed study looked at survey responses from over 1,300 people with migraine in the U.S. to compare those taking rimegepant (Nurtec) with those taking triptans. Researchers examined treatment satisfaction, quality of life, work productivity, and disability. The goal was t…

This study explored whether adding mindfulness training to physical therapy is practical for people with long-term muscle and joint pain who also take opioid painkillers. Researchers developed a training manual for physical therapists and tested different ways to teach them mindf…

This study reviewed records of 201 adults who received a common back pain injection (transforaminal epidural steroid injection) to see if using sedation made a difference. Researchers compared patient satisfaction, pain scores, radiation exposure, and complication rates between t…

This completed study looked at 164 women with and without fibromyalgia to see if certain autoantibodies are linked to more severe symptoms. Researchers compared patients with high and low antibody levels, and healthy controls, using questionnaires, blood tests, skin biopsies, and…

This study looked at whether ivabradine, a medicine used for heart conditions, could stop migraines triggered by another drug called levcromakalim. 37 adults with migraine without aura took part. The goal was to see if ivabradine could reduce the number of migraines caused by the…

This observational study looked at 210 people with migraine or tension-type headache to see if a strong dislike of smells (osmophobia) is a reliable sign of migraine. Participants tracked their headaches and smell sensitivity for six months using diaries and questionnaires. The g…

This study aimed to uncover what factors most affect functional capacity—like walking, standing, and daily tasks—in people with fibromyalgia. Researchers assessed 42 adults using physical tests, pain and fatigue scales, posture analysis, sleep quality, and psychological questionn…

This completed study from the University of Valencia looked at 133 adults with chronic pain to see if jaw (temporomandibular) pain is linked to pelvic pain. Participants filled out questionnaires about their pain, emotions, and sensitivity. The goal was to understand why these pa…

This study looked at whether the type of anesthesia used during hernia surgery affects pain levels afterward. Ten men having hernia repair were randomly assigned to receive either intravenous propofol or inhaled sevoflurane. Researchers measured pain right after surgery and over …

This completed study of 292 women looked at tailbone pain (coccydynia) after childbirth. Researchers used the Paris Questionnaire to measure pain and compared it with quality-of-life and functional scores. The goal was to see if this simple questionnaire could help doctors better…

This completed study compared 72 adults with cervicogenic headache (headache from the neck) to healthy volunteers. Researchers used questionnaires to measure central sensitization (overactive pain signaling) and neuropathic pain (nerve pain). The goal was to see if these pain mec…

This study looked at whether a balance test called the Mini-BESTest is a reliable tool for people with long-term pain. Researchers tested 73 adults with chronic non-cancer pain and also interviewed some about their balance experiences. The goal was to understand how well the test…

This study tested whether an AI-powered voice chatbot is better than a traditional paper diary for tracking migraines in Hong Kong women. 49 women used both methods for one month each. The goal was to see which tool was more accurate, complete, and easy to use. The chatbot aims t…

This study followed 2,365 adults from urban areas of Chile for 12 months to learn more about chronic pain and its effects. Researchers looked at how chronic pain relates to mental health issues like depression and anxiety, as well as work stress and daily functioning. The goal wa…

This study looked at how many women with fibromyalgia at a pain clinic might have iron deficiency. 81 women completed a questionnaire about symptoms like heavy periods and past iron issues. The goal was to see if iron deficiency is common and if treating it could help their pain.

This study looked at 65 women with deep infiltrating endometriosis to see if the number of nerve fibers in their lesions is linked to how much pain they feel. Researchers measured nerve density in surgically removed tissue and compared it to pain scores reported by patients. The …

This study looked at 151 adults with shingles to find clues that might predict who will develop lasting nerve pain (postherpetic neuralgia). Researchers collected blood samples and health information at the start and checked for pain three months later. The goal was to create a r…

This study looked at 116 adults with non-specific neck pain to understand how it relates to jaw joint problems and migraines. Researchers measured pain, disability, and quality of life using questionnaires. The goal was to uncover connections that could help design better, more p…

This study looked at how a special exercise approach called BETY affects people with rheumatic diseases (like arthritis) who have chronic pain. Researchers reviewed past records of 300 participants to see if BETY improved their physical function, mood, and quality of life compare…

This completed study compared how well people with complex regional pain syndrome (CRPS), people with other muscle or bone pain, and healthy individuals can imagine movements. Researchers used a questionnaire called the MIQ-RS to measure motor imagery skills. The goal was to see …

This study looked at whether measuring a protein called S100B in the blood can help emergency doctors tell the difference between primary headaches (like migraines) and secondary headaches (caused by something serious like a bleed or infection). Researchers enrolled 81 adults wit…

This study looked at 173 adults with fibromyalgia to see if doomscrolling—constantly reading negative news online—and social media addiction are linked to worse symptoms. Participants completed surveys about their social media habits, fear of missing out, and fibromyalgia-related…

This study looked at how headaches impact sleep, pain sensitivity, and emotional well-being in 132 adults aged 18-65. Researchers measured sleep quality, central sensitization (a heightened pain state), and levels of depression, anxiety, and stress using standard questionnaires. …