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A wearable ankle robot may boost walking recovery after stroke

NCT ID NCT07804342

Disease control Sponsor: University of Maryland, Baltimore Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 04, 2026 · Last updated Sep 04, 2026

Summary

This pilot trial tests whether training with a portable robotic ankle exoskeleton, called AMBLE, can improve ankle push-off and walking speed in adults with chronic stroke and ankle weakness. Participants will complete 30 walking training sessions over 8 to 9 weeks while wearing the device. Researchers will measure ankle propulsion and walking speed before, during, and after training to see if the robot helps restore ankle motor control.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
AMBLE, a portable robotic ankle exoskeleton that assists or resists ankle movement during walking training
What this could lead to
If it works, this could point toward a practical home or clinic-based robotic therapy to improve walking speed and ankle strength after stroke.
What could go wrong
This is a small pilot study with only 10 participants, so results may not apply to everyone. The device may not be comfortable or effective for all users, and training requires many sessions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 10 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2025

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 88 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Chronic stroke, more than 6 months post-stroke * Clinical evidence of hemiparetic gait * Ankle dorsiflexion and plantarflexion strength on the affected side graded 1/5 (trace contraction) to 4/5 (reduced strength) on manual muscle testing * Able to independently complete the 10-Meter Walk Test at a walking speed less than 1.0 m/s, with or without an assistive device Exclusion Criteria: * Self-reported unstable angina, myocardial infarction within the past 3 months, congestive heart failure (NYHA Class II), or hemodynamically significant valvular disease * Self-reported hypertension that is a contraindication to routine physical therapy (greater than 160/100 mmHg on two assessments) * Self-reported hospitalization within the past 3 months for severe medical illness * Self-reported symptomatic peripheral arterial occlusive disease * Self-reported orthopedic conditions or chronic pain that significantly alter gait function * Self-reported pulmonary or renal failure * Self-reported active cancer * Self-reported history of a non-stroke neuromuscular disorder restricting gait * Aphasia or cognitive functioning that confounds participation, defined as unable to follow two-step commands or by judgment of the evaluating therapist * Self-reported history of cerebellar stroke or observable cerebellar signs * Self-reported botulinum toxin prescribed for the lower extremities within the previous 3 months

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Conditions

The condition(s) this trial relates to.

stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic stroke

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Allied Health Research Building

    Baltimore, Maryland, 21042, United States

  • Allied Health Research Building

    Baltimore, Maryland, 21201, United States

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