Thalamic disorder

This phase 3 trial tests a new long-acting version of the drug octreotide (Debio 4126) for people with acromegaly, a condition caused by too much growth hormone. The drug is given as a shot every 12 weeks, instead of the usual monthly injections. The study will compare it to a pl…

This early-stage trial tests whether personalized immune cells (T-cells) can safely treat young children with aggressive brain tumors. The T-cells are designed to attack unique markers found on each child's tumor. Up to 12 children under 5 with embryonal brain tumors or recurrent…

This study tests a new drug called Lu AG13909 in 18 adults with Cushing's disease, a rare condition where the body produces too much cortisol. The goal is to see if the drug can safely lower cortisol levels to normal. Participants will receive the drug through an IV or injection,…

This study tests whether adding the drug olutasidenib to standard chemotherapy (temozolomide) can help children and young adults with a specific type of brain cancer (IDH1-mutant high-grade glioma) live longer. About 60 participants will receive the combination as maintenance the…

This early-phase study tests whether adding chemotherapy directly into the spinal fluid (intrathecal topotecan) followed by maintenance pills is feasible for children under 6 with high-risk embryonal brain tumors. About 15 children will receive this treatment after standard high-…

This early-stage study tests an experimental pill called CRN04894 in 18 adults with Cushing's syndrome caused by too much ACTH hormone. The drug works by blocking the receptor that ACTH acts on, aiming to lower cortisol levels and control the disease. The main goals are to check …

This phase II trial is testing whether giving a lower dose of radiation after chemotherapy can effectively treat children and young adults with central nervous system germinomas, a type of brain tumor. The study will enroll 240 participants aged 3 to 29. After initial chemotherap…

This phase 2 trial tests a personalized approach for children and young adults with a rare brain tumor called non-germinomatous germ cell tumor (NGGCT). Patients first receive chemotherapy, and then the type and amount of radiation they get depends on how well the tumor responds.…

This early-phase trial is testing a combination of three treatments for children whose brain tumors have come back or not responded to standard care. The experimental drug SGT-53 delivers a normal TP53 gene to tumor cells, and is given alongside the immunotherapy Nivolumab and ra…

This study is testing proton radiation as a treatment for adults with benign or slow-growing brain tumors. Researchers want to see how well it controls tumor growth and how it affects quality of life and side effects. About 100 participants will receive proton radiation and be fo…

This early-phase study tests whether a new type of immunotherapy, called B7-H3 CAR T cells, can be safely given directly into the brain or spinal fluid of children and young adults with aggressive brain tumors like DIPG, DMG, or other recurrent central nervous system cancers. The…

This study tests whether a higher dose of the drug cabergoline, taken for about 6 months, can achieve lasting remission in women with small prolactinomas (non-cancerous pituitary tumors that cause excess prolactin). 70 premenopausal women will be randomly assigned to either the h…

This study tests a drug called pasireotide for people with prolactinomas (pituitary tumors) who cannot take standard dopamine agonist therapy due to side effects, resistance, or medical reasons. About 10 adults will receive pasireotide to see if it safely lowers prolactin levels …

This study tests a shorter course of high-dose proton radiation for people with non-cancerous brain tumors like meningiomas and schwannomas. The goal is to see if fewer treatments can still control tumor growth while reducing side effects and being more convenient. About 70 adult…

This study tests whether a modified Atkins diet (a type of ketogenic diet) can help children and young adults with brain tumors lose weight. The tumors often damage the hypothalamus, leading to severe obesity that doesn't respond to standard diets or exercise. Researchers will en…

This early-phase trial tests a new treatment for children and young adults with medulloblastoma or similar brain tumors that have come back or not responded to standard therapy. The treatment uses the patient's own immune cells, modified to recognize and attack tumor cells, deliv…

This early-stage study tests an oral drug called ONC206 in adults with brain tumors that have come back. The main goal is to find the safest dose and check for side effects. About 102 participants will take the drug once or several times a week.

This study compares two numbing medicines, prilocaine and lidocaine, given as a nerve block behind the nose during pituitary tumor surgery. The goal is to see which one better controls blood pressure swings and reduces the need for extra painkillers. About 54 adults aged 21-45 ha…

This study looks at how different doses of the drug cabergoline affect blood sugar control in people with prolactinoma, a type of pituitary tumor. Researchers will randomly assign 60 adults to different treatment strategies and measure their glucose levels after a sugar drink. Th…

This phase 3 trial compares proton beam therapy to standard photon radiotherapy in 156 adults with primary brain tumors. The goal is to see if proton therapy, which delivers less radiation to healthy brain tissue, improves functional survival—meaning living longer without tumor r…

This phase 2 trial tests seliciclib, an oral drug, in 13 adults with Cushing disease. The goal is to see if 4 weeks of treatment can lower high cortisol levels to normal or reduce them by at least half. Researchers will also monitor safety and check for changes in tumor size and …

This early-stage trial tests a fluorescent dye called panitumumab-IRDye800 that attaches to cancer cells. Before surgery, 30 adults with brain tumors will receive a single infusion of the dye. During their operation, a special camera will detect the dye's glow, helping surgeons d…

This study tests whether a special PET scan (FET PET/CT) can better locate small pituitary tumors that cause Cushing disease. About 50 adults with confirmed Cushing disease who are scheduled for pituitary surgery will receive the scan before their operation. The goal is to see if…

This study aims to improve how doctors diagnose Cushing's syndrome, a condition caused by too much cortisol. Researchers will test the accuracy of the desmopressin stimulation test in 140 people aged 18-70 who have or may have Cushing's, plus healthy volunteers. Participants will…

This study tests whether a special PET scan, combined with a drug called desmopressin, can find tiny pituitary tumors that standard MRI scans miss in people with Cushing's disease. About 22 participants will receive the drug and a radioactive tracer, then undergo imaging. The goa…

This study is testing whether a special PET scan using [18F]FET can better locate small pituitary tumors that cause Cushing's disease. Standard MRI misses these tumors in up to 30% of cases. Researchers will compare PET results with MRI and surgical findings in 20 adults to see i…

This early study tests a special PET/MRI scan using a radioactive tracer called FET to find small pituitary tumors that don't show up on regular MRI. The goal is to improve detection of these hormone-producing tumors in 5 adults with confirmed biochemical disease. If the scan wor…

This study tests a device called the CONVIVO system, which acts like a high-powered microscope during brain tumor surgery. It helps surgeons tell the difference between normal and abnormal tissue right away. About 30 adults with various brain tumors will take part. The goal is to…

This study tests a new ultrasound method to help surgeons find pituitary tumors during surgery. Researchers will compare ultrasound images with MRI scans to see if the new technique can better identify tumors in people with Cushing's disease and other pituitary tumors. About 110 …

This pilot study at the University of Cambridge is testing whether a new PET scan tracer called FET can locate pituitary tumors as well as the standard tracer, methionine. The study involves 20 adults with suspected pituitary adenomas who have already had a methionine PET scan. I…

This study tests whether a special PET/MRI scan using a radioactive tracer called Ga68-DOTATATE can better detect certain brain tumors (like meningioma) and tell them apart from changes caused by past treatments. About 200 adults with these tumors will get the scan alongside stan…

This trial tests a new anti-fog suction device that keeps the camera lens clear during nose-to-pituitary tumor surgery. Twenty adults with pituitary or craniopharyngioma tumors will either get the device or the usual water-squirt method. The goal is to see if the device reduces f…

This study tests whether a nerve block (injecting numbing medicine near a nerve cluster in the face) can improve the surgical view and reduce pain for people having pituitary tumor surgery through the nose. 70 adults will be randomly assigned to receive either the nerve block plu…

This study tests whether injecting a numbing medication (bupivacaine) near a nerve cluster in the nose can reduce pain after minimally invasive pituitary tumor removal. About 108 adults will be randomly assigned to receive the nerve block, a placebo (saline), or no extra injectio…

This study compares two surgical tools—cautery and scalpel—used during endoscopic skull base surgery to see which better preserves a patient's sense of smell. 80 adults who need this surgery will be randomly assigned to one method. Their smell function will be tested before and a…

This study tests whether a tailored physical activity program can improve quality of life and overall health in people who had surgery for a non-functioning pituitary adenoma. Participants will be randomly assigned to receive an individualized exercise plan from a physiotherapist…

This study aims to uncover the genetic causes of pituitary and hypothalamic tumors in children. Researchers will collect blood and tumor samples from up to 2,000 participants to analyze DNA and look for inherited patterns. The study also trains doctors and tests new MRI technique…

This study looks at the long-term health of people who were cured of Cushing disease before age 21. Researchers want to understand how past high cortisol levels affect the body and mind years later. Participants will complete surveys and have check-ups every 5 years. The goal is …

This study tests a small MRI coil placed inside the sphenoid sinus during pituitary tumor surgery. The goal is to see if it can provide clearer images of tiny tumors that standard MRI often misses. About 70 adults with pituitary tumors will take part. The coil is inserted through…

This study aims to find new genes that cause pituitary tumors, including those that lead to acromegaly (gigantism) and prolactinomas. Researchers will collect blood and tissue samples from up to 10,000 people with these tumors and their family members. By analyzing DNA, they hope…

This study looks at the immune cells inside pituitary tumors to better understand how they behave. Researchers will analyze tumor samples from 60 adults who are having surgery to remove their pituitary tumor. The goal is to find clues that could lead to new immune-based treatment…

This study is looking at how cortisol and other steroid hormones are produced over 24 hours in people with adrenal tumors. Researchers will use a special device called U-RHYTHM to take fluid samples every 20 minutes for up to 48 hours. The goal is to compare hormone patterns betw…

This study looks at how radiation to the brain affects memory in children who had a brain tumor. Researchers will test memory and thinking skills in 130 children ages 4 to 12, starting 2 years after radiation and again 2 years later. The goal is to learn which parts of the brain …

This study follows 1,250 people with pituitary tumors to learn what predicts tumor return or ongoing disease. Researchers will track survival and other health markers over time. No new treatment is given—the goal is simply to gather information that may improve future care.

This study investigates whether higher lifetime exposure to estrogen—from sources like birth control, pregnancy, or hormone therapy—is linked to the development of larger prolactin-secreting pituitary tumors (macroprolactinomas) compared to smaller ones (microprolactinomas). Rese…

This study is collecting data from 1,650 people with various brain tumors to see if the updated 2021 WHO classification system helps doctors group patients more accurately and choose better treatments. Researchers will track responses to therapy, survival, and tumor features over…

This international registry collects medical data and biological samples from children and adults with rare brain tumors like medulloblastoma and ependymoma. By gathering information from patients not in clinical trials, researchers hope to improve treatment recommendations and i…

This study looks at why people with damage to the hypothalamus or pituitary gland often have sleep problems. Researchers will compare 60 patients to healthy volunteers using sleep tests, hormone measurements, and brain scans. The goal is to find better ways to prevent and treat t…

This study looks at children with ROHHAD syndrome, a rare condition that causes rapid weight gain and breathing problems. Researchers will take blood samples to create special cells in the lab and study their genetic activity. The goal is to understand what goes wrong in the body…

This study is not testing a new treatment. Instead, it follows 300 people aged 14 and older with Cushing's syndrome to collect data on their health before and after standard treatments like surgery, medication, or radiation. The goal is to build a registry that helps doctors unde…

This study looks at how the drug mannitol changes levels of the anesthetic propofol in the blood and urine during brain surgery. Forty adults having either supratentorial tumor surgery or pituitary surgery will be enrolled. Half will receive mannitol, the other half a placebo, an…