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Can a scalp device quiet deep brain circuits? a new study investigates

NCT ID NCT07790224

Knowledge-focused Sponsor: Beijing Sanbo Brain Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 27, 2026 · Last updated Aug 28, 2026 · Updated 1 time

Summary

This study tests whether temporal interference (TI) stimulation, a non-invasive technique using scalp electrodes, can safely modulate activity in deep brain regions. Researchers will enroll 60 adults with epilepsy who already have implanted electrodes for monitoring. They will deliver TI stimulation at various frequencies and record brain signals before, during, and after. The goal is to understand how different stimulation parameters affect brain activity, which could help optimize this approach for future treatments.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Temporal interference (TI) stimulation, a non-invasive brain stimulation technique using scalp electrodes to target deep brain regions
What this could lead to
If it works, this could refine non-invasive deep brain stimulation for epilepsy and other brain disorders, offering a safer alternative to surgery.
What could go wrong
This is an early exploratory study with a small number of participants. The effects may be subtle or vary widely, and the approach may not translate into clinical benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged 18 to 70 years, inclusive, with no restriction on sex. * Has undergone stereoelectroencephalography (SEEG) electrode implantation, with electrode contacts covering the target deep brain region(s), such as the thalamus, hippocampus, amygdala, or cingulate cortex. * Is in the postoperative SEEG monitoring period, is clinically stable, and is able to comply with the study procedures. * The participant or the participant's legally authorized representative is able to fully understand the purpose and procedures of the study and voluntarily provides written informed consent. Exclusion Criteria: * Contraindications to magnetic resonance imaging (MRI), such as incompatible metallic implants or a cardiac pacemaker. * Psychiatric disorders or severe cognitive impairment. * Structural brain abnormalities, such as cerebral infarction, hydrocephalus, or severe thalamic atrophy. * Other severe neurological disorders that may interfere with participation in the study. * Medical or psychiatric contraindications, including recent myocardial infarction, cardiac arrhythmia, stroke, autonomic dysfunction, endocrine disorders, uncontrolled or difficult-to-control hypertension or hypotension, deep brain stimulation for other reasons, degenerative central nervous system disorders, or severe electrolyte disturbances. * Pregnancy or breastfeeding. * Participation in another drug or medical device clinical study within 3 months before screening. * Any other condition that, in the investigator's judgment, makes the participant unsuitable for the study.

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Conditions

The condition(s) this trial relates to.

epilepsy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Epilepsy

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Beijing Sanbo Brain Hospital

    Beijing, Beijing Municipality, 100018, China

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