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New epilepsy drug shows promise in long-term safety trial

NCT ID NCT05626634

Completed Disease control Sponsor: Longboard Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested the long-term safety of a drug called LP352 (bexicaserin) in 41 people aged 12 to 65 with severe epilepsy syndromes like Dravet or Lennox-Gastaut. Participants took the drug three times daily for up to 52 weeks. The main goal was to check for side effects, while also tracking seizure changes. Results will help decide if larger, more definitive studies are warranted.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
LP352 (bexicaserin)
What this could lead to
If successful, this could show that LP352 is safe enough to use long-term for controlling seizures in people with severe epilepsy syndromes.
What could go wrong
This is a small, early-phase study (41 people) focused on safety, not proof of effectiveness. Side effects or lack of seizure reduction could limit future use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

developmental and epileptic encephalopathy developmental and epileptic encephalopathy, 2 Dravet syndrome Epilepsies, Myoclonic epilepsy Lennox-Gastaut syndrome tuberous sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEVELOPMENTAL AND EPILEPTIC ENCEPHALOPATHY DRAVET SYNDROME LENNOX GASTAUT SYNDROME

Contacts and locations

Locations

  • Advent Health Orlando

    Orlando, Florida, 32803, United States

  • Alfred Health

    Melbourne, Victoria, 3004, Australia

  • Arkansas Children's Hospital

    Little Rock, Arkansas, 72202, United States

  • Austin Epilepsy Care Center

    Austin, Texas, 78758, United States

  • Austin Health

    Heidelberg, Victoria, 3084, Australia

  • Boston Children's Health Physicians LLP

    Hawthorne, New York, 10532, United States

  • Child Neurology Consultants of Austin

    Austin, Texas, 78757, United States

  • Hawaii Pacific Neuroscience

    Honolulu, Hawaii, 96817, United States

  • Mayo Clinic

    Rochester, Minnesota, 55905, United States

  • Mid-Atlantic Epilepsy and Sleep Center

    Bethesda, Maryland, 20817, United States

  • Northeast Regional Epilepsy Group

    Staten Island, New York, 10305, United States

  • Northwell Health

    New York, New York, 10075, United States

  • Northwest Florida Clinical Research Group

    Gulf Breeze, Florida, 32561, United States

  • Northwestern University Feinberg School of Medicine

    Chicago, Illinois, 60611, United States

  • OnSite Clinical Solutions LLC

    Charlotte, North Carolina, 98277, United States

  • Providence Neurological Specialties-East

    Portland, Oregon, 97213, United States

  • Queensland Children's Hospital

    South Brisbane, Queensland, 4101, Australia

  • Rancho Los Amigos National Rehabilitation Center (RLANRC)

    Downey, California, 90242, United States

  • Research Institute of Orlando

    Orlando, Florida, 32806, United States

  • Spectrum Health

    Grand Rapids, Michigan, 49503, United States

  • University Hospitals Cleveland Medical Center

    Cleveland, Ohio, 44106, United States

  • University of California San Francisco

    San Francisco, California, 94158, United States

  • University of Miami

    Miami, Florida, 33136, United States

  • University of South Florida

    Tampa, Florida, 33606, United States

  • University of Utah

    Salt Lake City, Utah, 84132, United States

  • University of Washington Valley Medical Center

    Renton, Washington, 98055, United States

  • Wake Forest University School of Medicine

    Winston-Salem, North Carolina, 27157, United States

  • Washington University School of Medicine

    St Louis, Missouri, 63110, United States

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