Dravet syndrome drug trial halted early: did lorcaserin help?

NCT ID NCT04572243

Terminated Disease control Sponsor: Eisai Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether lorcaserin, when added to current medications, could reduce convulsive seizures in people with Dravet syndrome, a severe form of epilepsy. The trial planned to enroll about 22 participants aged 2 and older, but it was terminated early. The main goal was to measure the change in seizure frequency over 28 days compared to a placebo.

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Conditions

The condition(s) this trial relates to.

Dravet syndrome Epilepsies, Myoclonic epilepsy myoclonic epilepsy visual epilepsy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EPILEPSIES, MYOCLONIC

Contacts and locations

Locations

Alberta Children's Hospital

Calgary, Alberta, AB T3B 6A8, Canada
BC Children's Hospital

Vancouver, British Columbia, V6H 3N1, Canada
Children's Hospital - VH, London Health Sciences Centre

London, Ontario, N6A 4G5, Canada
Children's Hospital Colorado

Aurora, Colorado, 80045, United States
Children's Hospital of Pittsburgh of UPMC

Pittsburgh, Pennsylvania, 15224, United States
Children's of Alabama / University of Alabama at Birmingham

Birmingham, Alabama, 35226, United States
Duke University Hospital Center

Durham, North Carolina, 27710, United States
Institute of Neurology and Neurosurgery at Saint Barnabas

Livingston, New Jersey, 07039, United States
Joe DiMaggio Children's Hospital

Hollywood, Florida, 33021, United States
Miami Children's Hospital - Nicklaus Children's Hospital

Miami, Florida, 33155, United States
Mid-Atlantic Epilepsy and Sleep Center - Bethesda

Bethesda, Maryland, 20817, United States
MultiCare Institute for Research & Innovation

Tacoma, Washington, 98405, United States
NYU Langone Comprehensive Epilepsy Center

New York, New York, 10016, United States
New York Medical College

New York, New York, 10019-1147, United States
NorthWell Health - Lennox Hill Hospital

New York, New York, 11021, United States
Northwell Health - Neuroscience Institute at Great Neck

New Hyde Park, New York, 10075, United States
Northwest Florida Clinical Research Group

Gulf Breeze, Florida, 32561, United States
Pediatric Neurology, P.A.

Winter Park, Florida, 32789, United States
Rare Disease Research Center Pediatrics, LLC

Atlanta, Georgia, 30318, United States
Seattle Children's Hospital

Seattle, Washington, 98105, United States
Spectrum Health/ Helen DeVos Children's Hospital

Grand Rapids, Michigan, 49503, United States
Stollery Children's Hospital

Edmonton, Alberta, T6G 1C9, Canada
The University of Texas Health Science Center at Houston

Houston, Texas, 77030, United States
UCSD Rady's Children's Hosptial

San Diego, California, 92123, United States
University Hospitals Cleveland Medical Center

Cleveland, Ohio, 44106, United States
University of California Los Angeles (UCLA)

Los Angeles, California, 90095, United States
University of Missouri, Department of Child Health, Division of Neurology

Columbia, Missouri, 65201, United States
University of North Carolina

Chapel Hill, North Carolina, 27599-7025, United States
University of Rochester Medical Center

Rochester, New York, 14642, United States
University of Toronto Division of Hematology Oncology/The Hospital for Sick Children

Toronto, Ontario, M5G 1X8, Canada

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