New cream could fight HPV lesions in HIV patients
NCT ID NCT06233331
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-stage trial tests a topical ointment called ACU-D1 for HPV-related vulvar and perianal lesions in people with HIV. Nine participants will apply the cream twice daily for 4 weeks. The main goal is to find the safest dose and see if the treatment can boost immune markers against HPV.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ACU-D1 ointment (proteasome inhibitor)
What this could lead to
If successful, this could point toward a topical treatment for HPV-related lesions in people with HIV, potentially reducing the need for surgery.
What could go wrong
This is a very early Phase 1 trial with only 9 participants, so it is primarily testing safety and dosing. It may not show clear effectiveness, and side effects are unknown.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Grady Memorial Hospital
Atlanta, Georgia, 30303, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••