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Can a simple ultrasound scan reveal which neck plaques threaten the brain?

NCT ID NCT02360137

Diagnosis Sponsor: University Hospital Ostrava Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 09, 2026 · Last updated Sep 10, 2026 · Updated 1 time

Summary

Researchers are studying whether ultrasound images of carotid artery plaques can reveal which plaques are unstable and more likely to cause a stroke. They compare scan features with the actual tissue composition of plaques removed during surgery, and they track plaque growth, stroke, and death over time. The study also checks how common carotid webs are and whether they add to stroke risk. About 1,863 adults aged 30 to 90 with visible carotid plaque take part.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
duplex ultrasound imaging of carotid plaque
What this could lead to
If ultrasound can reliably flag unstable carotid plaques, doctors could better decide who needs surgery or stenting and who might need a change in drug therapy.
What could go wrong
This is an observational study, so it cannot prove that acting on ultrasound findings prevents strokes. Plaque appearance on scans may not match its actual behavior, and results from one hospital group may not apply everywhere.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

1,863 people

The number who actually took part.

Started

Apr 2015

Finished

Jun 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The project follow-up period for each enrolled patient will take 10 years. Total of 1863 patients with atherosclerotic plaque in carotid arteries and 250 healthy controls will be included to the study. In the substudy, total of 413 patients with atherosclerotic plaques in the carotid bifurcation and internal carotid artery causing arterial stenosis ≥ 30% detected by duplex sonography will be included to the study - 152 patients indicated for carotid endarterectomy according to the currently valid guidelines (American Heart Association/American Stroke Association \[AHA\], European Stroke Organisation \[ESO\]) and 261 patients indicated for conservative treatment. Patients will be screened and enrolled in sonographic laboratories of the Military University Hospital in Prague and University Hospital Ostrava.

Ages

18 to 90 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * age 30 - 90 years * sufficient image quality of atherosclerotic plaque in the carotid bifurcation and ICA using ultrasound * independency of the patient (0 - 2 points in the modified Rankin scale) * signed informed consent. Exclusion Criteria: * serious disease with a low probability of survival of at least 3 years * other objective obstacles preventing regular 6-month ultrasound scan.

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Conditions

The condition(s) this trial relates to.

carotid stenosis carotid web Plaque, Amyloid stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Carotid artery plaque Carotid web

Contacts and locations

Locations

  • University Hospital Ostrava

    Ostrava, Czech Republic, 70852, Czechia

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