Brain tumor drug trial halted before results
NCT ID NCT01068782
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested the drug cabozantinib in 19 people with a severe type of brain tumor (grade IV astrocytic tumors) that had come back after initial treatment. The goal was to see if the drug could shrink tumors or slow progression. However, the company stopped the trial early for business reasons, so no effectiveness data were collected. The study only provides safety information from a small group.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- cabozantinib (XL-184)
- What this could lead to
- If it had succeeded, this could have pointed toward a new treatment option for recurrent brain tumors.
- What could go wrong
- The trial was terminated early for business reasons before any efficacy data were collected, so we don't know if cabozantinib works for this cancer. Only 19 people enrolled, making results very limited.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Study site
Birmingham, Alabama, 35294, United States
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Study site
Encinitas, California, 92024, United States
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Study site
Pleasant Hill, California, 94523, United States
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Study site
Chicago, Illinois, 60611, United States
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Study site
Chicago, Illinois, 60637, United States
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Study site
Boston, Massachusetts, 02115, United States
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Study site
Detroit, Michigan, 48202, United States
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Study site
Minneapolis, Minnesota, 55407, United States
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Study site
Amherst, New York, 14226, United States
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Study site
Rochester, New York, 14642, United States
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Study site
Cleveland, Ohio, 44195, United States
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Study site
Hershey, Pennsylvania, 17033, United States
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Study site
Dallas, Texas, 75246, United States
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Study site
Dallas, Texas, 75426, United States
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Study site
San Antonio, Texas, 78229, United States
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Study site
Charlottesville, Virginia, 22908, United States
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Study site
Seattle, Washington, 98122, United States
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Study site
Calgary, Alberta, Canada
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Study site
Montreal, Quebec, Canada