Engineered macrophages take on Hard-to-Treat cancers
NCT ID NCT07409766
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial tests a new type of cell therapy called CAR-Macrophages in 20 adults with advanced solid tumors. The immune cells are modified to target specific markers on cancer cells (HER2, PSMA, FAP) and are given by IV. The main goals are to check safety, find the best dose, and see if the cells can shrink tumors.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- CAR-Macrophage cells (genetically modified immune cells targeting HER2, PSMA, FAP)
- What this could lead to
- If successful, this could point toward a new cell therapy for advanced solid tumors that are hard to treat with current options.
- What could go wrong
- This is a very early (Phase 1) trial with only 20 participants, so safety and effectiveness are not yet proven. The therapy may cause severe side effects like cytokine storms.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences
Beijing, 100000, China
Contact Phone: •••-•••-••••
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