Periventricular leukomalacia
MONDO:0015742Periventricular leukomalacia (PVL) is a brain injury disorder characterized by the death of the white matter of the brain due to softening of the brain tissue. It can affect fetuses or newborns, and premature babies are at the greatest risk of the disorder. PVL is caused by a lack of oxygen or blood flow to thearea around the ventricles of the brain, which results in the death of brain tissue. Although babies with PVL generally have no apparent signs or symptoms of the disorder at delivery, they are at risk for motor disorders, cerebral palsy, delayed mental development, coordination problems, and vision and hearing impairments. There is no cure for PVL. Treatment is generally supportive. Prognosis is dependent on the extent of damage to the ventricles.
Also known as: PVL
11 clinical trials for this condition and its sub-types.
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Cord blood hope: new infusion option for kids with brain damage
Disease control AVAILABLEThis program gives children with brain disorders like cerebral palsy or stroke access to umbilical cord blood infusions. The treatment uses donated cord blood cells to help repair brain damage. Kids up to age 26 with normal immune function may qualify. The goal is to improve symp…
Sponsor: Joanne Kurtzberg, MD • Aim: Disease control
Last updated Jun 27, 2026 08:13 UTC
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Simple baby exercises may boost brain development in preemies
Disease control Recruiting nowThis study tests whether early physiotherapy, taught to parents, can improve movement and development in babies at risk for problems like cerebral palsy. Fifty infants from the NICU will be randomly assigned to get either the special program or standard care. Researchers will mea…
Phase: NA • Sponsor: Kahramanmaras Sutcu Imam University • Aim: Disease control
Last updated Jun 27, 2026 07:52 UTC
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Smart baby gym could predict motor delays before they start
Diagnosis Recruiting nowThis study is testing a new way to detect motor delays in infants using a special play mat with sensors and a smart toy. Researchers will watch how babies move and interact with the toy, then use AI to spot early signs of disability. The goal is to create an easy, objective tool …
Sponsor: University of Pennsylvania • Aim: Diagnosis
Last updated Jun 27, 2026 07:51 UTC
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Infant brain recovery study seeks clues to heal stroke damage
Knowledge-focused Recruiting nowThis study follows 65 infants who had a stroke around birth, tracking their brain development and motor skills over two years. Researchers use MRI scans, brain stimulation, and movement tests to find markers of recovery. The goal is to understand how the brain heals, which could …
Sponsor: University of Wisconsin, Madison • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:09 UTC
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New study aims to catch hidden vision problems in infants early
Knowledge-focused Recruiting nowThis study follows 60 infants at high risk for Cerebral Visual Impairment (CVI), a brain-based vision problem often missed until later childhood. Researchers will collect data from clinical exams, brain scans, and vision tests up to 24 months of age. The goal is to create a model…
Sponsor: Brigham and Women's Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:03 UTC