New hope for Hard-to-Treat seizures: phase 3 trial launches

NCT ID NCT06719141

First seen Jun 27, 2026 · Last updated Jul 17, 2026 · Updated 1 time

Summary

This study tests an experimental drug called LP352 to see if it can safely reduce seizures in children and adults with developmental and epileptic encephalopathies (DEE), a group of severe epilepsy syndromes. About 320 participants will receive either LP352 or a placebo, and researchers will track changes in seizure frequency over several months. The goal is to find a better treatment option for people whose seizures are not controlled by current medications.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • AP-HM- Hôpital de La Timone

    Marseille, 13386, France

  • AP-HP - Hôpital universitaire Robert-Debré

    Paris, 75019, France

  • Ann and Robert H Lurie Childrens Hospital of Chicago - PIN

    Chicago, Illinois, 60611, United States

  • Arkansas Children's Hospital - PIN

    Little Rock, Arkansas, 72202, United States

  • Austin Hospital

    Heidelberg, Victoria, 3084, Australia

  • Azienda Ospedaliera Universitaria Integrata Di Verona

    Verona, Veneto, 37126, Italy

  • Azienda Ospedaliero Universitaria A Meyer (Duplicate)

    Florence, Tuscany, 50139, Italy

  • Beijing Children's Hospital, Capital Medical University - PIN

    Beijing, 100045, China

  • CHU de Rennes - Hôpital Pontchaillou

    Rennes, 35203, France

  • CHU de Strasbourg - Hôpital de Hautepierre

    Strasbourg, 67098, France

  • Centre Hospitalier Universitaire de Toulouse

    Toulouse, 31330, France

  • Child Neurology Consultants of Austin - 6811 Austin Center Blvd

    Austin, Texas, 78757, United States

  • Children's Clinical University Hospital

    Riga, Rīgas Apriņķis, LV-1004, Latvia

  • Children's Healthcare of Atlanta - Center for Advanced Pediatrics - PIN

    Atlanta, Georgia, 30329, United States

  • Children's Hospital Colorado.

    Aurora, Colorado, 80045-7106, United States

  • Children's Hospital Los Angeles - PIN

    Los Angeles, California, 90027-6062, United States

  • Children's Hospital at Westmead

    Westmead, New South Wales, 2145, Australia

  • Children's Hospital of Fudan University

    Shanghai, Shanghai Municipality, 201102, China

  • Children's National Medical Center

    Washington D.C., District of Columbia, 20010-2916, United States

  • Children's and Women's Health Centre of British Columbia-4480 Oak St

    Vancouver, British Columbia, V6H 3V4, Canada

  • Clinic for Neurology and Psychiatry for Children and Youth

    Belgrade, 11000, Serbia

  • Consultants In Epilepsy and Neurology PLLC

    Boise, Idaho, 83702-5029, United States

  • Cook Children's Jane and John Justin Neurosciences Center - PIN

    Fort Worth, Texas, 76104-2710, United States

  • David Geffen School of Medicine at UCLA

    Los Angeles, California, 90095-3075, United States

  • Dokkyo Medical University Hospital

    Mibu-Machi, 321-0293, Japan

  • Epilepsie-Zentrum Bodensee

    Ravensburg, 88214, Germany

  • Epilepsiezentrum Kleinwachau gemeinnützige Gmbh

    Radeberg, Saxony, 01454, Germany

  • Fondazione IRCCS Istituto Neurologico Carlo Besta

    Milan, Lombardy, 20133, Italy

  • Fondazione Istituto Neurologico Nazionale Casimiro Mondino IRCCS

    Pavia, Lombardy, 27100, Italy

  • Fondazione Policlinico Universitario A Gemelli - Rome - PPDS

    Rome, Lazio, 00168, Italy

  • Fukuoka Children's Hospital

    Fukuoka, Fukuoka, 813-0017, Japan

  • Fundacao Faculdade Regional de Medicina de Sao Jose Do Rio Preto Hospital de Base - PPDS

    São José do Rio Preto, São Paulo, 15090-000, Brazil

  • Gesellschaft für Epilepsieforschung e.V.

    Bielefeld, 33617, Germany

  • Great Ormond Street Hospital - PPDS

    London, WC1N 3JH, United Kingdom

  • Hokkaido University Hospital

    Sapporo, Hokkaidô, 060-8648, Japan

  • Hospices Civils de Lyon - Hôpital Pierre Wertheimer

    Bron, 69500, France

  • Hospital Das Clinicas da Faculdade de Medicina de Ribeirão Preto - USP - PPDS

    Ribeirão Preto, São Paulo, 14051-140, Brazil

  • Hospital For Sick Children

    Toronto, Ontario, M5G 1X8, Canada

  • Hospital Infantil Universitario Niño Jesus - PIN

    Madrid, 28009, Spain

  • Hospital Moinhos de Vento

    Porto Alegre, Rio Grande do Sul, 90035-001, Brazil

  • Hospital Regional Universitario de Malaga - Hospital General

    Málaga, Málaga, 29010, Spain

  • Hospital Ruber Internacional (Grupo Quironsalud)

    Madrid, 28034, Spain

  • Hospital Sant Joan de Deu - PIN

    Espluges de Llobregat, Barcelona, 08950, Spain

  • Hospital Universitari i Politecnic La Fe de Valencia

    Valencia, 46026, Spain

  • Hospital Universitario Vall d'Hebron - PPDS

    Barcelona, 08035, Spain

  • Hospital Universitario Vithas Madrid La Milagrosa

    Madrid, 28010, Spain

  • Hospital Universitario de Navarra

    Pamplona, Navarre, 31008, Spain

  • Hospital Vithas Malaga

    Málaga, 29016, Spain

  • Hospital das Clinicas - UNICAMP

    Campinas, São Paulo, 13083-888, Brazil

  • Hospital de La Santa Creu i Sant Pau

    Barcelona, 8041, Spain

  • Hôpital Necker - Enfants Malades

    Paris, 75015, France

  • Hôpital Roger Salengro

    Lille, Nord, 59000, France

  • IRCCS Ospedale Pediatrico Bambino Gesu

    Roma, 00165, Italy

  • IUHW Narita Hospital

    Narita, Chiba, 286-8520, Japan

  • Institute of Neurology and Neurosurgery at Saint Barnabas, LLC

    Livingston, New Jersey, 07039-5817, United States

  • Instituto Nacional de Pediatría

    Mexico City, 4530, Mexico

  • Instituto de Neurologia de Curitiba (INC)

    Curitiba, Paraná, 81210-310, Brazil

  • Instituto de Psiquiatria HC FMUSP

    São Paulo, 05403-010, Brazil

  • Instituto do Cerebro do Rio Grande do Sul - InsCer

    Porto Alegre, Rio Grande do Sul, 90610-000, Brazil

  • Istituto G Gaslini Ospedale Pediatrico IRCCS (Duplicate)

    Genova, 16147, Italy

  • Klinikum der Johann-Wolfgang Goethe-Universitat

    Frankfurt am Main, Hesse, 60596, Germany

  • Le Bonheur Childrens Outpatient Center - PIN

    Memphis, Tennessee, 38103-2816, United States

  • London Health Sciences Centre -800 Commissioners Rd E

    London, Ontario, N6A 5W9, Canada

  • Massachusetts General Hospital - 175 Cambridge St

    Boston, Massachusetts, 02114, United States

  • Mayo Clinic - PIN

    Rochester, Minnesota, 55905-0001, United States

  • Mid-Atlantic Epilepsy and Sleep Center

    Bethesda, Maryland, 20817-1844, United States

  • Mother and Child Health Care Institute of Serbia Dr Vukan Cupic

    Belgrade, 190133, Serbia

  • Multicare Health System - Mary Bridge Pediatrics

    Tacoma, Washington, 98405-4048, United States

  • NW FL Clinical Research Group, LLC

    Gulf Breeze, Florida, 32561-4458, United States

  • NYU Comprehensive Epilepsy Center - BRANY - PPDS

    New York, New York, 10016-4852, United States

  • National Center of Neurology and Psychiatry

    Kodaira-Shi, Tokyo, 187-8502, Japan

  • National Hospital Organization Nishi-Niigata Chuo National Hospital

    Niigata, Niigata, 950-2074, Japan

  • National Hospital Organization Shizuoka Institute of Epilepsy and Neurological Disorders

    Shizuoka, Shizuoka, 420-0953, Japan

  • Nicklaus Children's Hospital - PIN

    Miami, Florida, 33155-3009, United States

  • Noah's Ark Children's Hospital for Wales - PIN

    Cardiff, South Glamorgan, CF14 4XW, United Kingdom

  • Northeast Regional Epilepsy Group - Morristown - 310 Madison Ave

    Morristown, New Jersey, 07960, United States

  • Northwestern Memorial Hospital

    Chicago, Illinois, 60611-5975, United States

  • Okayama University Hospital

    Okayama, Okayama-ken, 700-8558, Japan

  • Oregon Health and Science University

    Portland, Oregon, 97239-3011, United States

  • Osaka City General Hospital

    Osaka-Shi Miyakojima-Ku, Osaka, 534-0021, Japan

  • Pediatric Epilepsy and Neurology Specialists

    Tampa, Florida, 33609-4190, United States

  • Peking University First Hospital - Daxing Campus

    Beijing, Beijing Municipality, 102627, China

  • Prince of Wales Hospital

    Randwick, New South Wales, 2031, Australia

  • Queen Elizabeth Hospital Birmingham

    Birmingham, B15 2GW, United Kingdom

  • Queen Elizabeth University Hospital - PPDS

    Glasgow, G51 4TF, United Kingdom

  • Queensland Children's Hospital

    South Brisbane, Queensland, 4101, Australia

  • Rare Disease Research, LLC - Atlanta - RDR - PIN

    Atlanta, Georgia, 30329, United States

  • Research Institute of Orlando LLC

    Orlando, Florida, 32806-5411, United States

  • Royal Brisbane & Women's Hospital

    Herston, Queensland, 4006, Australia

  • Royal Children's Hospital Melbourne

    Parkville, Victoria, 3052, Australia

  • Royal Victoria Infirmary

    Newcastle upon Tyne, Northamptonshire, NE1 4LP, United Kingdom

  • Saitama Prefectural Children's Medical Center

    Saitama-shi, Saitama, 330-8777, Japan

  • Shenzhen Children's Hospital

    Shenzhen, Guangdong, 518000, China

  • Southampton General Hospital

    Southampton, SO16 6YD, United Kingdom

  • Sydney Children's Hospital

    Randwick, New South Wales, 2031, Australia

  • The Alfred Hospital

    Melbourne, 3004, Australia

  • The Second Affiliated Hospital of Guangzhou Medical University

    Guangzhou, Guangdong, 510260, China

  • The Stanford Division of Child Neurology

    Palo Alto, California, 94304-1510, United States

  • The University of Texas Medical School at Houston

    Houston, Texas, 77030, United States

  • Toronto Western Hospital

    Toronto, Ontario, M5T 2S8, Canada

  • UCSF Children's Hospital

    San Francisco, California, 94143-2350, United States

  • ULS de Coimbra, EPE - Hospital Pediátrico de Coimbra

    Coimbra, 3000-602, Portugal

  • ULS de Santa Maria,EPE - Hospital de Santa Maria - PPDS

    Lisbon, 1649-035, Portugal

  • ULS de Santo António, EPE - Centro Materno Infantil Norte

    Porto, 4050-651, Portugal

  • UZ Antwerpen

    Edegem, Antwerp, 2650, Belgium

  • UZ Leuven - PPDS

    Leuven, 3000, Belgium

  • Universitair Medisch Centrum Utrecht - PPDS

    Utrecht, 3584 CX, Netherlands

  • University Clinical Center Kragujevac

    Kragujevac, 34000, Serbia

  • University Clinical Center of Serbia - Dr Subotica 6 - PPDS

    Belgrade, Belgrade, 11000, Serbia

  • University College London Hospitals (UCLH) - PPDS

    London, NW1 2PG, United Kingdom

  • University of Iowa Hospitals & Clinics - (CRS)

    Iowa City, Iowa, 52242-1009, United States

  • University of Miami - 1120 NW 14th St

    Miami, Florida, 33136-2107, United States

  • University of South Florida - 2 Tampa General Circle

    Tampa, Florida, 33606, United States

  • Universitätsklinikum Bonn

    Bonn, North Rhine-Westphalia, 53127, Germany

  • Universitätsklinikum Schleswig-Holstein - Campus Kiel

    Kiel, 24105, Germany

  • Wuhan Children's Hospital

    Wuhan, Hubei, 430010, China

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