Brain disorder

This study tests whether taking propranolol, a beta blocker, before and after surgery can reduce complications like delirium, kidney problems, and pain in people with post-traumatic stress disorder (PTSD). Participants are veterans scheduled for certain surgeries and will take th…

This early-phase trial is testing a new treatment called CHM-1101 for people with a type of brain cancer (glioblastoma) that has come back or is getting worse. The treatment uses the patient's own immune cells, which are modified in a lab to recognize and attack tumor cells. The …

This study tested four different cooling treatments for newborns who suffered brain injury from lack of oxygen at birth. The treatments varied in how low the body temperature was lowered (33.5°C or 32.0°C) and how long cooling lasted (72 or 120 hours). The goal was to see which a…

This study tested whether a robotic exoskeleton could help children aged 6 to 12 with severe cerebral palsy improve their walking and motor skills. Participants used the robot for 45-minute sessions three times a week over six months. The trial aimed to measure changes in movemen…

This study follows 197 people who previously had a procedure called TCAR to treat carotid artery disease. Researchers will check for strokes, deaths, and whether the artery narrows again over 2 to 5 years. The goal is to see how well the treatment holds up over time.

This study tests whether an additional dose of a COVID-19 vaccine can improve immune protection in adults and children with autoimmune diseases like rheumatoid arthritis, lupus, multiple sclerosis, and others who are taking immunosuppressive medications. Participants who had a we…

This trial tested a single dose of CAP-002 gene therapy in children aged 18 months to 8 years with STXBP1 encephalopathy, a rare genetic brain disorder causing seizures and developmental delays. The study aimed to check safety and whether it could reduce seizures and improve skil…

This study tested whether repeatedly inflating and deflating a blood pressure cuff on the arm (remote ischemic conditioning) could improve recovery in 458 people who had a severe stroke caused by a blocked artery in the brain. The goal was to see if this simple, non-drug treatmen…

This study looked at the long-term safety of soticlestat when added to standard seizure medicines for people with Dravet syndrome or Lennox-Gastaut syndrome. It included 352 children and adults who had already been in earlier studies. The trial was terminated early, so results ar…

This study tested whether adding the drug aticaprant to standard antidepressants could prevent depression from returning in people with major depressive disorder who also experience a loss of interest or pleasure (anhedonia). The study enrolled 47 adults who had responded well to…

This early-phase trial tested giving chemotherapy drugs directly into the brain's arteries to treat two rare types of choroid plexus tumors. The goal was to shrink the tumor before a second surgery. Only 1 person was enrolled, and the study was terminated, so we have very little …

This early-stage study tested a new drug called PF-07265807 in people with advanced or metastatic solid tumors that had spread. The main goals were to find a safe dose and check for side effects. The trial was terminated early, so results are limited.

This study tested a combination of two drugs, pembrolizumab and lenvatinib, in 18 adults with melanoma or kidney cancer that had spread to the brain. Participants had already received anti-PD-1/PD-L1 therapy. The goal was to see if the drug combo could shrink or eliminate brain t…

This study tested an early speech therapy program for children born very prematurely or with severe growth restriction. The program involved 10 to 20 sessions with a trained speech therapist from 6 to 24 months of age. The goal was to see if it could reduce language and communica…

This study aimed to see if sodium lactate could improve blood flow in the brain after a severe type of stroke called subarachnoid hemorrhage. Only 3 patients were enrolled before the study was stopped early. The goal was to measure changes in brain blood flow using a special scan…

This study looked at the long-term safety of the drug NBI-921352 for people with a rare genetic seizure disorder called SCN8A-DEE. It was an extension of an earlier study, and participants took the drug alongside their usual seizure medications. The study was stopped early and on…

This study tested whether injections of MYOBLOC (botulinum toxin type B) can safely reduce muscle tightness in the arm and hand of adults with spasticity caused by stroke, brain injury, multiple sclerosis, or other conditions. The trial planned to enroll about 300 participants bu…

This study aimed to find the best dose of MCI-186 for people who had an acute ischemic stroke. It compared a new way of giving the drug (a bolus followed by continuous infusion) with the standard twice-daily dosing for 14 days. The trial was terminated early and included only 17 …

This study looked at whether tesamorelin (Egrifta), a daily injection that boosts growth hormone, can improve body composition in people with HIV who have excess belly fat (lipodystrophy). Six participants received the drug for up to 12 months, with researchers measuring liver fa…

This phase III trial compared two radiation strategies for cancer that had spread to the brain and returned in new spots after initial radiosurgery. One group received focused radiation only to the new tumors, while the other received whole brain radiation that avoided the memory…

This study tested the anti-inflammatory drug naproxen sodium for treating obsessive-compulsive symptoms in children aged 6-15 with PANDAS, a condition linked to strep infections. The trial was double-blind and placebo-controlled, but it was terminated early after enrolling only 2…

This pilot study tested deep brain stimulation (DBS) in 15 people with treatment-resistant schizophrenia who still had severe hallucinations despite medication. The device was placed in a brain area linked to schizophrenia to try to calm symptoms. The study was terminated early, …

This study looked at whether people with treatment-resistant depression who got better with electroconvulsive therapy (ECT) could switch to a less intense treatment called transcranial magnetic stimulation (TMS) to stay well. TMS is done in a clinic without anesthesia and has few…

This study looked at whether taking high doses of statins for two weeks before carotid artery surgery could prevent memory and thinking problems after the operation. It included 31 adults with severe carotid artery narrowing. The study was stopped early, so the results are limite…

This study tested whether clemastine fumarate, an allergy medication, could improve eye movement problems in people with multiple sclerosis (MS). The trial planned to enroll 80 MS patients with a specific eye condition called internuclear ophthalmoparesis, but was terminated earl…

This early-phase study tested whether natural progesterone, a hormone normally involved in pregnancy, could help control recurrent glioblastoma (a fast-growing brain cancer). Four adults whose cancer had returned after standard treatments received daily progesterone injections un…

This study offered continued treatment with EryDex to 101 people with ataxia telangiectasia (A-T) who had finished a previous trial. The main goal was to monitor safety, including side effects and serious events. The study was terminated early, and it did not aim to cure the dise…

This study tested the drug fenfluramine (FINTEPLA) in adults with Dravet syndrome whose seizures were not controlled by other medications. The trial was open-label and added fenfluramine to existing treatments. It aimed to see if the drug could reduce monthly seizures by at least…

This early-stage study tested a new drug, ADEL-Y01, in healthy volunteers and people with mild Alzheimer's or mild cognitive impairment. The goal was to check safety and how the drug moves through the body. The trial was stopped early, so results are limited.

This study looked at whether adding the drug pioglitazone to a keyhole brain surgery (MIPS) could help people recover from a severe bleeding stroke. Only one person took part before the study was stopped early. The goal was to see if the combination was safe and helped clear the …

This study tested a new device called Envi™-SR for removing blood clots in people having a severe ischemic stroke. The goal was to see if it works as well as devices already approved by the FDA. However, the trial was stopped early after enrolling only 12 people, so we don't have…

This study tested a brain implant (deep brain stimulation) to reduce seizures in 29 adults with epilepsy whose seizures were not controlled by medication. Participants kept diaries to track seizure frequency over three years. The goal was to see if the device safely and effective…

This early-stage trial tested the safety of an intravenous drug called talineuren (liposomal GM1) in 22 people with Parkinson's disease. The study was open-label and designed to find a safe dose, but it was terminated before completion. No conclusions about effectiveness can be d…

This study tested a long-acting form of glatiramer acetate (GA Depot) given as a monthly shot to people with primary progressive multiple sclerosis (PPMS). The goal was to see if it could safely slow down worsening disability. The trial was stopped early, but it involved 30 adult…

This study tested the long-term safety of a drug called aticaprant when added to a standard antidepressant for adults with major depression. The trial planned to enroll 871 people but was terminated early, so the full safety and effectiveness data are not available. Researchers w…

This phase 2 trial tested telitacicept (RC18) in 8 people with relapsing-remitting multiple sclerosis. The drug aims to reduce relapses by targeting B cells. The study was terminated early, so we have limited data on safety and effectiveness.

This study tested a new steerable guidewire called SmartGUIDE for treating unruptured brain aneurysms. The wire has a bendable tip that doctors can control during the procedure, potentially making it easier to reach the aneurysm. Only 5 people took part before the study was stopp…

This study tested whether taking people with severe stroke symptoms directly to the angio-suite for clot removal, instead of first doing a CT or MRI scan, leads to better recovery at 3 months. About 120 adults aged 18-85 with severe stroke were randomly assigned to either direct …

This study looked at the long-term safety of a medicine called iclepertin in adults with schizophrenia who had already finished earlier studies. About 1,356 participants took iclepertin tablets once a day for one year, along with their usual schizophrenia medications. The main go…

This study tested a drug called edaravone dexborneol (Sanbexin IV) in 80 people who had a brain bleed (intracerebral hemorrhage). The goal was to see if it is safe and helps recovery when added to standard care. The trial was stopped early, so the results are limited and more res…

This study looked at whether taking UCB0599 early or later could slow brain changes in people with Parkinson's disease. It involved 428 adults who had already completed an earlier study. The trial was stopped early, but researchers measured brain scans and medication use over 18 …

This study tested a drug called vatiquinone in 68 people with mitochondrial disease and epilepsy that doesn't respond to standard treatments. Participants were randomly assigned to receive either vatiquinone or a placebo for 24 weeks to see if the drug could reduce the number of …

This was a very early Phase 1 study testing the safety of a drug called bryostatin in just 4 people with multiple sclerosis. Participants received multiple doses over 26 weeks. The study was terminated, meaning it stopped early, so we don't have clear results on whether the drug …

This study tested whether BHV-7000, taken alongside other medications, could reduce generalized tonic-clonic seizures in people with idiopathic generalized epilepsy. The trial was terminated early and enrolled only 27 adults aged 18-75. The main goal was to see how long it took f…

This Phase II trial tested a drug called N-Acetyl-L-Leucine (IB1001) in 17 people with Ataxia-Telangiectasia, a rare genetic disease that affects movement and immunity. The study aimed to see if the drug could improve symptoms and slow the disease over time. The trial was termina…

This study looked at the long-term safety of soticlestat, an experimental drug, in children and adults with severe forms of epilepsy like Dravet syndrome and Lennox-Gastaut syndrome. Participants took soticlestat twice a day along with their usual seizure medicines. The study was…

This study tested a combination of two drugs, bintrafusp alfa and pimasertib, in people whose cancer had spread to the brain. The goal was to find the safest dose and see if the treatment could slow or stop the cancer from growing. The trial was stopped early after enrolling only…

This study tested whether checking blood clotting levels every week with a small finger-prick device is better than the usual monthly lab test for elderly nursing home residents on blood thinners. The goal was to see which method keeps patients in the safe therapeutic range longe…

This study looked at whether fremanezumab (Ajovy), an FDA-approved monthly injection for migraine prevention, could also improve sleep in people with migraines. Researchers planned to track 22 participants over 4 months, comparing their migraine days and sleep quality before and …

This study gave Alzheimer's patients who had already completed earlier XPro1595 trials an extra 55 to 74 weeks of the drug to check long-term safety and effects on memory and brain health. Only 11 people took part, and the trial was terminated early, so the findings are limited. …

This study tested the drug cabozantinib in 19 people with a severe type of brain tumor (grade IV astrocytic tumors) that had come back after initial treatment. The goal was to see if the drug could shrink tumors or slow progression. However, the company stopped the trial early fo…

This study looked at the long-term safety of a drug called troriluzole for people with obsessive-compulsive disorder (OCD) who hadn't improved enough with standard treatments. The trial planned to enroll 772 participants but was terminated early. The main goal was to check for si…

This study tested a new drug called zotiraciclib (TG02) combined with the standard chemotherapy temozolomide in adults with recurrent anaplastic astrocytoma or glioblastoma. The goal was to find the safest dose and see if the combination worked better than temozolomide alone. The…

This study tested whether adding melatonin to the standard drug ocrelizumab could safely slow disability in people with progressive primary multiple sclerosis. The trial was terminated early, so results are limited. Participants were adults aged 18–65 with this type of MS.

This study tested a completely virtual early intervention program for toddlers with autism, using telehealth coaching to help parents embed learning into daily activities. Researchers planned to enroll 240 children from eight US regions, but the trial was terminated early with on…

This study looked at the long-term safety of a drug called NBI-827104 in children with a rare epilepsy that causes seizures during sleep. The trial was stopped early and only enrolled 19 children, so the results are limited. The main goal was to see how many children had serious …

This study tested a dental health education program for people with schizophrenia to see if it could improve their oral hygiene and quality of life. Participants were randomly assigned to either the education program or standard monitoring. The study lasted 12 months and included…

This study aimed to see if the steroid dexamethasone could help people with traumatic brain injury who had brain contusions and swelling. It planned to enroll 600 adults, giving them a short course of dexamethasone or a placebo. The main goal was to measure recovery using the Gla…

This study tested a combination of long-acting injectable antipsychotic medication and cognitive/functional skills training in people with early schizophrenia. The goal was to see if this approach helps patients achieve stable symptom remission and improve daily functioning. Only…

This early-phase study tested whether a fecal transplant from a healthy donor could be safe and affect the immune system in people with relapsing-remitting multiple sclerosis. Only 5 participants were enrolled before the study was stopped. The goal was to see if changing gut bact…

This study tested a new approach using a virus that attacks cancer cells (oncolytic immunotherapy) along with two standard drugs (atezolizumab and bevacizumab) in people with advanced colorectal cancer that had stopped responding to other treatments. The trial was stopped early a…

This early-stage trial tested a drug called nomlabofusp (CTI-1601) in 18 adolescents and children with Friedreich's ataxia, a rare genetic disease that affects movement and coordination. The goal was to check safety and how the body processes the drug. However, the study was term…

This Phase 3 trial tested an oral drug called venglustat in 75 adults and children with late-onset Tay-Sachs or Sandhoff disease, rare genetic disorders that cause progressive nerve damage. The drug aimed to lower toxic fat buildup in the brain and slow disease worsening. However…

This study looked at a device called the Pipeline Flex Embolization Device with Shield Technology to treat ruptured brain aneurysms that are hard to fix with surgery or coils. The goal was to see if it could safely block the aneurysm and prevent rebleeding. The study was stopped …

This study tested the safety of giving a second dose of an experimental virus (C134) directly into the brain tumor of patients whose malignant glioma had returned. Only one patient was enrolled before the study was stopped. The goal was to see if repeat dosing was safe and tolera…

This trial tested two immune-boosting drugs, tiragolumab and atezolizumab, with or without chemotherapy, in people with non-small cell lung cancer that had spread to the brain. The goal was to see if the combination could control the brain tumors and delay the need for radiation.…

This study tested a drug called VS-01 for people with severe confusion caused by liver disease (overt hepatic encephalopathy). The trial planned to enroll many participants but was stopped early after only 3 people joined. Researchers wanted to see if VS-01 could help patients re…

This early-stage trial aimed to see if combining three drugs (tucatinib, trastuzumab, and capecitabine) with precise radiation (SRS) is safe for people with HER2-positive breast cancer that has spread to the brain. Only one person enrolled before the study was terminated, so we h…

This study aimed to see if the antibiotic minocycline could improve outcomes after a stroke. Participants were to receive either standard care plus minocycline pills for five days, or standard care alone. However, the trial was stopped early after enrolling only 2 people, so no m…

This study looked at the long-term safety of a daily drug called BHV-7000 in people with bipolar I disorder. It involved 94 participants who had completed an earlier study. The trial was terminated early, so the full safety picture is not available.

This study tested a smartphone-based program to help stroke survivors with high blood pressure lower their risk of another stroke. The program involved tracking blood pressure and getting tailored reminders. The study was terminated early, so results are limited.

This study looked at the long-term safety of an experimental drug called CVL-865 in adults whose focal seizures were not controlled by other medications. About 105 people who completed a previous trial took CVL-865 alongside their usual seizure drugs for up to 57 weeks. The study…

This phase 3 trial tested whether adding the immunotherapy drug pembrolizumab (Keytruda) to precise, high-dose radiation (SBRT) could help prevent early-stage non-small cell lung cancer from returning. The study enrolled 448 people with stage I or II lung cancer who could not hav…

This study tested the drug alemtuzumab in children aged 10 to 18 with relapsing-remitting multiple sclerosis (MS) whose disease was still active despite other treatments. The goal was to see if the drug could reduce new brain lesions and improve quality of life. However, the tria…

This study tested the drug natalizumab in 21 Japanese adults with relapsing-remitting multiple sclerosis (MS). The goal was to see if injections under the skin every 4 weeks could reduce new brain lesions over 24 weeks, and to check safety for up to 48 weeks. The study was termin…

This early-phase study tested a new formulation of octreotide (Debio 4126) that lasts 12 weeks, aiming to control hormone levels in people with acromegaly or certain neuroendocrine tumors. Only 19 participants were enrolled before the trial was terminated. The main goal was to me…

This early-phase trial tested the drug navtemadlin in 32 adults with glioblastoma, a type of brain cancer. The study aimed to find the best dose and check side effects, both for newly diagnosed and recurrent cases. The trial was terminated early, so results are limited.

This study tested a long-acting form of methylphenidate (Ritalin) given in the evening to children aged 4-5 with ADHD. The goal was to see if it improved ADHD symptoms and was safe. However, the trial was stopped early and only enrolled 26 children, so we cannot draw firm conclus…

This study looked at whether adding the drug pembrolizumab to chemotherapy could help people with a type of lung cancer that has spread to the brain but isn't causing symptoms. The goal was to control the cancer in the brain and body while keeping quality of life. Only 3 people t…

This study tested an oral drug called CX-4945 (silmitasertib) in 21 children with recurrent SHH medulloblastoma, a rare brain tumor. The trial aimed to find the best dose and see if the drug could shrink tumors. However, the study was stopped early, so we don't have clear answers…

This early-phase trial tested a new immunotherapy approach for children with DIPG, a rare and aggressive brain stem tumor. After standard radiation and chemotherapy, patients received special vaccines and immune cells designed to attack the tumor. The study was small (11 particip…

This study tested an experimental drug called VENT-02 in 29 people with mild to moderate Parkinson's disease. The drug aims to reduce brain inflammation by blocking a protein called NLRP3. The trial was terminated early, so we don't have clear results on whether it helps symptoms…

This phase 2 trial tested a personalized treatment approach for post-pubertal patients with newly diagnosed medulloblastoma, a rare brain cancer. The experimental group received a targeted drug called sonidegib along with reduced radiation, based on the tumor's genetic subtype. T…

This early-phase study tested a new drug called PF-07284890, alone or with another drug (binimetinib), in 65 people with advanced cancers that have a specific genetic change (BRAF V600 mutation), including cancers that spread to the brain. The trial was terminated early, but rese…

This study tested cariprazine (VRAYLAR), an approved schizophrenia drug in the U.S., for people with acute schizophrenia in Japan and Taiwan. Participants received either cariprazine or a placebo for 6 weeks, then could continue on cariprazine for 18 more weeks. The trial was ter…

This study tested an experimental drug called NBI-921352 in people aged 2 to 21 with a rare, severe form of epilepsy caused by a change in the SCN8A gene. The goal was to see if adding this drug to their current seizure medicines could reduce how often they had seizures. The tria…

This study tested an oral drug called SAR443820 in 174 adults with multiple sclerosis (MS) to see if it could lower a marker of nerve damage in the blood. The trial was stopped early because the drug did not meet its main goal of reducing that marker. Participants were followed f…

This study tested the drug perampanel in adults whose seizures did not stop with standard treatments. The goal was to see if it could safely stop seizures and reduce time in the hospital. Only one person enrolled before the study was ended early, so no clear conclusions can be dr…

This early-phase trial tested a combination of three drugs—ribociclib, topotecan, and temozolomide—in children with relapsed or refractory neuroblastoma and other solid tumors. The goal was to find a safe dose and see if the combination could shrink tumors. Only 12 children took …

This study tested whether lorcaserin, when added to current medications, could reduce convulsive seizures in people with Dravet syndrome, a severe form of epilepsy. The trial planned to enroll about 22 participants aged 2 and older, but it was terminated early. The main goal was …

This study tested the drug lacosamide in newborns with repeated seizures that were not controlled by standard medicines. The trial was small (29 babies) and was stopped early. Researchers compared lacosamide to usual care to see if it could reduce seizure time on brain monitoring…

This study aimed to see how two antipsychotic drugs, aripiprazole and ziprasidone, affect heart risk in people with schizophrenia, schizoaffective disorder, or bipolar disorder. Researchers measured blood fats and heart electrical changes in 48 adults over 12 months. The trial wa…

This early-stage trial tested two drug combinations—TNO155 plus spartalizumab or ribociclib—in 122 adults with advanced solid tumors like lung, head and neck, and colorectal cancers. The goal was to check safety and see if the drugs could slow cancer growth. The study was termina…

This study looked at whether a procedure to remove large blood clots from the brain could help people who had a severe stroke. It included 335 adults with a large stroke who could be treated within 7 hours. The goal was to see if the procedure reduced disability compared to stand…

This study tested whether giving lithium carbonate before carotid artery surgery could reduce brain damage and confusion after the operation. The trial planned to include 107 adults undergoing elective carotid surgery, but it was terminated early. The goal was to see if lithium c…

This early pilot study tested whether a combination of injectable naltrexone and oral bupropion could help people with schizophrenia who smoke cigarettes. Only 2 participants were enrolled before the study was terminated. The main goals were to see if the treatment was feasible a…

This phase 3 trial tested the drug miglustat (Zavesca) in 30 infants with Sandhoff or Tay-Sachs diseases, rare genetic disorders that destroy nerve cells. The goal was to see if the drug could reduce hospitalizations, seizures, and feeding problems while improving motor function.…

This study tested a new drug called VAL-083 in people with glioblastoma, an aggressive brain cancer that had returned after standard treatments. The trial aimed to see if VAL-083 could help patients live longer. However, the study was stopped early after only 2 people enrolled, s…

This early-stage trial tested a gene therapy called AXO-AAV-GM2 in children with Tay-Sachs or Sandhoff disease, rare and fatal genetic brain disorders. The therapy delivers healthy genes directly into the brain and spinal fluid to try to restore a missing enzyme. The study was te…

This study tests whether a tear sample can diagnose primary progressive multiple sclerosis (MS) as accurately as a spinal tap. Currently, doctors need to collect spinal fluid to confirm this type of MS, which is invasive and uncomfortable. Researchers will compare proteins in tea…

This study tested whether a cone beam CT scan, done right after a stroke procedure called thrombectomy, could tell the difference between a brain hemorrhage and harmless contrast dye buildup. Only 5 adults were enrolled before the study was stopped early. The goal was to see if t…

This study tested a special radioactive tracer (68GaNOTA-Anti-HER2 VHH1) to see if it can find HER2-positive brain metastases on PET/CT scans. Seven adult cancer patients with at least one brain lesion were enrolled. The goal was to compare tracer uptake in HER2-positive versus H…

This Phase II study tested a radioactive tracer called 68GaNOTA-Anti-MMR-VHH2 to see if it can light up certain immune cells (macrophages) on PET scans. The trial included 29 people with head and neck cancer, lymphoma, atherosclerosis, or sarcoidosis. The goal was to see if the t…

This study tested a new oral drink (GS3-007a) to diagnose adult growth hormone deficiency (AGHD). It compared the drink to the standard insulin tolerance test in 120 adults suspected of having AGHD and healthy volunteers. The goal was to see if the oral test works as well as the …

This study tested a new imaging method to detect inflammation in fatty plaques that cause strokes. It involved 3 men who had a recent stroke and were scheduled for surgery to remove a plaque in their neck artery. The goal was to see if a special PET scan tracer could highlight in…

This study tested a wearable device that sits on the neck to detect swallowing problems in people with conditions like stroke, Parkinson's, multiple sclerosis, Alzheimer's, or dementia. The device was compared to a standard X-ray test. Unfortunately, the device did not meet the a…

This study tested a new imaging device called cCeLL-Ex vivo that uses laser microscopy to quickly detect brain tumors during surgery. The goal was to see if it could diagnose tumors faster than the standard frozen section method, which takes 20-30 minutes. The study enrolled 285 …

This early-phase trial tested a radioactive imaging agent called 68Ga-FF58 in 14 adults with certain advanced solid tumors (glioblastoma, brain metastases from breast cancer, gastroesophageal cancer, or pancreatic cancer). The goal was to see if the agent could help detect these …

This study tested whether a PET scan using a radioactive tracer called 18F-Fluciclovine can tell the difference between a returning brain tumor and damage from past radiation therapy. Nineteen people with brain metastases who had suspicious MRI findings took part. The goal was to…

This study looked at whether giving radiation to the brain could prevent cancer from spreading there in people with HER2-positive breast cancer that had already spread to other organs. Participants were receiving trastuzumab (Herceptin) plus chemotherapy. The study was stopped ea…

This study looked at whether intensive treatment for gum disease (periodontitis) could prevent dementia in older adults who already have mild cognitive impairment and narrowed neck arteries. Participants received either standard dental care or deep cleaning and root planing. The …

This study tested a drug called SPN-538 to prevent migraines in children aged 6 to 11. The trial was a randomized, double-blind, placebo-controlled study, meaning some children got the drug and some got a placebo. However, the study was terminated early and only enrolled 26 parti…

This study tested whether BOTOX injections can prevent migraine attacks in adults who have 6 to 14 migraine days per month (episodic migraine). About 775 participants received either BOTOX or placebo injections into their muscles twice, 12 weeks apart. The main goal was to see if…

This study tested whether a single 200 mg dose of American Ginseng (Cereboost) could improve attention and brain function in healthy young adults aged 18-40. Participants completed cognitive tests and gave blood samples over 6 hours. However, the trial was terminated early and on…

This study compares two treatments for transformed migraine (chronic daily headache): a sphenopalatine ganglion nerve block using lidocaine gel applied inside the nose, versus daily oral amitriptyline (Elavil), an antidepressant often used for migraine prevention. Ten adults aged…

This study tested whether a non-invasive brain stimulation technique called TMS could help reduce negative symptoms of schizophrenia, like low motivation and reduced facial expression. The trial enrolled 47 adults with schizophrenia or schizoaffective disorder and compared active…

This study looked at whether practicing walking while doing other tasks (multitasking) helps people recovering from a stroke walk faster than just walking practice alone. It included 26 adults who had a stroke within the past 6 months and had trouble walking. The trial was stoppe…

This study tested the migraine drug lasmiditan in children aged 6 to 17 who have migraines. The goal was to see if it is safe and works for quick relief. The trial was stopped early, so the results are limited.

This study tested whether a 12-week home-based resistance training program, supervised via telehealth, could improve strength and function in children aged 6–15 with cerebral palsy. Participants used elastic bands and weights during live-streamed sessions. The study aimed to see …

This study tested whether a motorized orthosis (Innowalk) that mimics walking is better tolerated by children with cerebral palsy than standard standing devices. The trial included 25 children aged 6-16 who had never walked. Researchers measured pain, muscle stiffness, and joint …

This study tested whether N-acetylcysteine (NAC), an antioxidant, could help reduce impulse control disorders caused by Parkinson's medications. Only 14 people with mild-to-moderate symptoms were enrolled before the trial was stopped early. The goal was to see if 10 weeks of NAC …

This study tested whether smelling lavender essential oil before and during an office hysteroscopy (a procedure to look inside the uterus) could lower women's anxiety and pain. Twenty-two women were randomly assigned to inhale either lavender oil or distilled water (placebo). The…

This study tested whether closing a small hole in the heart (called a PFO) with a device could reduce migraine headaches. It planned to compare the real procedure to a sham (fake) procedure in adults aged 18-55 with frequent migraines. However, the study was stopped early after e…

This study observed 18 chronic stroke patients who received botulinum toxin injections into their elbow muscles as part of routine care. The goal was to see if the injections reduced muscle tightness (spasticity) and improved active arm extension. Researchers measured muscle acti…

This study looked at whether adding an iPACK nerve block to standard pain treatments (adductor canal block and local injections) helps people feel less pain and recover faster after total knee replacement. Only 10 people were enrolled before the study was stopped early. The goal …

This study tested a fast-dissolving film (BXCL501) placed under the tongue to quickly reduce severe agitation in older adults with dementia. The trial aimed to enroll many participants but was stopped early after only 5 people joined. Because it ended so soon, we cannot draw reli…

This early-phase trial tested whether brivaracetam, a seizure medication, is safe for people with diffuse gliomas (a type of brain tumor). Only 3 participants were enrolled before the study was terminated. The main goal was to track side effects, not to measure tumor shrinkage or…

This study tested a new way to treat hand tremors caused by essential tremor or Parkinson's disease using a linear accelerator, a common radiation machine. Instead of one large dose, the radiation was given in three smaller sessions to protect healthy brain tissue. The goal was t…

This study tested whether MYOBLOC, a botulinum toxin injection, can safely reduce muscle stiffness in the lower leg of adults with spasticity caused by stroke, brain injury, or spinal cord injury. About 40 participants received either a low or high dose of MYOBLOC or a placebo in…

This study tested a brace called CALIGALOC designed to correct foot drop (ankle varus) in people with hemiparesis after a stroke or other brain injury. The goal was to see if wearing the brace for 15 days improved walking speed and balance. Only 5 people took part, and the study …

This pilot study tested a 24-hour IV infusion of brexanolone in 10 adult women with PTSD from non-military trauma. The goal was to see if it could reduce PTSD symptoms and lead to remission by 12 weeks. The trial was terminated early, so results are limited.

This small pilot study aimed to see if it's possible to start neck therapy earlier for people with concussion and neck pain. Only 2 people enrolled before the study was stopped. The main goal was to check if the study process worked, not to measure how well the treatment helped s…

This study tested a new, short therapy module for people with obsessive-compulsive disorder (OCD) who struggle with compulsive checking. The therapy focuses on fixing unhelpful beliefs about memory that drive the urge to check. Researchers aimed to see if this approach reduces ch…

This study tested a music therapy program for adults with acquired brain injury, aiming to improve their comfort and well-being. Researchers worked with 27 hospitalized patients to see if group music sessions could help them feel better. The study was stopped early, so results ar…

This study tested an experimental drug called MIJ821, given as an IV infusion, to see if it could quickly reduce depression symptoms in people with major depressive disorder who also have active suicidal thoughts. About 199 adults aged 18 to 65 took part, receiving either MIJ821 …

This study tested a smartphone app that teaches mindfulness meditation to help Black and Latino adults with anxiety during the COVID-19 pandemic. About 400 participants were assigned to one of two mindfulness programs or a waitlist. The trial was terminated early, so we don't hav…

This study tested a drug called AVP-786 to see if it could safely reduce disinhibition—impulsive or inappropriate behavior—in people with neurodegenerative disorders like Alzheimer's or frontotemporal dementia. The trial planned to include many participants but was terminated ear…

This study tested a personalized touchscreen device (My PATI) to help people with Alzheimer's or related dementias communicate their care preferences. The goal was to improve quality of life for both patients and their caregivers. The study was terminated early, so results are li…

This phase 2 trial tested whether darigabat, an oral tablet, could help people with panic disorder. About 80 participants took either darigabat or a placebo for several weeks. The goal was to see if the drug could reduce panic attacks and improve overall symptoms. The study was t…

This study tested a robotic device called the G-EO Gait Trainer to help people with Parkinson's disease improve their walking. The device supports the body and guides leg movements to make walking practice safer and more effective. The trial was terminated early, so only limited …

This study followed 26 people with major depressive disorder for one year after they received a single dose of psilocybin or a niacin control. Researchers used web surveys and phone interviews to track depression symptoms over time. The study was terminated early, so results are …

This study looked at two FDA-approved migraine medications (a dissolving tablet and a nasal spray) given to adults in the emergency department. The goal was to see if these easy-to-use options could relieve pain quickly and shorten ER visits. The study was stopped early with only…

This small pilot study tested whether combining a gentle brain stimulation technique (tDCS) with a thinking-strategies training program could help people who had a stroke more than six months ago perform everyday activities better. Eleven participants were enrolled to see if the …

This early-stage trial tested whether adding a device that creates electric fields (NovoTTF-200M) to standard radiation and immunotherapy is safe for people with melanoma that has spread to the brain. Only one person took part before the study was stopped early. The main goal was…

This study tested whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) could help children aged 8-15 with prolonged post-concussion syndrome after a mild brain injury. The trial planned to enroll 52 participants but was terminated early. The goal was…

This study aimed to see if acceptance and commitment therapy (ACT), a type of talk therapy, could help HIV-positive men with mental health issues like stress and anxiety. Only one person enrolled before the study was stopped early. Because of this, no meaningful results were obta…

This early-stage study tested an experimental drug called MK-6552 in 9 people with narcolepsy type 1, a condition that causes sudden sleep attacks. The goal was to see if the drug was safe and could help patients stay awake during the day. The trial was stopped early, so results …

This study tested whether a mindfulness program (including meditation, body scans, and gentle yoga) could help people with implanted heart devices like ICDs or pacemakers feel less anxious, stressed, and depressed. The study planned to enroll 34 adults who had recently received s…

This study looked at whether adding osteopathic manipulative treatment (OMT) — a hands-on therapy that moves muscles and joints — to standard care helps people recover from concussions. It included 39 people aged 13 to 55 who had a concussion within the last 12 days. The goal was…

This study tested whether adding sophrology (a relaxation method using breathing, visualization, and gentle movement) to speech therapy could reduce anxiety in people with aggressive brain tumors. Only 13 patients were enrolled before the trial was stopped early. The goal was to …

This study tested whether a digital platform could improve collaborative care for depression in cancer patients. About 300 adults receiving cancer treatment with significant depression symptoms were enrolled. The platform aimed to help care managers track symptoms and coordinate …

This study aimed to see if a telephone-supported self-help program called Bounce Back could help people with mild to moderate depression. Participants used cognitive behavioral therapy (CBT) materials at home with coaching over the phone. The study was stopped early and only incl…

This study tested whether a mild electrical current applied to the forehead (tDCS) could make exposure therapy work better for people with social anxiety. Thirty-three adults with public speaking fears gave speeches in virtual reality while receiving either real or fake tDCS. The…

This small pilot study tested a noninvasive brain stimulation technique called tDCS in 5 adults with major depression that hadn't improved after at least 3 antidepressant trials. Participants received up to 20 sessions of higher-than-usual electrical current over 4 to 6 weeks. Th…

This study tested a wearable device that uses gentle vibrations to help stroke survivors improve arm strength and movement. The plan was to have 48 people use the device at home for 4 weeks, but only 4 enrolled before the study was stopped. Researchers measured usability and chan…

This early-stage trial tested an experimental drug called JZP441 in just 6 adults with narcolepsy type 1, a condition that causes sudden daytime sleepiness. The goal was to see if the drug could help people stay awake longer, as measured by a standard sleep test. However, the stu…

This study looked at whether different types of exercise—like treadmill running, balance training, or a mix of balance and thinking tasks—could improve ADHD symptoms and brain function in college students. It planned to enroll 130 students with ADHD and compare them to healthy st…

This study looked at whether using walking poles during an 8-week independent walking program could improve walking and activity levels in people with Parkinson's disease. Eleven participants were assigned to walk with or without poles at least three times a week. The trial was t…

This study looked at whether a cortisone injection into the shoulder joint, combined with physiotherapy, reduces pain and improves movement in people who had a stroke and developed shoulder pain. It included 50 adults in a rehab program. The study was stopped early, so results ar…

This study tested whether a brief 4-session version of cognitive-behavioral therapy (CBT) works as well as the standard 6-session version for treating insomnia in veterans. Insomnia is very common among veterans and can harm daily life and health. The study enrolled 15 veterans w…

This study looked at whether adding cognitive remediation therapy (a type of brain training) to supported education (help returning to school) improves academic functioning in young adults with psychotic disorders. Only 9 people enrolled before the study was stopped early. The go…

This Phase 2 trial tested a neuroscience-based technique combining memory structuring and deep vagal breathing to reduce PTSD symptoms in people with advanced, incurable cancer and their partners. The study enrolled 19 patients who had just received a terminal diagnosis. The appr…

This study tested a drug called CVL-871 to see if it is safe and can help reduce apathy (lack of motivation or interest) in people with dementia. The trial included 41 participants with mild to moderate dementia and clinically significant apathy. The main goal was to check for si…

This study looked at whether the drug safinamide (Xadago) could improve sleep quality in people with Parkinson's disease. Eleven participants took safinamide for 12 weeks while their sleep was measured. The trial was terminated early, so the results are not conclusive.

This pilot study tested whether combining repetitive transcranial magnetic stimulation (rTMS) with computerized cognitive training could help adults with schizophrenia who have thinking and memory problems. Twelve participants received either active or sham rTMS followed by cogni…

This study aimed to see if lasmiditan, a migraine medicine, is safe and works for children aged 6 to 17. It planned to treat migraine attacks and measure pain relief. The trial was stopped early, so final results are limited, but it may still provide useful information about trea…

This study looked at whether a special hand massage technique, called manual lymphatic drainage, could help clear fluid from the brain in people with moderate to severe traumatic brain injury. Only 2 people took part, and the study was stopped early. Researchers measured changes …

This study looked at whether weighted blankets can help reduce agitation and improve sleep in people recovering from a brain injury. Ten adults in a UK rehabilitation unit used the blankets for 7 days. The main goal was to see if such a study is practical in a hospital setting, n…

This study tested a text-message-based diet program called Txt4fasting for people with breast or lung cancer that spread to the brain. The goal was to see if eating only during certain hours could reduce thinking and memory problems after radiation. Only 1 person enrolled before …

This study tested whether the sleep medication suvorexant (20 mg) could help breast cancer survivors who have trouble sleeping. Participants were postmenopausal women taking hormone-blocking drugs. The study was stopped early after enrolling only 5 people, so results are limited.

This study tested whether memantine, a medication for Alzheimer's, could improve social skills in youth aged 8-18 with autism or nonverbal learning disability. The trial was stopped early after enrolling only 25 participants. The main goal was to measure changes in social functio…

This study tested whether adding aticaprant to standard antidepressants could help people with major depression who still feel no pleasure (anhedonia). The trial was stopped early after enrolling only 101 participants. No results are available, so it is unknown if aticaprant work…

This study tested a device called Agilik, a powered leg brace that helps children with cerebral palsy extend their knees while walking. The goal was to see if it improves gait, endurance, and speed. Only 9 children took part, and the study was stopped early, so the results are no…

This study tested whether EEG neurofeedback—a type of brain training that uses real-time brainwave readings—can help people with aphasia (trouble speaking or understanding language) improve their communication, sleep, and anxiety. Seven adults with aphasia from stroke or primary …

This study looked at whether a group therapy program combining psychotherapy and physiotherapy could help women with long-lasting pelvic or belly pain. Only 8 women took part, and the study was stopped early. Researchers measured changes in pain impact, daily activities, and emot…

This study tested whether istradefylline, a drug already approved for motor symptoms in Parkinson's, could also improve apathy and motivation. Only 8 people enrolled before the trial was terminated early. The results are too limited to draw any conclusions.

This study aimed to see if a smartphone app called IONA Mind could help treat depression in people who have had head and neck cancer. Participants would use the app for 6 weeks and fill out surveys. However, the trial was terminated early after enrolling only 1 person, so no mean…

This study compared two treatments for drooling in children with cerebral palsy: Botox injections into the salivary glands and scopolamine skin patches. Both groups also received rehabilitation therapy. The goal was to see which treatment reduced drooling more over 15 months. The…

This study tested whether deep brain stimulation (DBS) could help people with severe Tourette syndrome whose symptoms don't improve with medication. Researchers placed tiny electrodes in a part of the brain called the thalamus to try to calm abnormal signals that cause tics. Only…

This study looked at the long-term safety and symptom relief of an experimental drug called AXS-05 in 181 adults with treatment-resistant depression (depression that hasn't improved with other treatments). Participants took the drug and were monitored for side effects and mood ch…

This small study tested whether flibanserin (Addyi), a drug approved for low sexual desire in women, could also help men with low libido. Eight men aged 18–69 with low desire but normal mood and erectile function took either the drug or a placebo for three months. The trial was t…

This study tested a mindfulness-based mobile app designed specifically for young Black men (ages 18-29) to help them handle stress from racism and reduce alcohol or marijuana use. Participants used a self-guided app, some with real-time feedback, and reported their daily stress a…

This study tested a device called CoolStat that is placed in the nose to cool down brain-injured patients with fever in the ICU. The goal was to see if it could safely and quickly bring their temperature to normal. Only 9 patients were enrolled before the study was stopped early,…

This study tested the drug tianeptine in 38 adults with major depression that did not improve after at least two other treatments. Participants took tianeptine three times a day for 8 weeks. The goal was to see if it reduced depression symptoms and changed how the brain processes…

This study looked at whether oxytocin, a natural brain chemical that helps with social bonding, could improve social functioning in veterans with schizophrenia. Researchers planned to give oxytocin and use brain scans to see who might benefit. The study was stopped early, so resu…

This study tested whether a stepped-care approach using internet-based cognitive behavioral therapy (ICBT) works as well as group therapy or standard medical care for adults with obsessive-compulsive disorder (OCD). 46 adults in China received one of the three treatments for 6 we…

This phase 2 trial tested a combination of two drugs, NRCT-101SR and NRCT-202XR, for teens with ADHD. The goal was to see if the combo could ease symptoms and reduce side effects better than one drug alone. However, the study was terminated early and only enrolled 2 participants,…

This study aimed to see if adding Problem Solving Therapy to standard suicide safety planning could reduce suicidal thoughts in older veterans (age 55+) with depression, anxiety, or PTSD. The trial planned to enroll 117 veterans but was terminated early. The approach focused on t…

This study tested a new medicine called NRCT-101SR for teenagers aged 13 to 17 with ADHD. The goal was to see if it safely reduces ADHD symptoms compared to a placebo. The trial was stopped early, so results are limited. It involved 95 participants and used standard ADHD rating s…

This study tested whether a nasal spray version of the migraine drug Ketorolac, combined with oral Prochlorperazine and Diphenhydramine, could relieve migraine pain in children as effectively as the standard IV treatment. The trial aimed to enroll children aged 4 and older with m…

This study tested whether a magnetic device (rTMS) placed on the scalp could help people who had a stroke regain movement in their arm. The trial planned to include 60 adults with recent ischemic stroke. However, the study was terminated early, so the results are not complete.

This study tested whether using the SinuSonic device—a handheld tool that uses sound and gentle pressure to relieve nasal congestion—could also improve anxiety, depression, and overall well-being in adults with chronic stuffy nose. Sixteen participants used the device for 5 weeks…

This study tested whether adding baclofen (a muscle relaxant) to buprenorphine (a painkiller) could improve pain relief in 19 healthy volunteers. Participants received either a placebo or baclofen alongside buprenorphine and then underwent heat-based pain tests. The trial was ter…

This study aimed to see if a simple eye scan could predict which people with early schizophrenia would benefit from a drug called sodium nitroprusside. The drug was given to reduce psychosis symptoms like delusions and hallucinations. Only one person enrolled before the study was…

This study tested a personalized walking and balance training program using a KineAssist robotic treadmill for people recovering from traumatic brain injury, stroke, or other acquired brain injuries. The goal was to safely challenge and improve walking speed, balance, strength, a…

This study looked at whether adding functional electrical stimulation (FES) to robotic hand therapy could improve arm movement in people who had a stroke within the past year. Researchers planned to compare two groups: one getting standard rehab plus robotic therapy and FES, and …

This study tested a rehabilitation program for hand sensitivity problems in people with multiple sclerosis. The program used TENS (a mild electrical stimulation device) and hand exercises to improve the ability to feel and recognize objects. The goal was to improve quality of lif…

This study looked at the long-term safety of pimavanserin for treating irritability in children and teens (ages 5-17) with autism. It was an extension of an earlier 6-week study, lasting 52 weeks. The trial was terminated early, and results are not yet fully available.

This study aimed to see if the drug ozanimod could help reduce fatigue in people with multiple sclerosis (MS). Researchers planned to follow 26 adults with MS for three months, measuring fatigue using special questionnaires and brain scans. The study was terminated early, so resu…

This study tested an experimental drug called K-645 for people having a migraine attack. It aimed to see if the drug could stop pain and other bothersome symptoms better than a placebo. The trial was stopped early, so results are limited. About 134 adults with a history of migrai…

This study tested a nasal spray called PH94B to see if it could quickly reduce anxiety in adults with social anxiety disorder during a public speaking task. About 228 participants were expected to take the spray or a placebo before speaking. The trial was terminated early, so res…

This study tested whether a virtual reality (VR) tour of the delivery room and neonatal unit could reduce anxiety in pregnant women hospitalized with a high risk of preterm birth. The 85 participants were between 24 and 34 weeks pregnant and had received steroids for fetal lung d…

This study tested whether a high-dose magnetic stimulation (TMS) targeting both motor and cognitive brain areas could better reduce freezing of gait in people with Parkinson's disease compared to standard low-dose stimulation of just the motor area. The trial planned to enroll 64…

This study tested whether adding safe balance challenges (called perturbations) to body-weight supported walking therapy helps stroke survivors improve their balance and walking more than standard therapy alone. Participants were adults in inpatient rehab after a stroke. They use…

This study tested a school-based program called Proud & Empowered, designed to help LGBTQ students cope with minority stress and improve mental health. About 228 high school students took part. The program was led by school counselors and social workers. The study was terminated …

This study looked at whether using the Calm meditation app could help medical residents and fellows at Banner University Medical Center Phoenix feel less stressed, anxious, or burned out during the COVID-19 pandemic. Only 7 people signed up, and the study was stopped early, so we…

This study tested a new drug called REL-1017 as an extra treatment for adults with major depression who didn't get enough help from standard antidepressants. The trial was stopped early and included only 27 participants. The main goal was to see if the drug could reduce depressio…

This study tested a new drug called REL-1017 (esmethadone) as an add-on treatment for people with major depression who weren't helped enough by their current antidepressant. The trial was a Phase 3, double-blind, placebo-controlled study with 236 participants. However, the study …

This study tested a cannabidiol (CBD) oral solution in children under 2 years old with tuberous sclerosis complex, Dravet syndrome, or Lennox-Gastaut syndrome who had uncontrolled seizures. The goal was to see if CBD is safe and can reduce seizures. However, the study was termina…

This study tested a program called 5Minutes4Myself, designed to help caregivers of autistic children (ages 8-21) manage stress and improve their well-being. Participants worked with a coach to create a personalized wellness plan and used a phone app with reminders and mindfulness…

This study tested a wearable armband called Nerivio that uses mild electrical pulses to reduce pain from Botox injections in people with chronic migraine. About 80 participants were planned, but the study was stopped early. The goal was to see if the device could make the injecti…

This study tested the safety of a nasal spray called PH94B for people with social anxiety disorder. Participants used the spray up to 4 times a day for up to 12 months when feeling anxious. The trial was terminated early, so we don't have full results on its safety or effectivene…

This study tested an inhaled form of apomorphine (AZ-009) to quickly treat 'OFF' episodes in people with Parkinson's disease—times when symptoms like stiffness or trouble moving return between regular medication doses. The trial was planned for more participants but was terminate…

This study tested an online support group for young adults (ages 18-39) who had cancer treatment and were feeling anxious or distressed during the COVID-19 pandemic. The goal was to see if teaching healthy coping skills through a virtual group could improve their mood and confide…

This pilot study tested a digital training task called GAMBIT in 50 adults with PTSD. The goal was to see if playing this brain-training game could improve brain circuit flexibility and reduce PTSD symptoms. The study was terminated early, so the findings are limited.

This study tested whether adding a type of talk therapy (behavioral activation) to esketamine treatment helps people with depression that hasn't improved with other treatments. Six adults with major depression or bipolar disorder took part. The goal was to see if practicing new b…

This study tested a new medicine called fosigotifator for adults with major depressive disorder. The goal was to see if it is safe and helps with depression symptoms. About 20 people were enrolled before the study was stopped early. Participants took either the drug or a placebo,…

This study looked at whether a common painkiller (diclofenac potassium) works as well as a newer migraine drug (rimegepant) for stopping migraine pain within 2 hours. About 300 adults with migraine took one of the two medicines during a single attack. The goal was to see if both …

This study tested a sleep therapy program for teenagers aged 12-15 who have both insomnia and mental health issues. The program used cognitive behavioral therapy to improve sleep. Only 3 teens enrolled, and the study was stopped early, so we cannot draw firm conclusions about its…

This pilot study tested whether using brain scans to personalize magnetic stimulation (rTMS) could improve treatment for people with depression that hasn't responded to medication. 27 participants received either personalized rTMS, standard rTMS, or a different type of brain stim…

This study aimed to see if taking glutathione by mouth is safe and practical for children and teens with autism. Researchers planned to enroll 24 participants but stopped early with only 6. The goal was to measure changes in behavior and social skills over 12 weeks.

This study tested a program called PROPEL that combines group aerobic exercise with weekly self-management discussions for people recovering from a stroke. The goal was to see if this approach helps participants stay physically active for six months after leaving rehabilitation. …

This study tested whether nortriptyline, a common antidepressant, could ease headaches after a concussion better than a placebo. It included teens aged 13-21 with recent head trauma. The trial was stopped early after enrolling only 8 people, so the results are not reliable.

This study explored whether training typically developing siblings to teach reading and social skills can help children with autism. The approach used a simple teaching method called model-lead-test, where the sibling shows, practices, and gives feedback. Only 8 families took par…

This study followed 98 people with chronic migraine who used a device that delivers gentle oscillations inside the nose. The goal was to see if regular use could cut down on severe headache days. The trial was terminated early, so the full results are not available, but the appro…

This study tested whether reactive balance training—exercises that involve sudden pushes, pulls, or quick movements—can improve aerobic fitness and leg strength in people who had a stroke at least six months ago. The researchers expected that this training would be as good as sta…

This study tested a new therapy that uses eye-tracking to help veterans with PTSD change how they look at threatening faces. The treatment, called Gaze-Contingent Music Reward Therapy, gives feedback based on where participants look, aiming to reduce stress. The trial included 12…

This study tested whether adding clorazepate (a sedative) to standard migraine medications could provide faster pain relief for people having a migraine attack in the emergency room. The trial included 323 adults with moderate to severe migraine. However, the study was terminated…

This study tested whether a gentle electrical current applied to the scalp (tDCS) during speech therapy could help stroke survivors with aphasia name objects better. Only 5 people took part, and the study was stopped early, so the results are not reliable enough to draw conclusio…

This study observes people who have already been treated with the Pipeline Embolization Device for brain aneurysms. Researchers track neurological complications like stroke or bleeding to better understand the device's safety in everyday use. The goal is to expand knowledge on ho…

This pilot study looked at how the sleep drug zolpidem (Ambien) is processed in men with prostate cancer before and after they start hormone therapy that lowers testosterone. Researchers compared these results to healthy women, since women are known to have higher drug levels. Th…

This study used a special MRI technique to look at tiny brain changes in people who recently had a first episode of symptoms that could lead to multiple sclerosis (MS). Researchers compared 84 participants (patients and healthy controls) to see if early memory problems are linked…

This study compared signs of aging in 123 HIV-infected adults to the general population. Researchers measured bone density, muscle strength, skin changes, and thinking abilities. The goal was to understand if HIV speeds up aging in these areas. No new treatment was tested; it was…

This study tested whether injecting a contrast dye and using ultrasound during brain tumor surgery could help surgeons see the difference between tumor and healthy brain tissue. The goal was to remove more of the tumor safely. Only 2 people were enrolled before the study was stop…

This study tested whether real-time fMRI neurofeedback could help young adults with major depression reduce repetitive negative thinking. Participants received either real or fake feedback while their brain activity was monitored. The trial was terminated early, so the findings a…

This study aimed to see if a simple brain-wave test (LDAEP) could predict which veterans with PTSD or depression would improve with the SSRI medication sertraline (Zoloft). Participants took sertraline or a placebo for 14 weeks while researchers measured their brain activity and …

This study aimed to identify brain areas outside the main motor region that help arm recovery after a severe stroke. Researchers followed 28 patients over time, using MRI and movement tracking to see which brain areas became active as arm function improved. The goal was to find n…

This study tested whether a small implanted device that stimulates the vagus nerve could improve arm and hand function in people who had a stroke at least a year ago. Four participants received either real or sham stimulation paired with physical therapy. The goal was to see how …

This study aimed to understand why people with autism or schizophrenia sometimes struggle to recognize emotions on faces. Researchers used brain wave recordings (EEG) and eye-tracking to see how participants processed facial expressions. The study included people with autism, sch…

This study looked at how noninvasive brain stimulation techniques like rTMS, tDCS, and ECT change BDNF levels in people with depression or schizophrenia. Researchers took blood samples before and after stimulation to measure BDNF, a protein linked to brain health. The study was t…

This study looked at how anesthesia changes brain activity in people with Parkinson's disease or essential tremor who were already scheduled for deep brain stimulation (DBS) surgery. Researchers recorded brain signals during a short period of anesthesia to understand which circui…

This small Phase 2 study aimed to test the safety and dosing of an intravenous drug called allopregnanolone (also known as brexanolone) in 11 people with chronic PTSD. The trial was terminated before completion, so results are limited. The main goal was to monitor sedation levels…

This study compared two breathing techniques (CPAP and eSigh) in 18 patients with brain injury and acute respiratory distress syndrome (ARDS). The goal was to see which method better maintains oxygen levels in the brain without causing harm. The trial was terminated early, so fin…

This study looked at whether a robotic navigation device can help doctors take brain biopsies accurately. The goal was to see if the robot could achieve a 90% success rate in getting a clear tissue sample. Only 4 people with brain tumors took part before the study was stopped. Th…

This study aimed to understand why people with autism often feel overwhelmed by sensory input like bright lights or loud noises. Researchers planned to use virtual reality and brain scans to see how the brain reacts to unpleasant visual stimuli. The study was terminated early and…

This study looked at how memory for speech sounds and movements helps people learn to speak. Researchers used a gentle magnetic pulse to temporarily quiet a part of the brain linked to memory, then tested how well healthy adults could adjust their speech. The goal was to understa…

This study tested a French version of a questionnaire that measures how much patients know about lithium, a drug used for bipolar and schizoaffective disorders. Researchers wanted to see if higher knowledge scores matched safe lithium levels in the blood. The study included 22 ho…

This study looked at how stroke changes the brain's ability to recognize emotions like fear and happiness. Researchers used MRI and EEG to compare stroke patients with healthy volunteers. The study was stopped early and only included 2 participants, so findings are very limited.

This study looked at how being exposed to alcohol before birth might affect adults' ability to read emotions and make decisions. Researchers planned to compare adults with prenatal alcohol exposure to those without, using computer tasks. The study was terminated early and only en…

This study tested whether a single session of magnetic brain stimulation (called rTMS) over a specific brain area could improve pointing movements in people who had a stroke. Only one person took part, and the study was stopped early. The goal was to see if the stimulation could …

This study tested a serious game called Bipolife® for people with bipolar disorder who had already completed a psychoeducation program. The game encourages players to take their medication, keep a daily routine, and contact their doctor if symptoms return. The trial was terminate…

This study looked at whether children with dyslexia have trouble sensing their own body movements (proprioception). Researchers compared 56 French children aged 10-12, half with dyslexia and half without, by testing how well they could detect motion and position. The goal was to …

This small, early-terminated study explored whether measuring certain receptors on immune cells could predict disease activity and rebound risk in multiple sclerosis patients taking or stopping ozanimod. Researchers analyzed blood samples from 23 adults with relapsing-remitting M…

This study tested a software platform called ICU Cockpit that collects and displays vital signs and other data from brain-injury patients in the intensive care unit. The goal was to help doctors make faster, better decisions and to predict complications like strokes or unstable c…

This study followed 167 adults with mental health issues like anxiety, depression, or sleep problems who visited their primary care doctor. Researchers used health conversations and a blood test to track lifestyle changes and heart disease risks over up to 20 years. The goal was …

This study aimed to see if a blood test measuring platelet function could predict neurological events like stroke in people undergoing carotid artery surgery. Researchers planned to enroll 650 patients but the study was terminated early. The test uses a device called Multiplate t…

This pilot study tested a decision aid designed to help older adults with early dementia or depression think about safer ways to store firearms at home. Only 5 people took part, and the study was ended early. The goal was to see if the tool was practical and acceptable, and wheth…

This study looked at whether repeated MRI scans and blood tests could predict changes in thinking and memory after brain radiation. Researchers enrolled 9 adults with brain tumors who were scheduled for radiation. They collected blood samples and performed advanced MRI scans over…

This study looked at whether a liquid biopsy—testing the fluid around the brain and spinal cord—can find tumor DNA in children and young adults with brain tumors. The goal was to see if this safer, non-surgical test could replace risky tissue biopsies for diagnosis and monitoring…

This study tested whether a non-invasive brain stimulation technique called deep rTMS could change brain activity and reduce smoking in people with schizophrenia. Researchers used brain scans to measure changes in brain connections and smoking behavior. The study was small and en…

This study tested whether two gut hormones, GIP and GLP-2, could reduce bone breakdown in children with spinal muscular atrophy, cerebral palsy, or Duchenne muscular dystrophy who use wheelchairs. Participants received a liquid meal and then either a hormone injection or a placeb…

This study looked at how stress, hormonal cycles, illness, and missed medications might affect when symptoms appear or get worse in women with relapsing-remitting multiple sclerosis (RR-MS). Researchers planned to track 80 women over time, recording daily symptom changes. The stu…

This study looked at whether follow-up calls from a headache nurse could help patients with migraines, tension headaches, cluster headaches, or hemicrania continua stay on their preventive medication. 147 participants were randomly assigned to receive nurse calls at 2 and 6 weeks…

This study aimed to observe how MECP2 duplication syndrome progresses over time by measuring biological markers in spinal fluid and blood, and by tracking changes in development, behavior, and seizures. It enrolled 29 males aged 1 month to 65 years with a confirmed genetic diagno…

This small, early study tested a new approach called Auditory Control Enhancement (ACE) for people with schizophrenia who hear voices (auditory hallucinations) that don't respond to medication. ACE combines a mild brain stimulation technique called tDCS with cognitive training. T…

This study tested a smartphone-based program to help veterans with serious mental illness (like PTSD, bipolar disorder, or schizophrenia) better recognize and describe their emotions. The goal was to see if improving emotion awareness could lower suicide risk. Only 11 veterans to…

This study followed 97 people with drug-resistant epilepsy in the UK who had a vagus nerve stimulation (VNS) device implanted. Researchers looked at medical records and patient surveys to see how the therapy affected hospital visits and seizures over time. The goal was to underst…

This early-phase trial tested whether the antifungal drug ketoconazole could block a protein called tGLI1 in brain tumors. It included 15 people with breast cancer that spread to the brain or with a type of brain cancer called glioma. The study was terminated early, so we have li…

This pilot study tested a new brain PET-MR scanner to see if it can capture clear images of brain metabolism and blood flow in people who had COVID-19 and those who did not. Only 3 participants were enrolled before the study ended early. The goal was to develop an imaging protoco…

This study tested whether using a special image-guidance system (AxiEM Stealth) helps doctors place a brain drain more accurately at the bedside compared to the usual freehand method. The drain is needed to relieve pressure in the brain. The study included 31 adults who needed th…

This study looked at whether special MRI scans can detect early brain changes in people with multiple sclerosis who are starting treatment with Tysabri. Researchers planned to follow 70 patients for two years, comparing MRI images before and after treatment. The goal was to find …

This study aimed to track quality of life in 52 patients with brain metastases who received radiosurgery (Gamma Knife). Patients filled out questionnaires before treatment and every 3 months for a year. The study was terminated early, so the full impact on daily life remains uncl…

This study looked at how a gentle brain stimulation technique called tDCS affects thinking and behavior in children aged 10-17 with obsessive-compulsive disorder (OCD). The goal was to understand brain processes linked to OCD, not to treat the condition. Only 6 participants were …

This study tested a drug called Oxycyte in people with severe head injuries to see if it could safely increase oxygen levels in the brain. Only 9 patients took part before the study was stopped early. The main goal was to measure how the drug affected brain chemistry, but no clea…

This study aimed to compare the effects of clozapine versus other antipsychotic medications on inflammation in people with treatment-resistant schizophrenia. Researchers measured inflammatory markers like interleukin-6 in a small group of participants. The study was terminated ea…

This study aimed to create and test an educational resource for children with mild traumatic brain injury (concussion) and their parents. Researchers planned to work with stakeholders like doctors, coaches, and school nurses to develop the resource and see if it could be used in …

This study looked at whether repeatedly pairing facial skin stretches with speech sounds can change how people perceive speech. Researchers tested 160 right-handed adults with no known neurological issues. The study was terminated early, so results are limited.

This study looked at whether measuring a protein called S100B in the blood right after a first seizure could help predict if someone will have more seizures within a year. The researchers planned to follow 37 adults for one year, but the study was stopped early. The goal was to f…

This study looked at whether caregivers' negative beliefs about antipsychotic medications make it harder for people with schizophrenia to stick to their treatment. About 50 patients and their main caregivers answered questionnaires about medication beliefs and adherence. The goal…

This study looked at whether a special exam called Mechanical Diagnosis and Therapy (MDT) could help classify people with concussions based on how they respond to certain movements. Researchers planned to enroll people aged 13 to 65 with neck pain, headache, or dizziness after a …

This study aimed to find brain and movement markers in people with a type of depression that doesn't respond to standard antidepressants, called anhedonic depression. Researchers measured brain waves (P300), walking speed, and hand movements in 36 participants. The goal was to id…

This study tested whether a non-invasive electrical stimulation applied to the skin over the upper spine could temporarily improve arm and hand strength, control, and spasticity in people with traumatic brain injury. Only 14 participants were enrolled before the study was termina…

This study tested a care coordination and motivational interviewing program for women who recently had a preterm birth. The goal was to see if the program was feasible and acceptable to participants. Only 13 women enrolled before the study was terminated, so the findings are very…

This early-phase trial tested whether posaconazole, a drug used for fungal infections, can reach brain tumors in high enough amounts to stop cancer cells from dividing. Seven adults with glioblastoma took the drug before surgery, and researchers measured drug levels in their spin…

This study looked at how allopregnanolone, a natural brain chemical, affects mood and thinking in perimenopausal women with depression. Researchers gave participants either the drug brexanolone (a form of allopregnanolone) or a placebo to see how it changed their tendency to rumi…

This study aimed to see if giving patients extra encouragement before and after esketamine treatment could improve their depression symptoms. Researchers planned to compare a group that received a positive presentation and follow-up session with a group that did not. However, the…

This study looked at whether teens ages 14 to 21 with mild depression or anxiety would use a website to write articles for other teens. The goal was to see if this approach was practical and acceptable. The study was stopped early, and only 12 people took part.

This study looked at whether electrical stimulation of the spinal cord could help widen narrowed brain arteries after a type of stroke called subarachnoid hemorrhage. Only one person was enrolled before the study was stopped early. The goal was to measure changes in blood flow, b…

This study tested a new dry-electrode EEG headset that people with epilepsy can use at home to record their brain activity. Five adults with epilepsy first had a standard EEG in the clinic, then used the dry-electrode headset at home for 14 days. The goal was to see if the home r…

This early-phase trial tested whether ketoconazole, a drug normally used for fungal infections, can enter brain tumors in high enough amounts to stop tumor cells from dividing. Only 1 person was enrolled before the study was terminated. The goal was to measure drug levels in the …

This study looked at whether adding a special imaging test (Cytocam-IDF) to standard monitoring during major vascular surgery could help patients leave the hospital sooner. The trial was planned for more participants but was stopped early after only 22 people took part. Because i…

This study tested a wearable device called Syde® in 86 people with multiple sclerosis. Participants wore the device for one month every six months over two years. The goal was to see if the device's activity data matches standard clinic tests like walking speed and disability sco…

This observational study aimed to understand how stroke affects walking during early recovery. Researchers used motion analysis and brain stimulation to track changes in 6 participants over 6 months. The study was terminated early, so findings are limited.

This study looked at how certain brain areas help us remember new ways of speaking. Researchers used a gentle brain stimulation technique to temporarily quiet parts of the brain involved in touch and hearing, right after people practiced altered speech sounds. The goal was to see…

This study tested a new questionnaire called Prolac-10 to see if it can accurately measure quality of life in people with prolactinoma (a type of pituitary tumor) who are starting medical treatment. Only 8 people took part before the study was stopped early. The goal was to check…

This study aimed to monitor muscle strength and body composition changes in the first 10 days after a severe stroke. Researchers used a device called an impedancemeter to measure muscle mass and a dynamometer to test grip strength. Only 6 people participated before the study was …

This study looked at whether using a condom catheter instead of a standard indwelling urinary catheter (IUC) lowers the chance of delirium in men aged 70+ who had a stroke. Delirium is a sudden confused state that can happen after a stroke. The trial planned to compare two groups…

This study looked at whether having a family member work closely with hospital staff could improve recovery for stroke survivors with spatial neglect—a condition where people ignore one side of their world. The study planned to include more people but was stopped early, so only 1…

This study tested a new questionnaire called the Brain Injury Self-Efficacy Scale to see how well it measures a person's confidence in managing challenges after a brain injury. Researchers compared it with other standard self-efficacy scales. The study involved 150 adults with a …

This early-stage study looked at how two common drugs (carbamazepine and itraconazole) change the levels of radiprodil in the blood of 30 healthy adults. The goal was to understand safety and dosing for future use in neurological conditions like tuberous sclerosis. However, the s…

This study followed 37 migraine patients in the Gulf region who had just started taking erenumab. Researchers measured how satisfied patients were with the treatment over 12 weeks using a questionnaire. The study was observational, meaning patients received their normal care, and…

This pilot study aimed to see if antiseizure drugs like phenobarbital and levetiracetam change brain connectivity patterns in people with severe acute brain injury and reduced consciousness. Only 5 participants were enrolled before the study was terminated. Researchers used resti…

This study looked at stored tumor samples from 139 children with brain and central nervous system tumors. Researchers wanted to find DNA changes and biomarkers that could help understand these cancers better. The study was terminated early, so results may be limited.

This study used MRI brain scans to look at the brain's white matter connections in people with bipolar disorder. Researchers compared those whose illness responds to treatment with those who do not respond, as well as healthy volunteers. The goal was to find brain differences tha…

This study looked at whether measuring two proteins in the blood (S100B and copeptin) can help doctors decide if a child with a head injury needs a CT scan. Many children get CT scans that are normal, exposing them to radiation. The study enrolled 167 children aged 3 months to 15…

This study looked at why some people have more suicidal thoughts when they start or switch antidepressants. 38 adults with major depression used a smartphone app to rate their dark thoughts and mood daily for 30 days. The goal was to better understand and monitor this early risk …

This study looked at how a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) changes brain activity in people with hard-to-treat frontal lobe epilepsy. Researchers measured brain excitability before and after stimulation to unders…

This study tested a new 3D scanner to measure how the brain shifts during surgery for epilepsy or tumor removal. Only one person took part before the study was stopped. The goal was to see if the scanner could accurately track brain surface changes over time, which could help sur…

This study tested an online program called Teacher Help, designed to train teachers in evidence-based strategies for students with ADHD, autism spectrum disorder, or learning disabilities. Teachers worked through six online sessions with support from school psychologists. The goa…

This study looked at whether a digital platform called Horyzons could be used in clinics that help young people with early psychosis. The platform offers therapy content and a safe social network. Researchers wanted to understand what helps or hinders its use in real-world care. …

This study looked at a tiny molecule called microRNA-10b in people with brain tumors called gliomas. Researchers wanted to see if higher levels of this molecule could help predict how the disease might progress or how long patients might live. The study was stopped early, but it …

This study tested whether playing a recording of a mother's voice to premature babies in the NICU could improve brain development, measured by EEG. Fourteen infants born between 28 and 32 weeks gestation were randomly assigned to hear either their mother's voice or a blank record…

This study aimed to compare two common sedatives, propofol and midazolam, in patients with traumatic brain injury who needed a breathing tube. Researchers wanted to see if one drug led to better recovery or different levels of inflammation markers called cytokines. However, the t…

This study tested whether a program called Nurse Family Partnership (NFP) could help pregnant women who already had a child. The program involved regular visits from a nurse to support the mother's health, pregnancy, and child development. The trial enrolled 23 women and aimed to…

This study tested a small device implanted under the scalp to record brain waves (EEG) continuously for up to 12 weeks in people with epilepsy. The goal was to see if it could detect seizures better than standard short-term hospital monitoring and patient diaries. The trial invol…

This study looked at whether intensive treadmill exercise can improve motor symptoms and reduce inflammation in people with early-stage Parkinson's disease. Researchers measured changes in movement scores and blood markers of nerve damage and inflammation in 30 patients who eithe…