New hope for advanced colon cancer: combo therapy enters trial

NCT ID NCT07502014

First seen Apr 09, 2026 · Last updated May 01, 2026 · Updated 6 times

Summary

This study tests whether adding two immunotherapy drugs (iparomlimab and tuvonralimab) and targeted radiation to a standard targeted therapy (fruquintinib) can help people with metastatic colorectal cancer that has not responded to at least two prior treatments. About 60 adults aged 18-75 with limited spread (up to 5 tumors) will be randomly assigned to receive the combination or fruquintinib alone. The main goal is to see if the combination delays cancer growth or death.

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