Botox-Like shots could cut migraine days in half

NCT ID NCT06047457

Ongoing Prevention Sponsor: Ipsen Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 study tests whether Dysport (a botulinum toxin type A) injections can prevent episodic migraine in adults. About 751 participants receive either Dysport or placebo injections every 12 weeks for up to 36 weeks. The goal is to see if the treatment reduces the number of migraine days per month. The study is active but not recruiting, and results are pending.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Botulinum toxin type A (Dysport)

What this could lead to

If successful, this could provide a new preventive treatment option for people with episodic migraine, reducing the number of migraine days per month.

What could go wrong

This is a phase 3 trial, but results are not yet available. The treatment involves injections into head, neck, and shoulder muscles, which may cause side effects like muscle weakness or pain. It may not work for everyone.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

migraine disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EPISODIC MIGRAINE

Contacts and locations

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Locations

"Pineo Medical Ecosystem" LTD

Tbilisi, 0114, Georgia
840042

Miami, Florida, 33136, United States
AGA Clinical Trials

Hialeah, Florida, 33012, United States
Alliance Clinical Las Vegas (Excel Clinical Research)

Las Vegas, Nevada, 89109, United States
Alliance Clinical San Diego (Acclaim Clinical Research)

San Diego, California, 92120, United States
Asheville Neurology Specialists

Asheville, North Carolina, 28806, United States
Assistance Publique-Hopitaux de Paris (AP-HP) - Unite de Recherche Clinique Saint-Louis Lariboisere-Ferd Widal

Paris, France
Axiom Research LLC

Colton, California, 92324, United States
Axon Clinical, s.r.o.

Prague, Czechia
BCN Research, LLC

Greenfield, Wisconsin, 53228, United States
Beth Israel Deaconess Medical Center - Arnold Pain Management

Brookline, Massachusetts, 02115, United States
Blue Sky MD

Hendersonville, North Carolina, 28792, United States
Bluewater Clinical Research Group Inc.

Sarnia, N7T 4X3, Canada
Boston Clinical Trials Inc

Winter Park, Florida, 32131, United States
Boston Clinical Trials Inc

Boston, Massachusetts, 02131, United States
CARe Clinic-Calgary

Red Deer, Canada
CCT Research

Phoenix, Arizona, 85044, United States
CHRU d'Amiens

Amiens, France
CHU Nimes - Hôpital Caremeau

Nîmes, France
Cedar Crosse Research Center

Chicago, Illinois, 60607, United States
Central Research Associates

Birmingham, Alabama, 35205, United States
Centrum Medyczne Neuromed Pawel Lisewski

Bydgoszcz, Poland
Centrum Medyczne Pratia Katowice

Katowice, Poland
Charité - Universitätsmedizin Berlin KöR

Berlin, Germany
Chicago Headache Center & Research Institute

Chicago, Illinois, 60657, United States
Clinical Neuroscience Solutions Healthcare, Inc (CNS Healthcare, INC)

Jacksonville, Florida, 32256, United States
Clinical Neuroscience Solutions, Inc ((CNS Healthcare) - Psychiatry)

Orlando, Florida, 32801, United States
Clinical Research Professionals

Chesterfield, Missouri, 63005, United States
Clinical Trial Network

Houston, Texas, 77074, United States
Coastal Carolina Research Center - North Charleston

North Charleston, South Carolina, 29405, United States
Complejo Hospitalario Ruber Juan Bravo

Madrid, Spain
Comprehensive Neurology Services

Frederick, Maryland, 21702, United States
Conquest Research

Winter Park, Florida, 32789, United States
DADO MEDICAL s.r.o.

Prague, Czechia
Emovis GmbH

Berlin, Germany
Fakultni Thomayerova nemocnice

Prague, Czechia
Fakultni nemocnice Ostrava

Ostrava, Czechia
Frontier Clinical Research, LLC

Kingwood, West Virginia, 26537, United States
Fullerton Neurological Center

Fullerton, California, 92835, United States
Genge Partners Inc.

Montreal, H3A 2B4, Canada
Guardian Angel Research Center

Tampa, Florida, 33614, United States
Hasbani Neurology

New Haven, Connecticut, 06511, United States
Headache Center of Hope

Cincinnati, Ohio, 45236, United States
Headache Wellness Center

Greensboro, North Carolina, 27405, United States
Helios Clinical Research

Wooster, Ohio, 44691, United States
Helios Clinical Research LLC (Helios CR, Inc. Jackson TN)

Jackson, Tennessee, 38305, United States
Herzog, Steven MD

Dallas, Texas, 75214, United States
HonorHealth Neurology

Scottsdale, Arizona, 85251, United States
Hope Clinical Research, LLC

Canoga Park, California, 91303, United States
Hospital Universitari Vall D Hebron

Barcelona, Spain
Hospital Universitario 12 De Octubre

Madrid, Spain
Hospital Universitario Regional De Malaga

Málaga, Spain
Hospital Universitario y Politécnico La Fe

Valencia, Spain
ISR-GEO Med Res Clin Healthycore

Tbilisi, Georgia
Indywidualna Praktyka Lekarska dr hab. med. Anna Szczepanska-Szerej

Lublin, Poland
Infinity Clinical Research, LLC

Hollywood, Florida, 33024, United States
Inova Medical Group - Neurology

Fairfax, Virginia, 22031, United States
Institut neuropsychiatricke pece

Prague, Czechia
Instytut Zdrowia Dr Boczarska-Jedynak Sp. z o.o. S.K.

Oświęcim, Poland
J. Lewis Research Inc.-Foothill

Salt Lake City, Utah, 84109, United States
KCA Neurology, PLLC

Franklin, Tennessee, 37067, United States
Kopfschmerzzentrum Frankfurt am Main

Hessen, Germany
Krakowska Akademia Neurologii Sp. z o.o.

Krakow, Poland
Krakowskie Centrum MedyczneSp.z o.o

Krakow, Poland
LMU - Klinikum der Universität München - Campus Grosshadern

München, Germany
LTD New Hospitals

Tbilisi, 0114, Georgia
LTD S.Khechinashvili University Hospital

Tbilisi, 0179, Georgia
Lone Star Neurology

Frisco, Texas, 75035, United States
Lone Star Neurology,

Westborough, Massachusetts, 01581, United States
Ltd "Health"

Batumi, 6010, Georgia
M3 Wake Research - Las Vegas Wellness Way

Las Vegas, Nevada, 89106, United States
MD Fort Wayne Neurological Center

Fort Wayne, Indiana, 46804, United States
MedStar Health - Department of Neurology

Columbia, Washington, 20010, United States
Metrodora Institute

West Valley City, Utah, 84119, United States
Minneapolis Clinic of Neurology

Burnsville, Minnesota, 55337, United States
Multprofil Clinic Consilium Medulla

Tbilisi, 0186, Georgia
NEUROHK s.r.o.

Choceň, Czechia
Nemocnice Jihlava, p.o.

Jihlava, Czechia
Neurologie Brno s.r.o.

Brno, Czechia
Neurology Center of NE,PC - Neurology

Foxborough, Massachusetts, 02035, United States
Neurology Center of North Orange County

Fullerton, California, 92835, United States
Neurology Clinic, PC

Cordova, Tennessee, 38018, United States
Neuroscience Group of Northeast Wisconsin-Neenah

Neenah, Wisconsin, 54956, United States
New England Institute for Neurology and Headache (NEINH)/Medical Practice

Stamford, Connecticut, 06905, United States
New England Regional Headache Center, Inc.

Worcester, Massachusetts, 01609, United States
Nuvance Health Medical Practice

Poughkeepsie, New York, 12601, United States
OrthoNeuro

New Albany, Ohio, 43054, United States
Pratia Brno s.r.o.

Brno, Czechia
Pratia MCM Krakow

Krakow, Poland
Quantum Clinical Trials

Miami Beach, Florida, 33140, United States
Quest Research Institute

Farmington Hills, Michigan, 48334, United States
Research Your Health

Plano, Texas, 75093, United States
Robbins Headache Clinic

Riverwoods, Illinois, 60015, United States
Rochester Clinical Research

Rochester, New York, 14609, United States
SDS Clinical Trials

Orange, California, 92868, United States
SPRI Clinical Trials, LLC

Brooklyn, New York, 11235, United States
Suburban Research Associates

Media, Pennsylvania, 19063, United States
Synexus Polska Sp. z o.o.

Gdynia, Poland
The Los Angeles Headache Center

Savannah, California, 31406, United States
Thomas Jefferson University Hospital - Jefferson Hospital for Neuroscience - Jefferson Neurology Associates - Neurology

Philadelphia, Pennsylvania, 19107, United States
Universitätsmedizin Greifswald

Greifswald, Germany
Velocity Clinical Research - Hallandale Beach

Hallandale, Florida, 33009, United States
Visionary Investigators Network (VIN)

Aventura, Florida, 33180, United States
Yale University School of Medicine

East Hartford, Connecticut, 06118, United States
Zenos Clinical Research

Dallas, Texas, 75230, United States