Could probiotics tame Chemo's worst symptoms?

NCT ID NCT06772090

Not yet recruiting Symptom relief Sponsor: Masonic Cancer Center, University of Minnesota Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether taking probiotic supplements can help reduce common chemotherapy side effects like nausea, diarrhea, and loss of appetite in people with stage III colon cancer. Forty adults will be randomly assigned to receive either probiotics or a placebo during their chemo treatment. The main goal is to see if a larger, more definitive trial is even possible, so results will focus on how many people complete the study and how many side effects occur.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Probiotic supplement (Lactobacillus and Bifidobacterium)
What this could lead to: If it works, this could point toward a simple way to reduce common chemo side effects like nausea and diarrhea for people with colon cancer.
What could go wrong: This is a very small, early feasibility trial with only 40 people. It is designed to test whether a larger study is possible, not to prove the probiotics work. Results may not apply to other cancers or treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colon carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CYTOTOXICITY SOLID TUMOR, ADULT

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