Robotic exoskeleton may boost quality of life for MS patients
NCT ID NCT05835622
First seen Sep 21, 2026 · Last updated Sep 21, 2026
Summary
Researchers are testing whether wearing a lightweight robotic exoskeleton at home can improve quality of life for people with multiple sclerosis who have walking difficulties. The study includes 28 adults who use a walking aid and live at home. Participants wear the Keeogo exoskeleton for 8 weeks and then have an 8-week period with only advice on physical activity, or vice versa. The main measure is change in quality of life, with walking and balance tests as secondary measures.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Keeogo, a lightweight robotic lower limb exoskeleton worn for walking assistance
- What this could lead to
- If it works, this could offer a home-based tool to help people with multiple sclerosis walk more easily and feel better day to day.
- What could go wrong
- The trial is small, with 28 participants, and tests one device in a specific group. Results may not apply to others, and the exoskeleton could be uncomfortable or hard to use at home.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 28 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Feb 2024
- Expected to finish
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Oct 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patient with multiple sclerosis according to the revised Mac Donald diagnostic criteria (2017) in the relapsing-remitting form more than 6 months from a relapsing or progressive period. * An Expanded Disability Status Scale (EDSS) between 5 and 6.5 on the EDSS scale (Kurtzke 1983) * Living at home * Using a walking aid * 18 years old or older * Have freely consented to participate in this study * To be more than 1m52 tall * Hip Manual Muscle Testing (MMT) score ≥ 3+ (flexors and expanders) * Knee Manual Muscle Testing (MMT) score ≥ 2 (flexors and expanders) * Berg scale (BBS) score \> 20 * Patient affiliated with a social security plan or beneficiary of such a plan. Non-Inclusion Criteria: * Impaired comprehension preventing completion of the protocol * Inability to walk without assistance for 10 minutes * Have a rehabilitation stay scheduled during the follow-up period of the clinical investigation * Diagnosed psychiatric conditions that may have an impact on the experience of withdrawal of technical assistance at the end of the protocol * Severe cognitive impairment (MMSE\<24) * Person deprived of liberty by a judicial or administrative decision * A person under psychiatric care or admitted to a health or social institution for purposes other than research. * Spasticity \>3 on the Held and Tardieu scale affecting the hamstring, quadriceps, adductor or sural triceps muscles * Complete paralysis of the lower limbs * Severe osteoporosis * Hip and/or knee replacements that would sufficiently limit range of motion for walking and sitting or squatting * Severe vascular disorders of the lower limbs * Existing wounds or skin lesions where the device is worn * Pregnant woman or postpartum woman who has not completed lumbopelvic recovery * Orthopedic disorders of the lower limb that may prevent satisfactory adjustment of Keeogo * Uncontrolled epilepsy or tremors * Uncontrolled autonomic dysreflexia * Severe balance disorders, neurological disorders (any condition that prevents the safe control of balance and/or movement of the limbs at all times while wearing the Keeogo System) * Conditions that prevent safe moderate-intensity exercise
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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CHU Angers- SSR Les Capucins
Angers, Pays de la Loire Region, 49103, France
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CHU Nantes site de Saint Jacques
Nantes, Pays de la Loire Region, 44093, France
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Centre de rééducation Fonctionnelle Propara-Montpellier
Montpellier, Occitanie, 34090, France
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Hospices Civils de Lyon - Hôpital Henry Gabrielle
Saint-Genis-Laval, Auvergne-Rhône-Alpes, 69230, France
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Hôpital Saint Philibert-Groupement des Hôpitaux de l'Institut Catholique de Lille
Lomme, Hauts-de-France, 59160, France
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Pôle Saint Hélier
Rennes, Brittany Region, 35000, France
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