New pill aims to stop panic attacks in their tracks

NCT ID NCT05941442

Terminated Symptom relief Sponsor: AbbVie Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial tested whether darigabat, an oral tablet, could help people with panic disorder. About 80 participants took either darigabat or a placebo for several weeks. The goal was to see if the drug could reduce panic attacks and improve overall symptoms. The study was terminated early, so results are limited.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: darigabat (also known as CVL-865), an oral tablet
What this could lead to: If it works, darigabat could offer a new treatment option to reduce panic attacks and ease panic disorder symptoms.
What could go wrong: This was a small, early-phase trial that was terminated, so results may be incomplete. It is not yet proven to be safe or effective for widespread use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

panic disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PANIC DISORDER

Contacts and locations

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Locations

Atlanta, Georgia

Atlanta, Georgia, 30331, United States
Austin, Texas

Austin, Texas, 78737, United States
Berlin, New Jersey

Berlin, New Jersey, 08009, United States
Boston, Massachusetts

Boston, Massachusetts, 02131, United States
Brooklyn, New York

Brooklyn, New York, 11229, United States
Brooklyn, New York

Brooklyn, New York, 11235, United States
Decatur, Georgia

Decatur, Georgia, 30030, United States
Desoto, Texas

DeSoto, Texas, 75115, United States
Draper, Utah

Draper, Utah, 84020, United States
Elgin, Illinois

Elgin, Illinois, 60123, United States
Everett, Washington

Everett, Washington, 98201, United States
Lafayette, California

Lafayette, California, 94549, United States
Las Vegas, Nevada

Las Vegas, Nevada, 89102, United States
Los Angeles, California

Los Angeles, California, 90025, United States
Miami, Florida

Miami, Florida, 33175, United States
Monroe, North Carolina

Monroe, North Carolina, 28112, United States
New York, New York

New York, New York, 10016, United States
North Miami Beach, Florida

North Miami Beach, Florida, 33162, United States
Oceanside, California

Oceanside, California, 92056, United States
Oklahoma City, Oklahoma

Oklahoma City, Oklahoma, 73112, United States
Orange, California

Orange, California, 92868, United States
Orlando, Florida

Orlando, Florida, 32807, United States
Overland Park, Kansas

Overland Park, Kansas, 66210, United States
Phoenix, Arizona

Phoenix, Arizona, 85012, United States
Riverside, California

Riverside, California, 92506, United States
Rochester, New York

Rochester, New York, 14618, United States
San Jose, California

San Jose, California, 95124, United States
Savannah, Georgia

Savannah, Georgia, 31405, United States
Staten Island, New York

Staten Island, New York, 10314, United States
Torrance, California

Torrance, California, 90502, United States
West Chester, Pennsylvania

West Chester, Pennsylvania, 19380, United States

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