Neurological pain disorder

This study looked at whether fremanezumab (Ajovy), an FDA-approved monthly injection for migraine prevention, could also improve sleep in people with migraines. Researchers planned to track 22 participants over 4 months, comparing their migraine days and sleep quality before and …

This study tested a drug called SPN-538 to prevent migraines in children aged 6 to 11. The trial was a randomized, double-blind, placebo-controlled study, meaning some children got the drug and some got a placebo. However, the study was terminated early and only enrolled 26 parti…

This study tested whether BOTOX injections can prevent migraine attacks in adults who have 6 to 14 migraine days per month (episodic migraine). About 775 participants received either BOTOX or placebo injections into their muscles twice, 12 weeks apart. The main goal was to see if…

This study tested whether osteopathic care (hands-on manipulation) can help reduce pain in people with fibromyalgia. 32 participants received osteopathic treatments over 8 months, with a follow-up 3 months later. The goal was to see if this approach could improve pain and quality…

This study compares two treatments for transformed migraine (chronic daily headache): a sphenopalatine ganglion nerve block using lidocaine gel applied inside the nose, versus daily oral amitriptyline (Elavil), an antidepressant often used for migraine prevention. Ten adults aged…

This study tested the migraine drug lasmiditan in children aged 6 to 17 who have migraines. The goal was to see if it is safe and works for quick relief. The trial was stopped early, so the results are limited.

This study tested whether adding pregabalin (Lyrica) to standard treatment could reduce pain and improve function in people with complex regional pain syndrome (CRPS) of the upper limb. Only 14 adults were enrolled before the trial was stopped early. The goal was to see if the dr…

This study tested whether a six-week course of yoga, mindfulness, and breathing exercises could help people with chronic pain feel better and manage stress. Only 5 patients took part before the trial was stopped early. Because it was so small, we cannot say whether these techniqu…

This study tested whether closing a small hole in the heart (called a PFO) with a device could reduce migraine headaches. It planned to compare the real procedure to a sham (fake) procedure in adults aged 18-55 with frequent migraines. However, the study was stopped early after e…

This early-stage trial tested the safety and how the body processes Kindolor Tosylate, a potential new drug for chronic pain. It involved 16 healthy adults who received either the drug or a placebo. The study was terminated, so full results are not available.

This study looked at whether buprenorphine can effectively treat chronic pain in people who are dependent on opioid painkillers, while also reducing withdrawal symptoms and improving quality of life. It involved 4 adults with opioid dependence and chronic pain. The approach was t…

This study tested a new method for starting buprenorphine (a medication for opioid use disorder) in hospitalized adults who also have chronic pain. Instead of requiring patients to stop all other opioids and go through withdrawal first, the new method starts with very low doses o…

This study looked at whether a brief, noninvasive brain stimulation technique called tDCS could immediately reduce pain and improve function in people with fibromyalgia or chronic fatigue syndrome. About 20 participants received one session, and researchers measured changes in pa…

This study looked at two FDA-approved migraine medications (a dissolving tablet and a nasal spray) given to adults in the emergency department. The goal was to see if these easy-to-use options could relieve pain quickly and shorten ER visits. The study was stopped early with only…

This study looked at whether adding guanfacine to opioid painkillers could reverse the extra pain sensitivity that long-term opioid use can cause. It involved 8 adults with chronic neck or back pain who were already taking opioids. The study was terminated early, so results are l…

This study looked at whether adding guanfacine (a blood pressure medicine) to morphine could reduce pain sensitivity and tolerance in people with chronic neck or back pain. The study planned to enroll 137 adults who had not taken opioids recently. However, the study was terminate…

This study aimed to see if a personalized physical activity program, with one face-to-face session followed by phone coaching, could improve quality of life for people with fibromyalgia compared to standard group exercise classes. The trial was terminated after enrolling only one…

This study tested a device called Exablate, which uses focused sound waves to treat areas of the brain linked to pain. The goal was to see if it could reduce pain and improve quality of life in people with chronic nerve pain. Only 2 people enrolled before the study was stopped, s…

This study aimed to see if lasmiditan, a migraine medicine, is safe and works for children aged 6 to 17. It planned to treat migraine attacks and measure pain relief. The trial was stopped early, so final results are limited, but it may still provide useful information about trea…

This study looked at whether a group therapy program combining psychotherapy and physiotherapy could help women with long-lasting pelvic or belly pain. Only 8 women took part, and the study was stopped early. Researchers measured changes in pain impact, daily activities, and emot…

This study tested whether a digital home exercise program (SimpleTherapy) could work as well as standard in-person physical therapy for people with chronic knee osteoarthritis pain. The plan was to have 32 adults with knee pain do exercises at home three times a week for six week…

This study tested whether a nasal spray version of the migraine drug Ketorolac, combined with oral Prochlorperazine and Diphenhydramine, could relieve migraine pain in children as effectively as the standard IV treatment. The trial aimed to enroll children aged 4 and older with m…

This study tested an experimental drug called K-645 for people having a migraine attack. It aimed to see if the drug could stop pain and other bothersome symptoms better than a placebo. The trial was stopped early, so results are limited. About 134 adults with a history of migrai…

This study tested an experimental drug called GSK3858279 in 147 adults with chronic nerve pain from diabetes. The goal was to see if it could reduce pain better than a placebo. However, the trial was terminated early, so we have less information than planned.

This study looked at a new type of spinal cord stimulation called burst stimulation (Burst-SCS) to see how it reduces chronic pain. It included 12 people with long-term pain, mostly from failed back surgery. The trial was terminated early, so the findings are limited and not conc…

This study tested a wearable armband called Nerivio that uses mild electrical pulses to reduce pain from Botox injections in people with chronic migraine. About 80 participants were planned, but the study was stopped early. The goal was to see if the device could make the injecti…

This study looked at whether a common painkiller (diclofenac potassium) works as well as a newer migraine drug (rimegepant) for stopping migraine pain within 2 hours. About 300 adults with migraine took one of the two medicines during a single attack. The goal was to see if both …

This study tested a device called SinuSonic that uses sound vibrations and pressure to relieve sinus headache pain. The trial included 27 adults with facial pain lasting more than 3 months. Participants used either the real device or a sham device that looked the same but didn't …

This study followed 98 people with chronic migraine who used a device that delivers gentle oscillations inside the nose. The goal was to see if regular use could cut down on severe headache days. The trial was terminated early, so the full results are not available, but the appro…

This study tested whether adding clorazepate (a sedative) to standard migraine medications could provide faster pain relief for people having a migraine attack in the emergency room. The trial included 323 adults with moderate to severe migraine. However, the study was terminated…

This study looked at whether people with chronic pain who tend to catastrophize (imagine the worst) about their pain experience stronger cravings for prescription opioids. Researchers measured cravings, stress hormones, and mood in 93 adults who had been taking opioids for at lea…

This study looked at whether follow-up calls from a headache nurse could help patients with migraines, tension headaches, cluster headaches, or hemicrania continua stay on their preventive medication. 147 participants were randomly assigned to receive nurse calls at 2 and 6 weeks…

This study looked at a type of spinal cord stimulation (SCS) that doesn't cause tingling, called paresthesia-free SCS, in 10 adults with chronic pain. Researchers wanted to see how well it works and how it affects pain perception. The study was terminated early, so the findings a…

This study looked at using a mobile app to collect feedback from 91 adults with chronic pain who were already receiving spinal cord stimulation (SCS) therapy. The goal was to see how well the app worked for gathering information on their pain and overall improvement. The study di…

This study aimed to find out how many people experience short-term and long-term pain after a specific type of heart surgery called one-stage hybrid arrhythmia ablation. Researchers surveyed patients who had the procedure at UZ Brussels to see what factors, like medications or ge…

This study followed 37 migraine patients in the Gulf region who had just started taking erenumab. Researchers measured how satisfied patients were with the treatment over 12 weeks using a questionnaire. The study was observational, meaning patients received their normal care, and…

This study tested a new 3D scanning device that aims to help surgeons match a patient's spine bones to their MRI or CT scans during surgery. The goal was to see if the scanner could accurately and consistently map the spine to improve surgical precision. Only one person took part…