Could a probiotic fight anal cancer in HIV patients?
NCT ID NCT06949800
First seen Jun 26, 2026 · Last updated Jul 16, 2026 · Updated 3 times
Summary
This study tests whether a probiotic called EXE-346 can help treat anal high-grade squamous intraepithelial lesions (HSIL) and reduce persistent high-risk HPV infection in people living with HIV. The trial will enroll 90 participants who will take the probiotic or a placebo daily. The goal is to see if the probiotic can shrink or eliminate precancerous lesions and clear the virus, potentially preventing anal cancer.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- EXE-346 Probiotic
- What this could lead to
- If it works, this could offer a simple probiotic treatment to reduce anal precancer and HPV infection in people with HIV.
- What could go wrong
- This is an early phase 2 trial with only 90 participants, so results may not be conclusive. The probiotic may not effectively clear lesions or HPV, and side effects are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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University of California, San Francisco
San Francisco, California, 94143, United States
Contact Email: •••••@•••••
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University of Puerto Rico Comprehensive Cancer Center
San Juan, 00936, Puerto Rico
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