New drug tested for newborn seizures – but trial halted early

NCT ID NCT04519645

Terminated Disease control Sponsor: UCB Biopharma SRL Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested the drug lacosamide in newborns with repeated seizures that were not controlled by standard medicines. The trial was small (29 babies) and was stopped early. Researchers compared lacosamide to usual care to see if it could reduce seizure time on brain monitoring.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: lacosamide
What this could lead to: If it works, this could point toward a new treatment option for seizures in newborns that are not controlled by other medicines.
What could go wrong: This was a small, early-stage trial that was terminated, so results are limited. It is unclear if lacosamide is safe or effective for this use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

epilepsy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ELECTROENCEPHALOGRAPHIC NEONATAL SEIZURES EPILEPSY

Contacts and locations

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Locations

Sp0968 101

La Jolla, California, 92037, United States
Sp0968 102

Charlottesville, Virginia, 22903, United States
Sp0968 104

Jacksonville, Florida, 32207, United States
Sp0968 105

Salt Lake City, Utah, 84132, United States
Sp0968 107

Miami, Florida, 33155, United States
Sp0968 108

Long Beach, California, 90806, United States
Sp0968 109

Austin, Texas, 78723, United States
Sp0968 112

Iowa City, Iowa, 52242, United States
Sp0968 116

Los Angeles, California, 90095, United States
Sp0968 117

Portland, Oregon, 97239, United States
Sp0968 118

Aurora, Colorado, 80045, United States
Sp0968 122

Seattle, Washington, 98105, United States
Sp0968 125

Valhalla, New York, 10595, United States
Sp0968 190

San Diego, California, 92123, United States
Sp0968 192

Salt Lake City, Utah, 84113, United States
Sp0968 201

Toronto, Canada
Sp0968 301

South Brisbane, Australia
Sp0968 302

Parkville, Australia

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