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Ultrasound may predict Stroke-Causing plaques

NCT ID NCT05218421

Knowledge-focused Sponsor: Radboud University Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 19, 2026 · Last updated Aug 20, 2026 · Updated 1 time

Summary

This study is testing whether an advanced ultrasound technique can identify which carotid artery plaques are dangerous (vulnerable) and likely to cause a stroke. Researchers will compare ultrasound images taken before surgery with the actual plaque tissue removed during the operation. The goal is to see if this non-invasive imaging can reliably predict plaque risk, potentially helping doctors make better treatment decisions in the future.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Carotid ultrasound with flow and elastography measurements, plus blood and plaque analysis
What this could lead to
If successful, this could lead to a non-invasive way to identify high-risk carotid plaques before they cause strokes, guiding better treatment decisions.
What could go wrong
This is an observational study, so it won't test a treatment. The ultrasound technique may not accurately predict plaque vulnerability, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

70 people

The number who actually took part.

Started

May 2022

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients with a carotid artery stenosis ≥50% according to clinically performed imaging (i.e. duplex, computed tomography angiography (CTA), or magnetic resonance angiography (MRA)) that are scheduled for a CEA.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Presence of carotid artery stenosis (≥50%) according to conventional clinically performed imaging (duplex/CT(A)/MR(A)) and scheduled for a CEA; * Possibility to perform carotid ultrasound ≤2 weeks before the CEA * ≥18 years old; * Able to provide signed or oral informed consent. Exclusion Criteria: * Hampered carotid blood flow imaging during clinically performed duplex/doppler measurements due to near to total carotid occlusion at the side of interest or a calcified plaque; * Restenosis after carotid revascularisation at side of interest; * Participating in another clinical study, interfering on outcomes;

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Conditions

The condition(s) this trial relates to.

carotid stenosis Plaque, Atherosclerotic

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Carotid artery plaque

Contacts and locations

Locations

  • Radboud university medical center

    Nijmegen, Netherlands

  • Rijnstate Hospital

    Arnhem, Netherlands

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