New hope for rare seizure disorders: Long-Term drug safety trial underway

NCT ID NCT06908226

First seen Jan 08, 2026 · Last updated May 15, 2026 · Updated 26 times

Summary

This study is testing the long-term safety and effectiveness of an investigational drug called LP352 for controlling seizures in children and adults with developmental and epileptic encephalopathy (DEE), a group of severe brain disorders. About 324 people who completed earlier studies will take LP352 for around 14 months. The goal is to see if the drug remains safe and helps reduce seizures over time.

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Contacts and locations

Locations

  • AP-HP - Hôpital universitaire Robert-Debré

    Paris, 75019, France

  • Arkansas Children's Hospital - PIN

    Little Rock, Arkansas, 72202-3500, United States

  • Austin Hospital

    Heidelberg, Victoria, 3084, Australia

  • Children's Clinical University Hospital

    Riga, LV-1004, Latvia

  • David Geffen School of Medicine at UCLA

    Los Angeles, California, 90095, United States

  • Hospital Ruber Internacional (Grupo Quironsalud)

    Madrid, 28034, Spain

  • Hospital Universitario Vithas Madrid La Milagrosa

    Madrid, 28010, Spain

  • Hospital de La Santa Creu i Sant Pau

    Barcelona, 8041, Spain

  • Institute of Neurology and Neurosurgery at Saint Barnabas, LLC

    Livingston, New Jersey, 07039-5817, United States

  • Mid-Atlantic Epilepsy and Sleep Center

    Bethesda, Maryland, 20817-1809, United States

  • Mother and Child Health Care Institute of Serbia Dr Vukan Cupic

    Belgrade, 11000, Serbia

  • NW FL Clinical Research Group, LLC

    Gulf Breeze, Florida, 32561-4458, United States

  • Northeast Regional Epilepsy Group - Morristown - 310 Madison Ave

    Morristown, New Jersey, 07960, United States

  • Pediatric Epilepsy and Neurology Specialists

    Tampa, Florida, 33609-4181, United States

  • Research Institute of Orlando LLC

    Orlando, Florida, 32806-5411, United States

  • The University of Texas Medical School at Houston

    Houston, Texas, 77030-3000, United States

Conditions

Explore the condition pages connected to this study.