New drug combo aims to tame acromegaly hormone levels

NCT ID NCT07037420

Recruiting now Disease control Sponsor: Alexion Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial tests whether adding ALXN2420 (a growth hormone blocker) to standard acromegaly treatment can lower IGF-1 levels more than placebo. About 60 adults with acromegaly who are already on a stable dose of somatostatin analogs will receive either ALXN2420 or placebo injections for 15 weeks. The main goal is to see if the drug reduces IGF-1 levels, a key marker of disease control.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

ALXN2420 (a growth hormone blocker)

What this could lead to

If it works, this could offer a new treatment option for people with acromegaly whose disease is not fully controlled by current therapy.

What could go wrong

This is an early phase 2 trial with only 60 participants, so results may not apply to everyone. The drug may not lower hormone levels enough or could cause side effects.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

acromegaly

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACROMEGALY

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

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Los Angeles, California, 90048, United States
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Los Angeles, California, 90095, United States
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Torrance, California, 90502, United States
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WITHDRAWN

Aurora, Colorado, 80045, United States
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Boston, Massachusetts, 02114, United States
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Ann Arbor, Michigan, 48109, United States
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Las Vegas, Nevada, 89148, United States
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New York, New York, 10032, United States
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Portland, Oregon, 97239, United States
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CABA, C1012AAR, Argentina
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Ciudad de Buenos Aires, C1180AAD, Argentina
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Ciudad de Buenos Aires, C1199, Argentina
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Ciudad de Buenos Aires, C1405DCS, Argentina
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Curitiba, 80030-110, Brazil
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Ribeirão Preto, 14049-901, Brazil
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Rio de Janeiro, 20231-092, Brazil
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São Paulo, 01420-000, Brazil
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Beijing, 100730, China
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Guangzhou, 510120, China
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Kunming, 650032, China
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Shanghai, 201107, China
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Copenhagen, 2100, Denmark
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Odense, 5464, Denmark
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Budapest, 1083, Hungary
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Budapest, 1134, Hungary
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Pécs, 7624, Hungary
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Szeged, 6725, Hungary
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Cona, 44124, Italy
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Genoa, 16132, Italy
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Messina, 98125, Italy
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NOT_YET_RECRUITING

Milan, 20132, Italy
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Naples, 80131, Italy
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Pisa, 56126, Italy
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Roma, 00168, Italy
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Kaunas, LT50009, Lithuania
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Vilnius, 09112, Lithuania
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NOT_YET_RECRUITING

Leiden, 2333 ZA, Netherlands
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Rotterdam, 3015 CE, Netherlands
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WITHDRAWN

Bydgoszcz, 85-605, Poland
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NOT_YET_RECRUITING

Gliwice, 44-102, Poland
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NOT_YET_RECRUITING

Krakow, 31-501, Poland
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Warsaw, 03-242, Poland
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Wroclaw, 50-367, Poland
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Bucharest, 011863, Romania
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NOT_YET_RECRUITING

Cluj-Napoca, 400006, Romania