New drug shows promise for rare, severe childhood epilepsy
NCT ID NCT05066217
First seen Jun 27, 2026 · Last updated Jul 02, 2026 · Updated 1 time
Summary
This study tests whether clemizole HCl (EPX-100) can safely reduce seizures when added to current treatments for Lennox-Gastaut syndrome, a severe form of epilepsy. About 260 children and adults aged 2 to 55 will receive either the drug or a placebo. The main goal is to measure changes in seizure frequency over the treatment period.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
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Contact
Email: •••••@•••••
Locations
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AdventHealth Innovation Tower
RECRUITINGOrlando, Florida, 32804, United States
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Arkansas Children's Hospital
ACTIVE_NOT_RECRUITINGLittle Rock, Arkansas, 72202, United States
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Atrium Health STRIVE Research
ACTIVE_NOT_RECRUITINGCharlotte, North Carolina, 28207, United States
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Children's Hospital of Philadelphia
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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Children's Nebraska
ACTIVE_NOT_RECRUITINGOmaha, Nebraska, 68114, United States
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Clinical Neurosciences Center
RECRUITINGSalt Lake City, Utah, 84132, United States
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Duke University Medical Center
RECRUITINGDurham, North Carolina, 27705, United States
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Henry Ford Hospital
ACTIVE_NOT_RECRUITINGDetroit, Michigan, 48202, United States
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IRCCS Istituto Neurologico Mediterraneo Neuromed
RECRUITINGPozzilli, Molise, 86077, Italy
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Minnesota Epilepsy Group, P.A.
ACTIVE_NOT_RECRUITINGRoseville, Minnesota, 55102, United States
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NYU Comprehensive Epilepsy Center - BRANY - PPDS
RECRUITINGNew York, New York, 10016-4852, United States
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Nemours Children's Health
NOT_YET_RECRUITINGWilmington, Delaware, 19803, United States
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Neurology Center for Epilepsy and Seizures
RECRUITINGMarlboro, New Jersey, 07746, United States
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Neurosphera
RECRUITINGWarsaw, Masovian Voivodeship, 02-829, Poland
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Norton Children's Medical Center
ACTIVE_NOT_RECRUITINGLouisville, Kentucky, 40202, United States
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On-Site Clinical Solution
ACTIVE_NOT_RECRUITINGCharlotte, North Carolina, 28211, United States
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PPD Virtual-Science 37, Inc.
ACTIVE_NOT_RECRUITINGMorrisville, North Carolina, 27560, United States
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Pediatric Neurology and Epilepsy Specialists
ACTIVE_NOT_RECRUITINGWinter Park, Florida, 32789, United States
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Rare Disease Research
SUSPENDEDKissimmee, Florida, 34746, United States
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Re:Cognition Health
RECRUITINGChicago, Illinois, 60611, United States
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Tekton Research
RECRUITINGMarlboro, New Jersey, 07746, United States
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UC Irvine Medical Center
ACTIVE_NOT_RECRUITINGOrange, California, 92868, United States
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UCI Center for Innovative Health Therapies
RECRUITINGOrange, California, 92868, United States
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UTHealth Houston
ACTIVE_NOT_RECRUITINGHouston, Texas, 77030, United States
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University of Miami Miller School of Medicine
RECRUITINGMiami, Florida, 33136, United States
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Weill Cornell Medicine/New York Presbyterian Hospital
RECRUITINGNew York, New York, 10021, United States
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Other studies related to the condition(s) this trial covers.
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- New epilepsy drug shows promise in long-term safety trial