Brain disorder

This early-stage trial is testing a new vaccine called HydroVax-001B WNV to see if it is safe and triggers an immune response against West Nile virus, a mosquito-borne disease. About 30 healthy adults aged 18 to 49 will receive either the vaccine or a placebo. The study will comp…

This study tests a custom-made vaccine for people with two serious brain cancers: glioblastoma (GBM) and diffuse intrinsic pontine glioma (DIPG). The vaccine is made from the patient's own immune cells and designed to teach the body to attack the tumor. The main goals are to chec…

This study tests a new non-invasive brain stimulation device called kTMP (kilohertz transcranial magnetic perturbation) to see if it can help improve arm and hand movement in people who have had a stroke. The trial involves 7 adults aged 18-80 who had a stroke at least 12 months …

This phase 2a trial tests a nasal spray called foralumab in 54 people with non-active secondary progressive multiple sclerosis (SPMS). The spray contains an antibody that aims to calm overactive immune cells in the brain. Participants will receive either a low dose, a high dose, …

This Phase 2 trial tests a combination of pembrolizumab (Keytruda) and quavonlimab against other drug combos in 302 people with stage IV colorectal cancer that has a specific genetic feature (MSI-H or dMMR). The goal is to see if the new combo shrinks tumors better and for longer…

This study follows 165 children who previously took dabrafenib and/or trametinib for certain brain tumors. Researchers want to see if these drugs are safe over the long term and how they affect growth. The children continue their treatment and are monitored for side effects and d…

This Phase 3 trial compares the drug niraparib to the standard chemo temozolomide in 450 adults with newly diagnosed, aggressive glioblastoma that has a specific genetic marker (MGMT unmethylated). Participants take the assigned drug daily during radiation, then continue until th…

This study investigates whether combining the medication lovastatin with intensive reading tutoring can improve reading abilities in children and young adults (ages 8-20) with Neurofibromatosis Type 1 (NF1) who have reading disabilities. Participants first receive either lovastat…

This study tests whether a longer, family-involved form of cognitive behavioral therapy (CBT) can work as well as CBT combined with an antidepressant (SSRI) for children and teens with anxiety disorders. Participants aged 7 to 17 with separation, generalized, or social anxiety wi…

This large phase 3 trial tests whether newer blood thinner combinations (ticagrelor plus aspirin or rivaroxaban plus aspirin) are better than the standard clopidogrel plus aspirin at preventing stroke, brain bleeding, or death from blood vessel disease. Over 1,600 participants wi…

This trial tests whether a new type of MRI, called MR fingerprinting, can better show where a glioblastoma (an aggressive brain tumor) has spread compared to standard MRI. The goal is to help surgeons remove more of the tumor safely. The study involves adults with suspected gliob…

This study tests whether a daily pill called BHV-7000 can reduce seizures in adults with refractory focal epilepsy—a type of epilepsy that doesn't respond well to current medications. About 390 participants will receive either a low dose, a higher dose, or a placebo for 8 weeks. …

This study tests whether a rapid form of brain stimulation, called accelerated intermittent theta-burst stimulation (aiTBS), can relieve depression in people with bipolar II disorder whose depression has not responded to other treatments. Participants receive either real or sham …

This phase 2 trial tested the drug ivosidenib in children and young adults (ages 1 to 21) with solid tumors, lymphomas, or histiocytic disorders that have an IDH1 mutation and have either come back after treatment or not responded. The goal was to see if the drug could shrink or …

This study tests whether a wellness and behavior program can reduce seizures in adults with epilepsy that doesn't respond well to medication. About 1000 participants will be randomly assigned to the program or usual care. The goal is to see if lifestyle changes can lower seizure …

This study tests a behavioral program called Individualized Developmental Care (NIDCAP) for newborns with complex congenital heart disease. The program aims to reduce stress from the hospital environment by supporting parent involvement, creating a soothing setting, and adjusting…

This study tests whether a new drug called zanidatamab, combined with chemotherapy and sometimes another drug (tislelizumab), works better than the current standard treatment for advanced HER2-positive stomach and esophageal cancers. About 920 adults whose cancer has spread or ca…

This study offers NRX-101, a combination of two drugs, to adults aged 18-65 with treatment-resistant bipolar depression and suicidal thoughts. Participants receive the medication from their own psychiatrist and undergo regular check-ins on mood, suicidal ideation, and side effect…

This early-stage trial tests a single injection of ARO-ATXN2 in 36 adults with spinocerebellar ataxia type 2, a rare genetic disorder that affects movement and coordination. The main goal is to see if the drug is safe and how the body processes it. Participants are randomly assig…

This early-phase trial tests a new drug called Peposertib, combined with radiation and chemotherapy, for people with a hard-to-treat type of brain cancer called glioblastoma. The study aims to find the best dose and check safety in 29 participants. If it works, the drug may help …

This study tests whether a lifestyle physical activity program, supported by a Fitbit and phone counseling, can help women with depression who are in alcohol treatment reduce their risk of relapse. Participants are randomly assigned to either receive the full program or just a Fi…

This study tests whether measurement-based care — where therapists regularly track symptoms using questionnaires — adds extra benefit to weekly psychotherapy for adults with depression or anxiety. Participants are randomly assigned to measurement-based care, standard therapy, or …

This study tests an investigational drug called HRS-7450 in 208 people who have had an acute ischemic stroke within the past 4.5 to 24 hours. Participants receive either a low, intermediate, or high dose of the drug or a placebo. The goal is to see if the drug helps improve recov…

This phase 3 trial tests whether a new drug combination (MK-7684A) plus chemoradiotherapy helps people with stage III non-small cell lung cancer live longer than the current standard treatment. About 611 participants will receive either the new combo or durvalumab. The study is a…

This phase II trial tested whether adding bevacizumab to osimertinib works better than osimertinib alone for patients with a specific type of lung cancer (EGFR-mutant non-small cell lung cancer) that has spread to the brain. Only 5 patients were enrolled. The goal was to see if t…

This study tests a combination of laser heat therapy (LITT) and the immunotherapy drug pembrolizumab in 32 adults with recurrent glioblastoma, an aggressive brain cancer. The laser heats and destroys hard-to-reach tumors, while pembrolizumab helps the immune system fight cancer c…

This study is testing the long-term safety and effectiveness of a drug called TSND-201 for adults with PTSD. Participants who completed an earlier blinded trial of TSND-201 can receive up to three treatment courses over 48 weeks, each consisting of four weekly doses. The goal is …

This phase 2 trial tests the drug pembrolizumab in 101 adults with cancer that has spread to the brain or spinal cord. The goal is to see if the drug can shrink or stabilize these tumors. Participants receive pembrolizumab along with standard imaging and sometimes radiation. The …

This phase 2 trial tests the safety and effectiveness of avelumab, an immunotherapy drug, in people with thymoma or thymic carcinoma that has progressed after platinum-based chemotherapy. About 56 participants will receive avelumab intravenously every two weeks. The study aims to…

This study tests an implanted electrical stimulator to improve walking in people who have had a stroke. Six participants will first be screened, then receive the implant and use it at home. Researchers will compare advanced control settings to a simple trigger to see which works …

This phase 2 trial tests whether prasinezumab, given as an IV infusion every 4 weeks, can slow motor decline in people with early Parkinson's disease. The study includes 586 participants who are already on stable Parkinson's medication. Researchers are measuring how long it takes…

This study tests a program where community health workers help adults with epilepsy who frequently visit the emergency room. Over 9 to 12 months, the health workers provide home visits and phone support to help with medication, seizure tracking, and connecting to doctors. The goa…

This study planned to test whether injecting botulinum toxin (Botox) into the salivary glands could reduce drooling in people with true bulbar palsy, a condition that causes swallowing problems after a brain stem injury. The trial was designed to compare the injections against st…

This early-stage trial is testing an experimental drug called APX005M in 32 children with brain tumors that have come back or are hard to treat, including a type of brain stem glioma. The drug works by activating the immune system to attack cancer cells. The main goals are to fin…

This study tests whether adding perampanel (Fycompa) to current epilepsy medications can reduce seizures in children aged 1 month to 18 years. About 100 children with specific epilepsy syndromes or partial-onset seizures will receive the drug. The main goal is to see if at least …

This study tests whether adding the drug tucatinib to standard therapy (trastuzumab/pertuzumab or T-DM1) can prevent new or worsening brain metastases in people with advanced HER2+ breast cancer. About 48 participants who have stable disease elsewhere but a new brain tumor will r…

This study tests a new device called the eShunt System for treating normal pressure hydrocephalus, a condition that causes trouble walking, thinking, and bladder control in older adults. The device drains extra fluid from the brain through a small tube. Researchers will compare i…

This study aimed to test a new treatment called CABA-201, a CAR T-cell therapy made from a patient's own immune cells, for people with multiple sclerosis (MS). The goal was to see if it was safe and could control the disease by targeting and resetting the immune system. However, …

This study compares a targeted drug called selumetinib to standard chemotherapy (carboplatin/vincristine) in children aged 2 to 21 with neurofibromatosis type 1 (NF1) and low-grade glioma, a type of brain tumor. The goal is to see if selumetinib works as well or better at control…

This Phase 3 study compares fenebrutinib, an experimental oral drug, to teriflunomide, an approved MS therapy, in 751 adults with relapsing multiple sclerosis. The goal is to see if fenebrutinib better reduces relapse rates and delays disability progression. Participants take eit…

This study tests whether adding a second chemotherapy drug, lomustine, to the standard treatment (temozolomide plus radiation) helps people with a specific type of glioblastoma live longer. The trial includes 265 adults with newly diagnosed tumors that have a methylated MGMT gene…

This study tests a 4-month in-home rehabilitation program called HOME for Us for people who have had a traumatic brain injury (TBI) at least one year ago and their family caregivers. The program involves eight sessions with an occupational therapist, focusing on adapting the home…

This study tests a drug called entrectinib in children with advanced solid tumors or brain tumors that have come back or haven't responded to other treatments. The trial has two parts: first finding the best dose, then seeing how well it works in children whose tumors have specif…

This Phase 2 trial tests whether combining bevacizumab (Avastin) with atezolizumab (Tecentriq), with or without cobimetinib (Cotellic), can shrink or control melanoma that has spread to the brain. The study enrolls 29 adults with untreated brain metastases who are not taking ster…

This phase II trial tests whether combining two immunotherapy drugs (INCAGN1876 and INCMGA00012) with targeted radiation can help people with recurrent glioblastoma, an aggressive brain cancer. The 39 participants receive the drugs before and after surgery to remove the tumor, pl…

This 12-week study is for people who completed a previous trial of the ketogenic diet for first-episode bipolar disorder. Researchers want to see if the diet can improve symptoms like depression, mania, and psychosis, as well as brain energy metabolism and insulin resistance. Abo…

This trial tests the drug savolitinib in children and adults whose brain tumors (medulloblastoma, high-grade glioma, or DIPG) have come back or not responded to treatment. The drug works by blocking an enzyme that some tumor cells need to grow. The study aims to find the safest d…

This phase 3 trial tests whether the drug troriluzole can slow the progression of spinocerebellar ataxia, a rare genetic disorder that affects coordination and balance. About 300 adults with different types of SCA are randomly assigned to take either troriluzole or a placebo dail…

This phase 3 trial compares two drugs for primary progressive multiple sclerosis (PPMS), a form of MS that steadily worsens. About 985 adults with PPMS will receive either daily oral fenebrutinib or intravenous ocrelizumab (plus matching placebos) to see which better delays disab…

This study looks at whether starting a cardiac rehabilitation programme soon after leaving the hospital helps people with coronary artery disease live longer and avoid hospital stays for heart problems. The programme includes counseling, education, and exercise sessions three tim…

This study planned to test a new CAR-T cell therapy called LCAR-AIO in adults with relapsed or treatment-resistant neurological autoimmune diseases, including multiple sclerosis and myasthenia gravis. The goal was to check safety and find the right dose. However, the trial was wi…

This study tests whether a trauma-informed program called Strength at Home works better than the usual state-approved program for reducing intimate partner violence. About 800 men who are court-ordered to attend such programs, along with their partners, will take part. Researcher…

This Phase 3 trial tests whether the oral drug remibrutinib works better than teriflunomide at reducing relapses and slowing disability in people with relapsing multiple sclerosis. About 1,000 adults aged 18–55 with active MS are taking part. The study is double-blind, meaning ne…

This study tests a special deep brain stimulation (DBS) device that can both stimulate and record brain activity in people with treatment-resistant depression. Ten participants will have electrodes implanted in a brain region called the subcallosal cingulate. The goal is to ident…

This study tests a one-time gene therapy called CAP-003 in adults with Parkinson's disease caused by a GBA1 gene mutation. The goal is to see if it is safe and if it can help control the disease. Participants receive a single IV infusion and are monitored for two years.

This early-stage trial tested a drug called adavosertib together with radiation therapy for people with advanced esophageal or stomach cancer that cannot be surgically removed. The goal was to find the safest dose and see how well the combination works. Only 4 people took part, s…

This study tracks the safety of the drug Samsca (tolvaptan) in 300 Japanese patients with low sodium levels caused by SIADH. Researchers will record any side effects or special situations that occur during routine use. The goal is to confirm the drug's safety in real-world settin…

This study tests a drug called erdafitinib in children and young adults (ages 1 to 21) whose cancers have come back or are not responding to treatment and have specific changes in FGFR genes. The drug works by blocking enzymes that help cancer cells grow. The main goal is to see …

This phase 2 trial tests the drug selpercatinib in children and young adults (ages 1 to 21) with advanced cancers that have a specific genetic change called a RET alteration. The goal is to see if the drug can shrink tumors or stop them from growing. Only one participant has been…

This study tests whether adding the diabetes drug metformin to standard antidepressants helps people with both depression and obesity lose weight and feel better. Researchers will also check if certain gene variants affect how well the combination works. The trial involves 200 ad…

This phase 3 trial tests whether a shot (subcutaneous) of ublituximab works as well as the standard IV infusion for people with relapsing multiple sclerosis. About 360 participants are enrolled. The main goal is to compare drug levels in the blood over 24 weeks, along with safety…

This study looks at whether a one-year treatment with Ocrevus can improve walking and balance in people with relapsing multiple sclerosis, compared to other standard treatments. Sixty adults aged 18-65 who can walk at least 25 feet will be split into two groups. Their walking abi…

This study is a long-term follow-up for people with relapsing multiple sclerosis who previously completed a ublituximab trial. It aims to see if the drug remains safe and effective over time. About 1100 participants will receive ublituximab infusions, and researchers will track r…

This study tests a drug called olaparib in people with advanced cancers (like brain tumors, bile duct cancer, or other solid tumors) that have a specific gene change called IDH1 or IDH2 mutation. The drug works by blocking an enzyme that cancer cells need to grow. About 89 partic…

This early-stage trial tests a vaccine called PEP-CMV in 30 children and young adults (ages 3–35) whose medulloblastoma or malignant glioma has come back. The vaccine is designed to train the immune system to attack tumor cells that carry a common virus protein (CMV). Participant…

This study tests whether adding veliparib to the standard chemotherapy drug temozolomide helps people with a newly diagnosed, aggressive brain cancer called glioblastoma. The trial includes 447 patients whose tumors have a specific genetic change (MGMT promoter hypermethylation).…

This study tests a newer form of radiation called intensity-modulated proton therapy in children and young adults with craniopharyngioma, a rare brain tumor. The goal is to see if this precise radiation can better control the tumor while causing fewer side effects than older radi…

This early-stage study tested the safety and best dose of vorinostat when given with the chemotherapy drug temozolomide in 83 adults with aggressive brain tumors called malignant gliomas. The goal was to see if adding vorinostat could make the tumor cells more sensitive to chemot…

This study tests different dosing schedules of the drug donanemab in about 1,175 people with early symptomatic Alzheimer's disease. The goal is to find a regimen that lowers brain amyloid plaques while reducing the risk of a side effect called ARIA-E (brain swelling or small blee…

This study tests a drug called ulixertinib in children and teens whose advanced cancers have a specific genetic change in the MAPK pathway. The goal is to see if the drug can shrink or control the tumor. About 20 participants with various solid tumors, lymphomas, or related disor…

This phase 2 trial tests a new drug called HB-1, which combines two blood pressure medicines (telmisartan and verapamil), to see if it can reduce unexpected panic attacks in people with panic disorder. The study plans to enroll 240 adults aged 18 to 65 and compare HB-1 against pl…

This phase 2 trial is testing the drug larotrectinib in children and young adults (ages 1 to 21) with advanced solid tumors, non-Hodgkin lymphoma, or histiocytic disorders that have a specific genetic change called an NTRK fusion. The cancers have either come back after treatment…

This study tests whether giving a fructose (a type of sugar) injection soon after a stroke, along with standard clot-busting treatment, can improve brain recovery. About 46 adults who have a stroke within the last 4.5 hours will be randomly assigned to receive either fructose plu…

This study tested the drug ensartinib in 13 children and young adults (ages 1–21) whose cancers had come back or did not respond to treatment and had specific ALK or ROS1 gene changes. The goal was to see if the drug could shrink or stop tumor growth. While the drug targets cance…

This was a small, early-phase study designed to test the safety and feasibility of a cancer vaccine (SV-BR-1-GM) combined with the immunotherapy drug pembrolizumab (Keytruda) in patients with solid tumors that had spread to the brain or spinal cord lining. The trial planned to en…

This study tests whether offering PTSD therapy to people in jail who also have opioid or stimulant use disorder can help them start addiction treatment after release. Researchers will screen and refer participants, then randomly assign some to start therapy immediately in jail an…

This phase 3 trial is testing whether the drug retatrutide can lower the chance of serious heart problems (like heart attacks and strokes) and slow kidney disease in 10,000 overweight adults who already have heart or kidney disease. Participants receive either retatrutide or a pl…

This pilot study explores whether people with melanoma or non-small cell lung cancer that has spread to the brain can safely skip stereotactic radiosurgery (focused radiation) after having a brain tumor surgically removed. Instead of radiation, participants receive systemic thera…

This study tests whether inhaling nitric oxide gas can improve blood flow in the brain after a traumatic brain injury (TBI). The trial enrolls adults aged 18 to 75 with moderate TBI or mild TBI with abnormal scans. Participants receive either inhaled nitric oxide or standard care…

This study follows 158 people in France who are prescribed Epidyolex (a cannabidiol-based medicine) for seizures as part of their normal care. Researchers will track how long people stay on the treatment, side effects, seizure frequency, and changes in daily functioning and quali…

This study tests whether naloxegol, a drug that blocks opioid effects in the gut, can prevent constipation and pneumonia in brain-injured patients in the ICU. These patients often receive opioids for sedation, which can slow digestion and lead to serious complications. The trial …

This study tests whether people with atrial fibrillation who receive a WATCHMAN FLX Pro device can safely take just one blood thinner or aspirin instead of the usual two-drug plan. About 1,857 participants are being followed for six months to compare rates of death, stroke, major…

This study tests whether adding the drug azeliragon to targeted radiation therapy can safely shrink brain tumors and keep them under control longer. It involves 46 adults with cancer that has spread to the brain. The goal is to improve tumor control without causing serious side e…

This study tests a wireless device that stimulates the vagus nerve during rehabilitation exercises to help people who have had a stroke recover arm and hand function. The approach, called targeted plasticity therapy, aims to enhance the brain's ability to rewire itself. The trial…

This study tests whether a low dose of lithium (20 mg/day) can slow disease-related changes in the brain and blood of people with early-stage Parkinson's disease. Twenty participants will receive either lithium or a placebo for a period, and researchers will use MRI scans and blo…

This study planned to test whether giving a child their own stored umbilical cord blood is safe for treating perinatal arterial ischemic stroke. It was designed for children aged 6 weeks to 6 years with MRI-confirmed stroke. The trial was withdrawn before enrolling any participan…

This early-stage study tests a combination of two drugs, avutometinib and defactinib, in children and young adults (ages 3 to 30) with advanced or recurrent solid tumors that have specific genetic changes. The main goal is to find the safest dose with the fewest side effects. The…

This early study at Mayo Clinic tests whether ultra-low, anti-inflammatory doses of radiation can slow Parkinson's disease. Twenty people with early-stage Parkinson's will receive five daily radiation treatments guided by special brain scans. The main goal is to see if the treatm…

This study tested whether adding a special type of talk therapy (CBASP) to standard smoking cessation treatment helps depressed smokers quit and feel better. About 91 adults with depression who smoked at least 5 cigarettes a day took part. The goal was to see if the combined appr…

This phase 3 trial is testing the safety and tolerability of fenfluramine (Fintepla) in 25 infants aged 1 to 2 years with Dravet syndrome, a severe form of epilepsy. The drug is given as an oral solution twice daily alongside other seizure medications. Researchers will monitor he…

This study compares the standard fixed-interval dosing of ocrelizumab (every 24 weeks) with a personalized approach where infusions are given only when B cell levels rise above a certain threshold. The goal is to see if the personalized schedule is just as good at preventing rela…

This study was designed to test two immunotherapy drugs, nivolumab and ipilimumab, in children and young adults with cancers that returned or didn't respond to treatment and had many genetic mutations. The goal was to see if the drug combination was safe and could shrink tumors. …

This study tests whether adding an interleukin-6 receptor inhibitor (a drug that reduces inflammation) to standard emergency stroke treatment helps people recover better after a severe stroke caused by a large blood clot in the front part of the brain. About 692 adults who are el…

This phase 2 trial tests an oral drug called venglustat, given alongside the standard enzyme therapy Cerezyme, in adults with Gaucher disease type 3 (a rare genetic disorder affecting the body and brain). The study has four parts: first, it checks spinal fluid biomarkers to disti…

This early-phase study tested a new drug called BHV-7000 in 5 people with epilepsy who have a brain implant (RNS) that records brain activity. The goal was to see if the drug reduces abnormal electrical activity linked to seizures. Participants took the drug for 4 weeks, and thei…

This large study is testing whether a device called WATCHMAN FLX, which closes off a small pouch in the heart, can be a safe and effective alternative to daily blood thinners (NOACs) for preventing strokes in people with non-valvular atrial fibrillation. The trial involves 3,000 …

This phase 2 trial tests the drug cabozantinib in children and young adults with rare cancers like sarcomas, Wilms tumor, and others that have come back or not responded to treatment. Cabozantinib works by blocking enzymes that help tumors grow and form blood vessels. The study a…

This phase II trial is testing two different three-drug combinations in people with advanced BRAF-mutated melanoma that has spread or cannot be removed by surgery. One group receives nivolumab (immunotherapy) plus dabrafenib and trametinib (targeted therapy); the other receives n…

This study tests a new coil device (Kaneka i-ED) in 50 people with wide-necked brain aneurysms. The coil is placed inside the aneurysm to block blood flow and prevent rupture. Researchers will check how well it works, how safe it is, and whether it saves money compared to standar…

This study tests a special balloon catheter coated with the drug paclitaxel to treat narrowed or re-narrowed brain arteries. The balloon is inflated inside the artery to open it and release the drug, which may help prevent the artery from closing again. The trial includes 281 adu…

This phase 3 trial tests whether rituximab, a cheaper drug, works as well as ocrelizumab for active multiple sclerosis. About 600 adults with relapsing or progressive MS will receive one of the two drugs. The main goal is to see if rituximab can prevent new brain lesions as effec…

This early study tests a new treatment called UX-DA001 for people with Parkinson's disease. The treatment uses the patient's own cells, which are turned into dopamine-producing cells and implanted into the brain during surgery. The main goal is to check safety, but researchers wi…

This study tests a gene therapy called NGN-401 in 33 girls with Rett syndrome, a rare genetic disorder that affects development and movement. The therapy delivers a working copy of the MECP2 gene to try to improve skills and daily function. Researchers will measure success by whe…

This early-stage trial tests a one-time gene therapy called CLN-301 in 7 children aged 3 to 10 with CLN3 Batten disease, a rare genetic disorder that causes progressive loss of vision, movement, and thinking skills. The therapy delivers a working copy of the CLN3 gene directly in…

This phase 2 trial tests whether lamivudine, an antiviral drug, can improve symptoms in people with Rett syndrome, a rare genetic disorder that affects movement, communication, and behavior. Ten participants will take the drug by mouth for a set period, and researchers will measu…

This study tests whether a mobile app can help parents of children aged 5-8 with disruptive behavior. 324 families will use either a standalone app, a coach-assisted app, or a control app. The goal is to see if digital tools can improve parenting skills and child behavior at a la…

This pilot study in Malawi tests whether adding stigma-reduction counseling to standard depression treatment helps people living with HIV. Two hundred adults with HIV and depressive symptoms will receive counseling sessions that challenge myths and build coping skills. Researcher…

This study looks at whether the drug ofatumumab can slow down thinning of the retina (the light-sensitive layer at the back of the eye) in people with relapsing-remitting multiple sclerosis (MS). Researchers will follow 75 adults with MS who are either starting or already taking …

This study tests whether a new drug, ABP 692, works as well as the approved drug Ocrevus for people with relapsing-remitting multiple sclerosis (RRMS). About 152 adults with RRMS will receive either ABP 692 or Ocrevus to compare how the drugs move through the body and how well th…

This study tests whether a daily fingolimod capsule works better than a weekly interferon injection to prevent multiple sclerosis relapses in children. About 240 kids with MS will take one of the two treatments for 2 years, followed by a 5-year extension where everyone gets fingo…

This study planned to test a new treatment combining CYNK-001 (natural killer cells from donated cord blood) with interleukin-2 in adults whose glioblastoma had returned and could be surgically removed. The goal was to see if this combination was safe and could extend the time be…

This trial tests a personalized treatment plan for people with advanced colorectal cancer that has spread to the liver and stopped responding to standard treatments. The approach combines a liver-directed chemotherapy (HAIC), a targeted therapy (fruquintinib or cetuximab), and an…

This study looks at whether the drug troriluzole can slow the progression of spinocerebellar ataxia (SCA), a rare genetic disease that affects movement and balance. Researchers will compare 909 patients who took troriluzole for up to three years with similar patients who did not …

This study looks at the long-term safety and effectiveness of an experimental drug called NMRA-335140 for people with major depressive disorder. About 1,000 adults who completed earlier studies of this drug will take it for 52 weeks. Researchers will track side effects and change…

This early-stage study tests a gene therapy called ETX101 in 5 children with Dravet syndrome, a severe form of epilepsy. The therapy delivers a gene that helps calm overactive brain cells. Researchers will check if it safely reduces seizure frequency and improves thinking and dai…

This study tests whether giving pregabalin before brain tumor surgery can safely reduce pressure inside the skull. One hundred adults will receive either pregabalin or a placebo before and on the morning of surgery. Researchers will measure pressure using a painless eye ultrasoun…

This study planned to test the drug bumetanide in children aged 5 to 17 with autism of known cause. The goal was to see if it could improve autism symptoms. However, the trial was withdrawn before enrolling any participants, so no new information was gathered.

This study tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy (with or without radiation) after surgery can help prevent high-risk endometrial cancer from coming back. About 990 participants who had surgery to remove their uterus and ovaries will r…

This study tests whether daily phone reminders can help people with schizophrenia or schizoaffective disorder remember to take their medication. 104 participants will receive repeated cues on their mobile phones for 30 days. The goal is to see if this improves medication adherenc…

This study tests whether adding a personalized dendritic cell vaccine to standard chemotherapy can help people with newly diagnosed glioblastoma live longer. Twenty patients who had surgery and chemoradiation will receive the vaccine alongside temozolomide. The goal is to see if …

This study tests whether placing tiny radioactive seeds (Cs-131) in the brain during surgery can stop recurrent brain tumors from growing back. About 103 adults with previously treated brain metastases will be randomly assigned to receive either surgery alone or surgery plus this…

This large Phase 3 study tests whether milvexian, an experimental oral blood thinner, can prevent another stroke in people who recently had a mild stroke or a high-risk mini-stroke (TIA). Over 12,500 participants are randomly assigned to receive either milvexian or a placebo, alo…

This study tests whether a drug called Xiaflex (collagenase clostridium histolyticum) is safe and effective for men with Peyronie's disease who have already tried platelet-rich plasma (PRP) injections. Twelve men with stable penile curvature between 30 and 90 degrees will receive…

This study tests whether adding focused radiation (stereotactic radiosurgery) to a combination of targeted drugs (binimetinib and encorafenib) and an immunotherapy (pembrolizumab) can better control melanoma that has spread to the brain. It includes 10 adults with a specific gene…

This study tests a personalized deep brain stimulation (DBS) approach for people with severe obsessive-compulsive disorder (OCD) that hasn't improved with standard treatments. Ten adults will first undergo brain mapping to find the best stimulation targets, then receive a DBS dev…

This study looks at a device called ENTERPRISE 2 that helps doctors treat brain aneurysms (a bulging blood vessel in the brain). The device is used during a procedure to block the aneurysm with coils. The study includes 164 people aged 18 to 80 with certain types of brain aneurys…

This study tests a new device (Laminar) to close the left atrial appendage, a small pouch in the heart, in 1500 people with non-valvular atrial fibrillation. The goal is to see if it is safer and works better than existing devices to reduce the risk of stroke and blood clots. Par…

This early-stage study tests whether adding a drug called acetazolamide to standard chemotherapy (temozolomide) is safe for people with a newly diagnosed, aggressive brain cancer (glioblastoma). Ten adults will take both drugs daily for 21-day cycles. The main goal is to find any…

This study tests new drugs, alone or combined with pembrolizumab, in people with extensive-stage small cell lung cancer that has stopped responding to initial therapy. About 110 participants will receive experimental treatments to see if they are safe and can shrink tumors. The g…

This early-phase study tests a vaccine called SurVaxM in 35 children with certain brain tumors that have come back or are hard to treat. The vaccine is designed to teach the immune system to find and destroy tumor cells that have a protein called survivin. The goal is to see if i…

This study follows about 111 people with Lennox-Gastaut syndrome, Dravet syndrome, or tuberous sclerosis complex who are taking Epidyolex (a CBD oral solution) for seizures. Researchers track how many stay on the drug for a year and how many seizure-free days they have. It's an o…

This program provides brivaracetam (Briviact) to epilepsy patients who were already taking it in earlier studies, bridging the gap until the drug is commercially available. Patients continue their individual doses, up to 200 mg per day, with adjustments based on seizure control a…

This pilot study tests a new device called OsciPulse that rapidly compresses the calves to improve blood flow and reduce the risk of blood clots in people hospitalized after a stroke. About 40 adults with leg weakness will be randomly assigned to receive either OsciPulse or stand…

This study looks at how well the migraine prevention drug atogepant works in real-world settings. Over 1000 adults with migraine who are already prescribed atogepant will be followed for 2 years. Researchers will measure how much patients feel their migraines have improved since …

This study looks at 3,500 unconscious patients who survived a cardiac arrest to find the best combination of sedation, fever control, and blood pressure management in the ICU. Each patient gets one of two levels for each factor (e.g., deep vs. light sedation, tight vs. loose feve…

This early-phase study tests whether adding a drug called S-Gboxin to standard treatment can help people with glioblastoma, a fast-growing brain cancer. The drug works by cutting off the energy supply to cancer cells. Ten patients with recurrent or progressive disease will receiv…

This trial will test whether deep brain stimulation (DBS) surgery improves movement, balance, and daily function in 40 people with Parkinson's disease. Participants will have their walking speed, balance, muscle strength, and activity levels measured before and after surgery. The…

This study is testing the long-term safety of a daily pill called OLZ/SAM (olanzapine plus samidorphan) in 236 teenagers with schizophrenia or bipolar I disorder. Participants have already completed a previous study with the same drug. The goal is to see if the drug is safe and t…

This early-phase trial tests whether delivering the cancer drug bevacizumab (Avastin) directly into the brain's arteries can safely treat vestibular schwannoma (acoustic neuroma), a non-cancerous tumor that can cause hearing loss. The study enrolls up to 30 adults with growing tu…

This study tests a nurse-led program that uses home monitoring devices to help older adults with conditions like heart failure, diabetes, and depression manage their health after leaving the hospital. The goal is to improve care coordination and reduce hospital readmissions. Abou…

This study tests a program called REAL Fathers in Uganda, where respected community men mentor young fathers (ages 16-25) on positive parenting, conflict resolution, and family planning. Over 4,700 participants are involved. The goal is to see if this approach reduces intimate pa…

This study tests a device called Amulet 2 that is implanted in the heart to seal off a small pouch (the left atrial appendage) where blood clots can form in people with atrial fibrillation. The goal is to reduce the risk of stroke without needing long-term blood thinners. About 4…

This study looks at whether giving people with PTSD a personalized mix of gut bacteria (called pharmabiotics) can help their mental health. The researchers will track changes in PTSD symptoms, anxiety, depression, and thinking skills over 14 days. The goal is to see if fixing the…

This Phase 3 study tests the long-term safety and effectiveness of azetukalner, a daily pill, in 400 adults with bipolar I or II depression who previously completed a related study. Participants take the drug for 52 weeks, and researchers track side effects, mood changes, and qua…

This early-stage trial tests a new surgical approach for recurrent glioblastoma, an aggressive brain cancer. After standard tumor removal, surgeons place a piece of abdominal tissue (omentum) into the brain cavity to bypass the blood-brain barrier. The study involves 10 adults an…

This study follows about 1,756 adults who were part of a larger trial and received either ketamine or etomidate during emergency intubation. Researchers want to see if ketamine can reduce PTSD symptoms one year later, since it may block the brain's formation of traumatic memories…

This early-stage trial tests a drug called NIO752 in 38 people with mild Alzheimer's or mild cognitive impairment due to Alzheimer's. The drug is given as one or two injections into the spinal fluid to see if it can lower levels of tau protein, a key marker of Alzheimer's damage.…

This study tests whether giving three rounds of very strong chemotherapy with stem cell rescue works better than one round for children under 10 with high-risk brain tumors. The goal is to improve survival without adding too many side effects. About 250 children will take part.

This phase 3 study tests whether donanemab, an antibody given through an IV, can safely slow cognitive decline in 1500 people with early Alzheimer's. Participants receive either the drug or a placebo for up to 93 weeks. The main goal is to measure changes in thinking and daily fu…

This early-stage study tests a new long-acting injection called HNC364, which turns into the Parkinson's drug rasagiline in the body. Researchers want to see how much of the drug gets into the bloodstream compared to taking rasagiline pills daily. The study involves 30 healthy ad…

This phase 1 trial is testing a new imaging tracer called 68Ga-FAPI-46 to see where it collects in normal and cancerous tissues. About 30 people with various solid tumors or blood cancers will receive the tracer and then undergo a PET/CT scan. The goal is to understand how the tr…

This study offers voluntary screening for newborns in North Carolina to detect a wide range of rare health conditions early. Using a small blood sample already collected at birth, the program tests for dozens of disorders, including spinal muscular atrophy, cystic fibrosis, and m…

This study tests an AI tool called AIDP that analyzes MRI scans to help diagnose Parkinson's disease and two similar conditions (MSA and PSP). Researchers at 21 sites will compare the AI's diagnosis to that of movement disorder specialists. The goal is to see if the tool can impr…

This study uses special brain scans (PET imaging) to measure amyloid buildup—a protein linked to Alzheimer's—in healthy older adults, people with mild memory problems, and those with dementia. Participants receive scans every 2-3 years for up to 20 years to see how amyloid change…

This study is testing two different imaging techniques—SPECT and PET—to see how well they can spot brain tumors called gliomas. Forty patients with primary or recurrent glioma will receive injections of two special tracers, then undergo scans to measure how much tracer is taken u…

This study explores whether a taste test can serve as a diagnostic tool for depression. Participants with untreated major depressive disorder will take a taste test before and after starting an antidepressant prescribed by their doctor, and again six to eight weeks later. The goa…

This study tests whether a millimeter-wave radar system can accurately diagnose type 1 narcolepsy by monitoring sleep without physical contact. Forty patients will use the radar alongside standard sleep tests (PSG/MSLT) to see if the radar matches the standard results. If it work…

This study evaluates RDX-Aneurysm, a computer-assisted detection software designed to help radiologists find saccular intracranial aneurysms (bulging blood vessels in the brain) on MRI scans. Researchers will analyze 550 past scans—half with confirmed aneurysms and half without—t…

This study tests whether a special PET scan using a radioactive form of methionine (a natural amino acid) can help doctors see tumors in children and young adults with various cancers, including brain tumors and sarcomas. About 503 participants will be scanned to see if the metho…

This study tests whether a Turkish translation of the Four-Dimensional Symptom Questionnaire (4DSQ) helps Belgian general practitioners who don't speak Turkish better diagnose depression and anxiety in Turkish-speaking patients with language barriers. About 80 patients and their …

This study tests a laser-based imaging method that shows blood flow in the brain in real time during surgery. It involves 20 adults having brain surgery for conditions like aneurysms. The goal is to see if this technique can give surgeons continuous feedback, unlike the current d…

This small pilot study tests whether a special PET scan called Axumin can help doctors tell the difference between real tumor growth and treatment-related inflammation (pseudo-progression) in people with brain metastases who are on immunotherapy. The study enrolled 3 adults with …

This study tests whether a music-inspired community campaign, called Music4Health, can help lower blood pressure and improve stroke awareness among 1,412 youth (ages 14-24) and their caregivers (ages 40+) in Nigeria. Participants will take part in listening sessions and activitie…

This study compares two different doses of radiation aimed at the head (prophylactic cranial irradiation) to see which is better at preventing brain metastases in people with small cell lung cancer. Participants had their lung cancer diagnosed within the past year and have alread…

This study tests a self-guided online program called CATCH-IT, designed to prevent depression in teenagers who are at risk. Researchers are working with 400 teens aged 13-18 across four health systems to find the best way to deliver this program in primary care. The goal is to se…

This study tests two different programs designed to prevent depression in teenagers who are at risk. One program is an online course called CATCH-IT, and the other is an 8-session group program called TEAMS. About 636 teens aged 13-19 with mild depressive symptoms but no current …

This study tests whether a type of talk therapy called Interpersonal and Social Rhythm Therapy (IPSRT) can prevent bipolar disorder in teenagers (ages 12-18) who have a parent with bipolar disorder and are considered high-risk. Participants receive 8 sessions of IPSRT or a health…

This large Phase 3 study tests whether inclisiran, a twice-yearly injection, can prevent major heart problems like heart attacks, strokes, and heart-related death in people at high risk who have not yet had such an event. Over 14,000 participants are receiving either inclisiran o…

This study tests whether whole brain radiation can lower the chance of brain tumors in people with small cell carcinoma of the urinary tract (including the bladder). The 31 participants have already had chemotherapy and responded well. They receive radiation to the brain for 3 we…

This study tests a psychological empowerment program designed to prevent postpartum depression in pregnant women. 92 first-time mothers in Indonesia will take part in 5 group sessions over 3 weeks, focusing on control, confidence, and coping. Researchers will check if the program…

This study tests whether sulforaphane, a compound found in broccoli, can prevent psychosis in 300 people at high risk. Participants take either sulforaphane or a placebo daily for a year, then are followed for another year. The main goal is to see if fewer people in the sulforaph…

This study tests a non-invasive device that uses gentle electrical currents to stimulate the right amygdala, a brain area linked to emotion. Fifty adults with major depression will receive either real or sham stimulation for six weeks. Researchers will measure changes in mood, th…

This study tests whether listening to special audio fairy tales before sleep can improve speech, motor skills, and independence in a child with autism and central auditory processing disorder. The child stays at home with their mother, avoiding clinic stress. Early results from t…

This study tests a special bed called SuPerSense that senses how a person lies on it and gives feedback to help improve posture and balance. People with Parkinson's disease who have trouble with balance or posture will either do standard rehab exercises or use the smart bed plus …

This study compares two types of exercise—open kinetic chain (like leg raises) and closed kinetic chain (like squats)—to see which better reduces knee hyperextension in stroke survivors. Sixty adults who have had a stroke and can walk with some help will be randomly assigned to o…

This trial investigates whether combining two types of brain stimulation—intermittent theta burst stimulation (iTBS) and high-definition transcranial direct current stimulation (HD-tDCS)—can reduce negative symptoms of schizophrenia, such as lack of motivation, social withdrawal,…

This study explores whether joining a weekly reading group can improve reading comprehension and communication confidence in adults with aphasia, a language disorder often caused by stroke. Participants read a book at home and then discuss it in a 90-minute group session each wee…

This study explores whether adding a non-invasive brain stimulation technique called transcranial direct current stimulation (tDCS) to standard speech therapy can improve word-finding in people with aphasia after a stroke. The trial involves 50 adults who are at least six months …

This study tests whether a 24-week physical therapy program can help people with multiple sclerosis become more physically active. Forty participants will receive tailored exercise support and education. The goal is to see if this approach is feasible and helps manage MS symptoms…

This study investigates whether using a stress ball during port catheter needle changes can reduce pain, anxiety, and improve satisfaction in cancer patients. Fifty adult oncology patients will be randomly assigned to either use a stress ball or receive standard care. The goal is…

This study tests a new functional drink made with chicory inulin, B-vitamins, and vitamin D to see if it can improve constipation and overall well-being in people with Parkinson's disease. About 56 participants will drink either the active supplement or a placebo twice daily for …

This study tests whether smelling essential oils during skin surgery can reduce the unpleasant smell of burnt flesh from electrocautery and lower patient anxiety. About 111 adults having same-day skin procedures will be randomly assigned to receive either a real essential oil inh…

This study explores whether a new type of group therapy, based on Eastern cultural practices, can help people with anxiety disorders. Researchers will enroll 60 participants aged 15 to 55 to test the therapy's effects on anxiety symptoms. The goal is to see if this approach is bo…

This study investigates whether whole-body vibration (WBV) therapy, added to standard exercise, can improve balance, walking, thinking, and the ability to do two things at once in people with Parkinson's disease. Participants will be randomly assigned to receive either low-freque…

This study tests whether a targeted nerve block (retrolaminar block) provides better pain relief after lumbar discectomy than the standard method of injecting pain medicine into the surgical wound. 130 adults having elective single-level herniated disc surgery will be randomly as…

This study tests whether alternating between high and low frequencies of deep brain stimulation (DBS) can improve walking and balance in people with Parkinson's disease. Twelve participants who already have DBS implants will try different stimulation patterns while their gait and…

This study tests whether a smartphone app that delivers cognitive behavioral therapy (CBT) can help adults with social anxiety disorder. Participants use the app for 12 weeks, learning skills like cognitive restructuring and exposure exercises. The trial compares app users to a w…

This study looked at whether omega-3 fatty acids can reduce inflammation and improve mood in adults with treatment-resistant depression. Fourteen participants who were already on antidepressants but still depressed were randomly given either omega-3 supplements or a placebo for 1…

This study tests whether a dietary supplement called Dong'e Brand Ejiao Yuanjiang can help improve sleep quality. Researchers will enroll 66 adults aged 25 to 55 and track their sleep over 60 days using questionnaires and wearable devices. The goal is to see if the supplement lea…

This study tests a short, high-dose form of brain stimulation called repetitive transcranial magnetic stimulation (rTMS) in 20 people who had a stroke at least 6 months ago. The goal is to see if it is safe and acceptable, and whether it can improve cognitive problems like memory…

This pilot trial tests a 15-week telehealth program called Surviving and Thriving in the Real World (STRW) for teens aged 14–18 with epilepsy who struggle with daily living skills. The program includes weekly caregiver-teen sessions and separate caregiver group meetings, all deli…

This study tests whether DHA, a key omega-3 fatty acid found in fish oil, can improve symptoms of autism in children and adolescents aged 5 to 17. Participants receive either DHA or a placebo daily for 12 weeks. Researchers also look at genes and urine markers related to DHA to u…

This study looks at whether aquatic therapy in a warm pool can help children ages 3-9 with conditions like cerebral palsy improve their swimming safety, arm function, and ability to do daily tasks. Children attend sessions twice a week for ten weeks. Researchers will measure chan…

This Phase 3 study tests whether nightly doses of CBD (75mg or 150mg) can reduce insomnia severity in adults over 8 weeks. Participants take capsules or a placebo, and researchers measure changes in sleep quality using a standard questionnaire and sleep efficiency. The goal is to…

This study tests whether augmented reality (AR) games can improve walking and balance in children with cerebral palsy. Forty children will either do exercises wearing AR goggles or receive standard physical therapy. The goal is to see if the AR approach is more effective and enga…

This study tests whether a smartphone app called AIM+ can help juvenile justice officers and other professionals who work with youth in the legal system manage chronic stress, anxiety, and burnout. Over 30 days, participants use the app for short guided meditations and videos. Th…

This study tests a modified whole brain radiation technique that avoids a specific area of the brain called the corpus callosum genu, which is important for memory and thinking. The goal is to see if this approach helps preserve cognitive function in people with brain metastases …

This phase 2 study is testing whether fluoxetine, a widely used antidepressant, can reduce PTSD symptoms in 800 adults including active-duty service members, veterans, and civilians. Participants receive either fluoxetine or a placebo for 12 weeks, and researchers measure changes…

This phase 2 trial tests whether fasudil, a drug already used in Japan for blood vessel spasms, is safe and can help symptoms in people with early Parkinson's disease. 75 participants will take either fasudil or a placebo for 3 weeks. The study focuses on safety and tolerability,…

This study tests whether an injection of hyaluronidase can reduce muscle stiffness and spasticity in the arm after a stroke. 56 adults with moderate-to-severe stiffness will receive either the study drug or a placebo, and later switch to the other option. The goal is to improve r…

This study explores whether high-intensity interval training (HIIT) is a practical and acceptable treatment for adults with ADHD. Researchers will recruit 30 adults diagnosed with ADHD to participate in a 14-week exercise program combining strength and endurance training. The goa…

This study tests an internet-based cognitive behavioral therapy (CBT) program designed to help autistic adolescents aged 11-17 manage anxiety. The program, called LUNA-Adolescent, is parent-led and delivered online, making it easier for families who cannot access in-person therap…

This study looks at two ways to lower anxiety in children aged 3 to 10 who need surgical pins removed from an elbow fracture. One approach removes the pins right after the cast comes off, before an X-ray, instead of after. The other uses a virtual reality headset during the pin r…

This study tests whether daridorexant, a drug used for insomnia, can reduce PTSD symptoms in 200 adults, including active-duty service members, veterans, and civilians. Participants receive either the drug or a placebo for 12 weeks, and researchers track changes in PTSD severity …

This study tests whether adding personalized feedback to an online sleep program helps university students with insomnia. About 70 students will be split into three groups: standard online therapy, enhanced therapy with feedback, or a waitlist. The goal is to see if the extra fee…

This study tests an 8-week online stress management program for health students in Sfax, Tunisia. The program combines cognitive-behavioral therapy and mindfulness meditation through videos, exercises, and motivational messages. Researchers will measure changes in stress, anxiety…

This study investigates whether menopausal hormone therapy (MHT) can improve sleep quality in women going through menopause. Researchers will compare sleep in women who receive MHT to those who do not, using questionnaires and sleep diaries. The goal is to see if MHT can help wit…

This study tests whether an accelerated form of transcranial magnetic stimulation (TMS) can safely and effectively reduce depression symptoms in people with major depressive disorder. About 50 participants aged 15 and older will receive the treatment in an open-label design. The …

This study tests whether a short video and a 3-week text messaging program can help people who have recently experienced sexual assault. The goal is to see if these tools can reduce mental health problems like PTSD and prevent misuse of opioids and other substances. About 394 adu…

This study tests an oral medication called MM120 against a placebo in adults with major depressive disorder. The trial has two parts: a 12-week blinded phase followed by a 40-week open-label extension where everyone gets MM120. The main goal is to see if MM120 reduces depression …

This study compares a shorter therapy focused on guilt (TrIGR) to a standard PTSD therapy (CPT) in 160 U.S. Veterans. The goal is to see if TrIGR is no less effective at reducing PTSD, depression, and guilt symptoms. Participants are randomly assigned to one of the two treatments…

This trial explores whether spending time on a farm with animals and nature can help socially withdrawn young adults (ages 18–30) with autism spectrum disorder. Participants take part in supervised group activities on a farm twice a week for 12 weeks. Researchers will interview p…

This pilot study explores whether non-invasive electrical stimulation of the spinal cord, combined with hand and arm exercises, can improve upper limb function in people with multiple sclerosis. Participants use a home device with help from a partner over 8 weeks. The study focus…

This study looks at whether a peer support program is acceptable and helpful for people with mild depression or anxiety who are starting or receiving hormone care. One hundred participants are randomly assigned to either the peer support group or usual care. The program includes …

This study looks at whether Behavioral Activation (BA) therapy can change the habit of repetitive negative thinking (rumination) in people with major depression. Up to 120 adults will receive 12 sessions of BA over 11 weeks. Researchers will measure symptom changes and explore wh…

This study tests whether a parent-led therapy called Pathways can improve social skills in 80 toddlers (16-30 months old) who show early signs of autism. One group of parents learns a technique to encourage mutual eye contact during play, while the other group uses the same thera…

This pilot study is testing whether yoga-based movements, done online or in person, can help people with chronic migraine or cluster headache. Twenty adults aged 18-65 will participate. The goal is to see if yoga improves headache frequency, sleep quality, and overall well-being …

This study tests whether atogepant, a drug already used to prevent migraines, can also treat migraine attacks quickly. About 1300 adults with a history of migraines will take either atogepant or a placebo when they have a migraine, and then report pain levels and symptoms after 2…

This study tests whether adding home-based telerehabilitation via WhatsApp video calls to standard outpatient therapy improves hand function in people who had a stroke 1-6 months ago. Forty-eight participants will be split into two groups: one gets standard therapy plus daily 30-…

This small study tests a new treatment called TEST for people with depression that hasn't improved with standard treatments. TEST uses a lower electric current than standard electroconvulsive therapy (ECT), aiming to avoid memory and thinking problems. Eight adults aged 25-64 wil…

This study tests whether a simple ear acupressure technique, called auricular point sticking therapy, can reduce anxiety and improve sleep in women undergoing IVF. 178 women aged 20-45 with anxiety or insomnia will either receive standard IVF care or standard care plus ear acupre…

This early-phase trial tests whether inhaling a low dose of xenon gas can quickly improve depressive symptoms in 20 people with treatment-resistant major depression or bipolar depression. Participants receive either xenon or a placebo gas added to their usual treatment, and resea…

This study tests whether wearing a virtual reality (VR) headset during dental treatment can reduce fear and stress in children with mild intellectual disabilities or autism spectrum disorder. Two hundred children aged 6 to 12 will either receive standard dental care or use a VR h…

This study tests a new virtual reality program designed to help adults with autism improve their social skills and daily functioning. 140 participants will either receive the VR training plus usual care, or usual care alone, for 3 months. Researchers will measure changes in socia…

This study tests whether giving first-time mothers online education about childbirth starting at 30 weeks of pregnancy can lower their risk of post-traumatic stress after delivery. Researchers will enroll 400 women and track their mental health through surveys at 6 weeks and 6 mo…

This study tests a new method called Strategic Treatment Assessment for Youth (STAY) designed to help racial and ethnic minority teens with depression or suicidal thoughts stay in therapy. Researchers will compare STAY to standard care in 140 teens aged 12-18 across three communi…

This pilot study tests whether one-on-one peer support sessions can help people with relapsing-remitting multiple sclerosis stay on their prescribed medications. Sixty adults will be randomly assigned to receive either standard care or three hour-long sessions with a trained peer…

This study is testing whether a 6-month program of online exercise classes, guided meditation, and nutrition advice can improve thinking, sleep, and overall health in people with Parkinson's disease. 60 participants aged 40 to 85 will take part, with some starting the program rig…

This study tests whether personalized nutrition advice can improve nutrition, reduce stomach problems, and enhance quality of life in children with cerebral palsy. Fifty children aged 6 to 12 will be randomly assigned to receive either individualized dietary counseling or routine…

This study tests whether a pelvic floor massage technique (Thiele massage) can reduce pain during sex in women with chronic pelvic pain. It compares in-person treatment with guided self-massage at home via telehealth. The goal is to see if telehealth can be as effective as in-per…

This early-stage study tests whether psilocybin (the active ingredient in magic mushrooms) can safely help adults with long-term PTSD who are already taking antidepressants. Twenty participants will receive psilocybin, and some will also get trauma-focused talk therapy. The goal …

This study tests an oral medication called MM120 against a placebo in 245 adults with generalized anxiety disorder. Participants take the drug or placebo for 12 weeks, and those who complete may join a 40-week follow-up where everyone gets the active drug. The goal is to see if M…

This study tests two different movement training methods—sprinter-style and skater-style—to see which better improves balance and coordination in people who had a stroke at least six months ago. Twenty-two participants will do 30-minute sessions three times a week for four weeks.…

This study tests a behavioral program called SWITCH that teaches people with serious mental illness (like depression, schizophrenia, or bipolar disorder) to set goals, use rewards, and build habits to do more activities outside the home. 52 participants will attend weekly online …

This phase 3 study tests whether an oral medication called MM120 can reduce anxiety symptoms in adults with generalized anxiety disorder. About 214 participants will receive either MM120 or a placebo for 12 weeks, followed by a 40-week period where everyone can receive MM120. The…

This study tests whether injecting a dextrose (sugar water) solution around nerves in the neck can reduce PTSD symptoms like anxiety and brain fog. Twenty-four adults who have tried at least two medications and two non-drug treatments for PTSD will receive either the injection or…

This study tests a single cognitive behavioral therapy (CBT) program designed to help veterans who struggle with both anxiety (including PTSD) and hazardous drinking. The goal is to see if treating both issues together improves their daily functioning and reduces symptoms better …

This study tests whether adding cognitive training to balance and gait exercises helps people with Parkinson's disease improve their balance, walking, and thinking. Fourteen participants will undergo 12 sessions of combined training. The goal is to see if this approach eases move…

This study tests whether a unique music therapy, based on Traditional Chinese Medicine's five-element theory, can help men with depression and anxiety when added to their usual medication. One hundred male inpatients will receive either standard drugs alone, drugs plus regular mu…

This study tests whether a wearable headband that shines near-infrared light can improve depression and sleep in adults aged 60 and older with major depression. Participants will wear the device for up to 8 weeks, and researchers will track sleep, mood, and daily activity using a…

This study tests whether training early intervention providers in Reciprocal Imitation Training can help children with autism improve imitation and communication skills. The program involves 440 children and their caregivers, with providers learning simple strategies during play.…

This study tests two different therapies—digital mirror therapy and action observation therapy—to see which better improves arm movement and grip strength in children with hemiplegia (one-sided weakness). Forty-five children aged 6 to 8 will participate. The goal is to find a sim…

This study tests whether adding ketamine tablets to a new antidepressant can reduce depression symptoms faster in adults with major depression. Twelve participants will take four doses of ketamine over one week while starting a standard antidepressant. The goal is to see if sympt…

This study was designed to test whether a group therapy that uses basic communication skills common to all therapies can help people with depression, anxiety, PTSD, and stress. The therapy avoids specific methods like cognitive-behavioral therapy. The trial was withdrawn before a…

This study tests whether simple distraction tools—a ShotBlocker device and a finger puppet—can reduce pain and fear in children aged 5 to 10 during blood draws. About 90 children will be randomly assigned to use one of these tools or receive standard care. The goal is to see if t…

This study tests a new program called BRIDGES, designed with teens, to help young people with depression become more active at their own pace. The goal is to see if increasing physical activity can reduce depressive symptoms. The study will involve 60 adolescents aged 12-19 who a…

This study looks at whether a 60-day nerve stimulation device placed near the back of the head can help people with stubborn headaches. Researchers will track pain levels, daily function, and how often participants need emergency care. About 300 adults with various headache types…

This study aimed to see if a web-based self-help program called Deprexis could help orthopedic patients with major depressive disorder. The plan was to offer the 8-week online program to patients with depression and see if they would use it and if their mood and physical function…

This study tests whether daily exposure to different scents can retrain the sense of smell in 250 adults with smell disorders, including those from traumatic brain injury. Participants will use scented inhaler sticks at home and take smell tests before and after 12 weeks. The goa…

This study tests a telemedicine program called FOCUS that helps advanced cancer patients manage common symptoms like trouble sleeping, worry, tiredness, and low mood. The program uses counseling techniques delivered through a phone app. Researchers will enroll 120 adults with adv…

This study tests two 18-month talk therapy programs—Cognitive Enhancement Therapy and Enriched Supportive Therapy—for people with schizophrenia who have lasting negative symptoms like low motivation and social withdrawal. About 90 outpatients aged 18-60 will participate. The goal…

This study looks at whether an 8-week mindfulness course can help people who had a stroke at least 6 months ago. About 28 participants will take the course either right away or after a wait. The goal is to see if the course is practical and if it improves emotional well-being and…

This study tests whether real-time brain scans (fMRI) can help people with depression learn to reduce rumination—repetitive negative thinking. 80 participants will receive either real or sham neurofeedback while in a powerful 7T MRI machine. The goal is to strengthen a specific b…

This study tests whether a digital cognitive behavioral therapy program, supported by telephone coaching, can help reduce depression symptoms in pregnant women. About 634 mothers with mild to moderate depression were randomly assigned to either the guided digital program or stand…

This study tests whether an 8-week forest therapy program—combining walking, resistance band exercises, and sensory activities like aromatherapy—can improve muscle strength and well-being in older women with sarcopenia. Thirty-six women aged 55 and older will participate in 16 se…

This study compares two different remote support programs to see which one helps women feel better after surgery for suspected gynecological cancer. About 160 women will take part, and researchers will measure pain, mood, and sleep quality. The goal is to find simple, at-home way…

This study explores whether a photography-based program can help children aged 8-12 with ADHD better recognize and express emotions, and improve attention and impulsivity. Sixty children will take photos and learn photography skills as a tool to boost emotional well-being. The go…

This study compares a special exercise program called Coordinative Locomotor Training (CLT) to regular physiotherapy for children aged 8 to 12 with spastic hemiplegic cerebral palsy, a condition that causes stiffness on one side of the body. CLT uses running and skating movements…

This study tests a 7-session, peer-led self-management program for 234 cancer survivors who recently finished treatment with curative intent. The program aims to reduce anxiety and depression by teaching symptom management skills in a group setting. Participants are from central …

This study looks at whether a very mild, unnoticeable electrical stimulation to the legs can help children and young adults with cerebral palsy (ages 10–21) maintain balance during everyday movements like standing up, walking, and turning. Participants will perform simple tasks w…

This study tests whether a mobile app for PTSD, along with brief weekly support sessions, can help people who are already in treatment for alcohol problems. About 300 adults with both PTSD and alcohol use disorder will use the app or receive standard care. Researchers will track …

This study tests a modified version of Cognitive Behavioral Therapy for Insomnia (CBTi) to see if it can improve sleep and thinking in adults with insomnia. About 37 participants will receive the therapy and be monitored for changes in sleep quality and cognitive function. The go…

This study looks at whether mirtazapine, a drug often used for depression, can improve appetite in people with advanced cancer who have lost weight and have little desire to eat. About 98 patients will receive either mirtazapine or a placebo for 29 days. Researchers will track ch…

This study tests a personalized workplace intervention for 124 Dutch workers with Parkinson's disease, cerebellar ataxia, hereditary spastic paraparesis, or slowly progressive neuromuscular/mitochondrial disorders. A trained facilitator helps employees and their managers identify…

This study planned to see if wearing light therapy glasses could help reduce depression and tiredness in children and teens who had a stem cell transplant. Participants would have used the glasses for about four weeks while their mood and sleep were tracked. However, the study wa…

This study tests whether tolcapone, a drug used for Parkinson's disease, can reduce symptoms of obsessive-compulsive disorder (OCD) in adults. About 49 people with moderate to severe OCD will receive either tolcapone or a placebo. The main goal is to see if the drug safely lowers…

This study tests a structured 8-session group therapy called Integrated Grief Therapy (IGT) for adults who lost loved ones in the 2023 Türkiye earthquake. 190 survivors were randomly assigned to either the therapy or a waitlist. The goal is to see if the therapy boosts resilience…

This study tests whether chamomile or valerian extracts can reduce dental anxiety in healthy children aged 6 to 10 who need a tooth pulled. Kids are randomly given one of the herbal extracts or a placebo before the procedure. Researchers measure anxiety using child-friendly emoji…

This study tests whether a new type of group therapy, called Group Cognitive Evolutionary Therapy, can help reduce symptoms of depression and anxiety. Sixty-four adults with mild to severe depression will either receive two full days of therapy or be placed on a waiting list. Res…

This study tests whether a new therapy called Emotional Resolution (EmRes) can help reduce anxiety in healthcare workers. About 150 hospital workers with mild to moderate anxiety will either receive EmRes or a mindfulness-based gratitude exercise. The goal is to see if EmRes lead…

This Phase 2 trial tests a single intravenous dose of ketamine in 20 hospitalized teens and young adults with anorexia nervosa or atypical anorexia. Researchers want to see if ketamine helps the brain become more flexible, making it easier to learn new, positive associations with…

This study tests whether virtual reality (VR) brain exercises can help people with schizophrenia or bipolar disorder think more clearly and function better in daily life. 80 adults will either receive VR training twice a week for 12 weeks or continue their usual care. Researchers…

This study compares two parent training programs for 3-5 year olds with sleep problems and early signs of ADHD. One program focuses on behavior, the other adds sleep strategies. Researchers want to see if the sleep-focused approach is more helpful and practical for families in pe…

This study compares three proven PTSD treatments—talk therapy (prolonged exposure), antidepressant medication (paroxetine or venlafaxine), and their combination—in 304 veterans. Researchers aim to identify which treatment works best for whom, using personalized algorithms. Partic…

This study tests whether wearing a virtual reality headset during laser treatment for varicose veins can lower anxiety and pain. About 100 adults will use VR during the procedure, and researchers will measure their heart rate, blood pressure, and comfort levels. The goal is to se…

This study tests a single online session that teaches a simple coping skill to youth ages 9-17 who are on a waitlist for therapy. The goal is to see if this quick digital tool can help ease symptoms of anxiety, depression, and stress while they wait. About 226 youth and their par…

This study tests whether personalized sequences of behavioral interventions can help minimally verbal preschoolers with autism improve their language skills. Researchers will compare two teaching approaches—JASPER (play-based) and DTT (structured)—to see which works best for each…

This study tests a speech therapy method called Rapid Syllable Transition (ReST) in children aged 5 to 8 with childhood apraxia of speech, a condition that makes it hard to say sounds correctly. The goal is to see if the therapy is practical and helps improve speech clarity and m…

This study tests a therapy called RETELL that helps people with severe mental illness explore and reshape their life stories. The goal is to improve personal recovery, quality of life, and identity. Twenty adults with conditions like schizophrenia, bipolar disorder, or PTSD will …

This study tests whether a community-based music mindfulness program can reduce anxiety and depression in children aged 8-12 with ADHD or anxiety. Participants attend bi-weekly sessions for 8 weeks, wear fitness trackers, and complete surveys. The goal is to see if this approach …

This study compares two types of hand and arm therapy for people who had a stroke 3 to 6 months ago. One therapy involves restraining the good arm to force use of the affected arm, while the other focuses on using both arms together. Both groups also receive standard physical the…

This study tests an experimental drug called JNJ-89495120 in 107 adults with major depression. The goal is to see if it can reduce depression symptoms faster than a placebo, with checks as early as day 2 and day 5. Participants take the drug alone (no other antidepressants) and a…

This study looks at whether adding resistance (strength) exercises to standard aerobic and balance training can improve quality of life, daily activities, thinking skills, and muscle health in people with early-stage Parkinson's disease. About 34 adults aged 40-70 with mild to mo…

This study looks at whether a guided relaxation practice called Yoga Nidra can lower stress, anxiety, and sleep problems in nursing students during their hospital training. About 110 fifth-year nursing students will take part. Researchers will measure changes using questionnaires…

This study looks at whether nicotine patches can safely improve mood and thinking in adults aged 60 and older with depression. Participants who completed a previous blinded trial will wear a patch daily for up to 12 weeks, then taper off. The goal is to see if nicotine helps the …

This study tests a new program called PEAR that helps parents and teachers work together to manage ADHD and disruptive behavior in preschool children aged 2-5. The program adds extra support to a proven behavior tool called the Daily Report Card. Researchers want to see if PEAR i…

This study tests a single injection of F14, a long-acting form of the painkiller celecoxib, in 100 people undergoing total knee replacement. The goal is to see if it safely controls pain as part of a standard pain management plan. Participants receive the injection during surgery…

This study compares two treatments—Functional Electrical Stimulation (FES) and Whole Body Vibration Training (WBVT)—to see which better improves leg control, balance, and daily activities in people who had a stroke 6 months to 1 year ago. Thirty-four adults aged 35 to 70 will rec…

This pilot study tests a chatbot named SMILEY that teaches coping skills and safe social media practices to marginalized youth (ages 12-18) who experience depression and online victimization. Over 4 weeks, participants interact with the chatbot at their own pace to learn how to m…

This study tests whether nicotine patches can improve cognitive control (like focus and memory) and mood in adults aged 60 and older with depression. Sixty participants will wear either a nicotine or placebo patch daily for 12-15 weeks. Researchers will measure changes in depress…

This early-stage study is testing whether repeated doses of psilocybin, the active ingredient in magic mushrooms, can reduce symptoms of obsessive-compulsive disorder (OCD). Twenty-eight adults with moderate-to-severe OCD who have not responded to standard treatments will receive…

This Mayo Clinic study is testing whether eating fermented foods like yogurt, kimchi, and sauerkraut can improve gut microbiome diversity in people with long COVID. Forty adults with long COVID symptoms will either add fermented foods to their diet or continue as usual. Researche…

This study tests a remote speech therapy program for 32 Korean-speaking people with Parkinson's disease and their families. The therapy includes 16 sessions over four weeks, plus daily home practice, to improve speech clarity. The goal is to see if this culturally adapted approac…

This study compares two physical therapy approaches—Rood's techniques (using touch, stretch, and ice) and PNF patterns (diagonal movements)—to improve arm and hand function in people who recently had a stroke. 28 adults aged 40-60 with a first-time stroke will receive one of the …

This study tests whether an autism-friendly mobile app can help children and teens (ages 8-17) with autism improve their toothbrushing skills and habits. Participants use either the special app or a basic control app for 3 months while researchers track brushing quality and habit…

This study tests whether a 'social prescription' program can reduce loneliness in people with Parkinson's disease who already attend group exercise classes. About 40 participants who feel lonely will work with an occupational therapist to choose from 11 social activities, like sp…

This study tests whether adding a mild electrical stimulation to the diaphragm (the main breathing muscle) can improve lung function, head control, and sitting balance in children with severe cerebral palsy who cannot walk. Thirty children aged 5-18 will receive either standard r…

This study tests whether a diet rich in fermented foods (like yogurt and kimchi) is tolerable and can improve quality of life for survivors of critical illness, including severe COVID-19. The goal is to help restore gut health and reduce inflammation. The study involves 40 partic…

This pilot study tests whether a brief cognitive behavioral therapy delivered via video conference can help adults with mood disorders who are at high risk for suicide. Forty participants will either receive the video therapy plus usual care, or usual care alone. The study will m…

This study tests whether a guided internet-based physical activity program can improve cognitive processing speed in people with multiple sclerosis. 280 participants who have mild walking difficulties and slowed thinking will be randomly assigned to either the exercise program or…

This study tests an 8-week program called Step-CBT that combines physical activity goals with cognitive behavioral therapy for veterans with COPD who also have depression or anxiety. The program is delivered via video calls to make it accessible. Researchers want to see if it is …

This study tests whether a probiotic supplement called Neuralli® MP can help adults aged 18 to 50 who have autistic traits. Participants take two capsules daily and set their own personal goals to track progress. The trial is small and open-label, meaning everyone knows they are …

This study tests a short, enhanced cognitive behavioral therapy (E-BCBT) for people hospitalized after a suicide crisis. 30 participants will either receive 5 therapy sessions during their stay or standard care. The goal is to see if this therapy reduces suicide attempts and suic…

This study tests whether adding motor imagery—mentally practicing movements without actually moving—to standard physical therapy can improve balance and reduce fear of movement in people with Parkinson's disease. Forty-two participants will be randomly assigned to receive either …

This study explores whether individualized transcranial magnetic stimulation (TMS) can improve symptoms in adults with irritable bowel syndrome (IBS). Participants receive 10 TMS sessions over two weeks, with brain scans and stool tests before and after to understand how the trea…

This study investigates whether changes in brain chemicals (GABA and glutamate) can predict who will respond to ketamine for treatment-resistant depression. Researchers will give two intravenous ketamine infusions to 18 adults and measure chemical levels in the brain and blood. T…

This study tracks 80 adults with different smell disorders (like total loss, partial loss, or distorted smell) plus healthy volunteers over one year. Researchers use brain scans, smell tests, and questionnaires to see how the brain changes and how smell loss impacts mood and dail…

This study aims to identify genetic, biochemical, and clinical factors linked to disease severity in people with Gaucher disease and other lysosomal storage disorders. Researchers will evaluate up to 1,000 participants, including patients, carriers, and healthy controls, to bette…

This study looks at how surviving a pediatric brain tumor affects thinking and behavior. Researchers will use brain scans to examine brain structure in children who have completed treatment. The goal is to better understand the long-term cognitive challenges these survivors may f…

This study follows 25 people with spinocerebellar ataxia type 7 (SCA7) for up to 5 years to learn how the disease changes vision, coordination, and thinking. Participants will have yearly eye exams, brain scans, and neurological tests. No treatment is given; the goal is to gather…

This study follows 250 people who had a type of stroke called intracerebral hemorrhage (ICH) to understand why some experience progressive cognitive decline. Participants undergo advanced brain scans and tests of thinking and movement at 12–24 months after their stroke, with foll…

This study follows 125 people with Parkinson's disease or related conditions over two years. Researchers use special brain scans to measure changes in a chemical called acetylcholine, which is linked to walking problems, falls, and thinking skills. The goal is to understand how t…

This long-term study follows over 3,700 adults in Baltimore to understand why some people age healthier than others. Researchers are looking at how race, income, and neighborhood affect risks for diseases like diabetes, heart disease, and memory loss. Participants visit mobile he…

This trial investigates whether measuring high-sensitive troponin, a protein released during heart injury, can predict heart complications in people undergoing surgery to open a narrowed carotid artery. About 527 participants will have their troponin levels checked before and aft…

This study looked at how sounds played during sleep affect brain waves and memory in children with Rolandic epilepsy. Researchers used brain scans (MRI, MEG/EEG) to understand which brain circuits are involved. The goal was to find new treatment ideas for this type of childhood e…

This study follows 154 people taking Epidiolex (cannabidiol) for seizures caused by Lennox-Gastaut syndrome, Dravet syndrome, or tuberous sclerosis complex. Researchers will monitor for signs of chronic liver injury and fibrosis over time using blood tests and liver scans. The go…

This Phase 1 study aims to understand how the body processes ketamine after a cesarean delivery, and whether it can help with postpartum depression and pain. Fifty participants will receive a low-dose ketamine infusion, and researchers will measure drug levels and side effects. T…

This study was designed to look back at the health of people with Cushing's disease in Western France between 1990 and 2015. The goal was to find out how many patients went into remission and how many had their disease come back after their first surgery. However, the study was w…

This study looks at how much of the multiple sclerosis drug ofatumumab gets into breast milk. About 24 women with relapsing MS who are breastfeeding and starting or restarting ofatumumab will provide milk samples. The goal is to measure drug concentrations, which may help guide f…

This study tests whether simple changes to electronic health records can help doctors prescribe fewer Z-drugs (like Ambien) for insomnia. About 444 primary care clinicians will be randomly assigned to receive either a default of only 10 pills for new orders, an alert suggesting a…

This study investigates how the brain processes speech sounds to understand language. Researchers will record brain activity from people with epilepsy or brain tumors who already have electrodes implanted for medical reasons. Participants listen to short speech sounds while their…

This study aimed to see if Alzheimer's disease affects the nerves in the gut, similar to what happens in Parkinson's disease. Researchers planned to take extra colon biopsies during routine colonoscopies from people with Alzheimer's, Parkinson's, and healthy individuals to compar…

This study looks at whether intensive computer-based brain exercises can improve memory, attention, and problem-solving in people who have had a brain injury. Thirty adults aged 25-65 with mild cognitive problems will train on a computer for 45-60 minutes a day, five days a week,…

This study is creating a learning healthcare system for OnTrackNY, a program that helps young people (ages 16-30) who have recently experienced psychosis. Researchers will collect data and feedback from participants, families, and clinicians to continuously improve care. The goal…

This study tests a short guide called the 'Jumpstart Guide' to help doctors have better conversations with dementia patients and their families about healthcare goals. Over 1,800 patients and their caregivers are taking part. Researchers will compare whether those whose doctors u…

This study investigates how the brain's emotion network works by recording brain activity directly from the surface of the brain in people with epilepsy who are already undergoing surgery for seizure monitoring. Participants watch short video clips designed to trigger emotions li…

This study aims to improve how doctors test for autonomic failure, a condition where the body's automatic functions like blood pressure control don't work properly. Researchers will use advanced imaging, sweat tests, and skin biopsies in up to 89 adults with Parkinson's disease, …

This study tracks 130 adults with PTSD from childhood trauma as they undergo Cognitive Processing Therapy. Researchers will measure brain activity, genetics, and behavior before and after treatment to understand how recovery happens. The goal is to uncover biological markers of P…

This study, called PLINTH, is a feasibility trial for adults who had a stroke from a brain hemorrhage. Researchers want to know if patients and doctors would accept a future platform trial, and how to design it to be inclusive and efficient. About 169 participants will watch an i…

This study surveys over 21,000 nurses at Mayo Clinic to measure levels of moral distress, moral injury, and post-traumatic stress. Participants fill out questionnaires about their experiences and well-being. The goal is to understand how these issues vary by work setting, special…

This study looks at how vagus nerve stimulation (VNS) affects the nervous system, heart, immune system, and metabolism in people who already have a VNS device for epilepsy or depression. Researchers will measure things like nerve activity, blood pressure, and heart rate during di…

This long-running study follows nearly 100,000 French women, mostly teachers, since 1990 to understand what factors influence their risk of cancer, heart disease, diabetes, and other major illnesses. Participants fill out questionnaires every few years about their lifestyle, medi…

This study looks at how adults at risk for Alzheimer's disease react after learning their amyloid and tau biomarker test results. Researchers will track changes in distress, stigma, quality of life, and future planning over time. The goal is to understand the psychological and be…

This study looks at how childhood abuse and neglect change the brain in women with PTSD or dissociative identity disorder. Researchers will use MRI scans and cognitive tests to measure brain activity related to attention, emotions, and feelings of detachment. The goal is to bette…

This study tests whether a newer, less invasive heart-lung machine (MiECC) reduces brain swelling and stroke risk compared to the standard machine used during open heart surgery. Researchers will measure optic nerve sheath diameter (a marker of brain pressure) and track strokes o…

This study was designed to see if cognitive behavioral therapy for insomnia (CBT-I) could help teenagers with ADHD who also have trouble sleeping. It planned to enroll adolescents aged 11-18 with both ADHD and insomnia. However, the trial was withdrawn before any participants wer…

This observational study tracks 5,000 people taking common blood thinners (like rivaroxaban or apixaban) or antiplatelet drugs (like aspirin). Researchers regularly measure drug levels in the blood to see how they relate to clots or bleeding events. The goal is to find the best d…

This study was designed to compare decision-making skills between bipolar patients who had attempted suicide and those who had not. Researchers planned to use computer tasks and questionnaires to measure thinking patterns. However, the study was withdrawn before enrolling any par…

This study tests whether a special MRI scan, called DSC-MRI, can measure blood flow changes in brain tumors to predict if the drug bevacizumab is working early in treatment. Researchers will scan 146 patients with recurrent glioblastoma before and two weeks after starting the dru…

This natural history study follows 259 children, adolescents, and adults with Neurofibromatosis Type 1 (NF1) for up to 10 years. Researchers will track tumor growth, monitor quality of life, and perform genetic testing to better understand how the disease changes over time. The g…

This study aims to find genes that may increase the risk of developing bipolar disorder. Researchers are collecting DNA and health information from 4,185 adults to understand the genetic causes of the condition. The goal is to improve diagnosis and treatment in the future, but th…

This study aims to identify biomarkers—biological clues in the body—that can help distinguish between Parkinson's disease and similar conditions like progressive supranuclear palsy and multiple system atrophy. Researchers will follow people with early-stage parkinsonism and healt…

This study aims to uncover the genetic and environmental factors behind autism spectrum disorders (ASD), including autism, Asperger's syndrome, and PDD. Researchers will analyze gene expression in 240 participants aged 18 months and older who have an ASD diagnosis. The goal is to…

This study follows over 1,500 young adult survivors of childhood cancers like leukemia, brain tumors, and Hodgkin lymphoma to see how frailty—a measure of physical weakness and vulnerability—changes over five years. Researchers want to know if frailty can predict future chronic h…

This study looks at how caffeine is processed in newborns with hypoxic-ischemic encephalopathy (HIE), a brain injury caused by lack of oxygen, who are receiving cooling therapy. Researchers will test different doses of caffeine in 16 babies to find the safest and most effective a…

This study follows 2,500 people aged 10 and older with depression or bipolar depression over 10 years. Researchers collect data on symptoms, brain scans, genetics, and lifestyle to find patterns that predict how someone will respond to different treatments. No experimental drugs …

This study looks at how cancer and its treatment impact social and emotional development in children aged 4 to 6. About 119 children with brain or solid tumors will complete questionnaires and tasks to measure social skills, thinking abilities, and play behavior. The goal is to u…

This study uses MRI scans to look at the brains of children and adults with conditions like ADHD, autism, schizophrenia, and endocrine disorders, as well as healthy volunteers. Researchers aim to compare brain anatomy and function across different groups and ages. The goal is to …

This study screens children and teens with advanced solid tumors, lymphomas, or histiocytic disorders to find genetic changes in their cancer cells. Participants undergo biopsies and scans to identify mutations that can be targeted by specific drugs. The goal is to see if matchin…

This study looks at how children with cancer and their parents handle the emotional challenges of the disease. Instead of focusing only on negative effects like posttraumatic stress, researchers also explore positive changes, such as personal growth. The study compares these fami…

This study looks at how many women with multiple sclerosis (MS) use the drug interferon-beta during the second and third trimesters of pregnancy in Finland and Sweden. Researchers want to know if there are enough cases to study whether the drug affects pregnancy outcomes like bir…

This study follows 1,500 volunteers with normal memory, mild cognitive impairment, or Alzheimer's over several years. Researchers use brain scans, memory tests, and blood samples to track how the disease progresses. The goal is to find better ways to diagnose and treat Alzheimer'…

This study looks at whether taking short walks throughout the day is better for kids at risk for type 2 diabetes than one longer exercise session. Researchers will measure blood sugar, insulin, and thinking skills in 188 children aged 8-11 with overweight or obesity. The goal is …

This study investigates how genetic, lifestyle, and biological factors relate to memory and thinking problems in people over 60 with Alzheimer's disease, Parkinson's disease, or mild cognitive impairment. Researchers will use brain scans, spinal fluid and blood tests, and data fr…

This large observational study aims to collect medical data and biological samples from up to 5,000 people with chronic spinal cord injury or traumatic brain injury, as well as their family members and healthy volunteers. Researchers hope this information will help them better un…

This study looks at how common sleep breathing problems are in children with cerebral palsy across the UK, and how often they use breathing support like CPAP machines. Researchers will track new cases over a year and explore what helps or hinders access to care. The goal is to im…

This study looks at people and families who have a high risk of cancer to learn what genes and environmental factors might increase that risk. Over 5,000 participants are followed over time with questionnaires, medical records, and optional genetic testing. No treatment is given,…

This study tests a 10-week program called 'Grow to Recovery' for people with mental illness. The program is co-led by a peer (someone who also has a mental illness) and a professional. Researchers want to see if it helps participants feel more hopeful and capable. 138 people are …

This study looks at whether a blood test measuring a protein called neurofilament light (sNfL) can help doctors predict and manage disease activity in people with relapsing multiple sclerosis (MS). About 489 adults with MS in Germany will be observed for 24 months. The goal is to…

This study explores how anxiety contributes to treatment-resistant depression. Researchers will follow 37 adults with depression to see if anxiety levels can predict who will have a harder time recovering. The goal is to better identify at-risk patients and develop more targeted …

This study tests whether a single evening yoga session can improve sleep and heart health in adults aged 18–40, both those with insomnia and healthy sleepers. Participants will try a moderate-intensity vinyasa yoga session, a gentle yoga session, and a quiet rest period on separa…

This study tracks brain activity in 160 Parkinson's patients who have or will receive deep brain stimulation (DBS). Researchers record signals from the brain during memory tasks, with the stimulator on and off, to find patterns linked to cognitive side effects. The goal is to ide…

This study looks at how blood flow in the feet changes during a 12-week heart and blood vessel rehab program for people with narrowed arteries. Researchers will track 80 adults with conditions like peripheral artery disease or coronary artery disease. The goal is to better unders…

This study tests a program that helps parents and teens work together to improve safe driving. It includes 588 teens aged 16-17 who have already received a traffic ticket. The program uses a smartphone app and in-car device to track risky driving and give feedback, aiming to redu…

This study follows 350 people who survived a brain bleed (intracerebral hemorrhage) and were part of earlier trials. Researchers will test memory, thinking, and movement skills over time, and collect blood samples to look for signs of ongoing inflammation. The goal is to see if s…

This study looks at whether adding aripiprazole to the antidepressant escitalopram can reduce pathological rumination—repetitive, intrusive negative thoughts—in people with major depressive disorder. 108 participants will receive either escitalopram alone or escitalopram plus ari…

This study tests a new type of brain implant that can both sense brain activity and deliver stimulation in real time. It involves 25 people with Parkinson's disease or dystonia who already need deep brain stimulation. The goal is to see if closed-loop stimulation (which adjusts a…

This study tests a short, 6-session program for patients with a recent brain injury and their caregivers. The goal is to prevent long-term emotional distress and improve quality of life. About 388 pairs (patient and caregiver) will take part.

This study uses PET and MRI scans to measure brain cell connections in people with major depression or PTSD. Researchers will give ketamine to see if it can reverse synaptic loss linked to these conditions. The goal is to understand brain changes, not to provide treatment. About …

This observational study is creating a large database of up to 96,000 people with multiple sclerosis and related conditions in Italy. Researchers will collect information on patient demographics, treatments, and disease progression over time. The goal is to better understand thes…

This study uses special brain scans (MRS) to measure two natural chemicals, GABA and glutathione, in people with Friedreich's Ataxia (FRDA). Researchers want to see if these chemicals can serve as reliable markers of the disease and how they change after taking the drug Omaveloxo…

This study collects multiple samples from different parts of a glioblastoma tumor during surgery. Researchers will analyze the samples to learn how genetic changes vary within a single tumor. The goal is to improve future diagnosis and treatment of brain tumors. The study involve…

This study looks at whether a mindfulness program can improve attention and brain connectivity in 11-14 year olds who have a family history of mood disorders and high mood swings. About 224 teens will be randomly assigned to mindfulness or a health education class. The goal is to…

This study uses brain scans and behavioral data from 267 adults (80 with autism, 79 with schizophrenia, and 108 healthy controls) to explore shared brain activity patterns related to social thinking. No new treatments are given; researchers analyze existing data to understand how…

This study looks at 1,000 patients on blood thinners who had a minor head injury and a normal first CT scan. Researchers want to see if a second CT scan 24 hours later finds any delayed brain bleeding. The goal is to understand whether the extra scan is needed and how often it le…

This study looks at how fear of pain affects movement in 26 healthy adults. Researchers used verbal suggestions and inactive electrodes to create a sense of threat during walking and arm-pointing tasks. The goal is to understand how fear of movement changes walking speed, stride,…

This study follows 72 adults with cerebral palsy who had walking tests as children to see how their walking ability changes over time. Researchers measure joint movement, muscle activity, and blood markers related to metabolism and inflammation. The goal is to understand how walk…

This study aims to help people from underserved communities talk about their wishes for end-of-life care and complete advance directives. Researchers will use trusted community networks to host events where two conversation tools are tested. About 1500 adults will participate to …

This study tests a new radioactive compound called F 18 T807 that lights up tau tangles in the brain during a PET scan. Researchers want to see if the amount of tau relates to memory and thinking problems in people with a rare, inherited form of Alzheimer's disease. About 130 adu…

This study was designed to observe how patients with acute brain injury are taken off mechanical ventilation (breathing machines) in the ICU. It planned to include adults with brain injury who needed a ventilator for at least 24 hours, but the study was withdrawn before enrolling…

This study uses a radioactive tracer called [18F]MK-6240 to take detailed pictures of tau protein clumps in the brain, a hallmark of Alzheimer's disease. Researchers will scan 200 people from families with a rare genetic form of Alzheimer's to see how tau buildup changes over tim…

This study looks at how precise radiation (stereotactic radiosurgery) affects memory and thinking in people with 6 or more brain tumors that have spread from other cancers. About 80 adults will take part to find the safest radiation dose and measure any decline in memory over 4 m…

This study observes over 1,100 pregnant women with multiple sclerosis to see if taking the drug diroximel fumarate (VUMERITY) affects their babies' health. Researchers will compare birth defects, miscarriages, preterm births, and stillbirths among women who took DRF, other MS dru…

This study looks at sleep patterns in 94 adults with major depressive disorder, comparing those with moderate-to-severe insomnia to those with mild or no insomnia. Participants wear a headband at home that records brain activity during sleep and also fill out sleep diaries and qu…

This study looks at how the severity of depression relates to erectile dysfunction and premature ejaculation in 100 married men aged 25–60 in the Sohag region of Egypt. Participants are clinically diagnosed with depression and sexually active. Researchers will use standard questi…

This study combines data from over 2,500 people with treated and controlled high blood pressure to understand why some still die from heart attacks, strokes, or kidney failure. Researchers are looking beyond blood pressure numbers to find other factors that might predict these fa…

This study interviews 120 people—patients, relatives, and healthcare staff—to better understand what 'person-centered' means in rehabilitation. Researchers will use these insights to develop a tool that measures how well rehab services focus on individual needs. The goal is to im…

This study follows 600 mentally ill offenders in Italy and California over three years to compare two very different treatment systems. Italy uses community-based care, while California relies on long-term hospital stays. Researchers will track violence, recovery, and functioning…

This study looks at whether a simple scoring system, called the 5-SENSE score, can accurately predict where seizures begin in the brain. Researchers will test this in 400 people with hard-to-treat epilepsy who are already scheduled for an invasive brain test called SEEG. If the s…

This study is not a treatment trial. It aims to translate and test a new assessment tool (FARAS-IT) for adults with autism who are involved in the Italian criminal justice system. Researchers will enroll 100 adults with autism, including those in forensic psychiatric care, those …

This study adapts an existing stigma-reduction program specifically for pregnant and postpartum women living with HIV in Ghana. Researchers will interview 30 women and 20 providers to understand their experiences, then work with stakeholders to tailor the program. Finally, 90 pre…

This study tests a new imaging method to see if white blood cells enter the brain in people with multiple sclerosis, fibromyalgia, or chronic fatigue syndrome. Participants receive their own white blood cells tagged with a radioactive tracer, then undergo a brain PET/MRI scan. Th…

This study adapts a 'Health at Every Size' program for pregnant people with a BMI over 30. Ten first-time mothers will attend group sessions on nutrition, movement, and self-advocacy. The goal is to see if the program is acceptable and helpful in reducing weight stigma and improv…

This study looks for tiny plastic particles in brain tissue removed during surgery for spontaneous bleeding. Researchers will test if these plastics are linked to more inflammation and worse recovery in 150 patients. No new treatment is given; the goal is to understand if environ…

This study uses special MRI scans to see how radiation treatment affects the brain's white matter and thinking skills in people with cancer that has spread to the brain. Researchers will follow 15 patients to find early signs of memory or concentration problems. The goal is to be…

This study tests whether Electrical Impedance Tomography (EIT) can produce accurate images of brain activity in people with epilepsy. EIT uses harmless electrical signals through electrodes on the scalp or brain to create images, and is compared to standard methods like MRI and E…

This 10-year study follows 1,500 young people aged 10-24 to learn what makes some more resilient to depression and anxiety than others. Researchers will track lifestyle, brain scans, and mental health over time. No treatments or interventions are given—the goal is simply to obser…

This study is trying to find ways to diagnose chronic traumatic encephalopathy (CTE) in living people. Right now, CTE can only be confirmed after death. Researchers will study 350 former college and professional football players, using memory tests and other biomarkers. The goal …

This study was designed to use a special PET scan to measure brain inflammation in people with asymptomatic carotid artery disease (narrowing of neck arteries without symptoms). It aimed to compare inflammation levels between those with high-grade and low-grade narrowing. However…

This study looks at how the brain learns from past experiences and uses that knowledge in new situations. Researchers will monitor brain activity in 114 adults with hard-to-treat epilepsy who are already undergoing brain monitoring. The goal is to understand the process of abstra…