Can a video-based therapy tame tough behaviors in kids with rare genetic disorders?

NCT ID NCT06139172

Ongoing Symptom relief Sponsor: Rush University Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 14, 2026 · Updated 3 times

Summary

This study tests a virtual behavioral therapy (Functional Behavioral Training) for children aged 2-12 with genetic syndromes like Fragile X, Angelman, or Rett syndrome who have challenging behaviors. The therapy teaches parents how to identify what triggers problem behaviors and replace them with positive communication. Over 3-6 months, researchers will track changes in overall functioning and specific problem behaviors through monthly virtual visits.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Functional Behavioral Training (FBT)
What this could lead to: If it works, this could provide a practical, home-based therapy to help children with certain genetic syndromes communicate better and have fewer behavior problems.
What could go wrong: This is a small, early-stage study with no control group, so results may not apply broadly. The therapy requires consistent caregiver involvement, which may be challenging for some families.

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Conditions

The condition(s) this trial relates to.

Angelman syndrome Cowden disease Cowden syndrome 1 creatine transporter deficiency fragile X syndrome partial deletion of the long arm of chromosome 15 Phelan-McDermid syndrome Rett syndrome tuberous sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANGELMAN SYNDROME CHROMOSOME 15Q, PARTIAL DELETION CREATINE DEFICIENCY, X-LINKED FRAGILE X SYNDROME HAMARTOMA SYNDROME, MULTIPLE RETT SYNDROME TELOMERIC 22Q13 MONOSOMY SYNDROME TUBEROUS SCLEROSIS

Contacts and locations

Locations

Autism Assessment Research Treatment and Services (AARTS) Center at Rush University Medical Center

Chicago, Illinois, 60612, United States

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