New combo could ease pain after leg surgery
NCT ID NCT07310628
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether taking a pill called tizanidine before spinal anesthesia (levobupivacaine) improves pain control during and after lower leg surgery. Sixty-four adults scheduled for elective leg surgery were randomly assigned to receive either the standard spinal injection alone or with an added tizanidine pill. Researchers measured how quickly pain relief started, how long it lasted, and how much extra pain medicine was needed afterward.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
tizanidine and levobupivacaine
What this could lead to
If it works, this could lead to a simple, low-cost way to improve pain relief and reduce the need for additional painkillers after leg surgery.
What could go wrong
This is a small, completed Phase 4 trial with only 64 participants, so results may not apply to everyone. Tizanidine can cause side effects like drowsiness or low blood pressure.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Adabala Vijay Babu
Raebareli, Uttar Pradesh, 229405, India