Prion disease
MONDO:0005429A transmissible disease that is caused by a protein that is able to induce abnormal folding of normal cellular proteins, leading to characteristic spongiform brain changes, which are associated with neuronal loss without an inflammatory response. Such disorders have typically long incubation periods, but are then generally rapidly progressive and are uniformly fatal.
Also known as: spongiform encephalopathy
11 clinical trials for this condition and its sub-types.
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Broader categories
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Experimental drug ION717 aims to slow fatal brain disease
Disease control Recruiting nowThis study tests a new drug called ION717 for people with early-stage prion disease, a rare and fatal brain condition. The drug is given via a spinal injection and aims to reduce harmful prion proteins. The trial will check safety, side effects, and how the drug moves through the…
Phase: PHASE1, PHASE2 • Sponsor: Ionis Pharmaceuticals, Inc. • Aim: Disease control
Last updated Aug 07, 2026 00:00 UTC
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Could a single injection silence fatal brain disease?
Disease control Recruiting nowThis study tests an experimental drug called PrP-siRNA in 30 adults with symptomatic prion disease, a rare and fatal brain condition. The drug is given via a spinal injection and aims to reduce the harmful prion protein in the brain. The main goal is to check safety and find the …
Phase: PHASE1 • Sponsor: Broad Institute of MIT and Harvard • Aim: Disease control
Last updated Jun 27, 2026 13:02 UTC
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New study seeks to sharpen Alzheimer's diagnosis with simple tests
Diagnosis Recruiting nowThis study aims to find the best cutoff values for key Alzheimer's-related proteins in spinal fluid and blood to improve diagnostic accuracy. Researchers will compare results from Alzheimer's patients, those with mild memory problems, people with other dementias, and healthy olde…
Sponsor: Capital Medical University • Aim: Diagnosis
Last updated Jun 27, 2026 12:00 UTC
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Simple blood test could revolutionize Alzheimer's diagnosis
Diagnosis Recruiting nowThis study is testing a new blood test called the AD-seeds-detector that looks for specific protein clumps linked to Alzheimer's disease. Researchers will compare the test results from 1,500 people aged 55-75, including those with Alzheimer's, other dementias, and healthy individ…
Sponsor: Capital Medical University • Aim: Diagnosis
Last updated Jun 27, 2026 12:00 UTC
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Scientists hunt for clues to predict rare brain disease before symptoms strike
Knowledge-focused Recruiting nowThis study aims to find biological markers in spinal fluid and blood that could signal the start of prion disease before symptoms appear. Researchers will follow 150 people who carry a genetic mutation for prion disease, along with family members and healthy volunteers. Participa…
Sponsor: Massachusetts General Hospital • Aim: Knowledge-focused
Last updated Aug 15, 2026 00:00 UTC