Brain waves may reveal who responds to ketamine for depression in epilepsy

This study explores whether a single low-dose ketamine infusion can reduce depressive symptoms in adults with epilepsy who are already undergoing brain monitoring for their seizures. Participants receive one intravenous dose of ketamine while their brain activity is recorded directly from electrodes placed inside the skull. By comparing brain signals and mood assessments before and about 24 hours after the infusion, researchers hope to identify patterns that predict a positive antidepressant response.