Early trial of experimental cancer drug halted; data still under review

NCT ID NCT04543188

Terminated Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-phase study tested a new drug called PF-07284890, alone or with another drug (binimetinib), in 65 people with advanced cancers that have a specific genetic change (BRAF V600 mutation), including cancers that spread to the brain. The trial was terminated early, but researchers collected information on safety, dosing, and how the drug moves through the body. The goal was to find a safe dose and see if the drug shrinks tumors.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: PF-07284890 (also called ARRY-461), given alone or with binimetinib
What this could lead to: If successful, this could point toward a new treatment option for people with BRAF V600-mutated cancers, including those that have spread to the brain.
What could go wrong: This was a very early (Phase 1) study that was terminated, so results are limited. The drug may not prove effective or safe in larger trials.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

brain cancer brain disorder brain neoplasm cancer central nervous system cancer melanoma neoplasm non-small cell lung carcinoma primary brain neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRAIN NEOPLASMS BRAIN NEOPLASMS, PRIMARY CARCINOMA, NON-SMALL-CELL LUNG MALIGNANT MELANOMA MALIGNANT NEOPLASMS

Contacts and locations

Locations

Barnes-Jewish Hospital

St Louis, Missouri, 63110, United States
Brigham & Women's Hospital

Boston, Massachusetts, 02115, United States
City of Hope (City of Hope National Medical Center, City of Hope Medical Center)

Duarte, California, 91010, United States
Dana-Farber Cancer Institute

Boston, Massachusetts, 02215, United States
Dana-Farber Cancer Institute - Chestnut Hill

Newton, Massachusetts, 02459, United States
Duke Eye Center

Durham, North Carolina, 27705, United States
Duke University Medical Center

Durham, North Carolina, 27710, United States
Duke University Medical Center, Investigational Chemotherapy Services

Durham, North Carolina, 27710, United States
Hackensack University Medical Center

Hackensack, New Jersey, 07601, United States
Hadassah Medical Center

Jerusalem, Jerusalem, 9112001, Israel
Imaging: Brigham and Women's Ambulatory Care

Chestnut Hill, Massachusetts, 02467, United States
Imaging: Brigham and Women's Hospital

Boston, Massachusetts, 02115, United States
Imaging: Brigham and Women's Mass General Healthcare Center

Foxborough, Massachusetts, 02035, United States
Imaging: Brigham and Women's Radiology, Coolidge Corner Imaging

Brookline, Massachusetts, 02446, United States
John Theurer Cancer Center at Hackensack University Medical Center

Hackensack, New Jersey, 07601, United States
Johns Hopkins University / Johns Hopkins Hospital

Baltimore, Maryland, 21231, United States
MSK Commack

Commack, New York, 11725, United States
MSK Monmouth.

Middletown, New Jersey, 07748, United States
MSKCC-Westchester (500 Westchester Ave.)

Harrison, New York, 10604, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Memorial Sloan Kettering Cancer Center - David H. Koch Center for Cancer Care (74th Street).

New York, New York, 10021, United States
Moffitt Cancer Center

Tampa, Florida, 33612, United States
Northwestern Medical Group

Chicago, Illinois, 60611, United States
Northwestern Memorial Hospital

Chicago, Illinois, 60611, United States
Ophthalmic Consultants of Boston Inc (OCB)

Boston, Massachusetts, 02114, United States
Orlando Health Cancer Institute

Orlando, Florida, 32806, United States
Princess Margaret Cancer Centre

Toronto, Ontario, M5G 2M9, Canada
Rabin Medical Center

Petah Tikva, Central District, 49100, Israel
Rambam Health Care Campus

Haifa, ?eif?, 3109601, Israel
Richard M Schulze Family Foundation Outpatient Center at McKinley Campus

Tampa, Florida, 33612, United States
Rockefeller Outpatient Pavilion (53rd Street)

New York, New York, 10022, United States
Sheba Medical Center

Ramat Gan, Central District, 5262100, Israel
Siteman Cancer Center - North County

Florissant, Missouri, 63031, United States
Siteman Cancer Center - South County

St Louis, Missouri, 63129, United States
Siteman Cancer Center - St Peters

City of Saint Peters, Missouri, 63376, United States
Siteman Cancer Center - West County

Creve Coeur, Missouri, 63141, United States
Sourasky Medical Center

Tel Aviv, TELL ABĪB, 6423906, Israel
Tennessee Oncology PLLC

Franklin, Tennessee, 37067, United States
Tennessee Oncology PLLC

Nashville, Tennessee, 37203, United States
The University of Texas MD Anderson Cancer Center

Houston, Texas, 77030, United States
UCSF Helen Diller Family Comprehensive Cancer Center

San Francisco, California, 94143, United States
UNC Hospitals, The University of North Carolina at Chapel Hill

Chapel Hill, North Carolina, 27514, United States
University of Iowa Hospitals and Clinics

Iowa City, Iowa, 52242, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States

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