Pain relief combo falls short: early trial halted

NCT ID NCT04251819

Terminated Symptom relief Sponsor: University of Alabama at Birmingham Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether adding baclofen (a muscle relaxant) to buprenorphine (a painkiller) could improve pain relief in 19 healthy volunteers. Participants received either a placebo or baclofen alongside buprenorphine and then underwent heat-based pain tests. The trial was terminated early, so the results are not conclusive.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: buprenorphine and baclofen
What this could lead to: If it worked, this combination could offer better pain relief with lower opioid doses, potentially reducing side effects and addiction risk.
What could go wrong: The trial was terminated early and only included 19 healthy volunteers, so results are very limited. It is not known if the combination is safe or effective for people with pain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Acute Pain agnosia pain agnosia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE PAIN ANALGESIA

Contacts and locations

Locations

University of Alabama, Birmingham

Birmingham, Alabama, 35209, United States

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