Which treatment tames LGS seizures better: surgery or more meds?

NCT ID NCT05374824

Recruiting now Disease control Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago Source: ClinicalTrials.gov ↗

First seen Aug 06, 2026 · Last updated Aug 07, 2026 · Updated 1 time

Summary

This study looks at two ways to treat Lennox-Gastaut syndrome (LGS), a severe form of childhood epilepsy: adding more anti-seizure medications or undergoing palliative surgery (like a vagus nerve stimulator or corpus callosotomy). Researchers will track thousands of children across multiple hospitals to see which approach reduces seizure-related emergency visits and hospitalizations, and whether it helps with development and daily functioning. The goal is to give families clearer guidance on choosing the best treatment for their child.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Palliative surgery (vagus nerve stimulation or corpus callosotomy) versus additional anti-seizure medications
What this could lead to: If this trial succeeds, it could help families and doctors choose the best treatment approach for children with Lennox-Gastaut syndrome, potentially reducing seizures and improving quality of life.
What could go wrong: This is an observational study, so it cannot prove cause and effect. Results may vary widely between individuals, and both treatments carry risks of side effects or complications.

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Conditions

The condition(s) this trial relates to.

epilepsy Lennox-Gastaut syndrome visual epilepsy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LENNOX GASTAUT SYNDROME

Contacts and locations

Locations

Ann & Robert H. Lurie Children's Hospital of Chicago
RECRUITING

Chicago, Illinois, 60611, United States
C.S. Mott Children's Hospital
RECRUITING

Ann Arbor, Michigan, 48109, United States
Nationwide Children's
RECRUITING

Columbus, Ohio, 43205, United States
St. Louis Children's Hospital
RECRUITING

St Louis, Missouri, 63110, United States

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