New drug LP352 aims to control seizures in severe epilepsy over the long term

NCT ID NCT06908226

ENROLLING_BY_INVITATION Disease control Sponsor: Longboard Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Aug 13, 2026 · Updated 4 times

Summary

This phase 3 study is testing the long-term safety and effectiveness of LP352 (Bexicaserin) in 324 children and adults with developmental and epileptic encephalopathy (DEE), including Dravet and Lennox-Gastaut syndromes. Participants who completed earlier studies will receive LP352 orally or via feeding tube for about 14 months. The main goal is to track side effects, while also measuring changes in seizure frequency.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: LP352 (Bexicaserin)
What this could lead to: If successful, this could provide a long-term treatment option to reduce seizure frequency in people with developmental and epileptic encephalopathy.
What could go wrong: This is an open-label study without a placebo, so results may be less reliable. Side effects and lack of efficacy are possible, and the study only includes people who completed earlier trials.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

developmental and epileptic encephalopathy Dravet syndrome Epilepsies, Myoclonic epilepsy Lennox-Gastaut syndrome neurodevelopmental disorder visual epilepsy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEVELOPMENTAL AND EPILEPTIC ENCEPHALOPATHY

Contacts and locations

Locations

AP-HM- Hôpital de La Timone

Marseille, 13005, France
AP-HP - Hôpital universitaire Necker-Enfants malades

Paris, 75015, France
AP-HP - Hôpital universitaire Robert-Debré

Paris, 75019, France
Arkansas Children's Hospital - Cardiology Clinic

Little Rock, Arkansas, 72202-3500, United States
Austin Hospital

Heidelberg, Victoria, 3084, Australia
Azienda Ospedaliera Universitaria Integrata Verona - Centro Fibrosi Cistica di Verona (CFC Verona)

Verona, 37126, Italy
Azienda Ospedaliero Universitaria A Meyer (Duplicate)

Florence, Tuscany, 50139, Italy
Beijing Children's Hospital, Capital Medical University - PIN

Beijing, Beijing Municipality, 100045, China
CHU de Strasbourg - Hôpital de Hautepierre

Strasbourg, Ain, 67200, France
CHU de Toulouse-Hôpital Pierre-Paul Riquet-Site de Purpan

Toulouse, 31059, France
Centre Hospitalier Universitaire de Lyon, Hopital Pierre Wertheimer

Bron, 69500, France
Child Neurology Consultants of Austin - 6811 Austin Center Blvd

Austin, Texas, 78731-3157, United States
Children's Clinical University Hospital

Riga, LV-1004, Latvia
Children's Hospital at Westmead

Westmead, New South Wales, 2145, Australia
Children's Hospital of Fudan University

Shanghai, Shanghai Municipality, 201102, China
Childrens Hospital Colorado - PIN

Aurora, Colorado, 80045-7106, United States
Consultants In Epilepsy and Neurology PLLC

Boise, Idaho, 83702-5029, United States
David Geffen School of Medicine at UCLA

Los Angeles, California, 90095, United States
Dokkyo Medical University Hospital

Mibu-Machi, Tochigi, 321-0293, Japan
Fondazione IRCCS Istituto Neurologico Carlo Besta

Milan, Lombardy, 20133, Italy
Fondazione Mondino - Istituto Neurologico Nazionale a Carattere Scientifico IRCCS

Pavia, 27100, Italy
Fondazione Policlinico Universitario A Gemelli - Rome - PPDS

Roma, 00168, Italy
Gesellschaft für Epilepsieforschung e.V.

Bielefeld, 33617, Germany
Great Ormond Street Hospital for Children NHS Foundation Trust

London, WC1N 3JH, United Kingdom
Hospital Infantil Universitario Niño Jesus - PIN

Madrid, 28009, Spain
Hospital Regional Universitario de Malaga - Hospital General

Málaga, Málaga, 29010, Spain
Hospital Ruber Internacional (Grupo Quironsalud)

Madrid, 28034, Spain
Hospital Sant Joan de Deu - PIN

Espluges de Llobregat, Barcelona, 08950, Spain
Hospital Universitario Vall d'Hebron - PPDS

Barcelona, 08035, Spain
Hospital Universitario Vithas Madrid La Milagrosa

Madrid, 28010, Spain
Hospital Universitario de Navarra

Pamplona, Navarre, 31008, Spain
Hospital de la Santa Creu I Sant Pau

Barcelona, 8041, Spain
Hôpital Roger Salengro

Lille, Nord, 59000, France
IRCCS Ospedale Pediatrico Bambino Gesu

Rome, Lazio, 00165, Italy
IUHW Narita Hospital

Narita, Chiba, 286-8520, Japan
Institute of Neurology and Neurosurgery at Saint Barnabas, LLC

Livingston, New Jersey, 07039-5817, United States
Instituto de Neurologia de Curitiba (INC)

Curitiba, Paraná, 81210-310, Brazil
Instituto de Psiquiatria HC FMUSP

São Paulo, 05403-010, Brazil
Istituto G Gaslini Ospedale Pediatrico IRCCS (Duplicate)

Genoa, Liguria, 16147, Italy
Massachusetts General Hospital (MGH)

Boston, Massachusetts, 02114, United States
Mayo Clinic Children's - PIN

Rochester, Minnesota, 55905-0001, United States
Mid-Atlantic Epilepsy and Sleep Center - Bethesda

Bethesda, Maryland, 20817-1844, United States
Mother and Child Health Care Institute of Serbia Dr Vukan Cupic

Belgrade, 11000, Serbia
NHS Greater Glasgow and Clyde Glasgow Clinical Research Facility-Queen Elizabeth University Hospi...

Glasgow, Lancashire, G51 4TF, United Kingdom
NW FL Clinical Research Group, LLC

Gulf Breeze, Florida, 32561-4495, United States
NYU Langone Health-NYU Comprehensive Epilepsy Center

New York, New York, 10016-4852, United States
National Center Hospital, National Center of Neurology and Psychiatry

Kodaira-shi, Tokyo, 187-8551, Japan
National Hospital Organization Nishi-Niigata Chuo National Hospital

Niigata, Niigata, 950-2074, Japan
National Hospital Organization Shizuoka Institute of Epilepsy and Neurological Disorders

Shizuoka, Shizuoka, 420-0953, Japan
Noah's Ark Children's Hospital for Wales - PIN

Cardiff, South Glamorgan, CF14 4XW, United Kingdom
Northeast Regional Epilepsy Group - Morristown - 310 Madison Ave

Morristown, New Jersey, 07960, United States
Okayama University Hospital

Okayama, Okayama-ken, 700-8558, Japan
Oregon Health & Science University - Blood Brain Barrier and Neuro-Oncology Program

Portland, Oregon, 97239-3098, United States
Osaka City General Hospital

Osaka, Osaka, 534-0021, Japan
Pediatric Epilepsy and Neurology Specialists

Tampa, Florida, 33609-4190, United States
Peking University First Hospital - Daxing Campus

Beijing, Beijing Municipality, 102627, China
Queensland Children's Hospital

South Brisbane, Queensland, 4101, Australia
Research Institute of Orlando LLC

Orlando, Florida, 32806, United States
Royal Brisbane & Women's Hospital

Herston, Queensland, 4006, Australia
Saitama Prefectural Children's Medical Center

Saitama-shi, Saitama, 330-8777, Japan
Sydney Children's Hospital - Randwick

Randwick, New South Wales, 2031, Australia
The Newcastle upon Tyne Hospitals NHS Foundation Trust - Royal Victoria Infirmary (RVI)

Newcastle upon Tyne, North East, NE1 4LP, United Kingdom
The Royal Children's Hospital (RCH) Melbourne

Parkville, Victoria, 3052, Australia
The Second Affiliated Hospital of Guangzhou Medical University

Guangzhou, Guangdong, 510260, China
The Stanford Division of Child Neurology

Palo Alto, California, 94304-1510, United States
The University of Texas Medical School at Houston - UT Gastroenterology

Houston, Texas, 77030-1517, United States
UCSF Benioff Children's Hospitals - San Francisco

San Francisco, California, 94158, United States
ULS de Coimbra, EPE - Hospital Pediátrico de Coimbra

Coimbra, 3000-602, Portugal
ULS de Santa Maria,EPE - Hospital de Santa Maria - PPDS

Lisbon, Lisbon District, 1649-035, Portugal
ULS de Santo António, EPE - Centro Materno Infantil Norte

Porto Covo, Porto District, 4050-651, Portugal
UZ Antwerpen

Edegem, Antwerp, 2650, Belgium
UZ Leuven - PPDS

Leuven, Vlaams Brabant, 3000, Belgium
Universitat de Valencia - Hospital Universitari i Politecnic La Fe de Valencia (Hospital La Fe Bu...

Valencia, 46026, Spain
University Clinical Center of Serbia - Dr Subotica 6 - PPDS

Belgrade, Belgrade, 11000, Serbia
University College London Hospitals (UCLH) - PPDS

London, United Kingdom
University of Belgrade-Faculty of Medicine - Clinic of Neurology and Psychiatry for Children and ...

Belgrade, Beograd, 112112, Serbia
University of Miami - 1120 NW 14th St

Miami, Florida, 33136-2107, United States
University of South Florida - 2 Tampa General Circle

Tampa, Florida, 33606, United States
Universitätsklinikum Bonn

Bonn, North Rhine-Westphalia, 53127, Germany
Universitätsklinikum Frankfurt

Frankfurt am Main, 60590, Germany
Wuhan Children's Hospital

Wuhan, Hubei, 430016, China

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