Parkinson's inhaler trial halted after just 8 patients

NCT ID NCT05979415

Terminated Symptom relief Sponsor: Alexza Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested an inhaled form of apomorphine (AZ-009) to quickly treat 'OFF' episodes in people with Parkinson's disease—times when symptoms like stiffness or trouble moving return between regular medication doses. The trial was planned for more participants but was terminated early, with only 8 people enrolled. Because it stopped so early, we don't have enough information to know if the treatment works or is safe.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Staccato Apomorphine (AZ-009)
What this could lead to: If it works, this could provide a fast-acting treatment to quickly relieve Parkinson's 'OFF' episodes when symptoms return between medication doses.
What could go wrong: This trial was terminated early and enrolled only 8 people, so results are very limited. The drug may not prove effective or safe in larger studies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PARKINSON DISEASE

Contacts and locations

Locations

Accellacare of Piedmont Healthcare

Statesville, North Carolina, 28265, United States
Bradenton Research Center, Inc.

Bradenton, Florida, 34205, United States
CenExel iResearch Atlanta (Decatur)

Decatur, Georgia, 30030, United States
Cenexel Rocky Mountain Clinical Research

Englewood, Colorado, 80113, United States
Holy Cross Health

Fort Lauderdale, Florida, 33308, United States
KCA Neurology, (Part of Ki Health Partners, LLC)

Franklin, Tennessee, 37067, United States
Lone Star Neurology, (Part of Ki Health Partners, LLC)

Frisco, Texas, 75035, United States
Movement Disorders Center of Arizona

Scottsdale, Arizona, 85258, United States
Parkinson's Disease Treatment Center of Southwest Florida

Port Charlotte, Florida, 33980, United States
Quest Research Institute

Farmington Hills, Michigan, 48334, United States
The Parkinson's and Movement Disorder Institute

Fountain Valley, California, 92708, United States
Tuscon Neuroscience Research (M3 Wake Research)

Tucson, Arizona, 85710, United States
Visionary Investigators Network

Miami, Florida, 33133, United States

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