New hope for dravet syndrome: phase 3 trial of LP352 aims to cut seizure frequency

NCT ID NCT06660394

Recruiting now Disease control Sponsor: Longboard Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 11, 2026 · Updated 4 times

Summary

This study tests whether the drug LP352 can safely reduce seizures in children and adults with Dravet syndrome, a severe form of epilepsy. About 160 participants will receive either LP352 or a placebo, and researchers will track changes in seizure frequency over several months. The goal is to see if LP352 helps control seizures better than a dummy treatment.

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Conditions

The condition(s) this trial relates to.

Dravet syndrome Epilepsies, Myoclonic epilepsy neurodevelopmental disorder visual epilepsy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DRAVET SYNDROME

Contacts and locations

Show contact details

Study contacts

Contact

Email: •••••@•••••

Locations

AP-HM- Hôpital de La Timone
RECRUITING

Marseille, 13005, France
AP-HP - Hôpital universitaire Necker-Enfants malades
RECRUITING

Paris, 75015, France
AP-HP - Hôpital universitaire Robert-Debré
RECRUITING

Paris, 75019, France
Ann and Robert H Lurie Childrens Hospital of Chicago - PIN
RECRUITING

Chicago, Illinois, 60611, United States
Arkansas Children's Hospital - Cardiology Clinic
RECRUITING

Little Rock, Arkansas, 72202-3500, United States
Austin Hospital
RECRUITING

Heidelberg, Victoria, 3084, Australia
Azienda Ospedaliera Universitaria Integrata Verona - Centro Fibrosi Cistica di Verona (CFC Verona)
RECRUITING

Verona, 37126, Italy
Azienda Ospedaliero Universitaria A Meyer (Duplicate)
RECRUITING

Florence, Tuscany, 50139, Italy
Beijing Children's Hospital, Capital Medical University - PIN
RECRUITING

Beijing, 100045, China
CHU de Rennes - Hôpital Pontchaillou
RECRUITING

Rennes, 35203, France
CHU de Strasbourg - Hôpital de Hautepierre
RECRUITING

Strasbourg, 67200, France
Centre Hospitalier Universitaire (CHU) de Toulouse - Hopital de Psychiatrie
RECRUITING

Toulouse, Occitanie, 31059, France
Centre Hospitalier Universitaire de Lyon, Hopital Pierre Wertheimer
RECRUITING

Bron, 69500, France
Child Neurology Consultants of Austin - 6811 Austin Center Blvd
RECRUITING

Austin, Texas, 78731-3157, United States
Children's Clinical University Hospital
RECRUITING

Riga, Rīgas Apriņķis, LV-1004, Latvia
Children's Hospital Colorado.
RECRUITING

Aurora, Colorado, 80045-7106, United States
Children's Hospital Los Angeles - PIN
RECRUITING

Los Angeles, California, 90027-6062, United States
Children's Hospital at Westmead
RECRUITING

Westmead, New South Wales, 2145, Australia
Children's Hospital of Fudan University
RECRUITING

Shanghai, Shanghai Municipality, 201102, China
Children's National Medical Center
RECRUITING

Washington D.C., District of Columbia, 20010, United States
Children's and Women's Health Centre of British Columbia-4480 Oak St
RECRUITING

Vancouver, British Columbia, V6H 3V4, Canada
Cook Children's Jane and John Justin Neurosciences Center - PIN
RECRUITING

Fort Worth, Texas, 76104, United States
David Geffen School of Medicine at UCLA
RECRUITING

Los Angeles, California, 90095, United States
Dokkyo Medical University Hospital
RECRUITING

Mibu-Machi, Tochigi, 321-0293, Japan
Epilepsie-Zentrum Bodensee
RECRUITING

Ravensburg, 88214, Germany
Filadelfia - Epilepsihospitalet (Danish Epilepsy Centre)
RECRUITING

Dianalund, Region Sjælland, 4293, Denmark
Fondazione Mondino - Istituto Neurologico Nazionale a Carattere Scientifico IRCCS
RECRUITING

Pavia, Lombardy, 27100, Italy
Fondazione Policlinico Universitario A Gemelli - Rome - PPDS
RECRUITING

Rome, Lazio, 00168, Italy
Fukuoka Children's Hospital (FCH)
RECRUITING

Fukuoka, Fukuoka, 813-0017, Japan
Fundacao Faculdade Regional de Medicina de Sao Jose Do Rio Preto Hospital de Base - PPDS
RECRUITING

São José do Rio Preto, São Paulo, 15090-000, Brazil
Gesellschaft für Epilepsieforschung e.V.
RECRUITING

Bielefeld, 33617, Germany
Great Ormond Street Hospital for Children NHS Foundation Trust
RECRUITING

London, WC1N 3JH, United Kingdom
Hokkaido University Hospital
RECRUITING

Sapporo, Hokkaido, 060-8648, Japan
Hospital Das Clinicas da Faculdade de Medicina de Ribeirão Preto - USP - PPDS
RECRUITING

Ribeirão Preto, São Paulo, 14051-140, Brazil
Hospital Regional Universitario de Malaga - Hospital General
RECRUITING

Málaga, Málaga, 29010, Spain
Hospital Ruber Internacional (Grupo Quironsalud)
RECRUITING

Madrid, 28034, Spain
Hospital Sant Joan de Deu - PIN
RECRUITING

Espluges de Llobregat, Barcelona, 08950, Spain
Hospital Universitario Vall d'Hebron - PPDS
RECRUITING

Barcelona, 08035, Spain
Hospital Universitario Vithas Madrid La Milagrosa
RECRUITING

Madrid, 28010, Spain
Hospital Universitario de Navarra
RECRUITING

Pamplona, Navarre, 31008, Spain
Hospital Vithas Malaga
RECRUITING

Málaga, 29016, Spain
Hospital das Clinicas - UNICAMP
RECRUITING

Campinas, São Paulo, 13083-888, Brazil
Hospital de la Santa Creu I Sant Pau
RECRUITING

Barcelona, 8041, Spain
Hôpital Roger Salengro
RECRUITING

Lille, Nord, 59000, France
IRCCS Ospedale Pediatrico Bambino Gesu
RECRUITING

Roma, 00165, Italy
IUHW Narita Hospital
RECRUITING

Narita, Chiba, 286-8520, Japan
Institute of Neurology and Neurosurgery at Saint Barnabas, LLC
RECRUITING

Livingston, New Jersey, 07039-5817, United States
Instituto Nacional de Pediatria (INP) (National Institute of Pediatrics)
RECRUITING

Mexico City, Mexico City, 04530, Mexico
Instituto de Neurologia de Curitiba (INC)
RECRUITING

Curitiba, Paraná, 81210-310, Brazil
Instituto de Psiquiatria HC FMUSP
RECRUITING

São Paulo, 05403-010, Brazil
Instituto do Cerebro do Rio Grande do Sul - InsCer
RECRUITING

Porto Alegre, Rio Grande do Sul, 90610-000, Brazil
Istituto G Gaslini Ospedale Pediatrico IRCCS (Duplicate)
RECRUITING

Genova, 16147, Italy
Klinikum der Johann-Wolfgang Goethe-Universitat
RECRUITING

Frankfurt am Main, Hesse, 60596, Germany
Le Bonheur Childrens Outpatient Center - PIN
RECRUITING

Memphis, Tennessee, 38103-2816, United States
London Health Sciences Centre -800 Commissioners Rd E
RECRUITING

London, Ontario, N6A 5W9, Canada
Mayo Clinic Children's - PIN
RECRUITING

Rochester, Minnesota, 55905-0001, United States
Mid-Atlantic Epilepsy and Sleep Center - Bethesda
RECRUITING

Bethesda, Maryland, 20817-1844, United States
Moinhos de Vento Hospital (Hospital Moinhos de Vento) (HMV)
RECRUITING

Porto Alegre, Rio Grande do Sul, 90035-001, Brazil
Mother and Child Health Care Institute of Serbia Dr Vukan Cupic
RECRUITING

Belgrade, 11000, Serbia
Multicare Health System - Mary Bridge Pediatrics
RECRUITING

Tacoma, Washington, 98405-4048, United States
NHS Greater Glasgow and Clyde Glasgow Clinical Research Facility-Queen Elizabeth University Hospi...
RECRUITING

Glasgow, G51 4TF, United Kingdom
NW FL Clinical Research Group, LLC
RECRUITING

Gulf Breeze, Florida, 32561-4495, United States
NYU Langone Health-NYU Comprehensive Epilepsy Center
RECRUITING

New York, New York, 10016-4852, United States
National Center Hospital, National Center of Neurology and Psychiatry
RECRUITING

Kodaira-shi, Tokyo, 187-8551, Japan
National Hospital Organization Nishi-Niigata Chuo National Hospital
RECRUITING

Niigata, Niigata, 950-2074, Japan
National Hospital Organization Shizuoka Institute of Epilepsy and Neurological Disorders
RECRUITING

Shizuoka, Shizuoka, 420-0953, Japan
Nicklaus Children's Hospital - PIN
RECRUITING

Miami, Florida, 33155-3009, United States
Northeast Regional Epilepsy Group - Morristown - 310 Madison Ave
RECRUITING

Morristown, New Jersey, 07960, United States
Northwestern Memorial Hospital
RECRUITING

Chicago, Illinois, 60611-2908, United States
Okayama University Hospital
RECRUITING

Okayama, Okayama-ken, 700-8558, Japan
Oregon Health & Science University - Blood Brain Barrier and Neuro-Oncology Program
RECRUITING

Portland, Oregon, 97239-3098, United States
Osaka City General Hospital
RECRUITING

Osaka, Osaka, 534-0021, Japan
Pediatric Epilepsy and Neurology Specialists
RECRUITING

Tampa, Florida, 33609-4190, United States
Peking University First Hospital - Daxing Campus
RECRUITING

Beijing, Beijing Municipality, 102627, China
Prince of Wales Hospital (POWH)
RECRUITING

Randwick, New South Wales, 2031, Australia
Queensland Children's Hospital
RECRUITING

South Brisbane, Queensland, 4101, Australia
Rare Disease Research, LLC - Atlanta - RDR - PIN
COMPLETED

Atlanta, Georgia, 30329, United States
Research Institute of Orlando LLC
COMPLETED

Orlando, Florida, 32806, United States
Royal Brisbane & Women's Hospital
RECRUITING

Herston, Queensland, 4006, Australia
Saitama Prefectural Children's Medical Center
RECRUITING

Saitama-shi, Saitama, 330-8777, Japan
Shenzhen Children's Hospital
RECRUITING

Shenzhen Shi, Guangdong, 518026, China
Silmatautien Poliklinikka - Kuopion Yliopistollinen Sairaala (KYS) (Kuopio University Hospital) L...
RECRUITING

Kuopio, Northern Savonia, 70210, Finland
Sydney Children's Hospital - Randwick
RECRUITING

Randwick, New South Wales, 2031, Australia
The Alfred Hospital
RECRUITING

Melbourne, Victoria, 3004, Australia
The Hospital for Sick Children (SickKids)
RECRUITING

Toronto, Ontario, M5G 1X8, Canada
The Newcastle upon Tyne Hospitals NHS Foundation Trust - Royal Victoria Infirmary (RVI)
RECRUITING

Newcastle upon Tyne, North East, NE1 4LP, United Kingdom
The Royal Children's Hospital (RCH) Melbourne
RECRUITING

Parkville, Victoria, 3052, Australia
The Second Affiliated Hospital of Guangzhou Medical University
RECRUITING

Guangzhou, Guangdong, 510260, China
The Stanford Division of Child Neurology
RECRUITING

Palo Alto, California, 94304-1510, United States
The University of Texas Medical School at Houston - UT Gastroenterology
RECRUITING

Houston, Texas, 77030-1517, United States
Toronto Western Hospital
RECRUITING

Toronto, Ontario, M5T 2S8, Canada
UCSF Benioff Children's Hospitals - San Francisco
COMPLETED

San Francisco, California, 94158, United States
ULS de Coimbra, EPE - Hospital Pediátrico de Coimbra
RECRUITING

Coimbra, 3000-602, Portugal
ULS de Santa Maria,EPE - Hospital de Santa Maria - PPDS
RECRUITING

Lisbon, 1649-035, Portugal
ULS de Santo António, EPE - Centro Materno Infantil Norte
RECRUITING

Porto Covo, Porto District, 4050-651, Portugal
UZ Antwerpen
RECRUITING

Edegem, 2650, Belgium
UZ Leuven
RECRUITING

Leuven, Vlaams Brabant, 3000, Belgium
University Clinical Center Kragujevac
RECRUITING

Kragujevac, 34000, Serbia
University Clinical Center of Serbia - Dr Subotica 6 - PPDS
RECRUITING

Belgrade, Belgrade, 11000, Serbia
University College London Hospitals (UCLH) - PPDS
RECRUITING

London, NW1 2PG, United Kingdom
University of Belgrade-Faculty of Medicine - Clinic of Neurology and Psychiatry for Children and ...
RECRUITING

Belgrade, Beograd, 112112, Serbia
Universitätsklinikum Bonn
RECRUITING

Bonn, North Rhine-Westphalia, 53127, Germany
Universitätsklinikum Schleswig-Holstein - Campus Kiel
RECRUITING

Kiel, 24105, Germany
Wuhan Children's Hospital
RECRUITING

Wuhan, Hubei, 430016, China

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