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Ultrasound technique aims to spot Stroke-Prone plaque

NCT ID NCT04063709

Diagnosis Sponsor: University of North Carolina, Chapel Hill Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 14, 2026 · Last updated Sep 15, 2026 · Updated 1 time

Summary

Researchers are testing a noninvasive ultrasound method called ARFI to see if it can detect features of carotid plaque that raise stroke risk. The study includes adults with narrowed carotid arteries, some with symptoms and some without. By measuring plaque characteristics, the team hopes to improve how doctors identify patients who need timely treatment to prevent stroke.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Acoustic Radiation Force Impulse (ARFI) ultrasound, a noninvasive imaging method
What this could lead to
If it works, this imaging method could help doctors identify dangerous carotid plaque and act sooner to prevent strokes.
What could go wrong
This is an early diagnostic study with 72 participants, so the technique may not prove accurate enough for routine use, and it only applies to people with specific plaque narrowing.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

72 people

The number who actually took part.

Started

Jul 2019

Expected to finish

Aug 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * aged 18 years or older * having 50-99% stenotic symptomatic carotid plaque with clinical indication for endarterectomy * having 50-69% stenotic asymptomatic carotid plaque without clinical indication for endarterectomy Exclusion Criteria: * prior CEA or carotid stenting * carotid occlusion * vasculitis * malignancy * inability to provide informed consent * prior radiation therapy to the neck * treatment with immunomodulating drugs * oncological disease.

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Conditions

The condition(s) this trial relates to.

atherosclerosis carotid stenosis Plaque, Atherosclerotic stroke disorder prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Carotid artery plaque Carotid stenosis Plaque, atherosclerotic

Contacts and locations

Locations

  • The University of North Carolina at Chapel Hill Hospitals

    Chapel Hill, North Carolina, 27599, United States

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