Virus cocktail takes on tough liver tumors
NCT ID NCT07381309
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial tests whether injecting an oncolytic virus (H101) directly into liver tumors, along with radiation, chemotherapy, targeted therapy, and immunotherapy, can shrink or control colorectal cancer that has spread to the liver and cannot be removed by surgery. The study will enroll 114 adults with a specific type of colorectal cancer (MSS/pMMR). The goal is to see if this powerful combination improves response rates and helps patients live longer without their cancer growing.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- oncolytic virus H101
- What this could lead to
- If successful, this combination approach could offer a new treatment option for people with hard-to-treat colorectal cancer that has spread to the liver.
- What could go wrong
- This is an early phase 2 trial with only 114 participants, so results may not apply to everyone. Combining multiple therapies also raises the risk of side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Sixth Affiliated Hospital, Sun Yat-sen University
Guangzhou, Guangdong, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can a new drug combo shrink Hard-to-Treat tumors?
- Can a new immunotherapy combo shrink Hard-to-Treat tumors?
- Can a Cancer-Fighting virus shrink tumors when chemo fails?
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