Could simple Over-the-Counter drugs supercharge cancer immunotherapy?

NCT ID NCT07661459

Recruiting now Disease control Sponsor: Val Adams Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 1 time

Summary

This study tests whether adjusting common over-the-counter medications can make immune checkpoint inhibitors work better for people with solid tumors. Participants are asked to avoid acetaminophen and cannabis/THC/CBD, while taking aspirin and loratadine (or similar antihistamines) alongside their standard immunotherapy. The goal is to see if this combination improves tumor response at 18 weeks compared to similar patients from past studies.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Aspirin, loratadine, acetaminophen avoidance, THC/CBD avoidance
What this could lead to: If successful, this could point to a simple, low-cost way to boost the effectiveness of standard immunotherapy for several types of cancer.
What could go wrong: This is a Phase 2 trial with a moderate number of participants, and results are compared to historical controls, which may not be perfectly matched. The approach may not work for all cancer types or may have limited benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SOLID TUMORS

Contacts and locations

Locations

University of Kentucky Markey Cancer Center
RECRUITING

Lexington, Kentucky, 40506, United States

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