New combo aims to tackle tough rectal cancer
NCT ID NCT07383285
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial tests whether adding radiotherapy and two immunotherapy drugs (iparomlimab and tuvonralimab) to standard chemotherapy and bevacizumab can improve outcomes for people with a specific type of metastatic rectal cancer (RAS-mutant/MSS). About 106 participants will be randomly assigned to receive either the standard treatment or the enhanced combination. The main goal is to see if the new combo increases the chance of living without the cancer growing for at least 12 months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Iparomlimab and Tuvonralimab (immunotherapy), radiotherapy, capecitabine, bevacizumab, oxaliplatin
What this could lead to
If successful, this could offer a more effective first-line treatment option for people with a hard-to-treat form of metastatic rectal cancer, potentially slowing disease progression.
What could go wrong
This is an early phase 2 trial with only 106 participants, so results may not apply to everyone. Adding radiotherapy and immunotherapy could increase side effects without improving outcomes.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.