New combo could ease pain after leg surgery

NCT ID NCT07310628

Completed Symptom relief Sponsor: All India Institute of Medical Sciences Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether taking a pill called tizanidine before spinal anesthesia (levobupivacaine) improves pain control during and after lower leg surgery. Sixty-four adults scheduled for elective leg surgery were randomly assigned to receive either the standard spinal injection alone or with an added tizanidine pill. Researchers measured how quickly pain relief started, how long it lasted, and how much extra pain medicine was needed afterward.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: tizanidine and levobupivacaine
What this could lead to: If it works, this could lead to a simple, low-cost way to improve pain relief and reduce the need for additional painkillers after leg surgery.
What could go wrong: This is a small, completed Phase 4 trial with only 64 participants, so results may not apply to everyone. Tizanidine can cause side effects like drowsiness or low blood pressure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Chronic Pain chronic pain syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LEVOBUPICAINE LOWER LIMB SURGERY PAIN, CHRONIC TIZANIDIDNE

Contacts and locations

Locations

Adabala Vijay Babu

Raebareli, Uttar Pradesh, 229405, India

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