Treadmill training may slow Parkinson's by fighting inflammation

NCT ID NCT05815524

Terminated Knowledge-focused Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study looked at whether intensive treadmill exercise can improve motor symptoms and reduce inflammation in people with early-stage Parkinson's disease. Researchers measured changes in movement scores and blood markers of nerve damage and inflammation in 30 patients who either exercised or continued their usual routine. The goal was to see if physical activity could act as a disease-modifying approach, but the study was terminated early, so results are limited.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: treadmill training
What this could lead to: If successful, this could point toward physical activity as a way to slow Parkinson's progression by reducing inflammation and supporting brain health.
What could go wrong: The study was terminated early and enrolled only 30 people, so results are limited. It is not a treatment and may not apply to all Parkinson's patients.

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Conditions

The condition(s) this trial relates to.

Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PARKINSON DISEASE

Contacts and locations

Locations

Flavia Torlizzi

Roma, 00168, Italy

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