New hope for Hard-to-Treat seizures: phase 3 trial launches
NCT ID NCT06719141
First seen Jun 27, 2026 · Last updated Jul 17, 2026 · Updated 1 time
Summary
This study tests an experimental drug called LP352 to see if it can safely reduce seizures in children and adults with developmental and epileptic encephalopathies (DEE), a group of severe epilepsy syndromes. About 320 participants will receive either LP352 or a placebo, and researchers will track changes in seizure frequency over several months. The goal is to find a better treatment option for people whose seizures are not controlled by current medications.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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AP-HM- Hôpital de La Timone
Marseille, 13386, France
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AP-HP - Hôpital universitaire Robert-Debré
Paris, 75019, France
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Ann and Robert H Lurie Childrens Hospital of Chicago - PIN
Chicago, Illinois, 60611, United States
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Arkansas Children's Hospital - PIN
Little Rock, Arkansas, 72202, United States
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Austin Hospital
Heidelberg, Victoria, 3084, Australia
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Azienda Ospedaliera Universitaria Integrata Di Verona
Verona, Veneto, 37126, Italy
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Azienda Ospedaliero Universitaria A Meyer (Duplicate)
Florence, Tuscany, 50139, Italy
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Beijing Children's Hospital, Capital Medical University - PIN
Beijing, 100045, China
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CHU de Rennes - Hôpital Pontchaillou
Rennes, 35203, France
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CHU de Strasbourg - Hôpital de Hautepierre
Strasbourg, 67098, France
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Centre Hospitalier Universitaire de Toulouse
Toulouse, 31330, France
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Child Neurology Consultants of Austin - 6811 Austin Center Blvd
Austin, Texas, 78757, United States
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Children's Clinical University Hospital
Riga, Rīgas Apriņķis, LV-1004, Latvia
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Children's Healthcare of Atlanta - Center for Advanced Pediatrics - PIN
Atlanta, Georgia, 30329, United States
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Children's Hospital Colorado.
Aurora, Colorado, 80045-7106, United States
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Children's Hospital Los Angeles - PIN
Los Angeles, California, 90027-6062, United States
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Children's Hospital at Westmead
Westmead, New South Wales, 2145, Australia
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Children's Hospital of Fudan University
Shanghai, Shanghai Municipality, 201102, China
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Children's National Medical Center
Washington D.C., District of Columbia, 20010-2916, United States
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Children's and Women's Health Centre of British Columbia-4480 Oak St
Vancouver, British Columbia, V6H 3V4, Canada
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Clinic for Neurology and Psychiatry for Children and Youth
Belgrade, 11000, Serbia
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Consultants In Epilepsy and Neurology PLLC
Boise, Idaho, 83702-5029, United States
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Cook Children's Jane and John Justin Neurosciences Center - PIN
Fort Worth, Texas, 76104-2710, United States
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David Geffen School of Medicine at UCLA
Los Angeles, California, 90095-3075, United States
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Dokkyo Medical University Hospital
Mibu-Machi, 321-0293, Japan
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Epilepsie-Zentrum Bodensee
Ravensburg, 88214, Germany
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Epilepsiezentrum Kleinwachau gemeinnützige Gmbh
Radeberg, Saxony, 01454, Germany
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Fondazione IRCCS Istituto Neurologico Carlo Besta
Milan, Lombardy, 20133, Italy
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Fondazione Istituto Neurologico Nazionale Casimiro Mondino IRCCS
Pavia, Lombardy, 27100, Italy
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Fondazione Policlinico Universitario A Gemelli - Rome - PPDS
Rome, Lazio, 00168, Italy
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Fukuoka Children's Hospital
Fukuoka, Fukuoka, 813-0017, Japan
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Fundacao Faculdade Regional de Medicina de Sao Jose Do Rio Preto Hospital de Base - PPDS
São José do Rio Preto, São Paulo, 15090-000, Brazil
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Gesellschaft für Epilepsieforschung e.V.
Bielefeld, 33617, Germany
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Great Ormond Street Hospital - PPDS
London, WC1N 3JH, United Kingdom
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Hokkaido University Hospital
Sapporo, Hokkaidô, 060-8648, Japan
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Hospices Civils de Lyon - Hôpital Pierre Wertheimer
Bron, 69500, France
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Hospital Das Clinicas da Faculdade de Medicina de Ribeirão Preto - USP - PPDS
Ribeirão Preto, São Paulo, 14051-140, Brazil
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Hospital For Sick Children
Toronto, Ontario, M5G 1X8, Canada
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Hospital Infantil Universitario Niño Jesus - PIN
Madrid, 28009, Spain
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Hospital Moinhos de Vento
Porto Alegre, Rio Grande do Sul, 90035-001, Brazil
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Hospital Regional Universitario de Malaga - Hospital General
Málaga, Málaga, 29010, Spain
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Hospital Ruber Internacional (Grupo Quironsalud)
Madrid, 28034, Spain
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Hospital Sant Joan de Deu - PIN
Espluges de Llobregat, Barcelona, 08950, Spain
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Hospital Universitari i Politecnic La Fe de Valencia
Valencia, 46026, Spain
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Hospital Universitario Vall d'Hebron - PPDS
Barcelona, 08035, Spain
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Hospital Universitario Vithas Madrid La Milagrosa
Madrid, 28010, Spain
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Hospital Universitario de Navarra
Pamplona, Navarre, 31008, Spain
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Hospital Vithas Malaga
Málaga, 29016, Spain
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Hospital das Clinicas - UNICAMP
Campinas, São Paulo, 13083-888, Brazil
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Hospital de La Santa Creu i Sant Pau
Barcelona, 8041, Spain
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Hôpital Necker - Enfants Malades
Paris, 75015, France
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Hôpital Roger Salengro
Lille, Nord, 59000, France
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IRCCS Ospedale Pediatrico Bambino Gesu
Roma, 00165, Italy
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IUHW Narita Hospital
Narita, Chiba, 286-8520, Japan
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Institute of Neurology and Neurosurgery at Saint Barnabas, LLC
Livingston, New Jersey, 07039-5817, United States
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Instituto Nacional de Pediatría
Mexico City, 4530, Mexico
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Instituto de Neurologia de Curitiba (INC)
Curitiba, Paraná, 81210-310, Brazil
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Instituto de Psiquiatria HC FMUSP
São Paulo, 05403-010, Brazil
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Instituto do Cerebro do Rio Grande do Sul - InsCer
Porto Alegre, Rio Grande do Sul, 90610-000, Brazil
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Istituto G Gaslini Ospedale Pediatrico IRCCS (Duplicate)
Genova, 16147, Italy
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Klinikum der Johann-Wolfgang Goethe-Universitat
Frankfurt am Main, Hesse, 60596, Germany
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Le Bonheur Childrens Outpatient Center - PIN
Memphis, Tennessee, 38103-2816, United States
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London Health Sciences Centre -800 Commissioners Rd E
London, Ontario, N6A 5W9, Canada
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Massachusetts General Hospital - 175 Cambridge St
Boston, Massachusetts, 02114, United States
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Mayo Clinic - PIN
Rochester, Minnesota, 55905-0001, United States
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Mid-Atlantic Epilepsy and Sleep Center
Bethesda, Maryland, 20817-1844, United States
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Mother and Child Health Care Institute of Serbia Dr Vukan Cupic
Belgrade, 190133, Serbia
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Multicare Health System - Mary Bridge Pediatrics
Tacoma, Washington, 98405-4048, United States
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NW FL Clinical Research Group, LLC
Gulf Breeze, Florida, 32561-4458, United States
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NYU Comprehensive Epilepsy Center - BRANY - PPDS
New York, New York, 10016-4852, United States
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National Center of Neurology and Psychiatry
Kodaira-Shi, Tokyo, 187-8502, Japan
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National Hospital Organization Nishi-Niigata Chuo National Hospital
Niigata, Niigata, 950-2074, Japan
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National Hospital Organization Shizuoka Institute of Epilepsy and Neurological Disorders
Shizuoka, Shizuoka, 420-0953, Japan
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Nicklaus Children's Hospital - PIN
Miami, Florida, 33155-3009, United States
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Noah's Ark Children's Hospital for Wales - PIN
Cardiff, South Glamorgan, CF14 4XW, United Kingdom
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Northeast Regional Epilepsy Group - Morristown - 310 Madison Ave
Morristown, New Jersey, 07960, United States
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Northwestern Memorial Hospital
Chicago, Illinois, 60611-5975, United States
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Okayama University Hospital
Okayama, Okayama-ken, 700-8558, Japan
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Oregon Health and Science University
Portland, Oregon, 97239-3011, United States
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Osaka City General Hospital
Osaka-Shi Miyakojima-Ku, Osaka, 534-0021, Japan
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Pediatric Epilepsy and Neurology Specialists
Tampa, Florida, 33609-4190, United States
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Peking University First Hospital - Daxing Campus
Beijing, Beijing Municipality, 102627, China
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Prince of Wales Hospital
Randwick, New South Wales, 2031, Australia
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Queen Elizabeth Hospital Birmingham
Birmingham, B15 2GW, United Kingdom
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Queen Elizabeth University Hospital - PPDS
Glasgow, G51 4TF, United Kingdom
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Queensland Children's Hospital
South Brisbane, Queensland, 4101, Australia
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Rare Disease Research, LLC - Atlanta - RDR - PIN
Atlanta, Georgia, 30329, United States
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Research Institute of Orlando LLC
Orlando, Florida, 32806-5411, United States
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Royal Brisbane & Women's Hospital
Herston, Queensland, 4006, Australia
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Royal Children's Hospital Melbourne
Parkville, Victoria, 3052, Australia
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Royal Victoria Infirmary
Newcastle upon Tyne, Northamptonshire, NE1 4LP, United Kingdom
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Saitama Prefectural Children's Medical Center
Saitama-shi, Saitama, 330-8777, Japan
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Shenzhen Children's Hospital
Shenzhen, Guangdong, 518000, China
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Southampton General Hospital
Southampton, SO16 6YD, United Kingdom
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Sydney Children's Hospital
Randwick, New South Wales, 2031, Australia
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The Alfred Hospital
Melbourne, 3004, Australia
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The Second Affiliated Hospital of Guangzhou Medical University
Guangzhou, Guangdong, 510260, China
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The Stanford Division of Child Neurology
Palo Alto, California, 94304-1510, United States
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The University of Texas Medical School at Houston
Houston, Texas, 77030, United States
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Toronto Western Hospital
Toronto, Ontario, M5T 2S8, Canada
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UCSF Children's Hospital
San Francisco, California, 94143-2350, United States
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ULS de Coimbra, EPE - Hospital Pediátrico de Coimbra
Coimbra, 3000-602, Portugal
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ULS de Santa Maria,EPE - Hospital de Santa Maria - PPDS
Lisbon, 1649-035, Portugal
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ULS de Santo António, EPE - Centro Materno Infantil Norte
Porto, 4050-651, Portugal
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UZ Antwerpen
Edegem, Antwerp, 2650, Belgium
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UZ Leuven - PPDS
Leuven, 3000, Belgium
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Universitair Medisch Centrum Utrecht - PPDS
Utrecht, 3584 CX, Netherlands
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University Clinical Center Kragujevac
Kragujevac, 34000, Serbia
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University Clinical Center of Serbia - Dr Subotica 6 - PPDS
Belgrade, Belgrade, 11000, Serbia
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University College London Hospitals (UCLH) - PPDS
London, NW1 2PG, United Kingdom
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University of Iowa Hospitals & Clinics - (CRS)
Iowa City, Iowa, 52242-1009, United States
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University of Miami - 1120 NW 14th St
Miami, Florida, 33136-2107, United States
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University of South Florida - 2 Tampa General Circle
Tampa, Florida, 33606, United States
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Universitätsklinikum Bonn
Bonn, North Rhine-Westphalia, 53127, Germany
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Universitätsklinikum Schleswig-Holstein - Campus Kiel
Kiel, 24105, Germany
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Wuhan Children's Hospital
Wuhan, Hubei, 430010, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- New DNA reader aims to solve mystery of childhood epilepsy cases
- New drug LP352 aims to control seizures in severe epilepsy over the long term
- New epilepsy drug shows promise in long-term safety trial
- New hope for kids with rare epilepsy: drug trial targets seizure control
- Could a urea cycle drug help kids with rare epilepsy?
- Gene therapy trial for rare childhood epilepsy halted after just one patient