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Mouth microbes linked to artery damage in new study

NCT ID NCT07824921

Knowledge-focused Sponsor: Semmelweis University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
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Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
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Ongoing
Running, but no longer taking on new participants.
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Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

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Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

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Status unknown
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First seen Sep 17, 2026 · Last updated Sep 18, 2026 · Updated 1 time

Summary

Researchers at Semmelweis University are studying whether bacteria that cause gum disease also show up in damaged blood vessels. They will compare samples from the mouth and from diseased artery sites in 100 people who need surgery for aortic aneurysm or carotid artery narrowing. The goal is to see if these oral bacteria move from the mouth into the vascular system, which could point to oral health as a way to help prevent vascular disease.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If gum-disease bacteria do reach damaged arteries, this could support simple dental care as a way to lower the risk of vascular disease.
What could go wrong
This observational study can only show a link, not cause and effect. The 100 participants may not represent everyone, and other factors could explain any shared bacteria.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2025

Expected to finish

May 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

patients attending the clinic

Ages

18 to 110 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * aorta aneurysm or carotid arteriosclerosis needing surgery Exclusion Criteria: * antibiotic intake in last three months

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Conditions

The condition(s) this trial relates to.

aortic aneurysm carotid artery disorder carotid stenosis periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aorta aneurysm Carotid arteriosclerosis

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Center of Heart and Vascular Surgery

    Budapest, 1088, Hungary

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