Supercharged immune cells injected into brain to fight tumors
NCT ID NCT02442297
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This early-phase trial tests a new approach for people with HER2-positive brain tumors that have come back or not responded to standard treatment. Researchers take the patient's own T cells, attach a special antibody (anti-HER2) to them, and inject these 'CAR T cells' directly into the brain. The goal is to find a safe dose and see if this can help fight the cancer.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
HER2-specific CAR T cells
What this could lead to
If this works, it could point toward a new way to treat hard-to-cure brain tumors by using the patient's own immune cells to attack cancer.
What could go wrong
This is a very early, small phase 1 trial with only 10 participants, focused on safety and dosing. The CAR T cells may not last long in the body, and there is no guarantee they will shrink tumors or improve survival.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Houston Methodist Hospital
Houston, Texas, 77030, United States
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Texas Children's Hospital
Houston, Texas, 77030, United States