New drug shows promise for rare, severe childhood epilepsy
NCT ID NCT05066217
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether clemizole HCl (EPX-100) can safely reduce seizures when added to current treatments for Lennox-Gastaut syndrome, a severe form of epilepsy. About 260 children and adults aged 2 to 55 will receive either the drug or a placebo. The main goal is to measure changes in seizure frequency over the treatment period.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Arkansas Children's Hospital
ACTIVE_NOT_RECRUITINGLittle Rock, Arkansas, 72202, United States
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Atrium Health STRIVE Research
ACTIVE_NOT_RECRUITINGCharlotte, North Carolina, 28207, United States
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Children's Nebraska
ACTIVE_NOT_RECRUITINGOmaha, Nebraska, 68114, United States
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Duke University Medical Center
RECRUITINGDurham, North Carolina, 27705, United States
Contact Email: •••••@•••••
Contact
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Henry Ford Hospital
ACTIVE_NOT_RECRUITINGDetroit, Michigan, 48202, United States
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Minnesota Epilepsy Group, P.A.
ACTIVE_NOT_RECRUITINGRoseville, Minnesota, 55102, United States
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Nemours Children's Health
NOT_YET_RECRUITINGWilmington, Delaware, 19803, United States
Contact Email: •••••@•••••
Contact
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Neurology Center for Epilepsy and Seizures
RECRUITINGMarlboro, New Jersey, 07746, United States
Contact Phone: •••-•••-••••
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Norton Children's Medical Center
ACTIVE_NOT_RECRUITINGLouisville, Kentucky, 40202, United States
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On-Site Clinical Solution
ACTIVE_NOT_RECRUITINGCharlotte, North Carolina, 28211, United States
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PPD Virtual-Science 37, Inc.
ACTIVE_NOT_RECRUITINGMorrisville, North Carolina, 27560, United States
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Pediatric Neurology and Epilepsy Specialists
ACTIVE_NOT_RECRUITINGWinter Park, Florida, 32789, United States
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Rare Disease Research
SUSPENDEDKissimmee, Florida, 34746, United States
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Re:Cognition Health
RECRUITINGChicago, Illinois, 60611, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Tekton Research
RECRUITINGMarlboro, New Jersey, 07746, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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UC Irvine Medical Center
ACTIVE_NOT_RECRUITINGOrange, California, 92868, United States
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UCI Center for Innovative Health Therapies
RECRUITINGOrange, California, 92868, United States
Contact
Contact Phone: •••-•••-••••
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UTHealth Houston
ACTIVE_NOT_RECRUITINGHouston, Texas, 77030, United States
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University of Miami Miller School of Medicine
RECRUITINGMiami, Florida, 33136, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Weill Cornell Medicine/New York Presbyterian Hospital
RECRUITINGNew York, New York, 10021, United States
Contact Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••