Neurological pain disorder

This study looks at how well the migraine prevention drug atogepant works in real-world settings. Over 1000 adults with migraine who are already prescribed atogepant will be followed for 2 years. Researchers will measure how much patients feel their migraines have improved since …

This study looks at whether giving people with PTSD a personalized mix of gut bacteria (called pharmabiotics) can help their mental health. The researchers will track changes in PTSD symptoms, anxiety, depression, and thinking skills over 14 days. The goal is to see if fixing the…

This study tests a new way of managing chronic pain by improving teamwork between pain clinics, GPs, and other services. About 386 adults referred to pain clinics in Norway will either get this new pathway or standard care. The goal is to see if better coordination and a clear 6-…

This study planned to compare two methods of delivering a platelet-rich plasma patch to treat headaches caused by low spinal fluid pressure. The trial was withdrawn before any participants were enrolled, so no data was collected. The goal was to see if a simpler blind approach co…

This study tests whether Dysport injections can prevent chronic migraines in adults. Chronic migraine means having at least 15 headache days per month, with 8 being migraines. Participants receive injections into head, neck, and shoulder muscles every 12 weeks for up to 60 weeks.…

This trial tests a nasal spray called MIG-SPRAY for preventing migraines in 45 adults aged 18-55. The spray forms a protective film inside the nose to possibly stop migraine triggers. Participants use it three times daily for three months, and researchers track side effects and m…

This study tests whether galcanezumab, a monthly injection, can prevent chronic migraine in 312 adolescents aged 12 to 17. Participants receive either the drug or a placebo for 3 months. The main goal is to see if the drug reduces the number of migraine days per month.

This study compares two treatments for chronic migraine: a nerve block and a radiofrequency procedure. Researchers will measure blood levels of migraine-related proteins (CGRP and PACAP38) before and one month after treatment. The goal is to see which procedure works better and w…

This study aimed to test a closed-loop spinal cord stimulation device to reduce spasticity and pain in people who had a stroke or brain injury. It was designed for adults with chronic neuropathic pain and spasticity lasting more than three months. However, the trial was withdrawn…

This study compares two telemedicine approaches for people with chronic pain and opioid misuse. One program provides standard medication management via remote visits, while the other adds a 12-week self-help program with phone-based coaching. The goal is to see which approach bet…

This study tests whether galcanezumab, a monthly injection, can prevent migraines in children and teens aged 6 to 17 with episodic migraine. Over 500 participants received either the drug or a placebo for 3 months. The goal is to see if the drug reduces the number of migraine day…

This study is tracking 500 Italian adults with migraine to see how well the daily pill atogepant works in everyday life. Researchers will measure changes in monthly migraine days over a year. The goal is to find out if atogepant is a safe and effective preventive treatment for pe…

This phase 3 study tests whether erenumab (Aimovig), a monthly injection already approved for adults, can prevent migraines in children aged 6 to 17 with episodic migraine. About 457 participants receive either the drug or a placebo for 3 months. The main goal is to see if the dr…

This study tests a type of spinal cord stimulation that uses low-level electrical pulses (below the sensation threshold) against the best available medical treatments for people with ongoing back and leg pain after back surgery. About 114 participants will be randomly assigned to…

This observational study is testing whether measuring the nociceptive flexion reflex (a spinal reflex) can predict which patients with chronic back or neck pain will get significant pain relief from interventional procedures like epidural injections or nerve blocks. Researchers w…

This study uses a device that combines magnetic stimulation and brain wave recording (TMS-EEG) to find biological markers for chronic pain. Researchers will measure brain responses in 100 adults with chronic pain and see if these signals can help diagnose pain types and predict h…

This study tests a new medicine called atogepant to prevent migraines that happen around a woman's period. About 430 adult women with regular cycles and a history of migraines will take either atogepant or a placebo daily for 3 menstrual cycles. The goal is to see if the drug red…

This phase 3 study tests whether Dysport (a botulinum toxin type A) injections can prevent episodic migraine in adults. About 751 participants receive either Dysport or placebo injections every 12 weeks for up to 36 weeks. The goal is to see if the treatment reduces the number of…

This study tests whether desvenlafaxine, a drug typically used for depression, can help prevent migraines in adults who have frequent attacks. Researchers will compare the drug to a placebo in 440 participants over 12 weeks. The goal is to see if it reduces the number of migraine…

This study tests a small implanted device that sends mild electrical pulses to nerves to relieve chronic pain from injury or surgery. About 89 adults with long-lasting pain in the back, shoulder, knee, or foot will either get the implant plus usual care or usual care alone. The g…

This study tests whether adding monthly booster sessions to standard cognitive behavioral therapy (CBT) helps people with chronic pain manage their symptoms better over 18 months. About 716 military health system beneficiaries with chronic pain will receive either standard CBT or…

This study tests whether two non-invasive brain stimulation techniques—transcranial Direct Current Stimulation (tDCS) and Transcranial Ultrasound (TUS)—can reduce chronic pain in people with diabetic neuropathy. Participants, aged 40 to 80 with foot pain lasting at least 6 months…

This study tests a 9-week virtual group program that teaches mindfulness, yoga, nutrition, and self-massage to help people with chronic pain. It is being offered at Federally-Qualified Health Centers, which serve low-income patients. The goal is to see if the program can be succe…

This pilot study is testing whether yoga-based movements, done online or in person, can help people with chronic migraine or cluster headache. Twenty adults aged 18-65 will participate. The goal is to see if yoga improves headache frequency, sleep quality, and overall well-being …

This study tests whether atogepant, a drug already used to prevent migraines, can also treat migraine attacks quickly. About 1300 adults with a history of migraines will take either atogepant or a placebo when they have a migraine, and then report pain levels and symptoms after 2…

This study tests whether a directed massage technique works better than a classic symmetrical massage for people with long-term back or neck pain that hasn't improved with other treatments. Fifty adults aged 18 to 80 will receive both types of massage, and researchers will measur…

This study tests whether two devices, used one after the other, can reduce pain and disability from temporomandibular joint (TMJ) disorders. Adults aged 22 and older with TMJ pain will receive four treatment sessions and be followed for three months. Researchers will measure chan…

This study tests whether a pelvic floor massage technique (Thiele massage) can reduce pain during sex in women with chronic pelvic pain. It compares in-person treatment with guided self-massage at home via telehealth. The goal is to see if telehealth can be as effective as in-per…

This small early-phase trial tests whether a single oral dose of a hemp-derived CBD/CBD-A extract can reduce neuropathic pain and change brain activity in people with spinal cord injury. Six participants with moderate to severe nerve pain for at least three months will receive ei…

This study looks at whether pre-recorded yoga videos are as helpful as live online yoga classes for veterans with chronic pain. About 98 veterans will take part, first attending a 5-session primer, then practicing yoga for 12 weeks either on their own with videos or in a live VA …

This study tests whether a very low dose of naltrexone, a drug usually used for addiction, can reduce pain and other symptoms in people with Complex Regional Pain Syndrome (CRPS). Forty adults with CRPS will receive either the drug or a placebo for six months. The main goal is to…

This study tests a toolkit designed to help employees with chronic pain feel more confident managing their condition at work and stay productive. Over 600 workers from around 30 UK organizations will either use the toolkit or receive usual care. Researchers will measure work abil…

This study investigates whether foot massage using a roller can reduce nerve pain caused by chemotherapy in cancer patients. About 80 adults receiving certain chemotherapy drugs will either receive foot massage twice daily for three weeks or continue with routine care. The goal i…

This study looks at whether a 60-day nerve stimulation device placed near the back of the head can help people with stubborn headaches. Researchers will track pain levels, daily function, and how often participants need emergency care. About 300 adults with various headache types…

This study tests an 8-week program called PhYoMind, which blends physiotherapy, yoga postures, breathing exercises, and mindfulness, against home exercise alone in 40 adults with fibromyalgia. The goal is to see if the combined approach reduces disability, pain, fatigue, and stre…

This study tests a spinal cord stimulator that delivers fast-acting pain relief without the usual tingling sensation. About 177 adults with long-term back and limb pain will use the device. The main goal is to see if at least half of them get 50% or more pain reduction after 3 mo…

This study tests the long-term safety and effectiveness of an experimental drug called AXS-14 for people with fibromyalgia, a condition causing widespread pain and fatigue. About 300 adults who previously took part in a related study will receive AXS-14 for 52 weeks. Researchers …

This study tests whether a pain-relief gel (pregabalin) delivered through the skin using ultrasound can reduce pain and improve hand function in people with carpal tunnel syndrome. The treatment is given four times a week for a month, and compared to standard ultrasound therapy w…

This study tests whether giving Botox injections early can reduce nerve pain that occurs after chest surgery (thoracoscopy or thoracotomy). Participants have had daily nerve pain for three months. The trial compares Botox to a placebo to see if it lowers pain intensity and preven…

This study was designed to compare two types of nerve-blocking procedures for people with long-term knee pain from osteoarthritis. The goal was to see if targeting six nerves works better than the usual three nerves for reducing pain and improving daily function. The trial was wi…

This study tests whether a virtual program called Lin Health can improve daily life for people with fibromyalgia. Researchers at Mayo Clinic will follow 300 adults with fibromyalgia to see if online behavioral health support reduces symptoms and improves function. The goal is to …

This study tests a special nerve cap (Axoguard Large-Diameter Nerve Cap) in 15 adults who have had a limb injury or amputation. The cap is placed over the cut nerve end to protect it and may help reduce chronic nerve pain. The goal is to see if the cap is safe and works well befo…

This early-phase trial tests whether adding lacosamide, a drug normally used for seizures, can safely help people with chronic pancreatitis who still have abdominal pain despite taking opioids. The study involves 21 adults who will take lacosamide for 7 days alongside their usual…

This study tests Pain Reprocessing Therapy (PRT) for adults with chronic primary pain that may be due to a nociplastic pain mechanism. PRT includes education to reframe pain as a false alarm and specific techniques to reduce it. The trial involves 12 participants in Norwegian pri…

This Phase 3 trial tests whether a nurse-led phone program can help rural veterans better manage chronic pain. Over 600 participants will receive either the program or a one-time education session, and researchers will track pain interference for 12 months. The goal is to improve…

This study tests whether getting Chuna manual therapy every two weeks for 20 weeks helps people with mild but long-lasting neck pain feel better and have fewer flare-ups. 250 adults with neck pain for over a year will be split into two groups: one gets the hands-on therapy, the o…

This study looks at two different ways to manage pain after lower back surgery without relying on drugs. About 267 adults will be randomly assigned to either standard care or an enriched pain management plan. The goal is to see which approach better reduces pain and helps people …

This study is testing a spinal cord stimulator that automatically adjusts its electrical pulses based on real-time nerve signals. The goal is to see if this smart device can better guide treatment for people with long-term pain in the trunk or limbs. The trial involves 250 partic…

This study looks at whether a non-surgical treatment called spinal decompression can help people with chronic low back pain. About 42 adults with back pain from disc problems or sciatica will receive the treatment over 12 weeks. Researchers will use MRI scans and movement tests t…

This study compares two types of spinal cord stimulation—high frequency and burst—for treating chronic back and leg pain. Seven adults who are candidates for spinal cord stimulation will be randomly assigned to one waveform and tracked for at least 36 months. The goal is to see w…

This study tests a special spinal cord stimulator that automatically adjusts to your pain signals. It involves 70 adults with long-term pain in the back, arms, or legs. The goal is to see if the device safely reduces pain over time.

This study tests a small, battery-powered headband that delivers a gentle electrical pulse to the scalp to help reduce chronic pain in people with end-stage kidney disease who are on dialysis. About 125 adults will use the device at home and report their pain levels. The goal is …

This study aimed to see if a one-hour session of inhaled nitrous oxide (laughing gas) could reduce pain in people with fibromyalgia. It was designed for adults aged 18-75 with moderate to severe pain. However, the study was withdrawn before any participants were enrolled, so no r…

This study tests whether eptinezumab can reduce migraine days and improve quality of life in 164 adults who previously did not get enough relief from other CGRP-targeting migraine drugs. Participants receive the drug and report changes in migraine frequency and severity over time…

This study looks at whether taking vitamin D can reduce nerve pain caused by chemotherapy in people with low vitamin D levels. About 120 cancer patients will be split into two groups: one gets vitamin D supplements, the other gets standard care. The goal is to see if vitamin D he…

This study looks at whether a treatment called pulsed radiofrequency (PRF) on a nerve at the back of the head can help people with migraines. Researchers measured pain sensitivity and disability in 100 adults before and up to 3 months after the procedure. The goal is to see if th…

This study tests a 12-week Pain Self-Management (PSM) program for people with chronic pain and opioid misuse or opioid use disorder. Researchers want to see if the program helps participants manage pain better and stay in treatment for opioid use. About 204 adults from primary ca…

This study tests whether a group program called Partners4Pain, which teaches mind-body skills like meditation, relaxation, and gentle exercises, can reduce pain and improve daily life for people with chronic back or neck pain. About 376 adults will be randomly assigned to either …

This study tests whether two 90-minute pain science education sessions can help 54 adults with fibromyalgia living in rural Spain. The sessions aim to change how patients think about pain, using simple language and metaphors. Researchers will measure pain sensitivity, daily funct…

This study tests whether a brief behavioral class called Empowered Relief can reduce disability and symptoms in adults with chronic migraine. 300 participants will be randomly assigned to the class, a health education session, or usual care, all done remotely. The goal is to see …

This study tests a spinal cord stimulator (BurstDR) to relieve chronic pain from diabetic neuropathy. Twenty adults with long-lasting leg pain will try a temporary device for one week. If their pain drops by at least half, they can get a permanent implant. The study tracks pain l…

This study compares two minimally invasive procedures to treat chronic pelvic pain: laparoscopic presacral neurectomy and fluoroscopically guided nerve block. Sixty-two adults with pelvic cancer-related pain who still have significant pain despite standard treatment will be rando…

This study tests whether a type of pain education that teaches the brain's role in pain, combined with motivational interviewing, can reduce chronic pain in breast cancer survivors. 156 women who have finished primary treatment and still have pain will be randomly assigned to thi…

This study tests a treatment called Hypnosis Enhanced Cognitive Therapy (HYPCT) for people with new spinal cord injuries who are in rehab. It compares HYPCT to standard pain education to see if it can lower pain intensity and prevent chronic pain. Participants will attend four se…

This study looks at whether supervised physical activity helps people with fibromyalgia stay active longer than just getting advice. Fibromyalgia causes pain and fatigue, and inactivity can make symptoms worse. The study involves 330 adults who are currently sedentary. Researcher…

This pilot study tests whether a 7-week virtual lifestyle medicine program can help teens aged 14-18 with frequent migraines. Participants attend weekly group sessions covering sleep, nutrition, stress management, physical activity, and social connection. The main goal is to see …

This study tests whether walking with a robotic exoskeleton three times a week for 12 weeks can reduce nerve pain in people with spinal cord injury. Forty adults with traumatic spinal injury and persistent nerve pain will be randomly assigned to either robotic walking or a relaxa…

This study tests whether adding a non-invasive brain stimulation technique called rTMS to a three-week intensive pain rehabilitation program can help youth aged 10-18 with severe chronic pain. The goal is to see if the stimulation can reduce pain and improve daily function, mood,…

This study tests whether a nurse care management program can help rural adults with chronic pain feel better and function more in daily life. The program includes care coordination, cognitive behavioral therapy, and referrals to an exercise program. About 450 rural patients will …

This study tests whether online group cognitive behavioral therapy (CBT) is a practical way to help adults with cerebral palsy who have chronic pain. Fourteen participants will attend weekly virtual therapy sessions for 12 weeks. The main goal is to see if people will stick with …

This study tests a 24-week program called SC-POWR for 204 adults with opioid use disorder and chronic pain. Participants get medication, therapy, exercise (like Wii Fit and Tai Chi), and stress reduction (relaxation training and acupuncture). The goal is to reduce pain interferen…

This study tests a new drug called LY3848575 for people with long-term nerve pain starting in the feet and moving up the legs. About 558 participants will receive either the drug or a placebo to see if it safely reduces pain. The trial lasts up to 30 weeks and measures pain inten…

This study aimed to see if a device called Sana could improve quality of life for people with fibromyalgia, a condition that causes long-term pain. Researchers planned to compare the active device to a sham (fake) device in adults aged 18 to 65 who had fibromyalgia symptoms for a…

This study is testing a new device that uses gentle vibrations on the belly, back, or temples to help people with chronic pain conditions like pelvic pain, abdominal pain, low back pain, or migraine. About 50 adults will try the real device or a placebo to see if it safely reduce…

This early study tests a new device called PRIMUS that stimulates nerves in the head and face to treat chronic migraine. Only 7 people with hard-to-treat migraines are taking part. The main goal is to see if the device is safe, not yet if it works.

This early study tests the safety of a new device called PRIMUS that uses mild electrical pulses on nerves in the forehead and back of the head to treat chronic cluster headache. Five people with frequent, hard-to-treat attacks will be enrolled. The goal is to see if the device i…

This study tests whether virtual reality (VR) meditation can improve sleep and reduce anxiety in people with chronic pain and insomnia. About 30 adults with both conditions for at least 6 months will use VR meditation and track their sleep, pain, and mood. The goal is to see if t…

This study tests whether a mindfulness-based program (MBCT) delivered by phone or video can help people with migraines and depressive symptoms. About 145 adults with 4-20 headache days per month and mild to moderate depression will be randomly assigned to phone, video, or usual c…

This study looks at whether adding a daily 30-minute muscle stimulation session can improve pain control and quality of life for people who already have a spinal cord stimulator (BurstDR) for chronic back pain. Sixty adults with failed back surgery syndrome or persistent spinal p…

This study compares two exercise programs—asynchronous telerehabilitation (remote guidance) and a standard home exercise plan—for people with piriformis syndrome, a condition causing buttock and leg pain. About 46 adults aged 18-45 with confirmed diagnosis will participate. The g…

This study tests whether a digital version of cognitive behavioral therapy for insomnia (CBT-I) can improve sleep and reduce pain in 140 adults with chronic pain and insomnia. Participants will either receive the digital CBT-I program or digital sleep hygiene education. The goal …

This study is testing a new program led by physiotherapists to help teens and young adults (ages 12-25) who have had muscle or joint pain for at least 3 months. The program focuses on gradually increasing physical activity and reducing fear of movement. The goal is to see if this…

This study tests whether chairs with special foam materials and shapes can reduce tailbone pain and improve comfort for people with coccydynia. About 42 adults who sit at desks 5-6 hours daily will use the chairs for one week. Researchers will measure pressure distribution, pain …

This study tests a device that uses mild electrical pulses to treat chronic migraine. About 250 adults with frequent, hard-to-treat migraines will receive either the active device or a sham (inactive) device. The goal is to see if the device safely reduces the number of headache …

This study tests a new way to use deep brain stimulation for people with severe, treatment-resistant chronic pain from stroke, spinal cord injury, or phantom limb pain. Instead of constant stimulation, the device delivers electrical pulses only when the brain senses high pain sig…

This study tests a self-guided web program called Face-Forward-Web for adults with chronic orofacial pain (lasting over 3 months). The program includes five 30-minute video sessions teaching relaxation, mindfulness, and coping skills. Researchers will enroll up to 30 participants…

This early-stage study tests whether BHV-7000 can reduce chronic pain in people with inherited erythromelalgia, a rare condition causing severe burning pain due to a genetic mutation. Only 5 adults with a specific NaV1.7 mutation will participate, comparing the drug to a placebo …

This study tests two telehealth-based treatments—brief pain education and 10 weeks of physical therapy—to help 500 adults with chronic low back pain. The goal is to improve pain management and reduce opioid use in community health centers. Participants receive sessions via phone …

This study tests whether a program combining exercise, healthy eating advice, and education about migraine can reduce the number of attacks in people with frequent or chronic migraines. About 140 adults who are not very active will take part. The goal is to see if lifestyle chang…

This study tests an online program called Migraine Manager for teens aged 11 to 17 with frequent migraines (8 or more per month). The tool gives personalized tips on healthy habits like drinking water, eating regularly, exercising, and sleeping well. Researchers will compare 80 t…

This study was designed to see whether the drug amitriptyline or lifestyle changes work better for people with vestibular migraine, a condition that causes dizziness and headache. The plan was to randomly assign adults with definite vestibular migraine to one of the two treatment…

This study explores whether low-intensity focused ultrasound (LIFU) can temporarily change brain activity to reduce chronic pain. Eighty adults with moderate-to-severe pain lasting at least 3 months will receive brain scans, pain tests, and questionnaires over 10 weeks. The goal …

This study is testing a full-spectrum cannabis extract containing CBD and THC in 36 women with fibromyalgia, a condition causing widespread pain, fatigue, and sleep problems. Participants will receive different doses over six months to see if it improves symptoms and quality of l…

This study tests whether inhaling lavender, peppermint, or a mix of both can change how sensitive people with migraine are to pressure pain. Two hundred adults with migraine will inhale one of the oils or a control solution for 15 minutes. Researchers measure pain thresholds befo…

This Phase IIa trial tests whether a new drug called ONO-1110 can safely reduce pain in people with fibromyalgia. About 160 Japanese adults will take either the drug or a placebo once daily for 8 weeks. Researchers will measure changes in pain scores and watch for side effects.

This study tests whether stationary cycling (at a voluntary or assisted pace) and a type of psychotherapy called I-STOP can reduce drug cravings in adults with opioid use disorder and chronic pain. About 198 people in residential treatment will try these approaches alone or toget…

This study looks at whether adding a mobile app that guides teens through physical exercise and mindfulness training can make standard pain rehabilitation more effective. About 60 teens aged 13-19 with long-term pain will either get the app plus a shorter hospital program, or the…

This study compares two types of nerve blocks—interscalene and suprascapular—for controlling pain after arthroscopic shoulder surgery. 84 adults having shoulder arthroscopy will receive one of the blocks, and researchers will measure pain levels and side effects. The goal is to f…

This study looks at whether a special type of massage therapy, designed to be sensitive to trauma and different cultures, can help refugees and asylum seekers who survived torture or war. About 50 people will either get their usual care plus this massage, or just usual care. The …

This study compares a 6-month physiotherapy program focused on pelvic floor relaxation to no structured exercise in women with pudendal neuralgia, a chronic pelvic pain condition. Researchers will measure muscle stiffness using ultrasound and track symptoms like pain and sexual d…

This study tests whether combining pain neuroscience education (teaching patients about how pain works) with a gradual, timed increase in physical activity can reduce chronic pain in breast cancer survivors. About 122 survivors who have finished cancer treatment will be randomly …

This pilot study tested three different strengths of inhaled cannabis (2.5%, 5%, and 10% THC) against a placebo to see if they could quickly relieve migraine headaches. Twenty adults with migraine took part in a crossover design, meaning each person tried all options. The main go…

This study tests whether repeated magnetic pulses (rTMS) aimed at the brain's motor area can safely reduce chronic nerve pain that hasn't responded to other treatments. About 32 adults with conditions like post-stroke pain, trigeminal neuralgia, or spinal cord injury will receive…

This study tests a small, implantable device that stimulates nerves to relieve chronic pain after injury or surgery. About 185 adults with peripheral neuralgia will either receive the stimulator plus standard medical care or standard care alone. The goal is to see if the device p…

This study tests a small device that sends gentle electrical pulses to nerves far from the head (called Ultra-Distal TENS) to see if it can reduce migraine pain and related symptoms like nausea and sensitivity to light or sound. About 206 adults with frequent migraines will use t…

This study is testing whether applying peppermint oil to the skin can reduce chronic pain and improve daily function in people with fibromyalgia. Researchers will also look at whether this treatment is cost-effective compared to standard care. About 175 adults with fibromyalgia w…

This study tests whether an 8-week mindfulness yoga program, done mostly at home via video calls, can reduce the impact of fibromyalgia. Sixty-four adults with fibromyalgia are randomly assigned to either the yoga program or standard physiotherapy. The goal is to see if yoga impr…

This study is testing whether a drink containing CBD and CBN can reduce facial pain and headaches caused by muscle tension. 42 adults with pain lasting over 3 months will be randomly assigned to receive either the CBD/CBN drink or a placebo. Researchers will measure pain and musc…

This study compares two exercise programs for adults aged 65 and older living in residential care. One group does short, frequent 'exercise snacks' twice a day, while the other does longer, structured sessions a few times a week. Over 12 weeks, researchers will measure changes in…

This study tests two approaches to help people with opioid use disorder and chronic pain feel better. One is a pain self-management program with coaching and peer support. The other allows flexible dosing of buprenorphine based on pain levels. 268 adults from participating clinic…

This study tests an experimental drug called ONO-1110 to see if it can safely reduce pain in people with postherpetic neuralgia, a type of nerve pain that persists after a shingles infection. About 140 Japanese adults with pain lasting at least 3 months will receive either the dr…

This study tests whether a medicine called fremanezumab can reduce migraines that happen around a woman's period. Women aged 18 to 45 with menstrual migraines will get either the medicine or a placebo injection every three months for six months. Researchers will track migraine da…

This study planned to test whether a small vibrating bee with ice-pack wings, called Buzzy, could reduce pain during IV placement in adults with chronic pain who receive lidocaine infusions. Participants would have rated their pain and satisfaction after IV insertion. However, th…

This study tests whether a brief education and self-management program with home exercises can reduce pain and improve daily function in adults with long-lasting jaw pain (TMD) as effectively as more intensive hands-on physiotherapy. Forty adults aged 18–65 with jaw pain for at l…

This study explores whether shining specific colors of light into the eyes can help people with chronic low back pain or fibromyalgia feel less pain. Sixty adults will use a portable light device for 2 hours daily over 5 days. The goal is to see if this approach is practical and …

This study tests whether a nasal spray containing oxytocin, a natural hormone, can reduce pain and improve function in people with chronic pain. About 336 adults with nerve, muscle, or pelvic pain will try two doses of oxytocin and a placebo spray over several weeks. The goal is …

This study tests whether a progressive exercise program can reduce chronic pain in veteran lung cancer survivors aged 60-80. Nine participants will do treadmill walking, resistance bands, and balance exercises. The goal is to see if exercise can be a safe alternative to opioids f…

This study looks at whether slow breathing techniques can help women with fibromyalgia improve their heart rate control and exercise performance. About 159 women will be randomly assigned to breathe slowly (with or without a visual guide) or normally before doing arm curls. Resea…

This pilot study aimed to see if blocking a specific artery in the brain could help people with chronic migraines that don't respond to drugs. The procedure, called middle meningeal artery embolization, uses tiny particles or coils to block the vessel. However, the study was with…

This study looks at how well Rimegepant works for treating migraine attacks in everyday life. About 3,000 adults with migraine will take the drug as prescribed by their doctor and report their pain levels, relief timing, and satisfaction. The goal is to see if Rimegepant helps re…

This study tests whether yoga can reduce nerve pain caused by chemotherapy in cancer survivors. About 227 participants will either take yoga classes twice a week for 8 weeks, attend educational sessions, or receive standard care. Researchers will measure pain, balance, fall risk,…

This Mayo Clinic study tests whether a virtual reality meditation program called TRIPP can reduce the impact of fibromyalgia. Forty adults with fibromyalgia will use either the active VR meditation or a sham (fake) VR experience for two weeks each. Researchers will measure change…

This study tests a personalized yoga coaching program for people with lupus who have chronic pain. Fifteen participants work with a coach to create a yoga practice that fits their needs and limits. The goal is to see if the program is feasible and if it helps reduce pain. It is a…

This study tests whether daily listening to jazz music combined with mindfulness can reduce chronic pain and anxiety. About 90 adults with chronic pain and moderate-to-severe anxiety will listen to jazz recordings daily for 4 weeks. Researchers will measure changes in pain intens…

This study tests if acupuncture can reduce nerve pain caused by chemotherapy in cancer survivors. About 255 people who finished chemo at least three months ago will receive either real or sham acupuncture. The goal is to see if this drug-free approach can ease pain and improve da…

This early-phase study tests whether MRI-guided focused ultrasound can safely reduce severe facial pain in people with trigeminal neuralgia that hasn't responded to medication. Ten adults aged 21-75 with chronic pain for over 6 months will receive a precise ultrasound treatment t…

This study tests a daily drug called basimglurant for adults with trigeminal neuralgia, a condition causing severe facial pain often called the 'suicide disease.' The trial includes 166 people who still have pain despite current treatments. After an 8-week run-in on the drug, par…

This study looks at whether a digital health program (Hinge Health) plus a wearable pain relief device (Enso) can help people with chronic low back pain feel better and move more easily. About 196 adults with back pain for at least 3 months will be randomly assigned to either the…

This study looks at whether a single session of mild electrical brain stimulation (tDCS) over the cerebellum can help reduce pain in women with fibromyalgia. About 92 right-handed women aged 18-65 with confirmed fibromyalgia and moderate-to-severe pain will receive the stimulatio…

This study tests whether microcurrent therapy—a very mild electrical stimulation—can reduce pain and improve daily life for people with fibromyalgia. About 50 adults will use a device at home alongside their usual pain care. The goal is to see if this simple, self-administered tr…

This study looked at whether taking a probiotic supplement for 8 weeks could reduce inflammation and pain in teenagers (ages 13-17) who have chronic pain and a body mass index at or above the 85th percentile. Researchers measured changes in a blood marker of inflammation (C-react…

This study tested whether a nasal spray called zavegepant could relieve migraine pain within 2 hours. Adults with migraines for at least a year were to use the spray at home for up to 4 attacks. The study was withdrawn before enrolling participants, so no results are available.

This study looks at whether using the Nerivio wearable device more frequently than the label says is safe for people with migraines. About 2000 participants who already use Nerivio will use it at higher frequencies. The goal is to check for side effects and see if it remains safe…

This study looks at whether pranayama breathing exercises can help people with fibromyalgia feel less pain, anxiety, and sleep better. About 54 adults with fibromyalgia will practice these breathing techniques. The goal is to see if this gentle, low-cost approach can improve qual…

This study compares two types of hands-on therapy—Stecco Fascial Manipulation and Rolfing Structural Integration—for people with piriformis syndrome, a condition that causes buttock and leg pain. Forty-two adults aged 25 to 45 with at least four weeks of pain will receive four we…

This study tests whether a combined therapy (Acceptance and Commitment Therapy plus Mindfulness-Based Relapse Prevention) can reduce how much pain interferes with daily life in veterans who have both chronic pain and opioid use disorder. About 157 veterans taking buprenorphine fo…

This study tests an 8-week app-based breathing program that uses heart rate feedback to help people with chronic migraine. Thirty adults will use the app daily for 10 minutes, and researchers will track changes in migraine frequency and psychological well-being. The goal is to se…

This study tests whether a noninvasive electrical stimulation device placed on the skin over the spine can reduce pain and improve quality of life in people with neuropathic (nerve) pain. About 62 adults with chronic low back pain from nerve damage will receive either real or sha…

This study tests whether doing electrotherapy and neck exercises at home via video calls works as well as doing them in a clinic. One hundred adults with chronic neck pain will be split into two groups: one doing a remote program and one doing in-person sessions. Both groups will…

This small study tests whether eptinezumab, a drug used for migraines, can reduce pain in people with atypical facial pain that hasn't responded to other treatments. Ten participants will receive two intravenous infusions three months apart. The main goal is to see if the drug im…

This study looks at whether a combination of herbal medicine and Chuna manual therapy (a Korean spinal manipulation technique) can safely reduce pain and improve walking ability in people with low back pain or sciatica caused by lumbar spinal stenosis or spondylolisthesis. Resear…

This study looks at whether acupuncture can reduce migraine pain and lower signs of inflammation and brain stress in the blood. Researchers will compare three types of gentle stimulation: laser, electro, and traditional acupuncture. 75 adults with migraines will receive treatment…

This study looks at adults with chronic pain who receive ketamine infusions at Stanford's Pain Management Center. Researchers want to understand which patients improve and what factors predict a good response. The goal is to better tailor this treatment to individuals.

This study planned to test whether virtual reality-based guided mindfulness meditation could help adults with anxiety, depression, stress, or pain feel better. Researchers wanted to see if using VR meditation was practical and if it improved mood and pain scores. However, the stu…

This study compares a multidisciplinary treatment (combining pain management, pelvic floor therapy, and mucosal care) with standard care for women suffering from chronic vulvar pain (vulvodynia) lasting at least 3 months. About 106 women aged 18 and older will participate. The go…

This study looks at whether adding dynamic stretching to foam rolling helps people with piriformis syndrome more than foam rolling alone. Forty adults aged 35–50 with buttock pain will do either foam rolling or foam rolling plus dynamic stretches for several weeks. Researchers wi…

This study planned to test a combination of naltrexone and acetaminophen for treating migraine attacks. It was designed in two stages: first comparing the combo to each drug alone and placebo, then finding the best dose. However, the trial was withdrawn before any participants we…

This study compares personalized electro-acupuncture and auricular-acupuncture against usual care for treating chronic pain in adults with musculoskeletal pain or fibromyalgia. Participants are split into three groups: two receive different acupuncture methods, and one receives s…

This study tests a program called COMPASS-NP for home care workers who have chronic pain. The program combines pain education, coping strategies, and safety tips, led by a trained peer. About 140 workers will take part to see if it reduces how much pain interferes with their work…

This study compares carbamazepine and oxcarbazepine, two drugs used to treat trigeminal neuralgia, a condition causing severe facial pain. Researchers will enroll 122 adults aged 18-60 who have had the condition for at least two weeks. They will measure pain relief using a standa…

This study compares two procedures to relieve chronic tailbone pain (coccydynia) that is not related to cancer. About 74 adults aged 20-70 who have not responded to standard medical treatment will be split into two groups. One group will receive conventional radiofrequency ablati…

This study tests whether a single, two-hour pain relief skills session called Empowered Relief can reduce chronic pain after a cesarean delivery. Sixty women who still have moderate to severe pain six weeks after their C-section will attend the session and be followed for 12 week…

This study tests whether daily exposure to green LED light can reduce chronic pain. 55 adults with conditions like fibromyalgia or nerve pain will use a green or white light device at home for 2 hours each day over 3 months. Researchers will measure changes in pain levels, medica…

This pilot study is testing whether the Transcendental Meditation technique can reduce how often migraines happen and how much they interfere with daily life. Thirty adults with migraines will practice meditation twice a day for 20 minutes over three months while continuing their…

This study tests a treatment that combines two therapies (ACT and MBRP) to help people with both chronic pain and opioid use disorder. About 160 adults already on buprenorphine will be randomly assigned to either this combined therapy or their usual care. The goal is to see if th…

This study tests a precise radiation treatment for trigeminal neuralgia, a condition that causes severe facial pain. Instead of a metal frame screwed into the skull, a special face mask holds the head still while x-rays target the painful nerve. The trial includes 40 adults whose…

This study tests whether common migraine medications can reduce the impact of sudden tinnitus (ringing in the ears) in 100 adults aged 25 to 85. Participants receive the drugs and complete questionnaires about their symptoms, plus brain scans to look for changes. The goal is to f…

This study looks at two treatments for long-term tailbone pain (coccydynia) that hasn't improved with basic care like cushions or physical therapy. Researchers will compare a nerve block alone versus the nerve block plus a steroid injection into the lower back. They will check if…

This study tests whether a single dose of ketamine, given while patients are sedated, can reduce chronic pain and depression symptoms. Forty adults with both conditions will receive either ketamine or a placebo (saline) during sedation with propofol. Researchers will track pain a…

This study tested whether two types of gentle brain stimulation (tDCS and TUS) can reduce pain and improve daily function in people with chronic knee osteoarthritis. 64 adults with persistent knee pain received either real or sham stimulation. Researchers measured changes in pain…

This study tests whether two types of gentle brain stimulation—tDCS and TUS—can reduce pain and improve daily function in people with chronic low back pain. Researchers will compare active stimulation to a sham (fake) treatment in 40 adults aged 18-85 who have had persistent back…

This study treated one 58-year-old man with polyneuropathy caused by POEMS syndrome using his own fat-derived stem cells. He received eight infusions over 28 weeks to try to relieve nerve symptoms. The study is no longer available and was not a formal clinical trial.

This trial gave multiple infusions of a patient's own stem cells to treat chronic muscle and joint pain that had lasted at least a year. The patient received six infusions over about 32 weeks, with safety checks and pain scores tracked throughout. The goal was to see if this appr…

This study looks at whether cannabis oil can help reduce pain and improve sleep and quality of life in people with fibromyalgia who have not found relief from other treatments. Researchers will track pain levels, side effects, and how well patients stick to the treatment. The goa…

This study tests whether a mindfulness program called MORE can help people with long-term cancer pain. 76 adults with a history of cancer and ongoing pain will either learn mindfulness skills or continue their usual care. The goal is to see if this approach is practical and helpf…

This study tests a client-centered coping skills training program for people with migraine. Over 8 sessions, participants learn techniques like stress management and activity pacing to reduce pain and improve quality of life. The trial follows 60 adults for 6 months to see if the…

This study tests a psychological treatment called Pain Reprocessing Therapy (PRT) for people with chronic widespread pain, including fibromyalgia. PRT teaches patients that pain can come from 'stuck' brain patterns and helps them retrain their brain to stop sending false pain ala…

This study tests whether a gentle electrical brain stimulation device, used at home, can reduce chronic pain in people with rheumatoid arthritis whose inflammation is already well-controlled. Thirty-four participants will either receive real or sham stimulation over several sessi…

This study planned to test photobiomodulation (a type of light therapy) on nerve pain and sensation in one woman after mastectomy. The treatment used red and near-infrared light on the affected area for six weeks. However, the study was withdrawn before any participants enrolled,…

This study compares three approaches for chronic back pain: Pain Reprocessing Therapy (PRT), Cognitive Behavioral Therapy (CBT), and usual care. Researchers want to see if PRT helps lower pain intensity and improve daily functioning. The trial enrolls 150 racially and ethnically …

This study tests two types of nerve stretches—active (patient-controlled) and passive (therapist-applied)—to see which better reduces burning pain, improves muscle strength, and increases joint movement in people with diabetic neuropathy. Sixty adults aged 40 to 65 with diabetes …

This study looks at whether people with flat feet (pes planus) are more likely to have piriformis syndrome, a condition that causes pain in the hip and lower back. Researchers will compare foot posture and pain in adults aged 18-65 who have piriformis syndrome with those who do n…

This study compares three psychological treatments—CBT, ACT, and EAET—for adults with chronic back or neck pain. Researchers want to understand how each therapy works and which patients benefit most. 408 participants will receive weekly online therapy for 8 weeks and be followed …

This study investigates factors that may influence cognitive skills—like memory, attention, and problem-solving—in women diagnosed with fibromyalgia. Researchers will assess thinking abilities using a detailed cognitive test and measure how fibromyalgia affects daily life. The go…

This study explores how women with fibromyalgia experience pain using a smartphone app with animations and body maps. Participants will describe their pain by choosing and adjusting animations that match their sensations. The goal is to find better ways to measure pain quality an…

This study tests a new imaging method to see if white blood cells enter the brain in people with multiple sclerosis, fibromyalgia, or chronic fatigue syndrome. Participants receive their own white blood cells tagged with a radioactive tracer, then undergo a brain PET/MRI scan. Th…

This study looks at whether data from wearable devices like smartwatches can track and even predict migraine headaches. Twenty adults with chronic migraine will use a phone app and a smart device to record heart rate and movement. The goal is to see if this information can help f…

This study surveys 350 adults with hemophilia to better understand chronic pain—its type, location, and impact on daily life. Participants fill out questionnaires about their pain history, medication use, and emotional well-being. The goal is to help doctors recognize and treat p…

This study aims to develop a screening test for a pain control mechanism called DNIC, which is often faulty in people with chronic pain. Researchers will use cameras to capture facial expressions during pain tests and apply artificial intelligence to see if they can automatically…

This study looks at how stress affects the brain and body in 70 teenagers (ages 11-17) with chronic widespread pain. Participants will have an MRI scan while experiencing mild heat pain, and provide saliva samples to measure stress hormones. The goal is to understand the link bet…

This study looks at whether brain scans can help predict which people with migraine will respond to a class of drugs called CGRP antibodies. Researchers used MRI to measure brain structure, activity, and blood flow in 219 adults with frequent migraine before and after 12 weeks of…

This study looks back at medical records of 200 adults with Complex Regional Pain Syndrome (CRPS) to see which pain treatments doctors actually use first and how well they work. Researchers want to find patterns that could help choose the best treatment for each person. No new tr…

This study uses brain scans to see how the brainstem and other brain areas respond to mild electrical pulses on the face and arm in 40 healthy volunteers. The goal is to better understand the brain circuits involved in facial pain and touch, which could help future research on mi…

This study is creating a statewide collection of blood samples and medical information from people with various brain blood vessel diseases, such as stroke and dementia. The goal is to build a resource that scientists can use in future research to better understand and potentiall…

This study planned to use Apple Watches to track physical activity, diet, and environment in children with complex regional pain syndrome (CRPS) to identify what triggers sudden severe pain. However, the study was withdrawn before enrolling any participants, so no data was collec…

This study follows 250 adults in the UK who already use rimegepant for migraine attacks. Over 12 weeks, they report how quickly the drug eases pain and other symptoms. The goal is to see how consistently rimegepant works in everyday life.

This study reviewed the medical records of 2500 people who received hyperbaric oxygen therapy (HBOT) for conditions like traumatic brain injury, stroke, fibromyalgia, or age-related decline. Researchers compared computerized thinking and memory tests taken before and after treatm…

This study gathers opinions from 30 healthcare experts, including physiotherapists and midwives, to decide the best way to teach women about pain during and after childbirth. The goal is to create a standard pain education program that can be tested in future studies. No treatmen…

This study looks at how the nervous system becomes overly sensitive in people with different types of chronic pain. Researchers will assess 185 adults using questionnaires, thinking tests, and laser brain-wave measurements at the start and after one year. The goal is to better un…

This study aims to see if a short, 4-question Turkish version of the Pain Anxiety Symptom Scale is a reliable and valid tool for measuring pain-related anxiety. Researchers will enroll 350 adults aged 18-65 who have had chronic pain for at least 3 months. Participants will fill o…

This study is testing a Turkish version of a questionnaire that looks at how chronic pain conditions like fibromyalgia and back pain affect sexual function and satisfaction. Researchers will ask 170 people with chronic pain and a stable partner to fill out the survey. The goal is…

This study compares 120 adults with primary headaches (migraine or tension-type) to healthy individuals. Researchers will measure tenderness in head and neck muscles and general pain sensitivity elsewhere in the body. The goal is to understand how these factors relate to headache…

This pilot study looks at whether light, self-paced swimming is a tolerable activity for people with ME/CFS and related conditions like Long COVID and fibromyalgia. Participants will swim for 15-30 minutes at their own pace and track symptoms and heart rate variability using an a…

This observational study will follow 384 patients in Brazil who are using cannabis-based products (like CBD or THC oils) prescribed by their own doctors for chronic pain, anxiety, or depression. Researchers will not provide the medication but will track patients' quality of life,…

This study was designed to observe brain wave (EEG) changes in adults with chronic neuropathic pain during ketamine treatment. Researchers hoped to find patterns that could predict which patients benefit most. However, the study was withdrawn before enrolling any participants, so…

This study is investigating whether bruxism (teeth grinding or clenching) is associated with pelvic pain, erectile dysfunction, and anxiety in young men aged 18-30. Researchers will use questionnaires and physical exams to assess 100 participants. The goal is to better understand…

This study explores whether bruxism (teeth grinding or clenching) is related to pelvic floor dysfunction in young women aged 18-30. Researchers will use questionnaires and physical exams to assess jaw function, pelvic floor symptoms, and anxiety in 100 participants. The goal is t…

This study looks back at the medical records of about 4 million people who had physical or occupational therapy for muscle and joint problems. Researchers want to see if different ways of giving therapy lead to different results. No new treatments are tested—the goal is to learn …

This study explores whether the levels of certain receptors (CB1, CB2, TRPV-1) in the blood are linked to chronic orofacial pain from jaw muscles. Researchers will compare 102 adults with and without this pain, using blood tests and clinical exams. The goal is to understand how t…

This study looks at whether matching adults with chronic pain to specific psychological treatments—like cognitive behavioral therapy, mindfulness, or hypnosis—based on their personal traits (such as brain activity or thinking patterns) leads to better pain relief. Researchers wil…

This study looks at 500 adults having pituitary tumor surgery through the nose. Researchers want to find out who gets headaches soon after surgery and build a tool to predict that risk. Participants report their pain daily and fill out surveys for up to 3 months after surgery.

This study is enrolling 120 adults with Complex Regional Pain Syndrome (CRPS) to see if certain blood clotting factors are linked to how well they respond to neridronic acid treatment. Researchers will measure pain levels before and after treatment. The goal is to find markers th…

This study looks at people with trigeminal neuralgia, a condition that causes severe facial pain. Researchers want to see if adding virtual reality (VR) training before Gamma Knife surgery can improve pain relief. They will also use artificial intelligence (AI) and brain scans to…

This study follows 100 people with combat-related limb injuries to see if the mechanics of the injury—like force and direction—can predict who will develop chronic pain. Researchers will track pain levels at 3 and 6 months. The goal is to find early warning signs so doctors can s…

This study from Stanford University aims to find biological markers that can tell doctors whether a person with chronic musculoskeletal pain is likely to recover or develop long-term disability. Researchers will follow 250 adults aged 18-80, using questionnaires and possibly imag…

This study looks at how headaches work by using capsaicin (the spicy part of chili peppers) and ice water to trigger mild, temporary pain in people with and without headache disorders. Researchers measure changes in pain signals and tear production to better understand conditions…

This study aims to validate a self-report questionnaire that people with Complex Regional Pain Syndrome (CRPS) can fill out at home. Researchers will compare the self-report results with in-person clinical exams to see if the questionnaire accurately measures symptom severity and…

This study planned to use high-frequency brain signals to locate important brain areas and understand conditions like epilepsy, migraine, and ADHD. It aimed to create a large database of brain activity in people aged 1 day to 69 years. However, the study was withdrawn before any …

This study was designed to test a holistic education program for stress management in people from colonized English-speaking countries. It aimed to help with conditions like stress, PTSD, anxiety, and fatigue using pastoral counseling and self-care activities. However, the study …

This study looks at whether imagining positive future events (Episodic Future Thinking) and using low-intensity focused ultrasound on the brain can help people with both chronic pain and alcohol use disorder. Ten adults will try these interventions and report changes in pain, cra…

This study looks at how common nerve problems are in people who feel eye discomfort. Researchers will test 1,000 participants to see if their pain is linked to nerve damage rather than just dry eye. The goal is to better understand these conditions and improve diagnosis.

This study reviews the medical records of 20 adults who had a limb amputated to relieve severe, long-lasting pain from complex regional pain syndrome (CRPS). Researchers want to measure how many days pass between the amputation and when patients first use a functional prosthetic …

This study uses a driving simulator to test whether people with chronic pain can drive safely while taking oral opioids. 450 participants with a valid driver's license will be tested on measures like weaving and reaction time. The goal is to provide better guidance to patients an…

This study looks at whether the migraine medication rimegepant is safe to take during pregnancy. Researchers will compare pregnancy outcomes in women who took rimegepant to those who did not. The study includes women aged 16 to 49 with migraine. However, only one person has been …

This study looks at whether stressful or traumatic life events increase the chance of developing fibromyalgia. Researchers will follow 534 adults—some with rheumatic diseases and some healthy—for one year, checking for new fibromyalgia cases. The goal is to better understand how …

This observational study plans to enroll 120,000 people with various chronic diseases like pancreatitis, diabetes, and arthritis. Researchers will collect blood samples and health data to study how genetics and lifestyle affect disease progression. The goal is to find common dise…

This study tests whether green light can reduce pain by looking at brain activity in 30 healthy adults. Participants are exposed to green or white light for two hours while researchers measure pain pathways and brain waves. The goal is to understand how green light works, not to …

This study looks at women who have both chronic pain conditions (central sensitization syndromes) and post-traumatic stress disorder (PTSD). First, researchers will identify different psychological patterns in these women. Then, they will test a personalized talk therapy approach…

This study aimed to find out how many people with trigeminal neuralgia (a severe facial nerve pain condition) also have temporomandibular disorder (TMD), which causes jaw pain. Researchers planned to follow patients from three clinics and test a questionnaire to better diagnose b…

This study looks at how headaches, especially migraines, affect the work and daily life of Libbs employees. Researchers will analyze data already collected from over 1,300 workers through a health app. No new treatments or tests are given—the goal is to understand headache patter…

This study looks at how often a common heart side effect (first-degree atrioventricular block) occurs when verapamil is used at high doses to prevent cluster headaches. Researchers will monitor 60 patients starting or already on verapamil, using ECGs and blood tests. The goal is …

This study looks at whether the dose of sufentanil, a strong painkiller given during non-major abdominal surgery, is linked to chronic pain 3 months after the operation. Researchers will interview 855 patients by phone to check for pain and its severity. The goal is to identify a…

This study looks at 150 people with knee osteoarthritis to see how often night pain and nerve pain (neuropathic pain) occur together. Researchers will use questionnaires and physical exams to measure pain and sleep quality. The goal is to better understand these pain types and th…

This study aims to create a decision aid to help patients on long-term opioid therapy and their doctors have better conversations about safely reducing or stopping opioids. Researchers will interview patients and doctors to understand their experiences, then test the tool with 30…

This study was designed to explore what kinds of feelings (like touch or tingling) could be created by electrically stimulating the spinal cord in people with amputations who experience phantom limb pain. Researchers planned to work with patients who already had a spinal cord sti…

This study explores how sex hormones (like testosterone and estrogen) during puberty relate to migraine pain and sensitivity in adolescents aged 11-15. Researchers will test pain responses and track migraine disability in 100 teens with and without migraines. The goal is to bette…

This study from the Cleveland Clinic is looking at whether certain migraine medications (CGRP inhibitors) can also improve bladder symptoms like urgency, frequency, and pain. About 200 women with hard-to-treat migraines and bladder issues will be followed for 3 months. Their symp…

This study looks at whether alexithymia—trouble recognizing or describing emotions—is linked to how often women get migraines. Researchers will track 350 female migraine patients aged 12-65 using questionnaires. The goal is to understand if emotional awareness affects migraine se…

This study looks at whether muscle twitching in the neck during a standard pain treatment (radiofrequency ablation) can help predict who will get good pain relief. Researchers will grade twitching in 60 adults with chronic neck pain and then check if those with more twitching had…

This study follows 275 teens aged 11–18 with chronic muscle or joint pain to find biological and behavioral markers that predict recovery versus ongoing pain. Researchers measure pain intensity and how much pain limits daily activities. The goal is to better understand why some t…

This study looks at how a high-fat, high-carb meal affects inflammation and stress responses in women with migraine compared to healthy women. Thirty women aged 18-35, with and without migraine, will have blood tests and pain tests after eating a test meal. The goal is to underst…

This study uses advanced MRI scans and artificial intelligence to investigate small brain spots called white matter hyperintensities (WMH) in women with migraine. Researchers aim to tell these spots apart from those caused by other conditions like multiple sclerosis or small vess…

This early-phase study looks at whether a common blood pressure drug, hydrochlorothiazide, can affect chronic pain in people who already have a spinal cord stimulator implant. About 36 adults with chronic low back pain and high blood pressure will take the drug or a placebo for t…