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This study tests a personalized cancer vaccine (ABO2109) combined with an immunotherapy drug (toripalimab) in 50 adults with solid tumors. The goal is to see if the vaccine is safe and triggers an immune response against the cancer. Participants must have good organ function and …

This early-phase study tests a new vaccine called YMN-136 in 9 people with advanced colorectal cancer that has spread to the liver and has not responded to three prior treatments. The main goals are to check the vaccine's safety and find the best dose. Researchers will also watch…

This phase 2 trial tests whether the combination of pembrolizumab (an immunotherapy) and lenvatinib (a targeted therapy) can shrink tumors in people with advanced anal squamous cell cancer that cannot be removed by surgery or has spread to other organs. Participants must have alr…

This trial is testing a new drug called DS1025a in people with advanced solid tumors that have spread, cannot be removed by surgery, or have stopped responding to other treatments. The main goals are to check the drug's safety, how the body processes it, and whether it shows any …

This early-phase trial will test whether adding semaglutide (a GLP-1 drug used for diabetes and weight loss) to standard chemotherapy is safe and tolerable for people with metastatic pancreatic, colorectal, or liver cancer. About 30 participants will receive weekly semaglutide in…

This trial provides continued access to three experimental Bicycle therapies—zelenectide pevedotin, nuzefatide pevedotin, and BT7480—for people with advanced solid tumors who are already benefiting from them in another study. Participants continue their same treatment while resea…

This early-stage trial tests a new drug called SI-B036, a bispecific antibody designed to fight advanced gastrointestinal and other solid tumors. The study involves about 16 adults with tumors that have spread or cannot be removed. Researchers aim to find a safe dose and see if t…

This phase 2 trial is testing whether giving two drugs—Zanzalintinib and Retifanlimab—before surgery can help patients with early-stage colon cancer. The study enrolls adults aged 18 to 80 with a type of colon cancer called pMMR that can be removed surgically. Participants receiv…

This study tests an experimental oral drug called GFH276 combined with either cetuximab or standard chemotherapy in people with advanced solid tumors or pancreatic ductal adenocarcinoma (PDAC) that have a RAS mutation. The goal is to see if the combination is safe, tolerable, and…

This phase 3 trial tests whether adding the experimental drug SHR-A1811 to standard chemotherapy and bevacizumab works better than standard therapy alone for people with advanced colorectal cancer who have not had prior treatment. About 300 participants will receive either the ne…

This early-stage trial tests a new drug called SHR-4685 in people with advanced solid tumors that have not responded to other treatments. The main goals are to check the drug's safety, find the best dose, and see how the body processes it. About 170 adults aged 18 to 75 with meas…

This study tests a new biologic drug called XYA02 in 190 adults with advanced solid tumors (including lung, ovarian, and pancreatic cancers) that have not responded to standard treatments. The main goals are to check safety, find the best dose, and see if the drug can shrink tumo…

This phase 2 trial tests whether adding an experimental drug called tovecimig to standard chemotherapy (FOLFIRI) can shrink tumors or slow cancer growth in people with metastatic colorectal cancer who have already tried one prior treatment. The study will enroll 25 participants a…

This phase 2 trial tests whether combining sintilimab (an immunotherapy) with gossypol acetate (a compound from cottonseed) can shrink tumors in people with advanced colorectal cancer that has not responded to at least two prior treatments. The study will enroll 32 adults aged 18…

This extension trial follows patients with advanced solid tumors who are already receiving or have received gotistobart in earlier studies. The goal is to assess long-term safety and overall survival over an extended period. Participants must be 18 or older and have been part of …

This phase 2 trial tests whether adding a new form of interferon (rSIFN-co) to standard total neoadjuvant therapy (short-course radiation plus chemotherapy) can improve the chance of complete tumor disappearance in people with mid-low locally advanced rectal cancer. About 90 adul…

This Phase 1 trial tests D3L-002, a new drug that targets two immune checkpoints (TIGIT and PVRIG) to help the immune system fight cancer. It is for 24 adults with advanced solid tumors that have not responded to standard treatments. The main goals are to check safety, find the r…

This early-stage trial is testing a new cell therapy called GK01 in 10 people with advanced solid tumors that have stopped responding to standard treatments. The therapy uses the patient's own immune cells (T cells) that are trained to attack the tumor. The main goal is to check …

This study tests a new drug called LM-168 combined with other cancer treatments (tislelizumab or docetaxel) in 108 adults with advanced solid tumors. The first part finds a safe dose; the second part checks if the combination shrinks tumors. It is not yet recruiting.

This study tests whether adjusting common over-the-counter medications can make immune checkpoint inhibitors work better for people with solid tumors. Participants are asked to avoid acetaminophen and cannabis/THC/CBD, while taking aspirin and loratadine (or similar antihistamine…

This early-stage trial tests LNF2105, a drug designed to target and deliver a toxin to cancer cells that have a protein called Nectin-4 on their surface. It will enroll about 294 adults with advanced solid tumors (such as bladder, breast, or lung cancer) who have run out of stand…

This study tests an experimental pill called VS-7375, designed to block a specific cancer-driving protein (KRAS G12D). The trial includes people with metastatic colorectal cancer that has this mutation. Some participants receive VS-7375 alone, others get it combined with an antib…

This study looks at whether immunotherapy can shrink certain gastrointestinal cancers (like colorectal or stomach cancer) enough that some patients may not need major surgery. People whose tumors have specific genetic features (MSI-H/dMMR or POLE mutation) and who respond well to…

This early-stage trial tests a drug called ACM-CpG, which is injected directly into the abdomen to stimulate the immune system against cancer. It includes 24 adults with colorectal or appendix cancer that has spread to the lining of the abdomen or caused fluid buildup. The main g…

This early-stage trial tests a new approach to CAR-T therapy where a virus is injected directly into the bloodstream to reprogram a patient's own immune cells to attack cancer. It involves 91 adults with advanced solid tumors who have run out of standard options. The main goal is…

This study tests an experimental oral drug called VMD-102 in people with advanced solid tumors, including liver, lung, kidney, skin (uveal melanoma), and colorectal cancers that have not responded to standard treatments. The drug works by blocking a specific protein (PKC epsilon)…

This study tests a new drug called TQB2930, which targets the HER2 protein on cancer cells, combined with standard chemotherapy and possibly another drug (bevacizumab). The goal is to find the safest and most effective dose and see if it shrinks tumors in people with advanced col…

This early-phase trial tests a new drug called nelmastobart, combined with two existing cancer drugs (TAS-102 and bevacizumab), in 45 Chinese patients with advanced colorectal cancer that has not responded to standard treatments. The main goal is to check safety and how the body …

This study tests whether adding two immunotherapy drugs to radiation therapy can better shrink advanced rectal cancer than standard chemoradiation. About 342 adults with a specific type of rectal cancer will be randomly assigned to one of three treatment groups. The goal is to se…

This early-stage trial tests a new drug called CS5007 in people with advanced solid tumors that cannot be removed by surgery. The drug is designed to seek out and attack cancer cells while sparing healthy ones. The study will first find the safest dose and then check if the drug …

This phase II trial tests a new approach for high-risk locally advanced rectal cancer. Participants first receive short-course radiotherapy, followed by a combination of chemotherapy (NALIRIFOX) and immunotherapy (Pucotenlimab) for about 6 months. The goal is to see if this regim…

This early-stage trial is testing two experimental drugs, OVV-01 and AK112, in 30 people with advanced solid tumors that have not responded to standard treatments. OVV-01 is given both into a vein and directly into the tumor, while AK112 is given into a vein. The main goals are t…

This early-stage trial tests a new drug called EMB-01, a bispecific antibody that targets two cancer-related proteins, combined with standard chemotherapy. About 120 adults with advanced colorectal cancer that cannot be surgically removed will receive the combination. The main go…

This early-phase trial tests an experimental drug called CLSP-5282 in up to 140 adults with advanced solid tumors (like lung, pancreatic, or colorectal cancer) that have a specific genetic change called KRas G12V. The drug is given by IV infusion. The main goals are to check safe…

This study tests whether adding an experimental immunotherapy drug (QL1706) to standard chemotherapy and radiation can shrink liver tumors from colon cancer enough to allow surgery. About 30 adults with colon cancer that has spread only to the liver will receive the combination b…

This small study tests a new approach for people with stage II/III rectal cancer that has not spread. Instead of chemotherapy, patients receive targeted internal radiation followed by two doses of the immunotherapy drug nivolumab before surgery. The goal is to see if this combina…

This study looks at whether people with certain genetic types of gastrointestinal cancers (stomach, colorectal, or anal) can safely avoid major surgery after immunotherapy. Instead of removing the organ, doctors will monitor closely or do smaller procedures to remove any remainin…

This Phase 1 trial tests MST-168, an antibody-drug conjugate designed to target and kill cancer cells. It will enroll 420 adults with advanced solid tumors that have specific markers. The main goals are to check safety, find the right dose, and see early signs of tumor shrinkage.

This trial tests a drug called HRX215 in 80 adults with colorectal cancer that has spread to the liver. Before surgery to remove liver tumors, patients often get a procedure (PVE) that blocks blood flow to the tumor area to encourage the healthy part of the liver to grow. HRX215 …

This early-phase trial tests whether matching drug combinations to a patient's tumor characteristics can better control metastatic colorectal cancer. Researchers will use blood draws, biopsies, and imaging to track how tumors resist treatment. The study enrolls 100 adults with me…

This early-stage study tests a new drug called N-3C01, given alone or with an immunotherapy, in people with advanced solid tumors that have spread or cannot be removed. The main goals are to check safety, find the right dose, and see if the combination shrinks tumors. About 114 a…

This early-phase trial tests a combination of three drugs—TAS-102, bevacizumab, and serplulimab—in 20 people with metastatic colorectal cancer who have already had surgery to remove tumors. The goal is to see if the combination is safe and can delay cancer progression. Participan…

This early-phase trial tests a new drug called YKYY031 in 76 people with advanced solid tumors (like colorectal or pancreatic cancer) that have stopped responding to standard treatments. The main goals are to check safety, find the right dose, and get a first look at whether the …

This study tests a new drug (GV20-0251) combined with an immunotherapy (anti-PD-1) in people with advanced solid tumors that have not responded to or cannot tolerate standard treatments. About 227 adults with various cancers, including lung, breast, and colorectal, will participa…

This early-phase study tests a drug called zanidatamab in 10 adults with advanced HER2-positive solid tumors (like endometrial, bladder, or pancreatic cancer) that have worsened after at least one prior treatment. Participants receive the drug by IV every two weeks. The main goal…

This study tests a drug called Trastuzumab Rezetecan in 15 adults with advanced solid tumors that have the HER2 protein. The goal is to see if the drug can shrink tumors. Participants get the drug by IV every 3 weeks. This is for people whose cancer has worsened after other treat…

This phase 3 trial tests whether a blood test that measures tumor DNA (ctDNA) can help doctors decide when to reduce or switch chemotherapy in people with metastatic colorectal cancer. About 408 participants will be randomly assigned to either standard treatment or a strategy whe…

This study tests a drug called ifinatamab deruxtecan (I-DXd) in children with solid tumors that have returned or not responded to treatment. The drug is an antibody-drug conjugate that targets cancer cells directly. The trial aims to check safety and see if tumors shrink in about…

This study tests whether an intestinal or multivisceral transplant can help people with a rare abdominal cancer called pseudomyxoma peritonei (PMP) that cannot be removed by surgery. Twenty participants will receive the transplant and be followed for 12 months to see if they surv…

This phase 2 trial tests a combination of two drugs—becotatug vedotin (a targeted therapy) and pucotenlimab (an immunotherapy)—as a first treatment for advanced head and neck squamous cell carcinoma. It is for patients whose cancer has returned or spread and who cannot tolerate p…

This early-stage study tests a new tablet called GW01-200 in 100 people with advanced solid tumors or blood cancers that have stopped responding to standard treatments. The main goals are to check the drug's safety, find the right dose, and see if it can shrink tumors. Participan…

This early-stage trial tests a new drug called ONC-783 in 20 people with advanced solid tumors, including colorectal, ovarian, pancreatic, or breast cancer. The drug is a bispecific antibody designed to help the immune system attack cancer cells. The main goal is to find a safe d…

This study tests a new drug called FG-B901, a bispecific antibody that targets two immune proteins (PD-L1 and CD40) to activate the immune system against tumors while reducing side effects. It is given alone or with chemotherapy to 264 adults with advanced solid tumors that have …

This study tests a new chemotherapy regimen called FOLFOX8 against the standard mFOLFOX6, both combined with targeted drugs (bevacizumab or cetuximab), as a first treatment for people with metastatic colorectal cancer that cannot be surgically removed. About 229 participants will…

This early-stage study tests a new tablet, LT-010391, in people with advanced solid tumors (lung, colon, or pancreatic cancer) that have a specific genetic change called KRAS G12D. The main goals are to check safety and find the right dose. About 198 participants who have tried o…

This study tests whether injecting a special solution (KRC-01) into rectal tumors before radiation can make the radiation work better. The solution increases oxygen inside the tumor, which helps radiation kill cancer cells. About 24 adults with advanced rectal cancer that hasn't …

This phase 2 trial is testing whether adding an immunotherapy drug (adebrelimab) to a chemotherapy combo (NALIRIFOX) and radiation can improve outcomes for people with a certain type of locally advanced rectal cancer (pMMR/MSS). About 84 participants will be randomly assigned to …

This study tests a new drug called ICP-B208 in about 539 people with advanced solid tumors that cannot be removed by surgery or have spread. The main goals are to check the drug's safety, find the best dose, and see if it shrinks tumors. Participants must be 18-75, have failed pr…

This study tests a new drug called HDM2017 combined with standard treatment (fruquintinib) in 120 people with advanced colorectal cancer that has spread. The goal is to find the safest dose and see if the combination can shrink tumors. Participants must have tried other treatment…

This study tests a new drug (SYS6006) combined with another drug (Enlonstobart) in people with advanced solid tumors that cannot be removed by surgery or have spread. The goal is to see if the combination is safe and works better than Enlonstobart alone. About 264 adults will tak…

This early-stage study tests a new drug called QLC5508 in 48 adults with advanced solid tumors that have stopped responding to treatment. The main goals are to check if the drug affects heart rhythm, compare two versions of the drug, and see how it interacts with other medicines.…

This early-phase study tests a new treatment called CAR-DC for people with advanced solid tumors (like lung, liver, or stomach cancer) that have not responded to standard care. The therapy uses a patient's own immune cells, modified in a lab to recognize and attack cancer cells. …

This phase 2 trial is testing a combination of two targeted drugs (fruquintinib and serplulimab) plus chemotherapy as a first treatment for 80 people with advanced colorectal cancer that has RAS or BRAF mutations. The goal is to see if this mix can delay cancer growth and improve…

This early-stage trial tests a new drug called Hemay5087 in 24 people with advanced solid tumors that have not responded to standard treatments or have no standard options. The main goals are to check safety, find the right dose, and get a first look at whether the drug can shrin…

This long-term extension study offers continued access to several cancer drugs—including cabozantinib, atezolizumab, and nivolumab—for up to 5,000 patients who benefited from them in earlier Exelixis-sponsored trials. The study focuses on monitoring safety and ongoing clinical be…

This early-stage study tests a new drug called HH160 in about 56 adults with advanced solid tumors (cancers that have spread). The main goals are to check safety, find the best dose, and see if the drug shrinks tumors. Participants will receive HH160 alone or with other cancer tr…

This phase 2 trial tests a drug called BMS-986504 in people with advanced solid tumors that have lost a gene called MTAP. The drug is given alone or with other cancer medicines. The study aims to see if the drug shrinks tumors and how safe it is. About 260 adults will take part.

This early-phase trial tests a new drug called WSK-IM02 in 9 people with advanced solid tumors that have spread to cause fluid buildup around the lungs or in the belly. The drug is given directly into the chest or abdomen to see if it is safe and can shrink tumors or reduce fluid…

This early-phase trial tests a combination of two drugs, CVL006 and 9MW2821, in 108 adults with advanced solid tumors that have not responded to standard therapy. The goal is to find a safe dose and see if the combination can shrink tumors. The study is not yet recruiting.

This early-stage trial tests a new drug called CS231295 in 42 adults with advanced solid tumors that have stopped responding to standard treatments. The drug works by blocking certain proteins that help tumors grow and form blood vessels. The main goals are to check safety, find …

This early-phase trial is testing a new mRNA-based drug called YMN-A02 in 10 people with advanced colorectal cancer that has spread to the liver and has not responded to standard treatments. The drug is designed to help the immune system attack the cancer by producing a CTLA-4 an…

This early-phase study tests a new drug, BI 1831169, combined with an existing immunotherapy (nivolumab) in Japanese adults with advanced solid tumors that have spread or not responded to prior treatments. The main goal is to find a safe, tolerable dose. Up to 46 participants wil…

This study will test a new robotic device called the Triton 1.5 System for performing colonoscopies, which are exams to look for colon cancer. About 40 adults who need a routine colonoscopy will take part. The main goal is to see if the robot is safe and can successfully complete…

This Phase 3 trial tests whether giving chemotherapy directly into the liver artery (HAI) after surgery can prevent cancer from coming back in patients with colorectal cancer that spread to the liver. About 272 high-risk patients will receive either standard IV chemo or HAI chemo…

This phase II trial tests whether a stronger chemotherapy cocktail (cmFOLFOXIRI) plus an immunotherapy drug (PD-1 inhibitor) works better than standard chemotherapy (mFOLFOX6) when given before surgery for locally advanced colon cancer. About 138 patients with high-risk stage II …

This early-stage study tests a new drug called JL19001 in people with advanced solid tumors or a type of lymphoma that has come back or not responded to treatment. The main goal is to find a safe dose and check for side effects. About 14 participants will receive the drug as a sh…

This study tests an experimental drug called IDP-001 in people with advanced or metastatic solid tumors, including certain lung, head and neck, and other cancers. The trial has two phases: first to check safety and find the right dose, then to see if the drug can shrink tumors. A…

This study tests whether a special vacuum dressing (PICO 7®) placed on the surgical wound can reduce infections after rectal cancer surgery. About 100 adults who have had chemoradiotherapy followed by abdominoperineal resection will be enrolled. The device is designed to drain fl…

This early-stage trial tests a new drug called HF50 in 45 adults with advanced solid tumors that have not responded to standard treatments. HF50 is designed to target HER2 on cancer cells and boost the immune system. The main goals are to check safety, find the right dose, and se…

This study tests a new drug combination for people with metastatic solid tumors that lack a gene called MTAP. The drugs, BMS-986504 and pemetrexed, aim to stop cancer cells from growing. The trial will check safety and how well the combo works in 72 participants.

This study tests whether giving patients special nutritional drinks and a tailored diet before and after colorectal cancer surgery can lower the risk of complications like infections and improve recovery. About 190 adults with colorectal cancer who are scheduled for minimally inv…

This phase 3 study tests whether a new drug called Enlituo, combined with chemotherapy (FOLFOX), works as well as the standard treatment Erbitux plus FOLFOX for people with advanced colorectal cancer that has specific genetic traits (RAS/BRAF wild-type and MSS/pMMR). About 608 ad…

This phase 2 trial tests whether adding the immune-boosting drug ivonescimab to standard chemotherapy (FOLFIRI) helps people with advanced colorectal cancer live longer without their cancer growing. It compares this new combination to the current standard of FOLFIRI plus bevacizu…

This early-phase study tests a new drug called IN10028 in 75 adults with advanced solid tumors that have not responded to standard treatments. The main goals are to check safety, find the best dose, and see if the drug shrinks tumors when used alone or with other cancer drugs. Th…

This early-stage study tests a new treatment called DCTY1102 for people with advanced cancers (like pancreatic, colorectal, or lung cancer) that have a specific genetic change (KRAS/NRAS G12D mutation) and a certain immune type (HLA-A*11:01). The treatment uses the patient's own …

This phase 2 trial tests a short course of radiation followed by a mix of chemotherapy, targeted therapy, and immunotherapy in 60 people with locally advanced rectal cancer. The goal is to see if this approach can make the tumor disappear completely before surgery, possibly allow…

This study tests a combination of three drugs—S-531011, fruquintinib, and pembrolizumab—in people with advanced colorectal cancer that has not responded to standard treatments. The cancer type is called MSS or pMMR, which typically does not respond well to immunotherapy alone. Th…

This early-phase trial tests a new type of cell therapy called TCR1188-ABC for people with certain advanced cancers (pancreatic, colorectal, lung, or bile duct) that have a specific KRAS G12V mutation. The treatment involves taking a patient's own immune cells, engineering them t…

This early-stage trial tests a new drug (non-cationic peptide-CD47 siRNA) in about 9 people with advanced solid tumors that have not responded to other treatments. The drug works by blocking a 'don't eat me' signal on cancer cells, helping the immune system recognize and attack t…

This early-stage trial tests a new drug called JH021 in 60 people with advanced solid tumors that have stopped responding to standard treatments. JH021 is a special antibody that targets two cancer-related proteins, EGFR and cMET, to potentially slow or stop tumor growth. The mai…

This study tests whether a new form of chemotherapy (liposomal irinotecan) combined with other drugs works better than standard irinotecan for people with metastatic colorectal cancer that has progressed after first-line treatment. About 408 adults aged 18 to 75 will be randomly …

This early-stage trial tests a personalized cancer vaccine called ODI-2001 in 77 people with advanced colon or pancreatic cancer that has spread or cannot be removed. The vaccine is custom-made for each patient's tumor and is given along with a drug that boosts the immune system.…

This study tests a new drug called SKB118 in 332 adults with advanced solid tumors that have not responded to standard treatments. The drug is given by IV every three weeks. The trial will first find the safest dose, then check if it can shrink tumors. It is currently not recruit…

This early-stage trial tests a technique called PIPAC, which turns a chemotherapy drug (mitomycin C) into a mist and sprays it directly onto cancer spread inside the abdomen. It is for people with advanced gastrointestinal cancers that cannot be removed by surgery. The main goal …

This early-stage study tests a new drug called SNA028 in 20 people with advanced colorectal cancer that has a specific marker (GPA33). The drug uses a two-step process to deliver radiation directly to cancer cells. The main goals are to check if it is safe and how the body handle…

This trial looks at whether children with cancer who develop a fever and low white blood cells can safely stop antibiotics earlier than usual. About 136 children will be randomly assigned to either stop antibiotics within 24 hours or continue standard treatment. The goal is to se…

This phase 2 trial tests whether two immunotherapy drugs, botensilimab and balstilimab, can clear tiny amounts of cancer DNA from the blood of people with stage II or III colorectal cancer who have completed standard treatment. The study enrolls 20 adults whose blood still shows …

This early-phase trial tests a new drug called SYS6051 in 114 adults with advanced solid tumors that have not responded to standard treatments. The study aims to find a safe dose and check for early signs of tumor shrinkage. Participants receive the drug by IV every three weeks.

This study tests a personalized radiation approach for locally advanced rectal cancer. By adjusting the radiation dose halfway through treatment based on a special MRI scan, doctors hope to increase the number of patients whose tumors completely disappear before surgery. The tria…

This phase 2 trial is testing whether adding an experimental drug called DCSZ11 to standard radiation and chemotherapy can improve outcomes for people with a high-risk type of rectal cancer. The study will enroll 30 adults who have not had prior treatment. The goal is to see if t…

This study tests a new combination of drugs for people with advanced colorectal cancer that cannot be removed by surgery. About 70 participants will receive two immunotherapy drugs plus a targeted therapy and chemotherapy. The goal is to see if this combination can shrink tumors …

This study tests whether taking histidine, an amino acid supplement, can safely boost the immune system's ability to fight colorectal cancer. Twenty participants will take 2 grams of histidine daily for 9 weeks alongside their standard cancer treatment. Researchers will measure c…

This early-stage trial tests a topical ointment called ACU-D1 for HPV-related vulvar and perianal lesions in people with HIV. Nine participants will apply the cream twice daily for 4 weeks. The main goal is to find the safest dose and see if the treatment can boost immune markers…

This study tests an experimental drug called SKB565 in 180 adults with advanced solid tumors that have not responded to or cannot tolerate standard treatments. The trial has three stages to find the safest dose, check how the drug moves through the body, and see if it shrinks tum…

This study tests a new drug, BHB810, in adults with advanced stomach or gastroesophageal junction cancer that has not responded to standard treatments. The drug is given as an IV infusion every two weeks. The main goals are to check safety and find the best dose, while also seein…

This phase 2 trial is testing whether a lower dose of the immunotherapy drug nivolumab, given less often, can still control cancer in people with various advanced or metastatic cancers. The goal is to see if a cheaper, more accessible regimen works as well as the standard high-co…

This study looks at whether adding a short course of chemotherapy after standard chemoradiation can improve outcomes for people with stage I rectal cancer, allowing them to keep their rectum instead of needing major surgery. About 292 participants will be randomly assigned to rec…

This study tests whether two immunotherapy drugs, cemiplimab and fianlimab, can safely shrink colon tumors before surgery in people with stage II-III colon cancer that hasn't spread. Participants get two IV doses before surgery, then are followed for up to three years. The goal i…

This study tests whether a special omega-3-enriched nutritional drink can improve nutrition in people with advanced lung or colorectal cancer who are at risk of malnutrition. About 118 participants will either get the drink plus dietary advice, or just dietary advice alone. The g…

This early-stage study tests a new drug called NPX372 in people with advanced solid tumors that have not responded to standard treatments. The drug is designed to help the body's immune cells recognize and attack cancer cells. The main goals are to check the drug's safety and fin…

This study tests whether giving chemotherapy directly into the liver along with standard chemo pills and IV drugs can help prevent colorectal cancer from coming back after surgery to remove tumors from the liver. About 28 adults who have had successful surgery and show no remaini…

This early-phase study tests a new drug combination (L19IL2 plus ruxolitinib) in people with advanced kidney, pancreatic, or colorectal cancers that have stopped responding to standard treatments. The main goals are to find a safe dose and check for side effects. About 96 partici…

This study looks at envafolimab, a cancer drug given as a quick shot under the skin instead of a long IV drip. It is for adults with advanced solid tumors who have not responded to standard treatments. The goal is to see how well it controls tumors and what side effects occur in …

This study tests a combination of two types of radiation therapy for elderly or frail patients with rectal cancer who cannot or will not have surgery. The goal is to shrink or control the tumor while maintaining quality of life. Researchers will follow 80 participants for up to t…

This study tests whether a probiotic called EXE-346 can help treat anal high-grade squamous intraepithelial lesions (HSIL) and reduce persistent high-risk HPV infection in people living with HIV. The trial will enroll 90 participants who will take the probiotic or a placebo daily…

This early-phase trial tests an experimental drug called FXB0871 in about 138 adults with advanced solid tumors, including non-small cell lung cancer and liver cancer, that have stopped responding to standard treatments. The study has two parts: first, finding a safe dose, and se…

This phase 2 trial tests whether injecting an oncolytic virus (H101) directly into liver tumors, along with radiation, chemotherapy, targeted therapy, and immunotherapy, can shrink or control colorectal cancer that has spread to the liver and cannot be removed by surgery. The stu…

This early-stage study tests a new treatment plan for people with stomach or colorectal cancer that has spread to the lining of the abdomen. The approach combines low-dose radiation to the whole abdomen with chemotherapy and an immunotherapy drug. The main goal is to check if the…

This early study tests whether adding donor natural killer (NK) cells to standard maintenance therapy can safely help control advanced lung and colorectal cancers. About 20 adults will receive NK cell infusions alongside their usual drugs. The main goal is to check for side effec…

This study tests whether giving immunotherapy before surgery can help people with a common type of colorectal cancer (MSS) that has spread to the liver. About 24 participants will receive the drug dupilumab before their liver surgery. The goal is to see if this approach is safe a…

This early-phase trial is testing an experimental therapy called WTX-212C, which uses specially engineered red blood cells to treat advanced solid tumors. The study will enroll 24 adults whose cancer has not responded to standard treatments. The main goal is to check safety and f…

This Phase 1 trial tests a new drug called HLX05-N, which is a biosimilar (a copy) of the cancer drug Erbitux, in 387 people with metastatic colorectal cancer. Participants will receive either HLX05-N or Erbitux (from the US or EU) along with standard chemotherapy. The study aims…

This phase II trial tests whether a combination of three drugs—balstilimab, botensilimab, and agenT-797—can shrink tumors in adults with a specific type of advanced colorectal cancer that has spread to the liver. All 17 participants will receive the treatment, and researchers wil…

This phase 3 trial tests whether short-course radiation followed by chemotherapy and an immunotherapy drug (serplulimab) works better than standard long-course chemoradiation for high-risk locally advanced rectal cancer. 612 patients will be randomly assigned to one of the two tr…

This study tests if adding a common heart medication (propranolol) to standard chemotherapy and immunotherapy before surgery can improve outcomes for people with a certain type of colon cancer. About 45 adults with stage II or III colon cancer that is mismatch repair proficient (…

This early-stage trial tests a new drug called CT-202 in people with advanced triple-negative breast cancer, colorectal cancer, or bladder cancer that has come back or spread. The drug is a bispecific antibody designed to help the immune system attack cancer cells that have a pro…

This early-phase study tests a new drug called KIVU-305 in people with advanced solid tumors that have stopped responding to standard treatments. The drug is designed to target and attack cancer cells while sparing healthy ones. The main goal is to find a safe dose and see if the…

This early-phase study tests an experimental oral drug called KQB368 in 48 adults with advanced solid tumors (like lung, colorectal, or uterine cancer) that have a specific KRAS mutation (G12C or G12S). The main goals are to find a safe dose and see if the drug can shrink tumors.…

This phase 2 trial tests a mix of immunotherapy, a cancer-killing virus, short-course radiation, and chemotherapy in 20 people with locally advanced low rectal cancer. The goal is to see if this combination can make the tumor disappear completely for at least a year, potentially …

This phase 2 trial tests whether a daily dexamethasone enema can prevent or reduce acute rectal injury in 40 rectal cancer patients undergoing pelvic radiotherapy. One group starts the enema early (day 10 of radiation), while the other starts only after injury occurs. The goal is…

This study tests a device called ONCObind that filters cancer cells from the blood of people with advanced pancreatic or colorectal cancer that has not responded to standard treatments. About 120 adults will receive the filtering procedure multiple times to see if it is safe and …

This phase 2 trial tests whether adding targeted radiation (SBRT) and an immunotherapy drug (sintilimab) to standard chemotherapy (TAS-102) and bevacizumab can help people with recurrent metastatic colorectal cancer live longer without their cancer growing. The study will enroll …

This early-stage trial tests crotoxin, a protein from rattlesnake venom, given intravenously to 24 adults with advanced solid tumors that have not responded to standard therapy. The main goal is to see if a slow dose increase can make the drug safer and better tolerated. Research…

This phase 2 trial tests a new approach for high-risk locally advanced rectal cancer. It combines a shorter course of radiation with chemotherapy (capecitabine and oxaliplatin) and an immunotherapy drug (serplulimab). The study will compare this combo to standard chemoradiation i…

This study tests a new drug called ALK-N001 in 190 adults with advanced solid tumors that have not responded to standard treatments. The drug is given by IV every 2 or 3 weeks. Researchers will check if it shrinks tumors, how safe it is, and how the body processes it. The goal is…

This early-phase study tests an experimental drug called ZE94-0605 in about 60 adults with advanced solid tumors that have not responded to standard treatments. The main goals are to find a safe dose and check for any signs of tumor shrinkage. The study is not yet recruiting.

This study tests a new treatment plan for adults with locally advanced rectal cancer that hasn't spread. Participants get a week of radiation, then 8 cycles of three drugs (chemotherapy and immunotherapy) before surgery. The goal is to shrink the tumor enough to cure the cancer o…

This study tests a new drug called KHN922 in people with advanced solid tumors that have not responded to standard treatments. KHN922 is an antibody-drug conjugate designed to target HER3 proteins on cancer cells and deliver two anti-cancer drugs directly to them. The trial will …

This early study tests a new drug, SHR-3821, combined with fruquintinib in 12 people with advanced colorectal cancer that has not responded to at least two standard treatments. The goal is to see if the combination is safe and can shrink tumors or slow the disease. This is not a …

This study tests whether daily adaptive radiotherapy (ART) can safely deliver shorter, more intense radiation treatments for prostate, endometrial, cervical, and rectal cancers. About 264 participants will be randomly assigned to standard radiation or ART, which uses daily imagin…

This study tests a drug called fruquintinib in 88 adults with advanced colon cancer that has not responded to standard chemotherapies. The goal is to see if adding supportive care to manage side effects can help patients live longer without their cancer growing. Participants will…

This study tests a drug called sacituzumab tirumotecan in 20 people with advanced anal or rectal cancer that has spread or cannot be removed and has not responded to other treatments. The goal is to see if the drug can shrink tumors and how safe it is. Participants will receive t…

This phase II trial tests a chemotherapy regimen called FULIRI, combined with either bevacizumab or cetuximab, as a first treatment for colorectal cancer that has spread to the liver. The goal is to shrink the liver tumors enough so they can be surgically removed. The study will …

This study tests whether a short course of radiation followed by three drugs (disitamab vedotin, sintilimab, and capecitabine) can completely eliminate tumors in people with advanced HER2-positive rectal cancer. About 29 adults aged 18-75 will receive the treatment before surgery…

This study tests whether adding fecal microbiota transplantation (FMT) – transferring gut bacteria from a healthy donor – to standard chemotherapy can shrink tumors in people with advanced colorectal cancer that cannot be removed by surgery. About 220 adults will be randomly assi…

This study tests different drug combinations given before surgery for locally advanced colorectal cancer. The 134 participants are grouped by their tumor's genetic markers, and each group receives a tailored treatment. The main goal is to see how often the cancer completely disap…

This early-phase trial is testing a new chemotherapy drug called RP-001 in 66 adults with advanced solid tumors, including colorectal and pancreatic cancers. The main goals are to check safety, find the best dose, and see if the drug can shrink tumors. It is an open-label study, …

This phase 2 study tests whether adding an immunotherapy drug (iparomlimab and tuvonralimab) and targeted radiation to a standard targeted therapy (fruquintinib) can help people with metastatic colorectal cancer that has spread to a few spots. The trial will enroll 60 adults who …

This study tests an experimental drug called LRK-4189, given alone or with standard chemotherapy, for adults with advanced solid tumors that have not responded to prior treatment. The main goal is to check the drug's safety and find the best dose. About 120 participants will take…

This study tests a new two-drug combination for people with a certain type of advanced colorectal cancer that has not responded to prior treatments. About 31 adults will receive the drugs to see if tumors shrink and how long that lasts. The goal is to find a better option for lat…

This study tests whether adding ivermectin, a drug used for parasitic infections, can improve the immune response in people with solid tumors who are already receiving immunotherapy. About 80 adults will take either a moderate or high dose of ivermectin for four weeks alongside t…

This early-phase trial tests whether transplanting gut bacteria from young donors (via capsules or a tube) can help immunotherapy work better in people with a type of advanced colorectal cancer that usually doesn't respond to immunotherapy. Ten patients who have already tried sta…

This early-stage trial tests a new biologic drug, SIG001, in 66 people with advanced solid tumors. The main goals are to check safety, find the right dose, and see how the drug behaves in the body. Participants receive SIG001 intravenously every two weeks and are monitored for si…

This study tests whether a targeted chemoradiotherapy can completely eliminate early-stage rectal cancer, allowing patients to avoid surgery and keep their rectum. 90 adults with small, localized tumors will either receive standard surgery or the new treatment followed by close m…

This Phase 3 trial tests a new drug called TQB2102, which delivers chemotherapy directly to HER2-positive cancer cells, in people with advanced colorectal cancer that has stopped responding to standard treatments. About 142 participants will be randomly assigned to receive either…

This study tests a new drug called AMT-676 combined with standard chemotherapy and targeted therapy for people with advanced colorectal cancer that cannot be removed by surgery. The goal is to see if the combination is safe and helps shrink tumors or slow the disease. About 180 a…

This Phase 3 trial tests whether a three-drug chemotherapy combination (FOLFOXIRI) works better than the standard two-drug combination (CAPOX/FOLFOX) for people with high-risk locally advanced rectal cancer. Both groups also receive chemoradiation, and then either surgery or a wa…

This early-phase study tests a new drug combination (PX plus nab-paclitaxel) given directly into the abdomen for people with a type of advanced cancer that has spread to the lining of the belly. The main goal is to find a safe dose and check for side effects. About 22 adults with…

This study tests an experimental oral drug, BPI-572270, in 120 adults with advanced solid tumors (lung, colorectal, or pancreatic cancer) that have specific RAS gene mutations. The trial has two phases: first to find a safe dose and check for side effects, then to see if the drug…

This study compares two treatments for locally advanced rectal cancer: a shorter course of radiation plus chemotherapy (CAPOX) and immunotherapy (tislelizumab) versus a longer course of chemoradiation plus the same immunotherapy. The goal is to see which approach leads to a highe…

This phase II trial tests whether a special radiotherapy regimen followed by targeted therapy and immunotherapy can shrink tumors in people with advanced colorectal cancer that has not responded to prior treatments. About 33 participants will receive the treatment and be monitore…

This study tests a new drug called LCB02A for people with advanced solid tumors that have a specific marker (CLDN18.2) and haven't responded to standard treatments. The drug is designed to deliver a toxin directly to cancer cells. The trial has two phases: first, finding the safe…

This early-phase study tests a new drug called QLS5308 in about 192 adults with advanced solid tumors that have spread and cannot be removed by surgery or radiation. The main goals are to check the drug's safety, find the best dose, and see if it can shrink tumors. Participants m…

This study tests an experimental drug called QLS5132, given with other cancer treatments, for people with advanced solid tumors like stomach, lung, endometrial, and ovarian cancers. The goal is to find safe doses and see if the combination shrinks tumors. About 626 participants w…

This study tests whether adding a drug called enlonstobart to short-course radiotherapy before surgery can improve outcomes for people with a specific type of advanced rectal cancer (pMMR). About 128 adults will be randomly assigned to receive either the standard treatment or the…

This Phase 2 trial tests a combination of tunlametinib and anti-EGFR antibodies (cetuximab β or nimotuzumab) in 90 adults with advanced colorectal or pancreatic cancers that have RAS mutations and have not responded to standard treatments. The goal is to see if the combo shrinks …

This study tests whether combining chemotherapy (FOLFOX), a targeted drug (fruquintinib), and an immunotherapy (serplulimab) can shrink advanced colorectal cancer enough to allow surgery. About 42 adults with a specific genetic type (pMMR/MSS) who have not had prior treatment wil…

This trial tests whether two approved drugs, dabrafenib and trametinib, can treat rare cancers that have a specific genetic change called BRAF V600. These drugs are already used for melanoma and lung cancer, but researchers want to see if they help people with other cancer types.…

This study tests a drug called everolimus in people with advanced colorectal cancer that has a specific genetic change (CDK12 deficiency) and has not responded to other treatments. The goal is to see if the drug can shrink tumors or slow the cancer's growth. About 38 adults will …

This pilot study tests whether an Ayurvedic drug called Trishul can help shrink rectal tumors and improve survival. Forty adults with advanced rectal cancer will receive either Trishul or a placebo pill, in addition to their standard treatment (chemo-radiation and surgery). The s…

This early-stage study tests a new drug called T320 in 150 people with advanced solid tumors that have not responded to standard treatments. The main goals are to check the drug's safety, find the best dose, and see if it can shrink tumors. Participants receive T320 every two wee…

This study tests a device called ColoSeal ICD, placed during rectal cancer surgery to protect the bowel connection and reduce the need for a stoma (a bag on the belly for waste). About 250 adults aged 22-75 with rectal cancer will be split into two groups: one gets the device, th…

This early-stage study tests a new treatment for people with advanced ovarian cancer or other solid tumors that have come back or not responded to standard therapy. The treatment uses a patient's own immune cells that are genetically modified to better recognize and attack cancer…

This study tests giving an immunotherapy drug (pembrolizumab) before surgery to people with a specific type of colon cancer (dMMR). The goal is to see if the drug can shrink or eliminate the tumor so some patients may avoid surgery and instead be closely monitored. About 152 adul…

This early-phase study tests a combination of a specially modified virus (PIN) and an immunotherapy drug (sintilimab) in about 25 adults with advanced colorectal cancer that has spread to the liver and has not responded to at least two prior treatments. The main goals are to chec…

This study compares giving chemotherapy before surgery versus standard surgery-first treatment for people with stage II or III colon cancer that has a high CEA level. About 100 adults aged 18-70 will be randomly assigned to one of two groups. The goal is to see if pre-surgery che…

This early-phase study tests a new cell therapy called KT032 in 24 adults with advanced solid tumors (ovarian, mesothelioma, colon cancer) that have spread to the abdomen and haven't responded to standard treatments. The main goal is to check safety and find the best dose, while …

This early-phase trial tests a new type of cell therapy called CAR-Macrophages in 20 adults with advanced solid tumors. The immune cells are modified to target specific markers on cancer cells (HER2, PSMA, FAP) and are given by IV. The main goals are to check safety, find the bes…

This phase II trial tests a new device called the Maastro applicator, which delivers high-dose radiation directly to rectal tumors. The goal is to see if it can safely eliminate the cancer and allow patients to avoid major surgery. Twenty adults with rectal cancer will receive th…

This study tests whether giving immunotherapy drugs (nivolumab with or without ipilimumab) or immunotherapy plus radiotherapy before surgery can improve outcomes for people with a specific genetic type of colorectal cancer called MSI-H/dMMR. About 114 participants will be randoml…

This phase II trial is testing whether adding lubiprostone, a drug usually used for constipation, to standard maintenance therapy can delay cancer recurrence in adults with colorectal cancer that has spread to the lining of the abdomen. About 124 participants who have had surgery…

This phase II trial tests a new combination of short-course radiation, two immunotherapy drugs (Qibei'an and Camrelizumab), and chemotherapy (XELOX) in 19 people with locally advanced rectal cancer. The goal is to see if this approach can make the tumor disappear completely, allo…

This early study tests a new treatment called CAT-101, which uses a patient's own immune cells (dendritic cells) loaded with a cancer protein (mKRAS) to help the body fight tumors. It is for people with advanced pancreatic cancer or other solid tumors that have a specific KRAS mu…

This phase 2 trial is testing a combination of four drugs—irinotecan liposome, capecitabine, bevacizumab, and camrelizumab—as a second or later treatment for people with metastatic colorectal cancer. The study will enroll 68 participants and measure how long the disease stays und…

This study tests a new oral drug, LPM6690176, added to standard chemotherapy and bevacizumab for people with a specific type of advanced colorectal cancer (RAS mutation). The first part finds the safest dose, and the second part compares the new combo against standard treatment a…

This phase 2 trial is testing a new approach for people with stage II-III rectal cancer. It combines short-course radiotherapy that spares the tumor-draining lymph nodes with a PD-1 inhibitor (a type of immunotherapy). The goal is to see if this combination can lead to a complete…

This early-phase study tests a new drug called JSKN027 in 250 adults with advanced solid tumors that have stopped responding to standard treatments. The main goals are to check safety, find the best dose, and see if the drug can shrink tumors. The study focuses on colorectal, lun…

This study tests whether adding an immunotherapy drug (serplulimab) to standard chemotherapy before surgery can improve outcomes for people with a common type of locally advanced rectal cancer (MSS/pMMR). About 128 participants will be randomly assigned to receive either chemo al…

This Phase 3 trial tests a personalized cancer vaccine called OncoVAX for people with Stage II colon cancer. After surgery to remove the tumor, the patient's own cancer cells are used to create a vaccine that trains the immune system to attack any remaining cancer cells. The goal…

This trial will test a new robot system designed to help surgeons perform laparoscopic surgery from a remote location. The study includes 98 adults with cancers like colorectal, esophageal, liver, or cervical cancer who need surgery. The main goal is to see how often the surgery …

This phase 2 trial compares a rechallenge treatment (irinotecan plus cetuximab) against the current standard (trifluridine/tipiracil plus bevacizumab) for people with metastatic colorectal cancer whose disease has worsened after earlier therapies. Only patients with specific gene…

This phase 2 trial tests whether adding radiotherapy and two immunotherapy drugs (iparomlimab and tuvonralimab) to standard chemotherapy and bevacizumab can improve outcomes for people with a specific type of metastatic rectal cancer (RAS-mutant/MSS). About 106 participants will …

This Phase 3 trial tests a new drug called JSKN003 against standard treatments for people with advanced HER2-positive colorectal cancer that has not responded to three common chemotherapies. About 123 participants will be randomly assigned to receive either JSKN003 or a standard …

This study tests whether adding the immunotherapy drug dostarlimab to standard chemotherapy (XELOX) after chemoradiation improves outcomes for people with locally advanced rectal cancer. About 270 participants will be randomly assigned to receive either the combination or chemoth…

This study tests whether a step-by-step plan to manage body temperature during a long surgery can lower the chance of postoperative delirium (sudden confusion). The surgery is for a rare abdominal tumor called pseudomyxoma peritonei and involves heated chemotherapy. The trial wil…

This study compares two ways to remove small rectal neuroendocrine tumors (less than 1 cm). The new method, called modified double snare EMR, is expected to be just as effective as the standard ESD procedure but with shorter operation time, fewer complications, and lower cost. Ab…

This early-phase trial tests two immunotherapy drugs (ivonescimab and ADG126) alone or with chemotherapy in 30 adults with advanced or metastatic MSS colorectal cancer, a type that doesn't respond well to standard immunotherapy. The main goal is to find safe doses and check for s…

This study tests whether a new drug combination (fruquintinib plus chemotherapy) works better than the current standard (bevacizumab plus chemotherapy) for people with a specific type of advanced colorectal cancer that has a RAS mutation. About 224 adults aged 18 to 75 will be ra…

This early-phase study tests a new drug called QLS5316 in about 300 adults with advanced solid tumors (such as colorectal, stomach, head and neck, or lung cancer) that have not responded to standard treatments. The main goals are to check the drug's safety, find the right dose, a…

This early-phase study tests whether a new cell therapy called B7-H3 CAR T cells is safe and can help children and young adults whose solid tumors have returned or stopped responding to standard treatments. About 40 participants will receive their own immune cells that have been …

This study tests a new combination of an antibody drug (QL1706), a targeted therapy (fruquintinib), and short-course radiotherapy against standard third-line therapy in 76 adults with colorectal cancer that has spread to the liver and cannot be removed by surgery. The goal is to …

This study tests a new drug combination (HLX43 plus HLX07 or serplulimab) in people with advanced or metastatic colorectal cancer that has stopped responding to standard first-line treatment. About 126 participants will receive the experimental therapy to see if it can shrink tum…

This early-stage trial tests a procedure called microtransplantation (MST) combined with chemotherapy in 10 adults with advanced or relapsed solid tumors. The goal is to see if MST can help control the disease and improve recovery of blood cells after chemo. The study focuses on …

This study tests a new drug combination (SHR-1811 plus bevacizumab) as a second-line treatment for people with metastatic colorectal cancer that has worsened after initial therapy. About 80 adults aged 18-75 will participate. The goal is to see if the combo shrinks tumors and del…

This study tests whether a remote temperature monitor can help detect fever early in children undergoing chemotherapy who are at risk of a serious infection called febrile neutropenia. About 30 children from families with social or emotional challenges will either use a wearable …

This study tests a combination of two experimental treatments—AK112 (given through a vein) and VG2025 (injected directly into liver tumors)—in 72 adults with advanced colorectal cancer that has spread to the liver and hasn't responded to prior therapy. The goal is to see if the c…

This Phase 2 trial tests whether a new drug combination (fruquintinib plus trifluridine/tipiracil) works better than a standard combo (bevacizumab plus trifluridine/tipiracil) for people with advanced colorectal cancer that has not responded to standard chemotherapy. About 292 ad…

This early-stage trial tests a personalized cell therapy for adults with advanced solid tumors that have not responded to standard treatments. Doctors take immune cells from a patient's own tumor, grow more of them in the lab, and then infuse them back after a short course of che…

This early-phase trial tests SL-28, a cell therapy made from donor immune cells, in 60 people with advanced solid tumors (like lung, pancreatic, or breast cancer) that haven't responded to standard treatments. The study aims to find a safe dose and see if the therapy can shrink t…

This early-phase trial tests a new therapy called TCR-T cells, which are immune cells engineered to recognize and attack cancer cells with specific KRAS mutations (G12V or G12D). The study will enroll 25 adults with advanced solid tumors (like colorectal or lung cancer) who have …

This early-stage trial tests a new drug called FXS887 in 14 people with advanced solid tumors that have stopped responding to standard treatments. The drug works by blocking a protein (ATR) that cancer cells need to repair their DNA. The main goals are to check safety, find the r…

This phase 4 trial is for people with advanced colorectal cancer that started on the right side of the colon and has a normal RAS gene. Researchers want to see if adding the targeted drug cetuximab to standard chemotherapy helps shrink tumors more than chemotherapy alone or with …

This study tests a new drug, HX111, in about 70 people with advanced solid tumors or lymphoma that has not responded to other treatments. The goal is to find a safe dose and see if the drug can shrink tumors. It is an early-stage trial, so the main focus is on safety and side eff…

This phase 2 trial tests whether adding image-guided radioactive seed implants to standard cancer therapy can slow disease progression in patients with oligoprogressive metastatic lung or colorectal cancer. About 90 adults whose cancer has started to progress in a few spots while…

This phase 2 trial tests a combination of gossypol acetate (a drug from cottonseed), bevacizumab, and FOLFIRI chemotherapy in 20 people with metastatic colorectal cancer that has a TP53 mutation and is LRPPRC-positive. The goal is to see if this mix can shrink tumors or slow the …

This Phase 2 trial tests whether combining two platelet-boosting drugs (hetrombopag and rhTPO) works better than hetrombopag alone for cancer patients with dangerously low platelets from treatment. About 204 adults with solid tumors will be randomly assigned to one of the two gro…

This phase 2 trial tests a new immunotherapy drug (aipalolitovorelizumab) combined with standard chemotherapy and bevacizumab in 30 people with metastatic colorectal cancer that has a BRAF V600E mutation and is MSS/pMMR type. The goal is to see if the combination shrinks tumors a…

This study tests an experimental oral drug called XNW34017 in 150 people with advanced solid tumors who have not responded to or cannot tolerate standard treatments. The trial has two parts: first, finding a safe dose, then expanding to see if the drug can shrink tumors. It is an…

This early-stage trial tests a new approach for people with colorectal cancer that has spread to the liver and hasn't responded to standard treatments. It combines a virus designed to attack cancer cells (BioTTT001) with two drugs (toripalimab and regorafenib). The study will enr…

This study tests whether a new drug called IP-001, injected into the liver after standard heat-based tumor destruction, can help prevent colorectal cancer from coming back. About 717 adults with colorectal cancer that has spread only to the liver will be randomly assigned to rece…

This study tests whether adding a weight-loss medication (a GLP-1 drug) to standard chemo-radiation before surgery helps rectal cancer patients with a high BMI. About 42 participants will either get the drug plus standard treatment or standard treatment alone. Researchers will me…

This study tests a drug called ivarmacitinib in 72 people with advanced solid tumors who had to stop their cancer immunotherapy because of severe immune-related side effects. The goal is to see if the drug can control those side effects and, if successful, allow patients to safel…

This study tests several new anti-cancer drugs and technologies in 600 people with rare solid tumors that have spread or cannot be removed. Participants will receive treatments matched to their tumor's unique genetic profile. The goal is to see if these therapies are safe and shr…

This phase 2 trial tests a new approach for people with high-risk locally advanced rectal cancer. Participants will receive a short course of radiation with a boost to the tumor, combined with chemotherapy (capecitabine and oxaliplatin) and an immunotherapy drug (tislelizumab). T…

This early-phase study tests a new treatment called GC203 TIL, which uses a patient's own immune cells that are modified in a lab to better fight cancer. It is for adults with advanced solid tumors that no longer respond to standard therapies. The main goal is to check safety, an…

This study tests a new drug called TYK-01054 for people with advanced solid tumors that have not responded to standard treatments. The drug is taken as a capsule and works by blocking a protein (TEAD) involved in cancer growth. The trial will check safety, find the best dose, and…

This phase 2 trial tests whether adding an immunotherapy drug (iparomlimab and tuvonralimab) to standard chemoradiotherapy before surgery can improve outcomes for people with locally advanced rectal cancer. About 108 participants will be randomly assigned to receive either the st…

This early-stage study tests a new treatment called KXV01 TCR Lentinvivo in 30 adults with advanced solid tumors that have not responded to standard therapies. The main goal is to check safety and find the right dose. The treatment uses a virus to deliver cancer-fighting genes in…

This phase 3 trial tests a new method called PIPAC that delivers chemotherapy as a pressurized mist directly into the abdomen during a minimally invasive procedure. It compares this approach plus standard intravenous chemo (FOLFIRI) to standard chemo alone for people with appendi…

This early-phase trial tests an experimental drug called ISM5939, taken as a pill, in people with advanced or metastatic solid tumors that have not responded to standard treatments. The study will first test the drug alone, then in combination with chemotherapy (cisplatin or doce…

This Phase 3 trial tests whether adding an immunotherapy drug (serplulimab) to a strong chemotherapy mix (FOLFOXIRI) and radiation works better than standard chemo (CAPOX) plus radiation for people with locally advanced low rectal cancer that is microsatellite stable (pMMR). Abou…

This study tests a new radioactive tracer called 68Ga-FAPI-PSMA for PET/CT scans to see if it can find and stage solid tumors (like prostate, liver, and ovarian cancers) better than current tracers. About 20 adults with suspected or confirmed tumors will receive the tracer and ha…

This study aims to improve early detection of bowel cancer by having patients provide multiple stool samples (FIT tests) instead of just one. About 1,000 people referred to a hospital in Scotland with possible bowel cancer symptoms will take part. The goal is to see if tracking c…

This study tests a new, non-invasive method to detect colorectal cancer and precancerous growths by analyzing odors from breath and intestinal gas. About 453 participants—including people with colorectal cancer, precancerous lesions, and healthy volunteers—will provide samples an…

This study looks at whether offering a blood test (Guardant Shield) can increase colon cancer screening in people who are overdue. About 500 adults aged 45-85 will either get a standard reminder to screen or also have the option to give a blood sample. The goal is to see if the b…

This study aims to see if a simple blood test can find HPV-related oropharyngeal cancer early in men aged 50 and older who have no symptoms. Researchers will check blood for two markers of HPV and then follow up with those who test positive to find and treat any tumors. If succes…

This study tests whether spraying a mix of acetic acid and indigo carmine dye during colonoscopy helps doctors find more precancerous polyps (called sessile serrated lesions) in the right side of the colon compared to standard white-light colonoscopy. About 2,689 adults aged 45-8…

This study tests a new device that flattens colon polyps before they are examined under a microscope. The goal is to help doctors better identify sessile serrated lesions, a type of polyp that can lead to colorectal cancer. About 1,156 adults having polyps removed during a colono…

This study aims to see if testing stool samples for multiple markers can accurately screen for stomach and colorectal cancers. About 5,000 adults scheduled for endoscopy will provide a stool sample before the procedure and be followed for two years. The goal is to develop a non-i…

This study tests a special ultrasound technique called contrast-enhanced subharmonic ultrasound to see if it can predict whether chemotherapy is working for colorectal cancer that has spread to the liver. Currently, doctors wait about 2 months for CT or MRI scans to see if tumors…

This study tests a new radioactive tracer called 68Ga-MY for PET scans. It targets a protein (5T4) found on many cancer cells but rarely on healthy cells. About 20 people with lung or breast cancer will get both a standard FDG scan and a 68Ga-MY scan. Researchers will compare the…

This study focuses on American Indian communities, who face high colorectal cancer death rates. Researchers will test a program where a navigator helps clinics and patients schedule diagnostic colonoscopies within 60 days after a positive screening. The goal is to improve early d…

This study will compare two different PET/MRI scans to see which one is better at finding lymph node metastases in people with middle to high rectal cancer. Thirty participants will receive both types of scans before surgery. The goal is to see if the newer tracer, [68Ga]Ga-CTR-F…

This study tests whether a swallowable capsule camera (colon capsule endoscopy) can effectively screen for colorectal cancer in people with Lynch syndrome, a genetic condition that greatly increases cancer risk. Researchers will compare the capsule's ability to find polyps and ot…

This study tests whether a 3D computer model, made from a standard CT scan, helps surgeons better plan operations for locally advanced colon cancer. About 168 adults with stage cT3 or cT4 colon cancer will be randomly assigned to have surgery planned with or without the 3D model.…

This study tests a new PET imaging agent, 68Ga-cPP-BCH, to detect PD-L1 protein levels in tumors of people with lung cancer, melanoma, or other solid tumors. The goal is to see if this scan can identify who might benefit from anti-PD-1/PD-L1 immunotherapy without needing a tissue…

This early study tests a new radioactive antibody called NTH-2403 in 16 people with advanced colorectal, head and neck, lung, or triple-negative breast cancers. The antibody targets a protein found on cancer cells and their supporting cells, allowing doctors to see tumors on scan…

This study aims to see if measuring two proteins in the blood, Talin-1 and Cripto-1, can help diagnose colorectal cancer. Researchers will compare these levels in 70 newly diagnosed patients and healthy people. The goal is to find a simpler, more accurate way to detect the diseas…

This study aims to improve how doctors classify colon tumors by using artificial intelligence (AI) to analyze CT scans. The AI will be trained to tell early-stage tumors from advanced ones and to detect lymph node involvement, which is key for deciding on treatments like chemothe…

This study will check how well a non-invasive stool test (quantitative fecal immunochemical test, or qFIT) can detect colorectal cancer and precancerous lesions like adenomas and serrated polyps. Researchers will compare the test results with colonoscopy findings in 150 adults ag…

This study tests whether an artificial intelligence (AI) system can help doctors spot more precancerous polyps and colorectal cancers during colonoscopy compared to standard procedures. Over 3,300 adults scheduled for screening or surveillance will be randomly assigned to AI-assi…

This study tests whether annual liquid biopsies (from blood, urine, stool, and vaginal swabs) can safely replace colonoscopies every 18 months for people with Lynch syndrome. 2,000 participants will be split into two groups: one gets standard care (colonoscopy every 18 months), t…

This study tests a new blood test that looks for special molecules called ofCS, which reappear in most colorectal cancers. Researchers will collect blood and stool samples from 2000 people scheduled for a colonoscopy in Denmark. The goal is to see if combining the blood test with…

This study tests whether an artificial intelligence (AI) tool can help doctors spot precancerous growths in the upper part of the colon during a colonoscopy. About 1,200 people with symptoms like belly pain, constipation, or black stools will take part. The goal is to see if usin…

This study tests whether a multilevel screening program can increase colorectal cancer screening rates among Veterans aged 45-49, an age group now recommended for screening due to rising early-onset cases. Participants are randomly assigned to receive a patient education letter a…

This study tests whether giving people a personalized report about their cancer risk and screening options helps them complete recommended cancer tests. Adults aged 45 to 74 who are at high risk for lung, breast, colorectal, upper gastrointestinal, or liver cancer are invited to …

This Phase 2 trial tests whether psilocybin, a psychedelic compound, can prevent or lessen chemotherapy-induced peripheral neuropathy (nerve damage) in people with breast, colorectal, or head and neck cancer. About 83 participants will receive either psilocybin, a low-dose placeb…

This study tests whether an AI-powered chatbot and smart reminders can encourage more high-risk adults aged 45 to 74 to get a colonoscopy, the best way to detect colorectal cancer early. About 1,680 participants will be split into two groups: one gets usual care, the other also g…

This phase III trial tests whether a vaccine made from a person's own immune cells can prevent cancer in 372 adults with Lynch syndrome, a genetic condition that raises cancer risk. Participants receive either the vaccine or a placebo and are monitored for tumor development. The …

This study will test different methods to prevent infections and other problems from central lines (tubes placed in large veins) in 2,500 patients. It compares special antimicrobial caps and a skin anchor device against standard care. The goal is to find the best ways to keep pat…

This early-stage trial tests whether a daily supplement called SAMe can help prevent colorectal polyps (precursors to colon cancer) in 18 adults who have already had surgery for early-stage colon cancer. Participants will take SAMe for up to a year while researchers monitor for s…

This early-phase trial tests a personalized vaccine made from a person's own immune cells (dendritic cells) loaded with cancer-specific markers. The goal is to train the immune system to recognize and destroy precancerous cells in people with Lynch syndrome, who have a high risk …

This study tests whether taking S-adenosylmethionine (SAMe), a natural supplement, can prevent liver injury caused by the chemotherapy drug oxaliplatin. About 30 adults with colorectal cancer that has spread to the liver will take SAMe pills daily for 3-6 months alongside their c…

This study tests different methods to help people get screened for colorectal cancer. About 2000 adults from community health clinics will receive reminders or extra support to schedule a colonoscopy or stool test. The goal is to see which approach works best to increase screenin…

This study compares three topical treatments—sesame oil, aloe vera gel, and nitroglycerin ointment—against no treatment for preventing phlebitis (vein inflammation) caused by chemotherapy. Researchers will enroll 190 adults with breast or colon cancer receiving specific chemo dru…

This study tests a culturally tailored educational program to help Syrian migrants in Turkey get screened for breast, cervical, and colorectal cancers. About 30 participants will take part in the program, which uses a questionnaire to measure their motivation and knowledge before…

This study tests whether a traditional Chinese medicine herbal formula, Jianpi Lishi Jiedu Granules, can prevent colorectal adenomas (precancerous polyps) from returning after they are removed during a colonoscopy. About 376 adults who recently had such polyps removed will take e…

This study tests whether two existing drugs—memantine (used for Alzheimer's) and rosuvastatin (a cholesterol-lowering statin)—can prevent nerve damage caused by the chemotherapy drug oxaliplatin in people with colorectal cancer. About 46 adults will receive these drugs alongside …

This study tests whether wearing tight compression garments on hands and feet during chemotherapy can prevent nerve damage (peripheral neuropathy) caused by taxane or oxaliplatin drugs. About 358 breast and colorectal cancer patients will be randomly assigned to wear compression …

This study tests a gel called TAR-0520 to see if it can prevent hand-foot syndrome, a painful skin reaction caused by the chemotherapy drug capecitabine. About 25 people with breast or colorectal cancer will apply the gel to their hands twice daily for 12 weeks. Their feet will n…

This study tests whether the HPV vaccine can prevent the return of high-grade squamous intraepithelial lesions (HSIL) in people who have already been treated for them. About 984 adults aged 18–55 with HPV-related HSIL of the cervix, vulva, vagina, penis, or anus will receive eith…

This study compares two ways to prevent colon cancer in people who have had multiple advanced polyps removed. One group gets a standard colonoscopy after three years, while the other group does a simple stool test every year for two years, and only gets a colonoscopy if the test …

This study looks at whether people who have had large colon polyps removed can safely wait longer for their next colonoscopy. About 760 adults will be split into two groups: one getting the standard schedule (colonoscopy at 6, 18, and 48 months) and another getting a relaxed sche…

This study tests whether a modified high-fiber version of the UK's EatWell diet can improve health markers linked to early-onset colorectal cancer. Two hundred adults in the UK will follow either the standard EatWell diet (30g fiber/day) or a modified version (40g fiber/day) for …

This study tests whether a daily Bergmann enema can prevent severe rectal injury caused by radiation therapy in 40 rectal cancer patients. Participants will receive the enema from the start of radiotherapy until 10 days after. The goal is to reduce the rate of moderate-to-severe …

This study tests whether the supplement glutamine can prevent nerve damage caused by the chemotherapy drug vincristine in children and teens with cancer. About 70 participants, aged 6 to 18, will take glutamine twice daily for 14 days during their treatment. Researchers will trac…

This study tests if eating only within an 8-hour window each day (time-restricted eating) can reduce treatment side effects and improve quality of life for people with solid tumors starting adjuvant therapy after surgery. Fifty adults will be randomly assigned to follow this eati…

This pilot study tests whether a daily transanal irrigation (TAI) routine can help people who have bowel urgency, leakage, and diarrhea after rectal cancer surgery (low anterior resection syndrome). Sixty adults who have had a temporary ileostomy and are about to have it closed w…

This study tests whether taking high doses of vitamin E and CoQ10 daily for 90 days can reduce chronic side effects from pelvic radiation in people treated for prostate, uterine, cervical, or anal cancer. Researchers will monitor safety, side effects, and quality of life in 200 a…

This study tests whether sucking on ice chips during chemotherapy can prevent or reduce the severity of painful mouth sores (oral mucositis) in cancer patients. 102 adults receiving 5-fluorouracil or methotrexate will be randomly assigned to either get ice chips during infusion p…

This study tests whether an artificial intelligence-based dietary care app can reduce distress from bowel changes and improve quality of life in rectal cancer patients who have had anal-preserving surgery. One hundred participants will be randomly assigned to either standard diet…

This study looks at whether a prehabilitation program—including physical therapy, dietary advice, and emotional support—given before major cancer surgery can reduce deaths and serious complications within 30 days after the operation. About 180 adults with cancers of the pancreas,…

This study tests whether a 6-week dance-based exercise program can reduce nerve pain and improve quality of life in cancer patients who have nerve damage from chemotherapy. About 76 adults with solid tumors will either join the dance program or receive usual care. The goal is to …

This study tests a 6-week health behavior program for 40 colorectal cancer patients who are at least 3 months past surgery. The program uses counseling and support to encourage healthy habits like diet and exercise. Researchers want to see if it's practical and helps improve pati…

This pilot study tests whether a community health worker (promotora) can help Latinx patients recently diagnosed with colorectal cancer. Sixty participants will either get a navigator for up to 6 months or just a list of social services. The goal is to see if this support improve…

This study tests a 4-week AI chatbot program called AI-EGG that teaches emotional skills to young and middle-aged colorectal cancer survivors. The goal is to see if it helps them build resilience and improve quality of life. Fifty-four participants will be randomly assigned to ei…

This study tests whether a 12-week exercise program, delivered via Zoom, is practical and helpful for older adults (65+) with cancer who live in rural areas. Participants will do two supervised exercise sessions per week. The goal is to see if the program improves quality of life…

This study tests whether combining two ultrasound-guided nerve blocks (transversus abdominis plane block and rectus sheath block) can better control pain and speed recovery after robotic colon cancer surgery. About 90 adults having their first robotic colectomy will receive the b…

This study looks at whether using a drug combination without opioids during anesthesia can lower the chance of confusion (delirium) after surgery in people 65 and older having gastrointestinal surgery. About 174 participants will be randomly assigned to receive either opioid-free…

This study tests whether a home-based exercise program can help people with gastrointestinal or lung cancer handle chemotherapy better. Up to 120 participants will be randomly assigned to either an aerobic and resistance exercise group or a stretching group. All activities are do…

This study tests a non-invasive device called transcutaneous electrical acustimulation (TEA) in 190 elderly patients (65+) recovering from colorectal cancer surgery. The device delivers mild electrical pulses to the skin to stimulate bowel function. Participants receive TEA or a …

This study tests whether a 15-minute hand and foot exercise routine can reduce nerve pain caused by Taxane chemotherapy in cancer patients. Fifty-eight adults with mild nerve symptoms will either do the exercises plus standard care or receive standard care alone. Researchers will…

This pilot study tests whether freeze-dried miracle fruit (MiraBurst) can improve taste changes in people with solid tumors undergoing cancer treatment. About 45 adults will take one mini-square before each meal for 90 days. The goal is to see if this simple supplement can ease a…

This study tests whether electroacupuncture (mild electrical pulses through thin needles) can help patients whose stomachs stop working properly after surgery for digestive tract tumors. Seventy-six adults who had such surgery and developed gastroparesis (stomach paralysis) will …

This study develops and tests a support program for cancer survivors who worry about their cancer returning. 150 adults who finished treatment for breast, head and neck, colon-rectal, or prostate cancer will join. Depending on their level of fear, they will receive education, psy…

This study tests whether transplanting healthy gut bacteria (fecal microbiota transplantation) can help advanced cancer patients who are losing weight and appetite—a condition called cachexia. About 66 adults with stomach, colorectal, or lung cancer will receive the treatment. Th…

This study tests a web-based program designed to help advanced cancer patients manage symptoms like depression, pain, fatigue, and sleep problems, while also supporting their caregivers. The program combines online tools with guidance from healthcare professionals. Researchers wi…

This study tests whether electroacupuncture can help bowel function return faster after minimally invasive colorectal cancer surgery. 240 adults will be randomly assigned to receive real acupuncture, sham acupuncture, or standard care. The main goal is to see how quickly patients…

This study tests whether a supervised exercise program, started two weeks before chemotherapy and continued for 16 weeks during treatment, can help adults aged 35 to 65 with breast, lung, or colon cancer tolerate chemotherapy better. The goal is to see if participants can receive…

This study tests whether a supervised strength-training program is safe and practical for people with locally advanced rectal cancer who are receiving chemotherapy and radiation before surgery. Fifteen participants will do personalized resistance exercises twice a week for about …

This study tests a new gel called SUBMO® to see if it works as well as the standard saltwater solution for lifting and removing large colon polyps (over 10 mm) during a colonoscopy. About 300 adults will take part. The goal is to make the removal process smoother and safer.

This study tests whether a personalized exercise program, tracked by a smartwatch, can help reduce fatigue in people who have finished chemotherapy for certain cancers (breast, colorectal, ovarian, pancreatic, or gastric). About 98 participants will be randomly assigned to either…

This study tests whether giving lidocaine through a vein during surgery, plus injecting ropivacaine into the surgical cuts, helps people recover better after laparoscopic colon cancer surgery. About 182 adults will be randomly assigned to get either the lidocaine plus ropivacaine…

This study looks at whether exercise can lessen nerve damage caused by certain chemotherapy drugs. About 140 people with colorectal or gynecologic cancer will either exercise or receive usual care. Researchers will measure nerve function, blood markers, and quality of life to see…

This study tests a support program called FamCASP for adult family members of people with colorectal cancer. The program includes a digital screening tool and counseling to help families cope better. Researchers will compare families who get the support with those who don't, meas…

This study tests if a 4-week prehabilitation program delivered through WhatsApp can help adults with colorectal cancer prepare for and recover from elective surgery. The program includes educational information, diet advice, exercises, and psychological podcasts. Researchers will…

This study tests whether taking probiotic supplements can help reduce common chemotherapy side effects like nausea, diarrhea, and loss of appetite in people with stage III colon cancer. Forty adults will be randomly assigned to receive either probiotics or a placebo during their …

This study tests a new health education program using a virtual 'metaverse' to help colorectal cancer survivors improve their quality of life and adopt healthier lifestyles. The program includes online lessons, immersive virtual interactions, and group support via WeChat. Researc…

This study tests whether a traditional Chinese medicine hand-foot soak can reduce nerve pain and skin reactions caused by chemotherapy. About 300 adults with solid tumors who have these side effects will use the soak. The goal is to see if it improves symptoms and quality of life…

This study tests a new device called Medstrom that monitors pain, sedation, and muscle relaxation all in one during laparoscopic colon cancer surgery. Thirty patients will be randomly assigned to either the Medstrom device or standard monitoring. The goal is to see if the device …

This study tests whether a special imaging mode called RDI helps doctors remove early-stage cancers from the stomach, esophagus, or colon more quickly and safely than standard white-light endoscopy. About 158 adults with early cancers or precancerous lesions will be randomly assi…

This study tests whether taking your own gut bacteria (autologous probiotics) can reduce bowel problems after ileostomy closure in rectal cancer patients. Forty adults who had rectal cancer surgery with a temporary ileostomy will receive capsules containing their own lactobacillu…

This study tests a daily digital mindfulness program designed to reduce depressive symptoms in people who have completed treatment for breast, prostate, or colorectal cancer. Researchers will enroll 76 participants with mild to moderate depression to see if the program is feasibl…

This study tests whether a simplified robot (FASTER) helps doctors remove abnormal growths from the colon or rectum more quickly and safely than the standard method. About 40 adults aged 18 to 80 with such growths will be randomly assigned to one of the two procedures. The main g…

This early study tests whether selpercatinib, a drug already used for certain cancers, can help with cachexia (severe weight loss and appetite loss) in people with advanced lung, colon, or pancreatic cancer. Seven participants will take the drug twice daily for 12 weeks, with reg…

This study looks at whether taking magnesium by mouth or soaking feet in a magnesium solution can help colorectal cancer patients who are on chemotherapy. The goal is to see if these simple treatments can reduce nerve damage (pain, tingling) and improve sleep quality. About 75 ad…

This study tests whether a personalized plan for removing urinary catheters after mid-low rectal cancer surgery can reduce the need for re-insertion. About 1,545 patients will be randomly assigned to one of three groups: catheter removal at 24 hours, at 48 hours, or an individual…

This study tests whether a prehabilitation (prehab) exercise program can reduce memory loss, forgetfulness, and brain fog caused by chemotherapy in older adults with colorectal cancer. Researchers will enroll 86 physically inactive people aged 60-85 who are about to start chemoth…

This early-phase study tests whether adding malic acid (a natural fruit acid) to standard immunotherapy is safe for people with solid tumors like colorectal, lung, or melanoma cancer. About 30 participants will take malic acid by mouth while continuing their immunotherapy. The ma…

This study compares an 8-week versus a 12-week supervised exercise programme in 50 colorectal cancer patients receiving chemotherapy. The goal is to see if exercise can reduce chemotherapy-induced peripheral neuropathy—nerve damage causing tingling, numbness, and pain—and improve…

This study tests whether watching a 10-minute training video through virtual reality glasses on the second day after colorectal surgery can improve patients' self-efficacy—their confidence in managing their own recovery. 66 adults aged 18–65 who had laparoscopic surgery will be s…

This study tests whether a newer drug, sugammadex, helps the bowels recover faster after colorectal surgery compared to an older drug combination (neostigmine/atropine). 560 adults having elective colorectal surgery will be randomly assigned to receive one of the two drugs at the…

This study looks at whether a blood test that finds tiny bits of tumor DNA (ctDNA) can help doctors monitor rectal cancer more closely than standard scans. Researchers will collect blood and tissue samples from 60 adults with non-spreading rectal cancer before and after standard …

This study looks at people who have had certain types of colon polyps (serrated lesions) removed. It aims to find out why some of them later develop new advanced growths in the colon. By tracking 750 adults over time, researchers hope to identify risk factors that could help doct…

This study uses advanced 4D MRI scans to measure blood flow and heart function in adults with heart disease or cancer. Researchers aim to see if these detailed images can help predict how these diseases will progress. The study involves 1,000 participants who are already schedule…

This study explores whether combining artificial intelligence analysis of tumor tissue with special blood tests (liquid biopsy) can more accurately predict if colon cancer will return after surgery. Researchers will follow 400 adults with stage II or III colon cancer for up to fi…

This study follows about 2000 people with colorectal cancer to track their health over time, including survival, disease progression, and side effects from treatments. Researchers aim to understand how the disease behaves in real-world settings, outside of controlled clinical tri…

This study tests an online tool called 'Let's Talk' designed to help people with Lynch syndrome encourage their relatives to get screened for the condition. Lynch syndrome is a genetic disorder that raises cancer risk, and only about half of close relatives currently get tested. …

This study is testing a new approach to personalize cancer treatment for people with colorectal or pancreatic cancer. Researchers will take a small sample of a patient's tumor, grow it in the lab, and test different drugs on it to see which one works best. The goal is to see if t…

This study looks at whether it's safe to skip mechanical bowel preparation (the drink that cleans out your colon) before colon surgery. Currently, the best practice combines that drink with antibiotics to prevent infections. The trial will compare two groups: one getting the drin…

This study tests a new surgical method for removing the splenic flexure during laparoscopic surgery for left-sided colorectal cancer. It compares the new technique (inferior mesenteric artery first with complete medial approach) to traditional methods. The goal is to see if it is…

This study will send different types of WhatsApp messages to 235,000 people in Chile who are due for cancer or chronic disease screenings. Researchers want to see if the way a message is worded (basic, risk-focused, or peace-of-mind) and whether it mentions one test or both tests…

This study will follow 110 adults in Poland with metastatic colorectal cancer (cancer that has spread) who are taking fruquintinib after at least two prior treatments. Researchers will track how long patients live without their cancer getting worse and their overall survival, usi…

This study will follow 57 people having minimally invasive colon surgery where the removed tissue is taken out through the rectum instead of a new abdominal cut. Researchers want to see how often this technique injures the internal anal sphincter muscle and how it affects bowel c…

This study will follow 200 people with colorectal cancer and healthy controls to explore how genes, blood sugar, and immune responses are connected. Researchers will analyze blood and tissue samples to find shared genetic factors that may influence both cancer and diabetes. The g…

This study tracks how the experimental drug AZD1390 moves through and leaves the body after a single dose. It involves about 8 adults with advanced solid tumors who are not currently on active cancer treatment. By using a tiny radioactive label, researchers can measure the drug i…

This study is testing whether a green dye called indocyanine green (ICG) can help surgeons see and remove lymph nodes that contain cancer during laparoscopic colon cancer surgery. About 25 adults with colon cancer will receive the dye injected around the tumor and into a vein. Th…

This study looks at the care paths of 300 people with anal cancer to find out what causes delays in diagnosis. Researchers will track the time from first symptoms to diagnosis and check how screening and access to care affect outcomes. The goal is to improve awareness and help ca…

This study looks at whether the type of stapler used to reconnect the bowel after colorectal cancer surgery affects the risk of a leak. About 600 adults having planned surgery will be observed, but their treatment won't change. The goal is to see if newer staplers are safer than …

This study looks at where cancer spreads to lymph nodes in people with colon or rectal cancer. Researchers will examine tissue from 1200 patients who had surgery to remove their cancer. The goal is to find patterns that could help doctors better plan treatment in the future.

This study looks at how often polyps in the stomach or colon grow back after being removed during a scope procedure. Researchers will follow about 2,000 adults for up to three years to track recurrence and identify risk factors like polyp size, lifestyle, and health history. The …

This study aims to develop a method using advanced MRI scans to predict whether rectal cancer has been completely eliminated after chemoradiation. About 115 patients will be enrolled to test the accuracy of this MRI-based prediction. If it works, some patients might safely avoid …

This study will test a new way to create CT images for people with colon cancer. The method uses deep learning to make the images clearer. Researchers will compare the quality of these new images to standard ones. The goal is to see if this technique helps doctors see tumors bett…

This study tests whether training healthcare providers to reduce stigma can increase the use of HIV and STI prevention services, like testing and preventive medications. It will involve 8 clinics in the Mississippi Delta and track changes in how often patients receive these servi…

This study will collect blood samples from 1,000 people with small colon growths to see if a liquid biopsy can accurately tell benign from malignant lesions and predict cancer spread to lymph nodes. Current methods often lead to unnecessary surgery. The goal is to create a bioban…

This study looks at how decision counseling affects people who get a positive result on the Shield blood test for colorectal cancer. Researchers want to see if counseling helps reduce confusion and increases the chance of getting a follow-up colonoscopy. About 350 adults aged 45-…

This study tests a new short camera called a rectoscope to check the lower bowel after rectal tumour removal. The goal is to see if it can be used in the clinic with a simple enema instead of strong bowel prep, making follow-up checks faster and reducing waiting lists. Thirty pat…

This study is a registry that collects medical information and biological samples from up to 100,000 people with gastrointestinal cancers, such as pancreatic or colorectal cancer. No new treatments or drugs are given. The goal is to gather real-world data to help researchers answ…

This study will check if people with Lynch syndrome, a genetic condition that raises cancer risk, have more gum disease than the general population. Researchers will look at dental records from 25 adults with Lynch syndrome. The goal is to see if gum disease is a hidden health is…

This study will compare treatment recommendations made by a large language model (AI) with those made by a team of cancer experts for 180 people with rectal cancer. The AI will analyze de-identified patient information and suggest a treatment plan. The goal is to see how often th…

This study tests a web-based program called Kindred that helps African American families understand their genetic cancer risk and talk about testing. About 150 people will use the tool to see if it improves knowledge and testing rates. The goal is to make genetic information more…

This study aims to see if a new, simpler tool called CRIS can help doctors better predict which large colon polyps contain cancer. About 764 patients and many endoscopists will take part, comparing the new score to an existing one. The goal is to make cancer risk assessment easie…

This observational study looks at how histidine, a common amino acid, and its transporter SLC15A3 influence colorectal cancer's sensitivity to immunotherapy. Researchers will analyze tumor tissue and blood samples from 150 patients to understand why some cancers resist treatment.…

This early-stage study looks at whether taking oral paclitaxel with encequidar on an empty stomach or after a meal changes how much drug gets into the body. About 46 adults with advanced solid tumors (like breast, lung, or stomach cancer) will take the drugs in different sequence…

This study tests whether berberine, a compound found in some Chinese herbs, can change the types of bacteria living in the gut. Researchers will give berberine to healthy volunteers and to people who have had colon polyps removed. They will measure changes in a specific bacterium…

This study looks at whether tumor DNA found in blood or peritoneal fluid can predict the spread of digestive cancers (stomach, colon, pancreas) to the lining of the abdomen. Researchers will follow 300 patients with early-stage tumors to see if those with positive DNA markers are…

This study reviews data from about 25,000 patients who were checked for bowel cancer in Scotland between 2022 and 2025. The goal is to see how well the current two-step stool test works and find ways to make diagnosis faster and more accurate. Researchers hope to reduce delays an…

This study tests a program to help people with inherited cancer gene mutations (like BRCA or Lynch syndrome) stick to recommended cancer screening schedules. Researchers will interview 80 female participants and provide standard care to see if this approach improves adherence and…

This observational study follows 200 patients with colorectal cancer whose liver tumors are found at the same time as the primary cancer. Researchers will compare one-step surgery (removing both tumors at once) versus staged operations (bowel first or liver first) to see which ap…

This study looks at whether a special decision aid helps patients with a cancerous colon polyp choose between more surgery or careful monitoring. About 110 adults in Denmark will use the aid during their doctor visit. The goal is to see if it changes treatment choices and improve…

This study will look at tumor samples and health records from 300 people who had surgery for rectal cancer. The goal is to find patterns in the tumor's immune environment that can predict which patients will respond well to chemotherapy or immunotherapy. This could help doctors i…

This study looks at 100 adults with advanced rectal cancer who received total neoadjuvant therapy (a combination of chemotherapy and radiation before surgery). Researchers want to see whether the response in the lymph nodes or the primary tumor better predicts how long patients s…

This study will collect information from 2,000 adults having colorectal surgery with the Hugo RAS robot. Researchers will track complications, recovery, and long-term outcomes to see how safe and effective the system is. The goal is to provide real-world evidence to improve minim…

This study will follow 46 people treated for stage III rectal cancer to see if PET-CT scans can help doctors make better treatment decisions during routine follow-up. Participants will already be getting these scans as part of their care and will be tracked for 5 years. The goal …

This study follows 42 women with HPV-positive pelvic cancer (cervix, vagina, vulva, or anus) to understand how radiotherapy, with or without surgery, affects their sexual quality of life. Participants complete questionnaires about sexual function and emotional distress over time.…

This study will look at 1,280 people who had colon polyps removed to find better ways to predict if polyps will come back. Researchers will combine lifestyle information, blood markers, and past medical records to build a risk prediction model. The goal is to improve follow-up sc…

This study looks at whether certain bacteria in your stool can help predict if colon cancer will come back after surgery. Researchers will collect stool and blood samples from 107 adults before and after their surgery. They want to see if bacteria that break down collagen are lin…

This study looks at why colorectal cancer spreads to the liver. Researchers will collect tumor samples from 156 patients during surgery to study a protein called SMYD3. They believe SMYD3 helps cancer cells survive and grow in the liver by changing how cells use energy and handle…

This study will enroll 210 people scheduled for colorectal cancer surgery. Researchers will collect data from wearable devices, continuous glucose monitors, and blood protein tests to see if they can better predict who will have complications after surgery. The goal is to improve…

This study looks at why some people with colorectal cancer feel very tired. Researchers will use blood tests and questionnaires to find links between body chemistry and Traditional Chinese Medicine body types. The goal is to better understand cancer-related fatigue, not to test a…

This study checks if a short questionnaire called G8 can correctly identify frailty in people aged 70 and older with solid tumors. Researchers will compare the G8 results with a full geriatric assessment in 150 patients. The goal is to see if the G8 tool works well for Portuguese…

This study tests a new robotic system (Intilume) for removing early-stage rectal tumors through the body's natural openings, avoiding incisions. Ten adults with non-cancerous or early cancerous growths in the rectum will be treated. The goal is to see if the robot makes the proce…

People with inflammatory bowel disease (IBD) have a higher risk of colon cancer and need regular colonoscopies. This study compares two advanced methods: one uses a dye spray to highlight abnormal areas, and the other uses built-in camera filters to enhance the view without dye. …

This study looks for biological markers in tumor tissue and blood that may be linked to anxiety and depression in people with solid tumors. Researchers will combine psychological assessments with lab tests to better understand these emotional struggles. The goal is to improve ear…

This study looks at how colorectal cancer grows when it spreads to the lining of the abdomen. Researchers want to see if the pattern of tumor growth can help doctors decide who will benefit most from surgery. The study will follow 30 adults who are already scheduled for surgery o…

This study looks at why some people have more pain than others after colorectal surgery. Researchers will test pain sensitivity, analyze blood for inflammation, and ask about emotional health and life stress. The goal is to find better ways to manage pain and prevent long-term di…

This study tests a new approach called 'Flipped Discharge' for people with colorectal cancer who have a stoma after surgery. Instead of focusing care in the hospital, it shifts support to the home, with a nurse visit or video follow-up three days after discharge. The goal is to s…

This study will test a new robotic surgical system, the Sentire Surgical System with a new Patient Side Single Arm, in 12 people needing colorectal surgery for cancer or large polyps. The goal is to see if the system is safe and effective, and if it can reduce costs compared to c…

This study will test two different imaging techniques to help surgeons see blood flow in the bowel during surgery for colorectal cancer. About 150 adults having a specific type of colon surgery will be included. The goal is to see which method works best to guide surgical decisio…

This study will interview 120 cancer patients in Texas to learn what makes it easier or harder to get timely cancer treatment. Researchers will talk with patients by phone or video to understand their experiences across different cancer types and insurance plans. The goal is to i…

This study enrolls 275 people with advanced solid tumors to test a new approach: using a rapid, detailed analysis of each patient's tumor and immune system to guide treatment choices. The goal is to improve the success rate of immunotherapy, which currently helps only 20-30% of p…

This study is for young adults (ages 21-45) who had certain cancers as teens or young adults. Researchers are adapting a program that helps survivors manage their health after cancer treatment. The goal is to see if this program improves survivors' confidence and ability to handl…

This study reviews medical records of 300 adults who had endoscopic or surgical removal of rectal tumors between 2015 and 2025. Researchers want to see if newer endoscopic methods are as safe and effective as traditional surgery. The goal is to help doctors choose the best approa…

This study tests whether a prepackaged low-residue diet (Colobox) helps clean the colon better than just following oral and written instructions before a colonoscopy. Around 230 adults will be randomly assigned to one of two diet plans for 24 hours before the procedure. The goal …

This study will enroll 5,500 average-risk adults in Texas to see if offering a blood test for colorectal cancer, along with an educational smartphone app, increases screening rates. Participants can choose the blood test, and some will get the app to help them follow up. The goal…

This study will examine tissue samples from 30 women having surgery for bowel endometriosis to see if genetic changes in the affected bowel might increase the risk of colorectal cancer. The goal is to better understand any hidden connection and improve how doctors assess cancer r…

This study looks at medical records of 51 patients aged 70 and older with metastatic colorectal cancer. Researchers want to see if using lower doses of chemotherapy along with full-dose targeted therapy can reduce serious side effects like low white blood cell counts and severe d…

This study will analyze tumor samples from 50 women with advanced or recurrent endometrial cancer to find biological markers that predict whether immunotherapy will work. Researchers will examine the tumor's DNA, epigenetics, and surrounding environment. The goal is to better und…

This study will examine genetic changes in colon polyps and stool samples from 32 Korean adults to find markers that could help detect colon cancer earlier. Researchers will compare DNA methylation levels in polyp tissue versus normal tissue. The goal is to improve screening and …

This study will check if people with metastatic breast or colon cancer have antibodies that might also attack the heart. Researchers will collect blood samples and ECGs from 196 participants over 12 months. The goal is to see if these antibodies raise the risk of dangerous heart …

This study tests whether an artificial intelligence (AI) system can help doctors in general hospitals accurately decide how to manage small colon polyps (5mm or smaller) during a colonoscopy. About 363 adults with at least one small polyp will be randomly assigned to have their p…

This study will review medical records of 100 adults with locally advanced rectal cancer treated between 2018 and 2025 at hospitals in Egypt. Researchers will look at which treatments patients received and how they fared, including survival and side effects. The goal is to unders…

This study looks at two ways to remove rectal cancer tumors. The newer method removes the tumor through the anus, avoiding extra cuts in the belly. The goal is to see if this leads to fewer wound problems and less pain after surgery. The study will review records from 190 adult p…

This study compares two types of surgery for right-sided colon cancer: laparoscopic (keyhole) surgery and open surgery. The goal is to see which approach leads to less blood loss, fewer complications, and a shorter hospital stay. The study will include 22 adults with right colon …

This phase 2 trial tests whether a highly sensitive blood test (ctDNA) can help manage treatment for 200 people with early-stage rectal cancer. After standard chemotherapy and radiation, some patients will have their treatment guided by the blood test results instead of immediate…

This study looks at whether doctors are properly reporting small cancer spots called tumor deposits in people with rectal cancer. These spots can show if the cancer is more aggressive and might need extra treatment like chemo or radiation. Researchers will compare reports from be…

This study is testing whether a blood test that looks for tumor DNA (ctDNA) can help doctors choose the right amount of chemotherapy for people with stage III colorectal cancer. About 2,450 participants will be split into groups based on their ctDNA results: those with negative c…

This study will test whether a computer model can accurately predict the chance of finding precancerous colon polyps in 1,000 Indian adults undergoing a routine colonoscopy. The model uses basic health information like age, sex, and lifestyle factors. If it works well, it could h…

This study tests whether a computer-aided detection system can help doctors find more polyps in the right side of the colon during a colonoscopy. About 686 adults aged 40-75 will have two colonoscopies in one session, with the AI system used in one of them. The goal is to see if …

This study looks at how a personalized strength training program affects people with different cancers, including lung, colon, breast, and blood cancers. 150 adults will either do supervised strength training plus home exercises, or just home exercises, for 12 weeks. Researchers …