Could a vaccine made from your own tumor stop colon cancer from returning?
NCT ID NCT02448173
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Phase 3 trial tests a personalized cancer vaccine called OncoVAX for people with Stage II colon cancer. After surgery to remove the tumor, the patient's own cancer cells are used to create a vaccine that trains the immune system to attack any remaining cancer cells. The goal is to prevent the cancer from coming back. The study will enroll about 550 participants and compare disease-free survival between those who receive the vaccine plus surgery versus surgery alone.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- OncoVAX (personalized cancer vaccine made from the patient's own tumor cells)
- What this could lead to
- If it works, this could offer a way to prevent colon cancer from coming back after surgery, potentially reducing the need for chemotherapy in some patients.
- What could go wrong
- This is still experimental and in a large Phase 3 trial, so results are not guaranteed. The vaccine is custom-made for each patient, which is complex, and it may not work for everyone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Halifax Health Medical Center
Port Orange, Florida, 32127, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.