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MS drug trial halted after failing to reduce nerve damage

NCT ID NCT05630547

Terminated Disease control Sponsor: Sanofi Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 10, 2026 · Updated 22 times

Summary

This study tested an experimental oral drug (SAR443820) in 174 adults with multiple sclerosis (MS) to see if it could lower a marker of nerve damage in the blood. The study was stopped early because the drug did not show a clear benefit compared to a placebo. Participants were followed for up to 96 weeks, but the main goal was not met.

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Contacts and locations

Locations

  • Investigational Site Number : 0560001

    Brussels, BE-1200, Belgium

  • Investigational Site Number : 0560002

    Ghent, 9000, Belgium

  • Investigational Site Number : 0560003

    Overpelt, 3900, Belgium

  • Investigational Site Number : 1000001

    Sofia, 1407, Bulgaria

  • Investigational Site Number : 1000002

    Sofia, 1431, Bulgaria

  • Investigational Site Number : 1000003

    Sofia, 1680, Bulgaria

  • Investigational Site Number : 1240001

    Gatineau, Quebec, J8Y 1W2, Canada

  • Investigational Site Number : 1240002

    Ottawa, Ontario, K1H 8L6, Canada

  • Investigational Site Number : 1240003

    Lévis, Quebec, G6W0M5, Canada

  • Investigational Site Number : 1240004

    Toronto, Ontario, M5B 1W8, Canada

  • Investigational Site Number : 1520001

    Santiago, Reg Metropolitana de Santiago, 8380456, Chile

  • Investigational Site Number : 1560001

    Tianjin, 300052, China

  • Investigational Site Number : 1560002

    Shanghai, 200040, China

  • Investigational Site Number : 1560003

    Chengdu, 610041, China

  • Investigational Site Number : 1560004

    Xi'an, 710038, China

  • Investigational Site Number : 2500001

    Paris, 75013, France

  • Investigational Site Number : 2500002

    Nice, 06001, France

  • Investigational Site Number : 2500003

    Strasbourg, 67098, France

  • Investigational Site Number : 2500004

    Caen, 14033, France

  • Investigational Site Number : 2760002

    Würzburg, 97074, Germany

  • Investigational Site Number : 3800001

    Pozzilli, Isernia, 86077, Italy

  • Investigational Site Number : 3800002

    Milan, 20132, Italy

  • Investigational Site Number : 3800003

    Milan, 20133, Italy

  • Investigational Site Number : 3800005

    Cagliari, 09126, Italy

  • Investigational Site Number : 6160001

    Krakow, 31-503, Poland

  • Investigational Site Number : 6160002

    Katowice, Silesian Voivodeship, 40-571, Poland

  • Investigational Site Number : 6160004

    Plewiska, Greater Poland Voivodeship, 62-064, Poland

  • Investigational Site Number : 6160005

    Katowice, Silesian Voivodeship, 40-686, Poland

  • Investigational Site Number : 6160006

    Zabrze, 41-800, Poland

  • Investigational Site Number : 7240001

    Barcelona, Barcelona [Barcelona], 08035, Spain

  • Investigational Site Number : 7240002

    Seville, Andalusia, 41009, Spain

  • Investigational Site Number : 7240003

    Madrid, Madrid, Comunidad de, 28040, Spain

  • Investigational Site Number : 7240004

    Madrid / Madrid, Madrid, Comunidad de, 28007, Spain

  • Investigational Site Number : 7240005

    Murcia, 30120, Spain

  • Investigational Site Number : 7240006

    Madrid, 28034, Spain

Conditions

Explore the condition pages connected to this study.

MULTIPLE SCLEROSIS