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Experimental drug ION717 aims to slow fatal brain disease

NCT ID NCT06153966

Recruiting now Disease control Sponsor: Ionis Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 06, 2026 · Updated 2 times

Summary

This study tests a new drug called ION717 for people with early-stage prion disease, a rare and fatal brain condition. The drug is given via a spinal injection and aims to reduce harmful prion proteins. The trial will check safety, side effects, and how the drug moves through the body. About 76 participants with a caregiver are needed.

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Conditions

The condition(s) this trial relates to.

prion disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PRION DISEASE

Contacts and locations

Locations

  • Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta

    RECRUITING

    Milan, 20133, Italy

  • Hospital Clinic De Barcelona

    RECRUITING

    Barcelona, 08036, Spain

  • Hôpital Universitaire Pitié Salpêtrière

    RECRUITING

    Paris, 75013, France

  • Massachusetts General Hospital

    ACTIVE_NOT_RECRUITING

    Boston, Massachusetts, 02114, United States

  • McGill University Health Centre

    ACTIVE_NOT_RECRUITING

    Montreal, Quebec, H3A 2B4, Canada

  • Mihara Memorial Hospital

    ACTIVE_NOT_RECRUITING

    Gunma, Isesaki-shi, 372-0006, Japan

  • NYU Langone Health

    RECRUITING

    New York, New York, 10016, United States

  • National Center of Neurology and Psychiatry

    RECRUITING

    Tokyo, Kodaira-shi, 187-8551, Japan

  • Neuromuscular Center Yoshimizu Hospital

    RECRUITING

    Yamaguchi, Shimonoseki-shi, 751-0826, Japan

  • Royal Melbourne Hospital

    RECRUITING

    Parkville, 3050, Australia

  • Tel Aviv Sourasky Medical Center

    RECRUITING

    Tel Aviv, 6423906, Israel

  • University Hospitals Cleveland Medical Center

    ACTIVE_NOT_RECRUITING

    Cleveland, Ohio, 44106, United States

  • University Medical Center Göttingen

    RECRUITING

    Göttingen, 37075, Germany

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