Brain disorder

Rett syndrome is a rare genetic disorder that mostly affects girls and stems from mutations in the MECP2 gene. This trial tests GCB-002, an experimental gene therapy given as a single injection into the spinal fluid, in 6 to 9 girls aged 2 to 10 who have a confirmed MECP2 mutatio…

This early-stage trial is testing a new vaccine called HydroVax-001B WNV to see if it is safe and triggers an immune response against West Nile virus, a mosquito-borne disease. About 30 healthy adults aged 18 to 49 will receive either the vaccine or a placebo. The study will comp…

This study tests a new device that uses brain signals to time magnetic pulses for stroke rehabilitation. The device reads blood flow changes in the brain and fires a magnetic pulse at the right moment to boost brain activity. Researchers will first test the system in healthy adul…

This study tests whether adding an interleukin-6 receptor inhibitor (a drug that reduces inflammation) to standard emergency stroke treatment helps people recover better after a severe stroke caused by a large blood clot in the front part of the brain. About 692 adults who are el…

This study compares two daily pills—fenebrutinib and teriflunomide—in about 746 adults with relapsing multiple sclerosis. The goal is to see which one better reduces relapses and delays worsening disability. Participants take one of the two drugs for several years, with an option…

This large phase 3 trial tests whether newer blood thinner combinations (ticagrelor plus aspirin or rivaroxaban plus aspirin) are better than the standard clopidogrel plus aspirin at preventing stroke, brain bleeding, or death from blood vessel disease. Over 1,600 participants wi…

This study tests whether a structured exercise program done at home can improve walking ability and overall recovery in people who recently had a stroke. About 208 adults who had a stroke within the past two weeks will be assigned to either the home exercise program or usual care…

This phase 3 study tests whether erenumab (Aimovig), a monthly injection already approved for adults, can prevent migraines in children aged 6 to 17 with episodic migraine. About 457 participants receive either the drug or a placebo for 3 months. The main goal is to see if the dr…

This study tests a drug called ulixertinib in children and teens whose advanced cancers have a specific genetic change in the MAPK pathway. The goal is to see if the drug can shrink or control the tumor. About 20 participants with various solid tumors, lymphomas, or related disor…

This early-phase trial tests whether a personalized vaccine made from each patient's tumor mutations, combined with Tumor Treating Fields (a device that sends electric fields to the brain), is safe and feasible for people with newly diagnosed glioblastoma. The 13 participants rec…

This phase 3 trial tests whether a shot (subcutaneous) of ublituximab works as well as the standard IV infusion for people with relapsing multiple sclerosis. About 360 participants are enrolled. The main goal is to compare drug levels in the blood over 24 weeks, along with safety…

This study tests a drug called selumetinib in children and young adults with low grade glioma that has come back or not responded to other treatments. The drug works by blocking certain enzymes that help tumor cells grow. The goal is to find the best dose and see if it can shrink…

This study tests a new drug called ION717 for people with early-stage prion disease, a rare and fatal brain condition. The drug is given via a spinal injection and aims to reduce harmful prion proteins. The trial will check safety, side effects, and how the drug moves through the…

This study tests an experimental drug called ALN-APP in 200 adults with cerebral amyloid angiopathy (CAA), a condition that causes bleeding in the brain. The drug is given via spinal injection and aims to slow disease progression and reduce new brain bleeds. Participants will be …

This early-stage trial tests a drug called NIO752 in 38 people with mild Alzheimer's or mild cognitive impairment due to Alzheimer's. The drug is given as one or two injections into the spinal fluid to see if it can lower levels of tau protein, a key marker of Alzheimer's damage.…

This study tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy (with or without radiation) after surgery can help prevent high-risk endometrial cancer from coming back. About 990 participants who had surgery to remove their uterus and ovaries will r…

This early study tests a new device (LAmbre II) that closes a small pouch in the heart called the left atrial appendage in people with atrial fibrillation. The goal is to reduce the risk of stroke without needing long-term blood thinners. Ten participants will be followed for abo…

This phase 2 trial tests two immunotherapy drugs, durvalumab and tremelimumab, in 30 adults with relapsed or refractory germ cell tumors. The goal is to see if the combination can shrink tumors or lower tumor markers. Participants must have measurable disease and have progressed …

This study tests a new gene therapy called LY3884961 in 32 people with moderate to severe Parkinson's disease who have a specific genetic change (GBA1 mutation). The treatment is given as a single injection into the fluid around the brain and spinal cord. The main goal is to chec…

This study tests a 9-session program called MILAP for young married women (ages 15-24) in Nepal who have experienced intimate partner violence. The program involves the woman, her husband, and her mother-in-law, aiming to reduce depression, violence, and PTSD. 900 participants wi…

This phase 3 trial compares two drugs for primary progressive multiple sclerosis (PPMS), a form of MS that steadily worsens. About 985 adults with PPMS will receive either daily oral fenebrutinib or intravenous ocrelizumab (plus matching placebos) to see which better delays disab…

This phase III trial tests whether giving several small doses of radiation (fractionated radiosurgery) after removing a brain tumor is better than a single large dose. About 242 patients with cancer that spread to the brain will be randomly assigned to one of the two radiation pl…

This study tests whether the drug LP352 can safely reduce seizures in children and adults with Dravet syndrome, a severe form of epilepsy. About 160 participants will receive either LP352 or a placebo, and researchers will track changes in seizure frequency over several months. T…

This Phase 3 study compares fenebrutinib, an experimental oral drug, to teriflunomide, an approved MS therapy, in 751 adults with relapsing multiple sclerosis. The goal is to see if fenebrutinib better reduces relapse rates and delays disability progression. Participants take eit…

This early-phase study tests whether adding the drug ibrutinib to standard radiation and chemotherapy is safe for people with newly diagnosed glioblastoma, a fast-growing brain cancer. About 36 adults with specific tumor types (MGMT methylated or unmethylated) will receive differ…

This study tests an experimental drug called LP352 to see if it can safely reduce seizures in children and adults with developmental and epileptic encephalopathies (DEE), a group of severe epilepsy syndromes. About 320 participants will receive either LP352 or a placebo, and rese…

This early-stage trial tests whether transplanting dopamine neurons made from a patient's own stem cells into the brain is safe for Parkinson's disease. Six people aged 55 to 80 with Parkinson's for at least 5 years will receive the cells in a single surgery. The main goal is to …

This study tests a brain-responsive neurostimulation system in 24 people aged 12 and older with Lennox-Gastaut syndrome whose seizures are not controlled by medication. The device detects and responds to seizure activity in the brain to reduce drop seizures. The goal is to see if…

This early-phase trial tests a new approach for people with HER2-positive brain tumors that have come back or not responded to standard treatment. Researchers take the patient's own T cells, attach a special antibody (anti-HER2) to them, and inject these 'CAR T cells' directly in…

This study tests a new way to give proton radiation to children with low-grade glioma, a common brain tumor. The goal is to avoid the hippocampus, a brain area key for memory, to reduce long-term memory loss. About 74 children will receive this targeted radiation, and researchers…

This phase 1 trial tests a peptide vaccine designed to target a specific mutation (H3K27M) found in certain aggressive brain tumors called diffuse midline gliomas. Fifteen newly diagnosed patients receive the vaccine along with the immunotherapy drug atezolizumab after standard r…

This phase 3 study is testing the long-term safety and effectiveness of LP352 (Bexicaserin) in 324 children and adults with developmental and epileptic encephalopathy (DEE), including Dravet and Lennox-Gastaut syndromes. Participants who completed earlier studies will receive LP3…

This Phase III trial tests whether giving radiation in three smaller doses (FSRS) works better than a single large dose (SRS) for cancer that has spread to the brain. About 269 adults with lung, breast, melanoma, kidney, or gastrointestinal cancers will be randomly assigned to on…

This early-stage study is testing a new drug called RO7121932 in 129 people with multiple sclerosis (MS). The goal is to check if the drug is safe and how the body handles it when given as a single or multiple doses, either through a vein or under the skin. Participants are not o…

This phase III trial is testing whether a precise, high-dose radiation technique called stereotactic radiosurgery (SRS) is better at preserving memory and thinking than the current standard of whole brain radiation that avoids the hippocampus (the brain's memory center) plus a dr…

This study looks at whether using focused radiation (stereotactic radiosurgery) only on the brain tumors, instead of the whole brain, can help preserve thinking and memory in people with small cell lung cancer that has spread to the brain. About 55 participants will receive this …

BP-REACH tests whether a team-based program can help people who have had a stroke or heart attack lower their blood pressure. Participants receive a home blood pressure monitor, self-management education, monthly coaching calls, and medication management from a pharmacist. Resear…

This study tests the safety and dosing of ocrelizumab in 23 children and teens (ages 10–18) with relapsing-remitting multiple sclerosis over 2 years. The goal is to find the best dose for a future larger study. Participants receive the drug and are monitored for side effects and …

This study tests the long-term safety and effectiveness of XEN1101 (azetukalner) in 880 adults with focal or tonic-clonic seizures. Participants who completed earlier studies will take XEN1101 capsules for up to 6 years. Researchers will track side effects and changes in monthly …

This study tests whether cognitive behavioral therapy for insomnia (CBT-I) can help lower blood sugar levels in people with prediabetes. About 300 adults with both prediabetes and insomnia will receive either CBT-I or a patient education program. The main goal is to see if improv…

This study tests whether people with atrial fibrillation who receive a WATCHMAN FLX Pro device can safely take just one blood thinner or aspirin instead of the usual two-drug plan. About 1,857 participants are being followed for six months to compare rates of death, stroke, major…

This study looks at two different sedative medicines given to children on breathing machines in the ICU. The goal is to see which one causes less confusion (delirium) and helps the brain recover better. About 372 children up to age 11 will take part. The results could change how …

This study tests two approaches—lifestyle medicine consultations and cognitive behavioral therapy (CBT)—to reduce cardiovascular risk in autistic individuals aged 9 to 26 who have a high body mass index. Participants are randomly assigned to receive lifestyle coaching, CBT sessio…

This study tests a combination of a vaccine targeting the CMV virus (PEP-CMV) and an immunotherapy drug (nivolumab) in children and young adults with certain aggressive brain tumors, including diffuse midline glioma and medulloblastoma. The goal is to see if this approach is safe…

This large study is testing whether a device called WATCHMAN FLX, which closes off a small pouch in the heart, can be a safe and effective alternative to daily blood thinners (NOACs) for preventing strokes in people with non-valvular atrial fibrillation. The trial involves 3,000 …

This study tests an experimental drug called prasinezumab in 316 people with early Parkinson's disease. The drug is an antibody designed to target and remove clumps of a protein linked to Parkinson's. Participants receive either the drug or a placebo for 52 weeks, with an option …

This study compares two treatments—special exercises called PNF and music therapy—to see which helps children with ataxic cerebral palsy improve balance, coordination, and daily activities. About 29 children aged 6 to 18 will take part, receiving either PNF or music therapy along…

This study tests an adaptive deep brain stimulation (aDBS) system that automatically adjusts stimulation based on real-time brain signals. It aims to improve symptom control for 62 people with Parkinson's disease in China who already have a compatible brain implant. The main goal…

This trial investigates whether drinking a beverage made from 30 different organic vegetables daily for four weeks can improve gut microbiome diversity, reduce inflammation, and ease PTSD symptoms in adults diagnosed with PTSD. Participants are randomly assigned to receive either…

This phase III trial tests whether giving focused radiation (stereotactic radiosurgery) before surgery is better than after surgery for people with 1 to 4 brain metastases. About 237 participants will be randomly assigned to one of the two sequences. The goal is to see which orde…

This phase 3 trial tests whether adding pembrolizumab (an immunotherapy) and olaparib (a targeted drug) to standard chemotherapy and radiation can help people with limited-stage small cell lung cancer live longer. About 672 participants will receive either the drug combo or a pla…

This phase 3 trial is testing the safety and tolerability of the drug cenobamate (Xcopri) in 140 children aged 2 to 17 with partial-onset (focal) seizures. Researchers will monitor side effects, lab results, and drug levels in the blood. The study is open-label, meaning everyone …

This study tests a drug called olaparib in people with advanced cancers (like brain tumors, bile duct cancer, or other solid tumors) that have a specific gene change called IDH1 or IDH2 mutation. The drug works by blocking an enzyme that cancer cells need to grow. About 89 partic…

This early study tests a combination approach for recurrent glioblastoma, an aggressive brain cancer. The treatment uses focused ultrasound (NaviFUS) to temporarily open the blood-brain barrier, allowing the drug Avastin (bevacizumab) to reach the tumor more effectively. Ten adul…

This study looks at how ketogenic diets impact heart health in adults with epilepsy. Researchers will measure cholesterol, blood pressure, weight, and artery thickness over 12 months. Participants are adults 18 or older who are already on a keto diet or starting the modified Atki…

This study tests a vaccine called AADvac1, which targets tau tangles in the brain, a hallmark of Alzheimer's. It will be given alone or with another drug (donanemab) to 450 adults aged 50-80 with very early Alzheimer's. The goal is to see if this approach can reduce tau buildup a…

This study tests whether a probiotic called Lactobacillus plantarum can improve social interactions, reduce inflammation, and enhance quality of life in adults with autism spectrum disorder. Twelve participants take the probiotic for 8 weeks, with assessments including blood test…

This UK trial tests whether cladribine tablets, taken for just 8-10 days a year over two years, can slow the loss of hand function in people with advanced multiple sclerosis (MS). The study includes 204 participants with significant disability (EDSS 6.5-8.5). Half receive cladrib…

This Phase 3 trial is evaluating how safe solriamfetol is when taken daily over a long period by children and adolescents with ADHD. Participants who completed earlier studies will receive the medication and be monitored for side effects. The goal is to see if this treatment rema…

This study tests a device called a motor neuroprosthesis, an implantable brain computer interface designed to help people with severe paralysis control digital devices like computers or tablets. The device aims to bypass damaged motor pathways and transmit brain signals directly …

This early-phase trial tests a single dose of YTB323, a CAR-T cell therapy, in 28 adults with non-active progressive multiple sclerosis. The study aims to check safety and track disability changes over time. Participants must be 18–60 and able to undergo lumbar punctures and MRIs…

This phase 2 trial tests whether prasinezumab, given as an IV infusion every 4 weeks, can slow motor decline in people with early Parkinson's disease. The study includes 586 participants who are already on stable Parkinson's medication. Researchers are measuring how long it takes…

This study tests whether adding spironolactone to standard blood pressure treatment helps lower blood pressure more effectively in people who have had a stroke. About 160 adults who had a bleeding or clot-caused stroke are taking spironolactone or continuing their usual care. Res…

This study tests a drug called abemaciclib in people whose glioblastoma (a type of brain cancer) has come back. The drug is given before surgery to see how much reaches the tumor, and then to a separate group to see if it helps control the cancer for at least 6 months. The trial …

This pilot trial tests whether training with a portable robotic ankle exoskeleton, called AMBLE, can improve ankle push-off and walking speed in adults with chronic stroke and ankle weakness. Participants will complete 30 walking training sessions over 8 to 9 weeks while wearing …

This study tests whether Dysport injections can prevent chronic migraines in adults. Chronic migraine means having at least 15 headache days per month, with 8 being migraines. Participants receive injections into head, neck, and shoulder muscles every 12 weeks for up to 60 weeks.…

This study is testing the long-term safety and effectiveness of a drug called TSND-201 for adults with PTSD. Participants who completed an earlier blinded trial of TSND-201 can receive up to three treatment courses over 48 weeks, each consisting of four weekly doses. The goal is …

This Phase 3 trial tests whether an experimental oral drug, KPS-0373, can improve movement and coordination in people with spinocerebellar degeneration, a condition that causes progressive clumsiness and balance problems. About 142 Japanese adults with mild to moderate ataxia wil…

This real-world study is following 7,000 Chinese adults with established heart disease to see if adding Repatha® (a cholesterol-lowering injection) to their usual care reduces major cardiovascular events like heart attacks, strokes, and heart-related death. Participants are eithe…

This study looks at the long-term safety and effectiveness of azetukalner in adults with major depressive disorder. Participants must have successfully completed a previous phase 3 study of this drug. The goal is to monitor side effects and track changes in depression symptoms ov…

Researchers are testing whether radotinib, a drug used for leukemia, can help people with Parkinson's disease. The trial will give the drug or a placebo to about 43 adults aged 40 to 80 who were diagnosed within the past three years. The study measures safety, how the drug moves …

This phase 2 trial tests whether pembrolizumab, an immunotherapy drug, can help the immune system attack recurrent glioblastoma, an aggressive brain cancer that has come back. Researchers will give the drug to about 18 patients who need surgery for their tumor, and then study how…

This study tests omaveloxolone, a drug already approved for adults with Friedreich's ataxia, in children aged 2 to 15. Researchers want to see how the drug moves through children's bodies and whether it is safe. The study involves two parts: a single dose followed by daily dosing…

This trial tests two early interventions for people who have had an ischemic stroke: a computerized cognitive training program for the patient and a psychoeducational program for the main caregiver. Both start about 20 days after hospital admission, much earlier than most rehabil…

This early-phase study tests an experimental cell therapy called YTB323 in about 28 people with relapsing multiple sclerosis whose disease is still active despite taking strong medications. The goal is to see if YTB323 is safe and can control the disease. Participants receive a s…

This trial compares two treatment strategies for people with relapsing-remitting multiple sclerosis: starting with high-efficacy drugs early versus starting with standard first-line therapies and switching if needed. The study involves 900 participants across multiple sites and t…

This trial tests whether low intensity focused ultrasound (LIFU), a non-invasive technique that uses sound waves to stimulate deep brain regions, can safely ease symptoms of obsessive-compulsive disorder (OCD). Researchers will target the ventral striatum, an area linked to OCD, …

This trial tests whether allowing adults in Basel to buy cannabis from pharmacies, instead of the illegal market, changes how much they use and their mental and physical health. About 374 adults who use cannabis at least monthly will be randomly assigned to either regulated pharm…

This trial tests an adaptive deep brain stimulation system for people with severe obsessive-compulsive disorder (OCD) that has not improved with standard treatments. The device, implanted in the brain, aims to detect brain signals linked to OCD distress and adjust its stimulation…

This early-phase study tests a new drug called MK-2870, either alone or with the immunotherapy pembrolizumab, in Japanese patients with advanced solid tumors or a type of lung cancer. The main goal is to check the safety and side effects of these treatments. About 30 people will …

This Phase 3 study tests the long-term safety and effectiveness of azetukalner, a daily pill, in 400 adults with bipolar I or II depression who previously completed a related study. Participants take the drug for 52 weeks, and researchers track side effects, mood changes, and qua…

This trial tests three deep brain stimulation (DBS) settings in people with Parkinson's disease who already have a Boston Scientific Vercise system implanted. The settings are pure anodic, pure cathodic, and a mix of both. Researchers want to see which setting offers the best sym…

This study follows people with Parkinson's disease who previously received AAV-GAD, a gene therapy infused into a brain region that helps control movement. The goal is to check how safe the treatment remains over many years, watching for any drug-related side effects. Researchers…

This study looks at whether people with early relapsing multiple sclerosis (MS) can stop taking ocrelizumab (Ocrevus) after two years without their disease coming back. All 123 participants will receive ocrelizumab for the first two years. Then, some will switch to a placebo whil…

This study tests a program called Mastering the World of Work (MWW) designed to help people with serious mental illness improve their job outcomes. The program focuses on building metacognitive skills — the ability to understand one's own thoughts and others' perspectives — throu…

This trial tests whether a 12-week program of core stabilization exercises can improve balance, trunk control, and gross motor function in children with spastic diplegic cerebral palsy. Sixty children who can walk with some assistance will be randomly assigned to receive either s…

This study tests whether TAK-861 can control symptoms of narcolepsy type 1, a condition causing sudden sleep attacks and muscle weakness. About 88 adults will take TAK-861 for several months, then some will switch to a placebo to see if symptoms return. The goal is to see if the …

This study tests whether a new drug called zanidatamab, combined with chemotherapy and sometimes another drug (tislelizumab), works better than the current standard treatment for advanced HER2-positive stomach and esophageal cancers. About 920 adults whose cancer has spread or ca…

This early-stage trial tests two experimental pills (PF-07799544 and PF-07799933) taken twice daily at home by adults with advanced solid tumors that have a specific gene change called BRAF V600. The study aims to find safe doses and see if the drugs can shrink tumors. About 124 …

This study tests a new device (Laminar) to close the left atrial appendage, a small pouch in the heart, in 1500 people with non-valvular atrial fibrillation. The goal is to see if it is safer and works better than existing devices to reduce the risk of stroke and blood clots. Par…

This phase II trial tests whether an experimental drug called LT3001, given as a single intravenous infusion, can safely improve outcomes for people with acute ischemic stroke who are undergoing endovascular thrombectomy, a procedure to remove the blood clot. The study enrolls ad…

This study is testing whether implanting a small piece of a patient's own nerve tissue into the brain during deep brain stimulation (DBS) surgery is safe and doable for people with Parkinson's disease. The nerve tissue contains cells that produce growth factors, which might help …

This early-stage trial tests whether implanting a small piece of a patient's own nerve tissue into the brain during deep brain stimulation (DBS) surgery is safe and feasible. Ten people with Parkinson's disease will receive the implant, and researchers will monitor them for a yea…

This trial tests whether adding brain stimulation techniques to standard swallowing therapy helps people who have trouble swallowing after a stroke. Researchers will compare neuromuscular electrical stimulation (NMES) alone with NMES combined with either transcranial direct curre…

This trial asks whether starting with highly effective MS drugs right away is better than starting with milder drugs and switching to stronger ones only if needed. Researchers will follow about 800 adults with relapsing-remitting MS for several years, using MRI scans and disabili…

This trial is testing two different forms of repetitive transcranial magnetic stimulation (rTMS) to see which might better ease depression and anxiety in people whose symptoms haven't improved with standard treatments. About 100 adults with treatment-resistant depression will rec…

This early-stage trial is testing whether focused sound wave pulses applied to the head—called transcranial pulse stimulation—can help people recover from a recent ischemic stroke. The study includes adults aged 20 to 80 who had a stroke 1 to 6 months ago and still have motor or …

This trial tests whether a procedure to remove blood clots from veins in the brain works better than standard blood-thinning medication for people with cerebral venous sinus thrombosis (CVST), a rare type of stroke. Participants will be randomly assigned to receive either the end…

This trial tests whether high-dose vitamin D supplements can improve cognitive function in people who have had a stroke and developed thinking or memory problems. Participants will receive either vitamin D or a placebo for six months, and researchers will measure changes in cogni…

This study tests a 6-month community-based program that pairs university students with Latinx immigrants and African refugees to provide mutual learning, resource help, and social support. The goal is to see if this approach can reduce psychological distress, financial problems, …

This Phase I trial tests whether infusing specially trained immune cells, called TAA-T, can safely target and attack high-risk brain tumors in children and adults. The cells are made from the patient's own blood and are designed to recognize multiple tumor-related proteins, poten…

This phase 2 trial is investigating whether psilocybin, the active compound in magic mushrooms, combined with psychological support, is safe and suitable for military veterans and first responders who have both alcohol use disorder (AUD) and posttraumatic stress disorder (PTSD). …

This early-stage trial is testing a new way to give ocrelizumab (Ocrevus) for multiple sclerosis — as a simple shot under the skin instead of a long IV infusion. About 75 adults with MS will receive increasing doses to see if the new form is safe and tolerable. If it works, it co…

This study tests a new approach called 'pill-in-pocket' anticoagulation for people with atrial fibrillation (AF), a heart rhythm condition that raises stroke risk. Instead of taking blood thinners every day, participants would stop them after a 30-day AF-free period and only rest…

This trial investigates whether a long-acting liquid stimulant medication (Quillivant XR) can safely and effectively reduce ADHD symptoms in children with Down syndrome, who are at higher risk for ADHD but often go untreated. The study will compare the medication against a placeb…

This pilot study is testing whether one 25 mg dose of psilocybin, given alongside psychotherapy, can ease depression in people with bipolar II disorder who haven't responded to at least two prior treatments. Using brain scans (fMRI), researchers will look at how the drug affects …

This early-stage trial is testing whether a single same-day treatment using a patient's own bone marrow cells is safe and tolerable for people with Parkinson's disease or related conditions. The procedure involves drawing bone marrow from the hip, giving one portion through an IV…

This trial tests whether an insomnia treatment can improve markers of heart health in adults with insomnia and risk factors for cardiovascular disease. Participants receive either a cognitive-behavioral therapy program for insomnia or a sleep education control. The study measures…

This trial tests whether a non-invasive technique called temporally-interfering electric field stimulation (TIEFS) can reduce abnormal brain activity linked to epilepsy. Researchers will measure seizure-related signals in patients with medial temporal lobe epilepsy who are alread…

This trial tests whether giving the immunotherapy drug durvalumab before surgery can help women with early, small triple negative breast cancer. Participants receive two infusions of durvalumab, then either proceed to surgery or, if needed, additional standard therapy. The study …

This study asks whether wearing a small heart monitor for two weeks at a time, twice, can better detect hidden irregular heartbeats (atrial fibrillation) in older adults who recently had a stroke or mini-stroke, compared to the usual 1-2 day monitoring. Atrial fibrillation is a m…

This study tests a new type of balance training for people who had a stroke within the past few weeks. The training uses controlled wobbles and shifts in the support surface to challenge patients' balance in a safe way, aiming to improve their ability to walk and perform daily ac…

This trial tests whether a culturally adapted program of case manager support can improve survival, reduce hospital readmissions, and boost quality of life for adults recovering from accidental burn injuries in Pakistan. Participants receive up to eight sessions with a case manag…

This study tests whether a focused, intensive stepping training program, called FIRST, can improve walking ability in people recovering from a recent stroke. Participants in inpatient rehabilitation receive physical therapy that prioritizes walking practice at higher cardiovascul…

This trial tests whether using optical coherence tomography (OCT) during a procedure to reopen a chronically blocked carotid artery is safe. The blockage can cause strokes, and doctors often need to see what's inside the artery after crossing the blockage. OCT provides high-resol…

This trial tests whether a personalized training program called 'Kleuter Extra' can improve executive functioning—skills like attention, self-control, and planning—in preschoolers aged 4 to 6 who have severe congenital heart disease. Many children with this condition face thinkin…

This study tests whether a digital expert team can help people on long-term sick leave with muscle or common mental health issues return to work. Participants fill out a digital questionnaire and have a video meeting with their doctor and a team of specialists who then create a p…

This study investigates whether intensively lowering systolic blood pressure with FDA-approved medications can reduce the buildup of amyloid and tau proteins in the brain—hallmarks of Alzheimer's disease. The trial enrolls adults aged 60-85 with high blood pressure who are cognit…

This study tests an experimental drug, NPI-001 (AT-001), in people with hereditary cystatin C amyloid angiopathy (HCCAA), a rare genetic condition that causes repeated brain bleeding and stroke. The trial includes about 15 participants aged 12 and older who carry the specific L68…

This trial tests whether a dietary supplement called Tertinat, containing epigallocatechin-3-gallate, can reduce major heart problems in people with atherosclerosis who have recently had bypass or stent surgery. Over two years, participants take either the supplement or a placebo…

This trial tests whether giving a low-dose infusion of desmopressin (dDAVP) during surgery for complex brain tumors around the pituitary gland can prevent dangerously high sodium levels (hypernatremia) in the first 24 hours after surgery. High sodium can cause brain bleeding, sei…

This study tests a specially designed psychological treatment module for men in Pakistan who struggle with both depression and substance use disorders. The module combines several therapy approaches and is culturally adapted. Half of the participants receive this 12-session progr…

This trial tests whether a quick procedure called umbilical cord milking—pushing blood from the cord into the baby before clamping—can improve brain development in newborns who are limp or not breathing well at birth. The study follows over 3,400 infants from the earlier CORDMILK…

This study tests whether a gentle, targeted electrical stimulation to the brain (HD-tDCS) can safely improve how stroke survivors perceive vertical balance. Participants who have had a stroke affecting one side of the brain will receive either active or sham stimulation while per…

This study tests whether one or two doses of psilocybin, the active ingredient in magic mushrooms, combined with talk therapy, can help people with treatment-resistant depression. Participants are adults aged 18 to 65 whose depression has not improved with standard treatments. Re…

This study tests whether choline, a vitamin-like nutrient, can improve memory, thinking, and behavior in children aged 2.5 to 5 years with Fetal Alcohol Spectrum Disorders (FASD). Participants receive choline daily for either 3 or 6 months. Researchers measure changes in memory, …

This study tests whether personalized smartphone notifications can improve mood, sleep, and physical activity in medical interns. Participants receive mood, activity, or sleep tips through a mobile app, with the content chosen by a learning algorithm. The goal is to see if these …

This trial tests a long-acting injection of leuprolide acetate in children with central precocious puberty, a condition where puberty starts too early. The goal is to suppress puberty-related hormones, slowing or stopping early development. The study includes children aged 4 to 9…

This study tests whether a non-invasive brain stimulation technique called deep transcranial magnetic stimulation (dTMS), combined with paired associative stimulation (PAS), can improve arm and hand movement in people who have had a stroke. The trial includes 40 adults who experi…

This trial investigates whether using a device to continuously measure pressure inside the brain's fluid-filled spaces can improve outcomes for people who have had a bleeding stroke from a ruptured aneurysm. About 372 adults with moderate to severe bleeding will be randomly assig…

This study tests whether a longer, family-involved form of cognitive behavioral therapy (CBT) can work as well as CBT combined with an antidepressant (SSRI) for children and teens with anxiety disorders. Participants aged 7 to 17 with separation, generalized, or social anxiety wi…

This study tests whether a lifestyle physical activity program, supported by a Fitbit and phone counseling, can help women with depression who are in alcohol treatment reduce their risk of relapse. Participants are randomly assigned to either receive the full program or just a Fi…

This study tests whether measurement-based care — where therapists regularly track symptoms using questionnaires — adds extra benefit to weekly psychotherapy for adults with depression or anxiety. Participants are randomly assigned to measurement-based care, standard therapy, or …

This study tests a 4-month in-home rehabilitation program called HOME for Us for people who have had a traumatic brain injury (TBI) at least one year ago and their family caregivers. The program involves eight sessions with an occupational therapist, focusing on adapting the home…

This study looks at whether starting a cardiac rehabilitation programme soon after leaving the hospital helps people with coronary artery disease live longer and avoid hospital stays for heart problems. The programme includes counseling, education, and exercise sessions three tim…

This study follows 158 people in France who are prescribed Epidyolex (a cannabidiol-based medicine) for seizures as part of their normal care. Researchers will track how long people stay on the treatment, side effects, seizure frequency, and changes in daily functioning and quali…

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare blood disorder that can cause dangerous blood clots. Researchers want to know how often PNH appears in people under 50 who have had a stroke, mini-stroke, or brain vein clot with no clear cause. The study will screen 200 partici…

Researchers are testing whether an implanted loop recorder can detect atrial fibrillation in people who have had a stroke. The device continuously monitors heart rhythm for up to a year or longer. The pilot trial enrolls 24 patients across three centers to see if a larger study o…

Researchers at Mayo Clinic are testing whether advanced PET and MRI brain scans can measure inflammation in people with multiple sclerosis and other inflammatory demyelinating diseases. The study includes about 200 participants, both patients and healthy controls. Participants re…

The GMFCS sorts children with cerebral palsy into five levels of gross motor function, largely based on two visible things: whether an adult physically helps the child move, and whether the child bears weight on an external object like a walker or furniture. Scoring these cues ta…

Researchers are testing a noninvasive ultrasound method called ARFI to see if it can detect features of carotid plaque that raise stroke risk. The study includes adults with narrowed carotid arteries, some with symptoms and some without. By measuring plaque characteristics, the t…

After a traumatic brain injury, pressure can build inside the skull and cause serious harm. Doctors usually rely on a CT scan to spot this, but moving a critically ill patient to the scanner carries risks. This study tests two non-invasive ultrasound methods, transcranial Doppler…

Researchers are testing whether artificial intelligence can combine ultrasound images with routine health data to track changes in a person's physiology over time. The study enrolls adults with heart, lung, kidney, or blood vessel conditions, as well as healthy volunteers. The go…

Researchers are testing whether a special MRI tracer called hyperpolarized pyruvate can detect changes in brain energy use after a traumatic brain injury (TBI). The study will compare images from people who had a TBI within the past 30 days with images from healthy volunteers. Th…

This trial tests an experimental imaging tracer called [11C]-CS1P1, which is designed to attach to a protein involved in brain inflammation. The study will first check the tracer's safety and how it moves through the body in healthy volunteers, then compare its signals in people …

This trial explores whether focused ultrasound can enhance the release of tumor DNA into the blood and spinal fluid, potentially making liquid biopsies a more reliable way to diagnose brain tumors. Researchers will use MRI-guided focused ultrasound to partially ablate the tumor i…

This trial tests whether a sudden, loud hand clap can help doctors quickly tell apart epileptic seizures from psychogenic non-epileptic seizures (PNES), which look similar but have different causes. About 400 people undergoing video-EEG monitoring will receive the clap test durin…

This study explores whether a low-cost, portable MRI machine enhanced with artificial intelligence can detect brain abnormalities in people with epilepsy as accurately as standard high-field MRI. About 30 adults with epilepsy who have already had a high-field MRI will also receiv…

This study explores whether a new screening procedure can detect cerebral palsy (CP) earlier in high-risk infants using video recordings and artificial intelligence. Traditionally, CP is diagnosed between 12 and 24 months of age, but earlier detection could lead to better outcome…

This study tests whether a special type of MRI scan can tell the difference between actual tumor growth and harmless treatment-related changes in people who have had surgery for a type of brain cancer called glioma. After treatment, it's often hard to know if a new spot on a scan…

This study evaluates RDX-Aneurysm, a computer-assisted detection software designed to help radiologists find saccular intracranial aneurysms (bulging blood vessels in the brain) on MRI scans. Researchers will analyze 550 past scans—half with confirmed aneurysms and half without—t…

Antiphospholipid syndrome (APS) raises the risk of blood clots and strokes, and doctors often prescribe warfarin to prevent another stroke. Warfarin requires frequent blood tests and carries bleeding risks, especially for younger patients. This trial compares clopidogrel-based an…

This study tests a new medication called IPN10200, given as injections into the head and neck muscles, to prevent migraines in adults. About 641 people with episodic or chronic migraine will receive either the drug or a placebo. The goal is to see if it safely reduces the number …

This phase 3 study tests whether Dysport (a botulinum toxin type A) injections can prevent episodic migraine in adults. About 751 participants receive either Dysport or placebo injections every 12 weeks for up to 36 weeks. The goal is to see if the treatment reduces the number of…

This study tests a new medicine called atogepant to prevent migraines that happen around a woman's period. About 430 adult women with regular cycles and a history of migraines will take either atogepant or a placebo daily for 3 menstrual cycles. The goal is to see if the drug red…

This large Phase 3 study tests whether inclisiran, a twice-yearly injection, can prevent major heart problems like heart attacks, strokes, and heart-related death in people at high risk who have not yet had such an event. Over 14,000 participants are receiving either inclisiran o…

This trial tests whether 5-10 minutes of daily mindfulness and compassion training in school can prevent anxiety and depression in children aged 6-16. About 1,750 pupils will take part, with some classes doing the training for 10 weeks and others not. Researchers will track menta…

This trial tests different vaccination schedules for Japanese encephalitis in healthy children starting at 8 months old. Researchers compare how well each schedule triggers and maintains protective antibodies through age 6, including the effect of booster doses. The study also mo…

This trial tests whether intensive heart rhythm monitoring after a stroke can prevent another stroke. People who have had a stroke may have atrial fibrillation, a heart rhythm problem that comes and goes and is easy to miss. Researchers compare standard care with extra monitoring…

This trial is testing a device called the Vine™ Embolic Protection System, which is implanted in the carotid arteries to trap blood clots before they travel to the brain. It is designed for people with atrial fibrillation who are already taking blood thinners but still have a hig…

This trial asks whether the type of pain relief a woman receives during labor can influence her risk of developing postnatal depression. About 10-15% of new mothers experience postnatal depression, and this study compares epidural analgesia with non-epidural options like laughing…

This trial tests whether a combination of lifestyle interventions—brain training, yoga, music therapy, and a special diet—can slow or reverse early signs of neurological disorders like dementia, stroke, epilepsy, and Parkinson's disease. Participants are healthy adults aged 50 an…

Researchers are testing whether a 12-week computerized cognitive training program can improve thinking and change brain activity in people with multiple sclerosis. The study enrolls 180 adults with MS who have mild to moderate disability. Participants train for one hour a day, th…

This study tests whether adding cognitive training to balance and gait exercises helps people with Parkinson's disease improve their balance, walking, and thinking. Fourteen participants will undergo 12 sessions of combined training. The goal is to see if this approach eases move…

This pilot study tests whether a smartphone app called AmDTx can help lung cancer patients manage anxiety before and after surgery. The app includes mindfulness training and a relaxing puzzle game. Only 6 participants are enrolled, and the main goal is to see if people will actua…

Researchers are testing whether a one-day course of targeted radiation works as well as the standard five-day course for people whose cancer has spread to the brain. The trial enrolls about 100 adults with brain metastases and a poor prognosis. Everyone receives precise, image-gu…

This study tests a program called Healthy ReStart that uses health coaching, motivational interviewing, and online tools to help adults with serious mental illness return to active lives after major disruptions like the COVID-19 pandemic. Sixty participants will receive either th…

Freezing of gait is a disabling symptom of Parkinson's disease that often does not respond well to current treatments. Researchers are testing whether spinal cord stimulation, a device-based therapy already used for chronic pain, can reduce these freezing episodes. In this trial,…

Researchers are testing whether wearing a lightweight robotic exoskeleton at home can improve quality of life for people with multiple sclerosis who have walking difficulties. The study includes 28 adults who use a walking aid and live at home. Participants wear the Keeogo exoske…

This study looks at whether medical hypnosis can help reduce anxiety in people with solid tumors who are getting radiation therapy. About 45 moderately to very anxious patients will either listen to relaxing music alone or combine it with hypnosis during their sessions. The goal …

Researchers are testing whether human urinary kallidinogenase, a protein-based drug, can improve recovery in adults who have had an acute ischemic stroke and received standard reperfusion treatment such as clot-busting drugs or clot-removal procedures. The trial enrolls about 1,2…

This study tests whether berberine, a natural compound, can safely improve negative symptoms of schizophrenia—like low motivation and emotion—that current medications often miss. Researchers will give berberine or a placebo to 120 Han Chinese adults with stable schizophrenia and …

This study tests whether combining a brain-computer interface with virtual reality can improve arm and hand movement in stroke survivors. Twelve adults who had a stroke 6 to 24 months ago will each try both the VR-enhanced training and a standard brain-computer interface training…

Researchers are testing whether a rehabilitation robot combined with neuromuscular electrical stimulation can improve upper limb movement in people who had a stroke at least six months earlier. The study enrolls 48 adults with moderate arm impairment. Participants receive up to 2…

This study looks at whether weekly phone counseling can help identify and treat depression in women with ovarian, peritoneal, or fallopian tube cancer. About 409 participants will either receive phone counseling or standard care with resource lists. The goal is to see which appro…

This study tests a small device called Cerogrin that gently stimulates a nerve in the ear, aiming to improve thinking and memory in people with vascular dementia or mild cognitive impairment. Twenty-four participants will use the device at home for 30 minutes daily over four week…

Researchers are testing whether a daily oral supplement regimen improves skin, hair, sleep, energy, cognition and sexual wellbeing in healthy adults aged 35 to 65. Participants take either the active supplement or a placebo for 12 weeks. The study measures skin elasticity, firmne…

This study tests whether two special diets—a modified Paleolithic elimination diet and a time-restricted ketogenic diet—can improve quality of life, fatigue, and mood in 162 people with relapsing-remitting multiple sclerosis. Participants are assigned to one of the diets or stand…

This study is testing whether an online course can help people with multiple sclerosis, long COVID, fibromyalgia, or cancer-related fatigue adopt healthier diets and self-care habits. Researchers will measure changes in quality of life, fatigue, and mental health. The goal is to …

This study is for people with a rare and aggressive brain tumor called diffuse midline glioma. Instead of the usual six weeks of daily radiation, researchers are testing a shorter course of just two weeks. The goal is to see if the shorter treatment works just as well at controll…

This study tests a virtual behavioral therapy (Functional Behavioral Training) for children aged 2-12 with genetic syndromes like Fragile X, Angelman, or Rett syndrome who have challenging behaviors. The therapy teaches parents how to identify what triggers problem behaviors and …

People with Parkinson's disease often struggle with motivation and motor learning, which can limit rehabilitation. This trial compares two ways of practicing a joystick task: one group chooses the stories and exercises they practice, while the other follows the same routine witho…

This study tests whether morning bright light therapy can improve sleep in 300 veterans who have had a traumatic brain injury. Participants use a special light box each morning, and researchers track changes in sleep quality, mood, thinking, and blood markers. The goal is to find…

People on hemodialysis receive needle sticks through a fistula or graft several times a week, and the pain and anxiety can build over time. This trial tests whether slow, deep breathing combined with lemongrass aromatherapy reduces pain and anxiety during needle insertion. Resear…

Researchers are testing whether a Joovv Mini infrared light device changes mood, sleep, and activity levels during winter months. Participants include US-based adults with a history of mental health issues such as depression who live in colder regions. They will use the device an…

This study is testing a digital care program for adults with migraine. The program includes a wearable device that uses nerve stimulation, personalized exercises, and support from a care team. The goal is to see if it can reduce the number of migraine days per month. About 140 pe…

This study adapts Project YES+, a behavioral program, to improve mental health and reduce HIV-related stigma for adolescent and young men who have sex with men living with HIV in Vietnam. Eighty participants aged 16-24 will receive individual and group sessions with peer mentors.…

Researchers are testing whether manual vagus nerve stimulation, a hands-on technique that targets the vagus nerve without surgery or electrical devices, can improve movement, autonomic function and thinking skills in people who had a stroke at least six months earlier. Participan…

This study tests whether a therapist-guided virtual reality (VR) program can help adolescents in psychiatric hospitals improve how they regulate their emotions. Participants, aged 11 to 18, are randomly assigned to either personalized VR exposure sessions or a VR relaxation contr…

Researchers are testing a personalized, non-drug treatment for adults with ongoing depression, anxiety, trauma-related symptoms, sleep problems, attention difficulties, or substance-use concerns. Instead of assigning treatment by diagnosis alone, the study selects approaches base…

This study compares two radiation treatments for people whose non-melanoma cancer has spread to the brain with 4 to 15 tumors. One method, stereotactic radiosurgery, delivers a high dose only to the tumors, while the other treats the whole brain. The goal is to see which better c…

The NeuroPace RNS System is an implanted brain stimulator approved for adults with focal epilepsy that medicines cannot control. Researchers are gathering real-world data on how safe and effective the device is in adolescents aged 12 to 17 who already received it in routine care.…

This study tests a new type of cycling called eccentric cycling for people with multiple sclerosis. Researchers want to see if it improves muscle strength, walking ability, fatigue, and quality of life better than standard cycling. Sixty adults with MS who can walk independently …

This study aims to develop and test a shortened version of Mindfulness-Based Cognitive Therapy (MBCT) to improve mood in older African American/Black women who have had breast cancer and now have mild to moderate depression. About 23 participants will attend group sessions and re…

This trial tests a wearable device that uses mild electrical pulses to stimulate the leg muscles of people with multiple sclerosis who have foot drop. The goal is to see if using the device for several months improves walking quality, physical activity, and participation in daily…

Researchers are exploring whether a wrist-worn device called the Beechband, which delivers intermittent vibrations, can change movement symptoms and everyday experiences for people with Parkinson's disease. About 60 participants will be randomly assigned to wear the device for ei…

This study adapts Written Exposure Therapy (WET), a brief 5-session treatment, for adolescents aged 12-18 with PTSD. Researchers will first gather feedback from experts and teens, then test the adapted therapy against the standard 12-16 session treatment in 48 teens. The goal is …

Researchers are testing whether limiting eating to a 10-hour window each day can improve quality of life, ADHD symptoms, sleep, and gut health in adults with ADHD who have disrupted body clocks. The trial enrolls 60 adults aged 18 to 65 who usually eat over more than 14 hours a d…

This study tests whether a program of supervised eye exercises can improve physical function, balance, and reduce fear of falling in people with Parkinson's disease. 34 participants will do progressive eye movements and gaze stabilization exercises in a clinic setting. The goal i…

Researchers are testing a virtual reality therapy for young people with depression and anxiety. The therapy adapts acceptance and commitment therapy to teach skills for viewing thoughts and emotions as temporary events. Up to 75 young people aged 12 to 25 will receive the clinici…

Researchers are testing whether occupational therapy that uses virtual reality can improve cognitive skills, daily performance, and motivation in children with autism. The study includes 32 children aged 6 to 12 with autism level 1. Half receive virtual reality-supported cognitiv…

Researchers at the University of Illinois at Chicago are studying which parts of a yoga practice affect anxiety, mood, and thinking in highly anxious college women. About 60 participants complete four sessions that include yoga postures, breathwork, meditation, or watching a yoga…

This study tests a smartphone app called MS CATCH that lets people with multiple sclerosis regularly report their mood to their neurologist. The goal is to improve how doctors screen and treat depression in MS. About 100 adults with MS and mild-to-moderate depression are taking p…

This study tests whether a drug called crisugabalin can safely reduce pain in people with Parkinson's disease who have a type of pain called nociplastic pain. About 166 adults will take either the drug or a placebo twice a day for 12 weeks. Researchers will measure pain levels an…

This study tests a new program that combines mindful eating with motivational interviewing to help people with overweight reduce binge eating. One hundred participants will either receive the full program (counseling plus daily meditation) or just daily meditation. The main goal …

This study looks at whether treating insomnia can help people with Crohn's disease feel better, including reducing pain and inflammation. About 83 adults with mild to moderate Crohn's and insomnia will receive a remote sleep treatment. The main goal is to see if the approach is p…

This study at Johns Hopkins tests whether using personalized mobile health assessments can improve cognitive-behavioral therapy (CBT) for children aged 8-17 with obsessive-compulsive disorder (OCD). 30 participants will receive either standard CBT or CBT guided by their own sympt…

Researchers are testing a virtual stress-management program for people who care for a spouse or partner with a solid tumor cancer while also holding a job. The program teaches skills such as paced respiration, relaxation, and coping with work and caregiving demands across eight s…

This study looks at whether doing heated or non-heated yoga can reduce symptoms of depression. Researchers will enroll 120 adults with moderate depression. Participants will practice yoga and report their mood changes over time.

This study tests whether a mobile app called PTSD Coach, with or without brief clinician support, can reduce PTSD, anxiety, depression, and sleep problems in World Trade Center responders living in Florida. About 120 English- or Spanish-speaking responders will be randomly assign…

This study tests whether a 12-week web-based support program can improve wellbeing in adults who survived a cardiac arrest 1 to 3 months earlier. The program includes educational modules, videos, breathing exercises, and a chat forum. Researchers will compare 120 participants who…

Researchers are testing whether a six-week group talk therapy program eases depression in Ugandan villages. The trial enrolls about 1,200 people aged 15 and older with at least moderate depressive symptoms across 100 villages in Luuka and Buikwe districts. Villages are randomly a…

Researchers in Greece are testing a nine-session group program called TRANSFORM for people who have finished treatment for blood cancers such as leukemia, lymphoma, and myeloma. The program combines teaching, reflection, coping exercises, and mindfulness to see whether it can spa…

Researchers are adapting a mobile health program that pairs the PositiveLinks app with video counseling from a community health worker. The study enrolls 60 people in Florida who have HIV and mild to moderate anxiety or depression. Participants receive either the enhanced counsel…

This study tests a new program called PA-ChatS that helps people increase physical activity in the first 6 weeks after a stroke. Participants wear a Fitbit to track steps and have weekly phone meetings with an occupational therapist for 6 weeks. The study includes 25 stroke survi…

This study tests a program called FOREST that teaches positive emotion skills to staff working in gun violence prevention. The goal is to reduce burnout, anxiety, and depression, and improve well-being and job retention. One hundred employees from UCAN in Chicago will take part o…

This study combines virtual reality with a gentle electrical pulse on the ear (called taVNS) to help people with chronic shoulder pain who are waiting for surgery. The goal is to see if this drug-free approach can reduce pain, anxiety, and depression. Only 10 people will take par…

Researchers test an 8-week online precision nursing education program for young colorectal cancer survivors. The program includes Qigong exercise and mindfulness training delivered through an e-flipped classroom model. The study measures changes in depression symptoms and mindful…

This pilot study tests whether a home-based program called HOBSCOTCH, originally designed for epilepsy, can be adapted for people with Parkinson's disease. Ten participants will work one-on-one with a coach in nine virtual sessions to learn problem-solving strategies and memory a…

Researchers are testing whether adding glenzocimab to standard endovascular therapy improves recovery in adults with acute ischemic stroke caused by a large blocked vessel and a large area of brain damage. Participants receive either glenzocimab or a placebo as an intravenous inf…

Depression is common among cancer survivors, but many don't get help. This pilot study tests a text-based referral platform that sends tailored messages and a video to encourage survivors to take up a mental health referral. The study will enroll 60 cancer survivors with depressi…

This study compares cognitive behavioral therapy (CBT) with online expert coaching to usual care for children aged 6-14 with autism who struggle with anxiety, irritability, or emotional outbursts. About 100 children and 50 therapists will take part. The goal is to see if the coac…

Researchers at the University of Hawaii are studying whether a weekly hula class can improve quality of life, well-being, balance, and motor symptoms in people with Parkinson's disease. The trial enrolls 40 adults with idiopathic Parkinson's disease who can attend in-person sessi…

Researchers at Evanston Hospital are testing whether a single intramuscular dose of ketamine can quickly reduce suicidal distress in adults who arrive at the emergency department and are waiting for psychiatric admission. The pilot study enrolls 8 patients who receive the injecti…

This trial tests whether adding Therapeutic Listening, a music-based auditory therapy, to a standard exercise program improves balance, trunk control, and reaction time in children with spastic diplegic cerebral palsy. Sixty children will receive either exercise alone or exercise…

This study tests a new, non-invasive brain stimulation method using low-intensity ultrasound waves aimed at specific brain areas linked to depression. Researchers will personalize the treatment for each of the 30 participants based on their brain scans. The goal is to see if this…

This trial tests whether adjusting deep brain stimulation (DBS) settings specifically for sleep can improve sleep quality in people with Parkinson's disease. Participants already use an adaptive DBS system that responds to brain signals. Researchers will compare three different s…

This study is testing a new behavioral program for pregnant women with ADHD. The program teaches skills to manage ADHD symptoms during pregnancy and after the baby is born. Ten participants will work with a therapist in an OB care setting. The goal is to see if the program is acc…

This study tests whether an online problem-solving therapy, matched to a person's specific symptoms using machine learning, can reduce depression and anxiety better than usual care. About 380 adults with moderate symptoms will take part. The goal is to create a precise, scalable …

This study explores whether a photography-based program can help children aged 8-12 with ADHD better recognize and express emotions, and improve attention and impulsivity. Sixty children will take photos and learn photography skills as a tool to boost emotional well-being. The go…

This study tests whether taking vitamin K2 supplements for one year can improve muscle strength and brain function in people who recently had an ischemic stroke. 190 participants will receive either vitamin K2 or a placebo daily. Researchers will measure handgrip strength and oth…

This study looks at whether trained service dogs can help reduce PTSD symptoms in military veterans. 150 veterans who already qualified for a service dog are randomly assigned to receive one or to a waitlist. Researchers track their PTSD severity, depression, and overall well-bei…

This study tests whether a higher dose of a gentle brain-zapping technique called tDCS can safely help people with major depression. About 20 adults will receive mild electrical pulses on their scalp over 5 days. Researchers will check for side effects and see if mood improves.

This study tests an oral medication called MM120 against a placebo in 245 adults with generalized anxiety disorder. Participants take the drug or placebo for 12 weeks, and those who complete may join a 40-week follow-up where everyone gets the active drug. The goal is to see if M…

This study tests whether a mobile app delivering cognitive behavioral therapy can help U.S. military veterans who have both insomnia and depression. 1,200 participants will receive either therapy for insomnia, depression, or both in sequence. The goal is to see which approach wor…

This study tests a multidisciplinary program for adults with chronic back pain. Participants will attend group sessions on pain education, healthy habits, and emotional coping, plus do therapeutic exercises. The goal is to see if the program improves physical function, reduces fe…

This study from Yale University will test whether listening to live music can reduce anxiety and improve brain activity in people with early Alzheimer's disease, dementia, or mild cognitive impairment, along with their caregivers. Sixty pairs (patient and caregiver) will attend b…

This study tests a 6-week mindfulness-based program designed to improve sleep and reduce stress in Black women with insomnia. Researchers will enroll 340 women and track changes in sleep quality, stress levels, and how acceptable and feasible the program is. The goal is to see if…

This study tests two online programs designed to help people with multiple sclerosis (MS) understand and manage their fatigue. Researchers will enroll 2,000 adults with MS across the U.S., including veterans, and compare the programs to usual care alone. The goal is to find pract…

This early-phase study at Johns Hopkins University is testing whether psilocybin, the active compound in magic mushrooms, can safely help people with obsessive-compulsive disorder (OCD). Thirty-five adults with moderate to severe OCD who have already tried other treatments will r…

This trial tests whether cognitive behavioral therapy (CBT) or mindfulness-based therapy (MBT) reduces post-traumatic stress disorder (PTSD) symptoms more effectively than psychoeducation alone. Female adults who have experienced interpersonal or domestic violence and meet criter…

This trial tests a structured, group-based training program designed to improve executive function skills in elementary school children aged 9 to 12 with autism spectrum disorder. Over 12 weeks, children attend weekly sessions that teach planning, organization, time management, e…

This study tests whether a 24-week collaborative care program can improve quality of life for adults with epilepsy who also have anxiety or depression. The program includes regular check-in calls and expert recommendations from a psychiatrist and neurologist. Researchers will com…

This study investigates whether breathing a 50:50 mix of nitrous oxide (laughing gas) and oxygen can reduce pain and anxiety during insertion of a central venous catheter, a common but uncomfortable procedure. Adults aged 18 to 65 who have never used nitrous oxide will be randoml…

This trial tests whether CranioSacral therapy, a gentle manual therapy applied to the feet, diaphragm, neck, and skull, can reduce tremors and improve movement precision in people with Parkinson's disease. Five participants will receive 90-minute sessions twice a month for three …

This study tests whether using advanced brain imaging to guide deep brain stimulation (DBS) can better control tremor in people with Parkinson's disease while avoiding side effects like involuntary movements. Twenty adults who already have DBS implants will have their stimulation…

This phase 3 study tests whether an oral medication called MM120 can reduce anxiety symptoms in adults with generalized anxiety disorder. About 214 participants will receive either MM120 or a placebo for 12 weeks, followed by a 40-week period where everyone can receive MM120. The…

This study tests whether a six-week, nurse-led virtual group program can help adult women with Multiple Sclerosis (MS) find more meaning and purpose in life, and improve their quality of life. Participants attend weekly online group sessions focused on reflection and values explo…

This study tests whether a special type of sleep therapy, adapted for trauma, can help women veterans with both insomnia and PTSD feel more ready to engage in PTSD treatment. About 100 women veterans will be randomly assigned to either the sleep therapy or a general education pro…

This study compares two low-intensity family treatments for children aged 7-13 with anxiety or obsessive-compulsive disorder (OCD): internet-delivered cognitive behavioral therapy (CBT) and a parent-led reading program. Both are delivered via telehealth and compared to a relaxati…

This study looks at whether a guided therapeutic writing program can help adult women with chronic pain and co-occurring mental health conditions. Participants will complete writing exercises focused on emotional processing and meaning-making over four weeks, then share their exp…

This study tests a communication coaching program for adolescent and young adult cancer survivors (ages 18-35) who have finished treatment at least a year ago. Participants complete online sessions and AI coaching to improve how they talk with peers. The goal is to see if the pro…

This pilot trial tests whether people with multiple sclerosis can safely and satisfactorily use a telemedicine platform for balance rehabilitation at home. After completing intensive in-hospital rehabilitation, participants either follow a 12-week home telerehabilitation program …

This study tests a behavioral sleep and circadian intervention for 50 school-aged children (6–12 years) with autism who have sleep problems. Parents receive 5 Zoom sessions over 12 weeks to learn strategies to improve their child's sleep. The goal is to see if the program is feas…

This study looked at whether a special exercise program focusing on muscle power (moving quickly) could help people with Parkinson's disease who have slow movements (bradykinesia). Twenty-two adults with Parkinson's were split into two groups: one did standard exercises, and the …

This trial tests whether a 20-minute session of mandala coloring while listening to slow instrumental music can reduce cancer fear and anxiety in women undergoing cancer screening. Women aged 30 to 65 attending a screening center will be randomly assigned to either the coloring a…

This study tests whether daily listening to Mozart's Sonata for two pianos in D major (K448) can reduce seizures and improve thinking skills in children with drug-resistant epilepsy. Researchers will compare a group that listens to K448 for 8 minutes each day for 2 months with a …

This trial tests a home-based program called the Sickle Cell Caregiver Collaboration for Child Development (SCCCD) for infants and toddlers with sickle cell disease. The program combines a parenting curriculum with occupational therapy to help families support their child's learn…

This study tests whether a drug-free vibrotactile patch, worn during sleep after night shifts, can improve sleep recovery in doctors. Twenty doctors who work regular night shifts will wear either the active patch or a sham patch across 3-4 post-shift sleep episodes. Researchers w…

This phase 2 trial tests whether adding oxytocin nasal spray to standard psychosocial treatment can improve social skills and reduce symptoms in adults with schizophrenia spectrum disorders. Participants receive either oxytocin or a placebo spray alongside their usual therapy. Th…

This study tests a digital tool that helps parents of young children with developmental delays or disabilities organize and share their priorities with early intervention professionals. The tool, called PEM+, is designed to make family-centered care more practical by guiding fami…

This trial tests whether Written Exposure Therapy (WET), a brief six-session therapy involving guided writing about a traumatic event, can reduce PTSD symptoms in adults receiving care at Federally Qualified Health Centers. The study enrolls 720 English- or Spanish-speaking adult…

This trial tests whether spending time in nature can reduce anxiety in children aged 9-12 who have experienced adverse childhood events. Participants are assigned to either group nature outings, family outings, or a waitlist. The goal is to see if these nature-based activities im…

This trial tests a counseling program called Mpata Yathu ('Our Space') for adolescent girls and young women in Zambia who have experienced gender-based violence and may be living with or at risk for HIV. The program uses problem-solving therapy delivered by trained lay counselors…

This study tests whether a 10-week program called Positive Minds, Strong Joints is feasible for Black adults aged 50 and older with knee osteoarthritis. The program combines recommended exercise with mental health strategies to address pain, depression, and anxiety. Researchers w…

This study tests a computer-based cognitive rehabilitation program designed to improve thinking skills, particularly time-based prospective memory—remembering to do things at a specific time—in people who have had a moderate-to-severe traumatic brain injury (TBI) at least a year …

This trial tests whether a virtual reality (VR) educational video can reduce anxiety and improve satisfaction in adults starting their first course of external beam radiotherapy for cancer. Half of the 122 participants will watch a VR video through a headset before treatment, whi…

This study tests an online pathway called iPath*D that guides cancer patients who report depression symptoms from screening to treatment options. The goal is to see if the tool is acceptable and easy to use for adults starting cancer treatment. Researchers will measure usability,…

This trial compares two forms of cognitive-behavioral therapy (CBT) for children and teens with anxiety or obsessive-compulsive disorder (OCD). One approach uses internet-delivered modules with therapist guidance; the other trains parents to lead exposure exercises with their chi…

This trial tests a 12-session cognitive-behavioral therapy designed to help people with substance use who also struggle with anxiety or depression. The therapy focuses on improving emotion regulation—the ability to understand and manage emotions—which may reduce addictive behavio…

This trial tests whether custom-designed sensorimotor insoles, worn daily for six months, can improve balance and walking in people with multiple sclerosis. Fifty adults with MS (mild to moderate disability) will be randomly assigned to receive the insoles or continue their usual…

People on hemodialysis need their fistula punctured with a needle three times a week, which can be painful and anxiety-provoking. This trial compares three approaches: usual care, applying an ice pack to a specific point on the hand before the needle, and using a numbing gel. Res…

This trial tests a web-based sex and relationship education program called Our Love, Our Style (OLOS) for autistic young adults in South Korea. Participants start with either web-based learning alone or web-based learning plus group coaching. Based on their progress, non-responde…

This pilot study explores whether robot-assisted walking devices can be used in schools to help children who cannot walk independently. The devices attach to a walker and power leg movements, allowing children to stand and walk upright. The study aims to identify the best ways to…

This study tests whether eye-tracking can predict if the drug brexpiprazole will improve symptoms in adults with major depressive disorder. One participant will take brexpiprazole or placebo while researchers measure their visual attention to emotional images. The goal is to see …

This study tests whether a sleep health coaching program, based on cognitive behavioral therapy for insomnia, can improve sleep in firefighters who have trouble sleeping. About 400 firefighters from 20 fire agencies in Arizona will take part. Half will receive the coaching progra…

This study tests whether adding home-based telerehabilitation via WhatsApp video calls to standard outpatient therapy improves hand function in people who had a stroke 1-6 months ago. Forty-eight participants will be split into two groups: one gets standard therapy plus daily 30-…

This study tests whether an 8-week online mindfulness program (MBSR) can improve emotional intelligence and reduce stress-related physical symptoms in adolescents aged 14 to 18 who have experienced bullying and childhood trauma. About 44 teens are randomly assigned to either the …

This pilot trial tests a 15-week telehealth program called Surviving and Thriving in the Real World (STRW) for teens aged 14–18 with epilepsy who struggle with daily living skills. The program includes weekly caregiver-teen sessions and separate caregiver group meetings, all deli…

This study investigates whether a painless, low-intensity electrical current applied to the scalp can improve cognitive function — specifically the ability to stop an action when needed — in people with Parkinson's disease. The trial includes 50 Parkinson's patients and 40 health…

This study tests whether a sphenopalatine ganglion block (SPGB) using lidocaine can reduce the severity and duration of post-dural puncture headache (PDPH) in new mothers. PDPH is a severe headache that can occur after an epidural or spinal needle insertion for labor pain relief.…

This trial tests whether an AI-powered chatbot can help reduce anxiety and improve coping in men about to have prostate cancer surgery. Participants will either receive standard preoperative communication or also have access to a large language model (LLM) that answers their ques…

This study tests whether structured hypnotherapy sessions can improve quality of life for women with breast cancer undergoing chemotherapy. Participants in the intervention group receive 10 hypnotherapy sessions alongside standard care, while the control group receives standard c…

This study tests whether augmented reality (AR) games can improve walking and balance in children with cerebral palsy. Forty children will either do exercises wearing AR goggles or receive standard physical therapy. The goal is to see if the AR approach is more effective and enga…

This study explores whether high-intensity interval training (HIIT) is a practical and acceptable treatment for adults with ADHD. Researchers will recruit 30 adults diagnosed with ADHD to participate in a 14-week exercise program combining strength and endurance training. The goa…

This study tests an internet-based cognitive behavioral therapy (CBT) program designed to help autistic adolescents aged 11-17 manage anxiety. The program, called LUNA-Adolescent, is parent-led and delivered online, making it easier for families who cannot access in-person therap…

This study investigates whether menopausal hormone therapy (MHT) can improve sleep quality in women going through menopause. Researchers will compare sleep in women who receive MHT to those who do not, using questionnaires and sleep diaries. The goal is to see if MHT can help wit…

This pilot study explores whether non-invasive electrical stimulation of the spinal cord, combined with hand and arm exercises, can improve upper limb function in people with multiple sclerosis. Participants use a home device with help from a partner over 8 weeks. The study focus…

This study tests a new virtual reality program designed to help adults with autism improve their social skills and daily functioning. 140 participants will either receive the VR training plus usual care, or usual care alone, for 3 months. Researchers will measure changes in socia…

This study tests a new method called Strategic Treatment Assessment for Youth (STAY) designed to help racial and ethnic minority teens with depression or suicidal thoughts stay in therapy. Researchers will compare STAY to standard care in 140 teens aged 12-18 across three communi…

This study tests whether a unique music therapy, based on Traditional Chinese Medicine's five-element theory, can help men with depression and anxiety when added to their usual medication. One hundred male inpatients will receive either standard drugs alone, drugs plus regular mu…

Researchers are sequencing the gut microbiomes of people with a wide range of conditions, from autism and Alzheimer's to Crohn's disease and multiple sclerosis, to see whether bacterial patterns differ by disease. The study also enrolls healthy participants for comparison. By mat…

This study follows 250 adults in the UK who already use rimegepant for migraine attacks. Over 12 weeks, they report how quickly the drug eases pain and other symptoms. The goal is to see how consistently rimegepant works in everyday life.

This study tracks 80 adults with different smell disorders (like total loss, partial loss, or distorted smell) plus healthy volunteers over one year. Researchers use brain scans, smell tests, and questionnaires to see how the brain changes and how smell loss impacts mood and dail…

This study looks at whether insurance claims data can be used to reliably identify two serious complications in people with Alzheimer's disease: brain hemorrhages larger than 1 cm and new-onset seizures. Researchers will analyze records from 600 Alzheimer's patients, linking insu…

Researchers at Cambridge Health Alliance are testing whether natural language processing and deep learning can analyze interviews with patients in a 16-week online group therapy program for posttraumatic stress disorder. The study enrolls 33 people already in the program, which u…

This study tests a short guide called the 'Jumpstart Guide' to help doctors have better conversations with dementia patients and their families about healthcare goals. Over 1,800 patients and their caregivers are taking part. Researchers will compare whether those whose doctors u…

This study tracks brain activity in 160 Parkinson's patients who have or will receive deep brain stimulation (DBS). Researchers record signals from the brain during memory tasks, with the stimulator on and off, to find patterns linked to cognitive side effects. The goal is to ide…

This study looks at a special training program called Fundamentals of Communication in Surgery (FCS) for surgeons and surgery trainees. The goal is to see if the training helps surgeons communicate better with patients and each other. About 600 people will take part, and research…

Researchers are running an international registry to follow adults who had an ischemic stroke or transient ischemic attack and also have a patent foramen ovale, a small opening between the upper chambers of the heart. The registry collects real-world information on how these pati…

This natural history study follows 259 children, adolescents, and adults with Neurofibromatosis Type 1 (NF1) for up to 10 years. Researchers will track tumor growth, monitor quality of life, and perform genetic testing to better understand how the disease changes over time. The g…

Researchers are comparing two ways of finding atrial fibrillation in people who have had an ischemic stroke or a transient ischemic attack (TIA). One method uses a standard electrocardiogram (ECG) in the hospital, and the other uses a prolonged cardiac monitor worn for a longer p…

This study looks at how precise radiation (stereotactic radiosurgery) affects memory and thinking in people with 6 or more brain tumors that have spread from other cancers. About 80 adults will take part to find the safest radiation dose and measure any decline in memory over 4 m…

The SHAKTI study is a 5-year observational project that will follow 6,000 people of Asian or Pacific Islander descent, aged 10 and older, with depression or related mood disorders. Researchers will collect a wide range of data—including lifestyle, clinical history, blood and stoo…

This study looks at how the brain learns, remembers, and makes decisions. Researchers will record brain activity from 200 epilepsy patients who already have electrodes implanted for medical monitoring. Participants perform simple computer tasks while their brain signals are measu…

Researchers at Semmelweis University are studying whether bacteria that cause gum disease also show up in damaged blood vessels. They will compare samples from the mouth and from diseased artery sites in 100 people who need surgery for aortic aneurysm or carotid artery narrowing.…

Researchers at the University of Management and Technology Sialkot are studying how motor coordination relates to postural stability in children with autism spectrum disorder. The study includes 30 children aged 5 to 12 who can stand and walk without help. Parents answer a questi…

This study is working to create a prediction model specifically for children with moderate to severe traumatic brain injury (TBI). Currently, doctors use models designed for adults, which may not be accurate for kids. Researchers will analyze data from 2000 children to develop a …

This study surveys over 21,000 nurses at Mayo Clinic to measure levels of moral distress, moral injury, and post-traumatic stress. Participants fill out questionnaires about their experiences and well-being. The goal is to understand how these issues vary by work setting, special…

This study tests a new computer-based visual training task for people who have lost part of their vision due to a stroke. Participants watch moving patterns on a screen and learn to detect motion direction, with the goal of improving visual abilities. The study first checks if th…

This study uses MRI scans to look at the brains of children and adults with conditions like ADHD, autism, schizophrenia, and endocrine disorders, as well as healthy volunteers. Researchers aim to compare brain anatomy and function across different groups and ages. The goal is to …

This study aims to identify genetic, biochemical, and clinical factors linked to disease severity in people with Gaucher disease and other lysosomal storage disorders. Researchers will evaluate up to 1,000 participants, including patients, carriers, and healthy controls, to bette…

Researchers want to understand how the brain handles faces, which people use constantly to make social decisions. The study enrolls adults with intractable epilepsy who already have electrodes implanted in their brains for clinical monitoring. While those electrodes are in place,…

This long-term study follows over 3,700 adults in Baltimore to understand why some people age healthier than others. Researchers are looking at how race, income, and neighborhood affect risks for diseases like diabetes, heart disease, and memory loss. Participants visit mobile he…

This study looks at people and families who have a high risk of cancer to learn what genes and environmental factors might increase that risk. Over 5,000 participants are followed over time with questionnaires, medical records, and optional genetic testing. No treatment is given,…

Researchers are studying how people with relapsing multiple sclerosis use ofatumumab in everyday practice in Germany and Japan. The study looks at insurance claims from about 5,000 adults to see how many stay on the treatment and how regularly they take it. It also tracks how oft…

This study is looking at whether changes in RNA found in saliva can help predict how long concussion symptoms will last in children aged 5 to 21. Researchers will collect saliva samples and track symptoms like dizziness and balance problems. The goal is to better understand recov…

This study looks at how the brain learns from past experiences and uses that knowledge in new situations. Researchers will monitor brain activity in 114 adults with hard-to-treat epilepsy who are already undergoing brain monitoring. The goal is to understand the process of abstra…

This study tests whether a special MRI scan, called DSC-MRI, can measure blood flow changes in brain tumors to predict if the drug bevacizumab is working early in treatment. Researchers will scan 146 patients with recurrent glioblastoma before and two weeks after starting the dru…

This study collects health information and test results from 317 people at high risk for pancreatic cancer, including those with cysts, genetic syndromes, or other risk factors. Researchers aim to build a database to find better ways to detect the disease early or prevent it. No …

This study follows 25 people with spinocerebellar ataxia type 7 (SCA7) for up to 5 years to learn how the disease changes vision, coordination, and thinking. Participants will have yearly eye exams, brain scans, and neurological tests. No treatment is given; the goal is to gather…

This 10-year study follows 1,500 young people aged 10-24 to learn what makes some more resilient to depression and anxiety than others. Researchers will track lifestyle, brain scans, and mental health over time. No treatments or interventions are given—the goal is simply to obser…

This study explores whether an Apple Watch can track walking, heart rate, breathing, and sleep in people with glioblastoma, a serious brain cancer. The goal is to see if the watch can detect symptom changes before they become serious, like seizures or blood clots. Twenty-five pat…

This study follows 2,500 people aged 10 and older with depression or bipolar depression over 10 years. Researchers collect data on symptoms, brain scans, genetics, and lifestyle to find patterns that predict how someone will respond to different treatments. No experimental drugs …

This study follows 817 military personnel who served in Iraq to see how war affects mental health, thinking skills, and daily life over time. Participants complete surveys and in-person tests on mood, stress, and memory. The goal is to learn how conditions like PTSD develop and c…

This study looks at 30 people who have had a moderate to severe traumatic brain injury. Researchers use special PET scans to measure inflammation in the brain at two weeks and two months after the injury. The goal is to see if the amount of inflammation is linked to a higher risk…

This study looks at how to help VA medical centers offer virtual programs that prevent heart disease, diabetes, and depression in women Veterans. Researchers are testing two different support strategies at 20 VA sites to see which works better. The study does not involve patients…

Researchers are testing whether certain proteins in the blood and advanced brain scans can detect hidden damage in people with moderate to severe traumatic brain injury. The study enrolls 50 adults and follows them for 3 months, taking blood samples and MRI scans shortly after in…

This study is a health check for students at Constructor University Bremen and employees at HAW-Hamburg. Researchers will use surveys and interviews to measure loneliness, anxiety, stress, and health habits. The goal is to understand what affects wellbeing and find ways to suppor…

This study looks at whether having physical therapy (PT) and occupational therapy (OT) together in one session works as well as having them separately for stroke patients in the hospital. About 567 adults admitted for acute stroke will be randomly assigned to either co-treatment …

This study trains police officers and first responders to better communicate with people who have aphasia, a condition that affects speech and understanding. 75 participants from the Madison Police Department will take part for up to 6 months. The goal is to see if training impro…

This study follows 110 people with brain metastases who are receiving either focused or whole-brain radiation. Researchers use advanced MRI scans and memory tests before treatment and for two years after to see if the scans can predict thinking and memory problems. The goal is to…

This study tests whether brain wave (EEG) measurements can predict who will get better from a non-invasive magnetic stimulation treatment for depression called rTMS. Researchers will treat 30 adults with depression using rTMS and compare their EEG patterns before and after treatm…

Mayo Clinic researchers are studying whether epilepsy changes how the body controls blood pressure, heart rate and breathing, and whether those changes relate to the risk of sudden unexpected death in epilepsy (SUDEP). The study enrolls adults aged 18 to 90 with epilepsy who can …

This study uses a noninvasive brain stimulation technique called TMS, combined with brain scans, to understand working memory problems in people with early psychosis. Twenty participants will receive both active and placebo TMS to see how it affects brain activity and memory perf…

Researchers at Chungnam National University Hospital are studying blood and cerebrospinal fluid from adults who had an out-of-hospital cardiac arrest and received post-resuscitation care. The goal is to map molecular changes over time and see how they relate to the severity of br…

Researchers in Finland are surveying about 2,000 adults who were treated for a stroke between 2020 and 2022 in two regions. The postal questionnaire asks about health, daily functioning, work and income, social inclusion, and experiences with social and health services. The goal …

This observational study will enroll 100,000 people over age 45 to track early signs of Alzheimer's and Parkinson's using smartphone-based tests, genetic data, and brain scans. Researchers aim to develop better ways to identify who is at risk before symptoms worsen. Participants …

This study looks at how common strokes and silent brain injuries are in young adults (ages 16-25) with sickle cell anemia, especially in Nigeria where the disease is widespread. Researchers will use brain scans and blood tests to check for damage and identify risk factors like hi…

Researchers are collecting blood and skin samples from people with ALS, people with MS, and healthy volunteers. They turn skin cells into stem cells and grow them into 3D organoids that mimic the brain and spinal cord. The goal is to see whether secretions from human amniotic mes…

This completed study tested different messages to see which ones make adults more willing to get the HPV vaccine, which prevents certain cancers. Over 5,300 adults aged 18-45 were randomly assigned to read one of five theory-based messages or a control message. The goal was to fi…

This study tracks 750 teens aged 13-18 with mild concussions to see if changes in their saliva can predict how long symptoms last. Researchers will check for persistent symptoms 30 days after injury. The goal is to find biological markers that help doctors personalize recovery pl…

This study enrolls 400 adolescents and young adults (ages 18-39) recently diagnosed with various cancers. Participants are randomly assigned to either choose which health-related questions they answer or receive a fixed set of questions. The goal is to see if giving patients a ch…

This study looks at whether the Parkinson's drug Levodopa-Benserazide affects gum health and inflammation. Researchers will measure gum health and saliva markers in 136 people, including Parkinson's patients with and without gum disease, and healthy controls. The goal is to under…

This study looks at how often nurses should check on people in the ICU after they have had a brain aneurysm treated. The goal is to see if checking every hour versus every two hours affects how well patients sleep. Thirty adults who had a planned aneurysm coiling will take part, …

This study follows over 1,000 adults who had their first stroke to see how many develop spasticity—a condition where muscles become stiff or rigid—within the first year. Researchers will monitor participants and create a best-practice guide for doctors to spot and treat this comm…

This study is creating a statewide collection of blood samples and medical information from people with various brain blood vessel diseases, such as stroke and dementia. The goal is to build a resource that scientists can use in future research to better understand and potentiall…

This study looks at whether tiny RNA particles called exosomal microRNAs in the blood can act as a 'stroke clock' for people with a severe type of stroke caused by a blocked large artery in the front of the brain. Researchers will compare blood samples from stroke patients to hea…

This study looks at how vagus nerve stimulation (VNS) affects the nervous system, heart, immune system, and metabolism in people who already have a VNS device for epilepsy or depression. Researchers will measure things like nerve activity, blood pressure, and heart rate during di…

Researchers are studying the natural fidgety movements of infants to see if these movements can help predict cerebral palsy and other developmental issues. They will follow 350 babies, including healthy full-term infants and those at higher risk due to medical conditions, trackin…

This study follows 30 people with Parkinson's disease who are scheduled to receive deep brain stimulation (DBS). Researchers will test whether brain scans, thinking tests, and other measures can predict who might experience cognitive decline after surgery. Participants complete t…

This study asks whether exercise can improve how the brain produces and uses energy in people with Parkinson's disease. Researchers will scan participants' brains before and after a six-month program of supervised aerobic cycling, comparing them to a group doing stretching or yog…

Researchers at Mayo Clinic are reviewing records from 1,500 women who had an epidural for labor pain and then needed a cesarean delivery. They are comparing three epidural placement techniques: traditional epidural, dural puncture epidural (DPE), and combined spinal-epidural (CSE…

Researchers at Baylor College of Medicine are studying how brain activity and visible behaviors, like head movements, facial expressions, and voice tone, change during tasks that trigger OCD symptoms. Adults with OCD and healthy volunteers will complete tasks that provoke distres…

This study follows 120 stroke survivors for six months, using brain scans and movement tests to understand why some people develop arm stiffness and weakness. Researchers hope to find early signs that predict recovery, which could guide future rehabilitation. Participants must ha…

This study tests whether artificial intelligence can accurately predict how patients recover after an ischemic stroke. Researchers will enroll 1000 adults from three European hospitals and use standard hospital data plus remote monitoring via a mobile app to train AI models. The …

Researchers are investigating whether brain connectivity and blood markers differ between adolescents with ADHD and healthy teens. The study includes 40 teens with ADHD and 40 matched controls, aged 10 to 18. Participants undergo brain imaging, blood tests, and assessments of exe…

Researchers at the University of Pittsburgh are testing whether brief exposure to blue light, compared with red light, can stabilize emotional brain function in adolescents and young adults with depressive symptoms. Participants undergo brain scans while viewing light, complete a…

This study looks at over 3,400 newborns who are not vigorous at birth (between 35 and 42 weeks). Doctors want to see if milking the umbilical cord (pushing blood into the baby) before clamping it leads to fewer cases of brain injury or death compared to clamping the cord right aw…

This study aims to find out how many people in Spain have been diagnosed with narcolepsy type 1 or type 2, and how many new cases are diagnosed each year. Researchers will review medical records from hospitals across Spain to count patients and understand patterns. No treatment o…

This trial tests a home-based intervention called Khanya-Ekhaya, delivered by community health workers, to support the mental health of people living with HIV in South Africa. The intervention combines counseling techniques like motivational interviewing and problem-solving thera…

This study tests whether wearable biosensors can accurately track symptoms like heart rate, breathing, sleep, and movement in people with Rett syndrome. Up to 30 participants will use the devices at home for 9 weeks and also undergo one overnight sleep study in the clinic. The go…

This study compares a new selegiline skin patch to an existing one (EMSAM®) to see how well the skin tolerates it. Researchers will apply both patches to 230 healthy adults and check for irritation or allergic reactions. The goal is to ensure the new patch is safe for the skin be…

This observational study follows about 2,400 people with relapsing-remitting multiple sclerosis (MS) across Germany for up to six years. It asks whether loss of volume in the thalamus—a deep brain region—tracks with worsening disability, measured by the EDSS scale. Using standard…

This study investigates whether biological markers can predict how well people with depression or bipolar disorder respond to an online cognitive behavioural therapy program called the Wellbeing Course. Researchers will enroll 200 adults who previously participated in a CAN-BIND …

This study is testing whether a wearable ECG patch, combined with AI analysis, can help doctors identify a wide range of heart conditions and risks from a single recording. The Cor360 system looks at many aspects of heart health at once, such as heart failure, rhythm problems, an…

This study follows 5,000 people who recently had an ischemic stroke or a high-risk transient ischemic attack (TIA, often called a mini-stroke). The goal is to see how well standard post-stroke care works in the real world and to track patients' health and quality of life for up t…

This study looks at children who had hypoxic-ischemic encephalopathy (HIE) at birth, a condition caused by lack of oxygen to the brain. Researchers want to see if combining MRI scans taken shortly after birth with scans taken at school age can better predict cognitive outcomes li…

This study follows 500 adults under 45 who have narrowing of a major brain artery, a condition that can raise stroke risk. Researchers will track participants over time to see how the narrowing progresses and who goes on to have a stroke. The goal is to better understand the natu…

This observational study aims to measure how many people in Portugal have Dravet syndrome (DS) or Lennox-Gastaut syndrome (LGS), two rare and severe forms of epilepsy. Researchers will review existing medical records from about three public hospitals to estimate the percentage of…

This study follows about 2,200 mothers and their children in Cox's Bazar, Bangladesh, including Rohingya refugees and local families. Researchers want to understand how growing up in conflict and displacement affects child development and mental health. They are also looking at w…

This study investigates whether people with neurodegenerative diseases—like Alzheimer's, Parkinson's, or ALS—show changes in behavior, social circumstances, or health before and after their diagnosis. Researchers will compare the records of over 61,000 patients with those of matc…

This study is looking at why some people develop persistent pain after breast cancer surgery while others do not. Researchers will follow 220 adults undergoing breast cancer surgery, using questionnaires and a pain sensitivity test to identify risk factors. The goal is to find re…

This study explores why some people with cerebral palsy respond well to gait training while others do not. Researchers will track brain activity and walking ability weekly during an 8-week physical therapy program in 20 participants. The goal is to identify brain patterns that pr…

This pilot study explores whether targeted visual attention training can improve cognitive processing in older veterans, particularly those with a history of mild traumatic brain injury (mTBI). Researchers will use EEG to measure brain wave activity during attention tasks, compar…

This study explores whether a brief, moderate-intensity walk can alter brain function and blood flow in people with multiple sclerosis. Participants will undergo MRI scans before and after either treadmill or overground walking at a brisk pace. The goal is to see if even a single…

This trial tests whether a six-session financial literacy and gender-equality program for married couples in rural India can change how women and men think about reproductive decision-making for younger generations. Researchers ask participants who should have the main say in whe…

This study tests whether a new scoring system, called PRO-ICH, can accurately predict how well people will recover after a spontaneous brain hemorrhage. Researchers will also check if adding certain blood markers improves the score's accuracy. The goal is to give doctors a reliab…

This study investigates whether a combination of brain MRI scans, sleep recordings, and cognitive tests can track early brain changes in people with idiopathic REM sleep behavior disorder (iRBD), a condition that often precedes Parkinson's disease. Researchers will follow 50 peop…

This study follows about 400 adults with liver cirrhosis admitted to internal medicine wards across Italy. Researchers will track how doctors manage hepatic encephalopathy—a brain complication of liver disease—during hospitalization and after discharge. The goal is to identify pr…

This study follows 375 children with epilepsy to find early clues—from brain wave patterns and clinical features—that may predict which cases become resistant to standard medications. Researchers will use statistical models and machine learning to build a risk profile. The goal i…

This study follows children aged 6 to 21 who have a CNKSR2 gene mutation, which can cause epilepsy, language difficulties, and intellectual disability. Researchers will use brain scans, EEGs, and developmental tests to track how the condition changes over time. The goal is to cre…

This study looks at how Friedreich's ataxia, a genetic nerve disease, affects thinking skills like memory and problem-solving. Researchers will compare cognitive test results between people with the condition and healthy volunteers, and see if these results relate to the number o…

This study explores new ways to improve patient education and care for adults who visit the emergency department with a mild traumatic brain injury or concussion. Researchers are testing different strategies to help clinicians provide clearer discharge instructions and follow-up …

This study explores whether complementary therapies like forest therapy (guided time in nature), phytotherapy (herbal treatments), and hirudotherapy (medicinal leeches) can improve physical and mental health in people with reduced work capacity or special needs. Participants are …

This observational study looks at how inserting a central venous catheter into the neck affects pressure inside the skull in patients with acute brain injury. Researchers will monitor brain pressure, blood flow, and oxygen levels during and after the procedure in about 120 ICU pa…

This study investigates how people physically interact with each other during tasks like collaboration, competition, and cooperation. The goal is to design robot controllers that mimic these human behaviors, which could then be used in devices like exoskeletons to improve motor l…

This study follows 300 people with multiple sclerosis to see whether advanced MRI scans, eye tests, and blood markers can better predict when disability will worsen. Current tools are not accurate enough to guide early treatment for each individual. The researchers will compare t…

This observational study follows thousands of people with multiple sclerosis (MS) over many years to identify factors that predict how the disease will progress. Researchers collect detailed clinical data, MRI scans, and quality-of-life questionnaires from participants treated at…

This study follows children and adolescents who experienced trauma to see how many still have PTSD or Complex PTSD two years later. Researchers will also look at factors like symptom severity, resilience, sleep, and anxiety that may influence recovery. The goal is to better under…

This study uses a new, child-friendly brain imaging technique called OPM-MEG to understand how immune-related brain diseases (like autoimmune encephalitis and multiple sclerosis) and other brain conditions affect children aged 2 to 25. Standard scans often miss problems with memo…

This observational study follows people with early Parkinson's disease, those at genetic risk, and healthy volunteers over time. Researchers collect clinical exams, brain scans, and biological samples (blood, spinal fluid, skin, stool) to identify markers that predict how the dis…

This study follows 250 people who had a type of stroke called intracerebral hemorrhage (ICH) to understand why some experience progressive cognitive decline. Participants undergo advanced brain scans and tests of thinking and movement at 12–24 months after their stroke, with foll…

This trial investigates whether measuring high-sensitive troponin, a protein released during heart injury, can predict heart complications in people undergoing surgery to open a narrowed carotid artery. About 527 participants will have their troponin levels checked before and aft…

This study was designed to look back at the health of people with Cushing's disease in Western France between 1990 and 2015. The goal was to find out how many patients went into remission and how many had their disease come back after their first surgery. However, the study was w…

This study aimed to see if Alzheimer's disease affects the nerves in the gut, similar to what happens in Parkinson's disease. Researchers planned to take extra colon biopsies during routine colonoscopies from people with Alzheimer's, Parkinson's, and healthy individuals to compar…

This study tests whether a newer, less invasive heart-lung machine (MiECC) reduces brain swelling and stroke risk compared to the standard machine used during open heart surgery. Researchers will measure optic nerve sheath diameter (a marker of brain pressure) and track strokes o…

This study aims to identify biomarkers—biological clues in the body—that can help distinguish between Parkinson's disease and similar conditions like progressive supranuclear palsy and multiple system atrophy. Researchers will follow people with early-stage parkinsonism and healt…

This study investigates how genetic, lifestyle, and biological factors relate to memory and thinking problems in people over 60 with Alzheimer's disease, Parkinson's disease, or mild cognitive impairment. Researchers will use brain scans, spinal fluid and blood tests, and data fr…

This study follows 600 mentally ill offenders in Italy and California over three years to compare two very different treatment systems. Italy uses community-based care, while California relies on long-term hospital stays. Researchers will track violence, recovery, and functioning…