Colorectal neoplasm

This phase 3 study tested the 9-valent HPV vaccine (Gardasil 9) in over 1,000 Japanese males aged 16 to 26. The goal was to see if the vaccine could prevent persistent HPV infections that can lead to genital warts and anal cancers. Participants received either the vaccine or a pl…

This study tested whether a personalized vaccine could be safely made and given to 25 adults with advanced cancers that cannot be cured. The vaccine was custom-made for each person. The main goal was to check for side effects and see if the approach is feasible.

This trial tests a temporary device called CG-100 that is placed inside the intestine during colorectal cancer surgery. The device is designed to protect the surgical connection while it heals, potentially reducing leaks and other complications. The study includes adults aged 22 …

This study tests whether a secure website with educational sessions, goal-setting, and tracking tools can help survivors of several cancers (including breast, prostate, colorectal, and others) improve their diet, increase physical activity, and manage weight. Participants are age…

This study tests an experimental drug called XmAb24306, given alone or with another cancer drug (atezolizumab), in people with advanced solid tumors that cannot be cured. The main goal is to check the drug's safety and how the body processes it. About 195 participants will take p…

This early-stage trial tests an experimental cell therapy called IBR854 in people with advanced solid tumors that cannot be surgically removed or have spread. The main goals are to check the treatment's safety and find the right dose. Participants receive the cells by infusion tw…

This phase 2 trial is testing whether a combination of chemotherapy (mFOLFOX6), a targeted therapy (bevacizumab), and an immunotherapy (PD-1 inhibitor) can help people with a specific type of locally advanced colorectal cancer called microsatellite stable (MSS). Unlike other colo…

This early-phase trial tests an experimental tablet called YZJ-5053 in people with advanced solid tumors who have no standard treatment options left. The main goals are to find a safe dose and check for side effects. Researchers will also look at how the drug moves through the bo…

This study tested the drug larotrectinib in 215 adults with various solid cancers that have a specific change in the NTRK gene. The drug is taken orally and works by blocking the action of the altered gene. The main goal was to see how many patients had their tumors shrink or dis…

This early-phase study tested the safety of combining two drugs—pembrolizumab (an immunotherapy) and AMG386 (which targets blood vessel growth)—in 62 people with advanced solid tumors like melanoma, ovarian, renal, or colorectal cancer. The main goals were to find the safest dose…

This pilot study tests whether a purified green tea extract called EGCG can help prevent colon cancer from coming back after surgery. 51 patients who had their colon cancer removed took either the extract or a placebo. Researchers are checking for changes in DNA methylation, a ma…

This study tests a combination of three immunotherapy drugs—PDS0101, M7824, and NHS-IL12—in people with advanced HPV-related cancers such as cervical, anal, and throat cancers. The goal is to see if the mix can shrink tumors or stop them from growing. Participants receive the dru…

This trial investigates whether adding a dietary supplement called sodium nucleinate to standard FOLFOX chemotherapy helps people with metastatic colorectal cancer (cancer that has spread). Participants are randomly assigned to receive either the supplement or a placebo alongside…

This study tests whether giving patients their own stool bacteria through a temporary stoma can reduce inflammation in the unused part of the colon, a condition called diversion colitis. Sixty-six people with rectal cancer who have a temporary ileostomy will receive either a dail…

This study is testing a new device called SEGER IDEA™ that helps surgeons close openings in the bowel during keyhole surgery. It is the first time this device is being used in humans. Ten adults having certain types of bowel surgery will take part. The main goal is to see if the …

This early-stage trial tested a new drug called BGB-15025, alone or with another drug (tislelizumab), in 157 people with advanced solid tumors that had stopped responding to standard treatments. The main goal was to check safety and find the best dose. The study is now complete, …

This early-phase trial tested an experimental drug called IOS-1002, given alone or with the immunotherapy pembrolizumab, in 47 adults with advanced solid tumors that had stopped responding to standard treatments. The main goal was to check safety and find the right dose. Research…

This phase 2 trial tested a combination of two drugs—paclitaxel (given intravenously and directly into the abdomen) and oral nilotinib—in 21 adults with cancers that had spread to the lining of the abdomen and could not be surgically removed. The goal was to see if the treatment …

This phase 2 study tested a combination of two drugs—olaparib and pembrolizumab—in 333 adults with advanced solid tumors that have specific DNA repair problems (HRR mutations or HRD). The goal was to see if the combo could shrink tumors or slow their growth. Participants had alre…

This large phase III trial studied whether adding the targeted drug cetuximab to standard chemotherapy after surgery helps prevent cancer from coming back in patients with stage III colon cancer. Over 3,300 patients took part, and the study focused on those with a specific geneti…

This study tested whether giving a mix of immunotherapy drugs (tislelizumab and IL-2) plus chemotherapy before surgery could shrink tumors more effectively in people with locally advanced rectal cancer. The trial involved 130 adults whose cancers had not spread but were hard to t…

This early-phase trial tested an experimental drug called IBI129 in 36 adults with advanced solid tumors that could not be removed by surgery or had spread. The main goals were to find a safe dose and check for side effects. Researchers also looked for any signs that the drug mig…

This Phase 1 trial tested an investigational oral drug called CFI-402257 in 52 people with advanced solid tumors, including breast cancer, that had stopped responding to standard treatments. The main goal was to find a safe dose and check how the drug moves through the body. It w…

This trial compares two types of oral nutritional supplements given to colorectal cancer patients before surgery. One group receives standard high-protein drinks, while the other gets immunonutrition drinks enriched with arginine, nucleotides, vitamin D, and omega-3 fatty acids. …

This study tested a fixed-dose combination of two immunotherapy drugs, tiragolumab and atezolizumab, given together as a single infusion every three weeks. The trial enrolled 64 people with advanced solid tumors that express a protein called PD-L1. The main goal was to check the …

This early-phase trial tested an experimental drug called KVA12123, given alone or with the immunotherapy Keytruda, in 40 adults with advanced solid tumors (like lung, breast, or colon cancer) that had stopped responding to standard treatments. The main goals were to check safety…

This completed study looked at whether adding an immune-boosting drug called thymalfasin to standard chemoradiotherapy and a PD-1 inhibitor could help shrink advanced rectal tumors before surgery. Researchers studied 47 patients with stage II/III mid-low rectal cancer. The main g…

This study tests whether a combination of three drugs—cisplatin, nivolumab, and temozolomide—can shrink tumors in people with advanced colorectal cancer that has not responded to other treatments. The cancer must be a specific type called MMR-proficient. The trial involves 18 par…

This trial tests whether a program of exercise, nutrition advice, and psychological support—started four weeks before surgery and continued afterward—can reduce complications in people having colon cancer surgery. Participants are adults over 40 with non-metastatic colon cancer w…

This study tested a drug called PF-06801591 in 155 people with advanced solid tumors or non-small-cell lung cancer. The drug works by blocking a protein that stops the immune system from attacking cancer cells. The goal was to check safety, how the drug moves through the body, an…

This pilot study tested whether combining high-dose radiation therapy with the immunotherapy drug pembrolizumab (Keytruda) could boost the immune system's ability to fight advanced solid tumors. Twenty-one patients with various advanced cancers received the combination either at …

This early-phase trial tested a new drug called vilastobart, alone or with another drug (atezolizumab), in 125 people with advanced solid tumors that had stopped responding to standard treatments. The main goals were to check safety and find the right dose. Researchers also looke…

This phase 1 trial tested the combination of dasatinib (a pill) and bevacizumab (an infusion) in 50 adults with advanced solid tumors that no longer respond to standard treatments. The goal was to find the safest dose and see how well the two drugs work together to slow cancer gr…

This study tested two experimental drugs (AK104 and AK117) together, sometimes with chemotherapy, in 128 people with advanced solid tumors. The goal was to see if the combination is safe and can shrink tumors. It focused on patients with stomach, esophageal, or other advanced can…

This early-phase trial tested a combination of two chemotherapy drugs (gemcitabine and carboplatin) plus lenalidomide, a drug that blocks blood vessel growth in tumors, in 18 adults with advanced solid tumors, especially urothelial (bladder) cancer. The main goal was to find the …

This study tested a new oral drug called BGB-43395 in 33 Chinese patients with advanced or metastatic HR+/HER2- breast cancer and other solid tumors. The drug blocks a protein (CDK4) that helps cancer cells grow. The goal was to find a safe dose and see if it can shrink tumors wh…

This early-phase study tested a new drug called BGB-C354, alone or with an immunotherapy (tislelizumab), in 63 people with advanced solid tumors that had not responded to standard treatments. The main goals were to check safety and find the right dose. Researchers also looked for…

This early-phase study tested a personalized cancer vaccine (RO7198457) in 273 patients with advanced solid tumors like melanoma, lung, and breast cancer. The vaccine was given alone or with an immunotherapy drug (atezolizumab) to see if it was safe and how the body responded. Th…

This early-phase study tested whether adding indomethacin, a common anti-inflammatory drug, to standard platinum-based chemotherapy is safe for people with colorectal, esophageal, or ovarian cancers. The 13 participants received escalating doses of indomethacin alongside their ch…

This study tested a new under-the-skin shot version of the cancer drug pembrolizumab (Keytruda) in 142 people with advanced solid tumors. The goal was to see how well the body absorbs the drug compared to the standard IV infusion. Researchers also checked for side effects and how…

This early-phase trial tested a new drug called TdCyd in 27 adults with advanced solid tumors that had stopped responding to standard treatments. The drug is designed to turn back on genes that may slow tumor growth. The main goal was to find a safe dose and check for side effect…

This phase III trial tested whether adding a monoclonal antibody called edrecolomab to surgery helps people with stage II colon cancer live longer or stay cancer-free longer. About 2,100 participants were randomly assigned to receive either the antibody or no additional treatment…

This phase 2 trial tested a combination of three drugs—encorafenib, binimetinib, and cetuximab—in 95 patients with a specific type of advanced colorectal cancer (BRAF V600E mutation) who had not received prior treatment for their metastatic disease. The goal was to see how many p…

This study tested whether a 20-minute arm cycling exercise, done twice daily for five days, could improve lung function and recovery in 60 elderly patients after colon cancer surgery. Participants also received standard physical therapy. The goal was to see if the arm exercise co…

This study tested whether adding the arthritis drug Celebrex to an experimental chemo drug called EPO906 could reduce severe diarrhea in people with advanced colorectal cancer. The trial enrolled 75 patients who had already tried other treatments. The first phase found the safest…

This study tested a new drug called XTX202 in 95 people with advanced solid tumors that had not responded to standard treatments. The goal was to check safety, find the right dose, and see if the drug could shrink tumors. The trial is now complete.

This early-phase study tested a combination of two drugs, cabozantinib and 13-cis-retinoic acid, in 15 children whose solid tumors had come back or were not responding to standard treatments. The main goal was to find the safest dose and understand side effects. The study did not…

This early-stage trial tested a new drug called AZD6244 combined with standard chemotherapies in 140 people with advanced solid tumors (breast, colon, lung, melanoma, kidney). The main goal was to see if the combination is safe and tolerable, and to find the best dose. Researcher…

This Phase 3 trial tested a new drug combination called MK-4280A (favezelimab plus pembrolizumab) against standard treatments (regorafenib or TAS-102) in 441 people with advanced colorectal cancer that had stopped responding to prior therapy. The goal was to see if the new combin…

This study tested two different ways of stitching the belly wall closed after colorectal cancer surgery to see which one better prevents the wound from bursting open. Forty adults having open surgery were randomly assigned to either an interrupted 'figure-of-X' stitch or a contin…

This early-phase trial tested two drugs together—pembrolizumab (Keytruda) and XL888—in 47 people with advanced gastrointestinal cancers like colorectal and pancreatic cancer that had spread or could not be removed. The main goal was to find the safest dose and check for side effe…

This study tested whether adding bevacizumab to a powerful four-drug chemotherapy regimen (FOLFOXIRI) could shrink liver tumors in people with colorectal cancer that had spread only to the liver and could not be removed surgically. The goal was to see if more patients could then …

This study tested whether adding the anti-inflammatory drug celecoxib to standard FOLFOX chemotherapy helps prevent cancer from returning in people with stage III colon cancer after surgery. Over 2,500 participants were randomly assigned to receive either celecoxib or a placebo a…

This study tested whether injecting a special dye (ICG) during laparoscopic colorectal cancer surgery helps surgeons see blood flow and choose a safer spot to cut. Over 560 adults took part, with half getting the dye and half relying on the surgeon's usual judgment. The main goal…

This study tested a temporary device called Colovac 2 in 24 people undergoing colon cancer surgery. The device is placed inside the bowel to protect the surgical connection while it heals, potentially avoiding the need for a temporary stoma. Researchers checked if the device stay…

This registry followed 152 patients with colorectal cancer that had spread mainly to the liver. Doctors used tiny beads called LifePearl Microspheres loaded with the chemotherapy drug irinotecan, delivered directly to the liver's blood supply. The goal was to see how and when thi…

This study tested whether placing a temporary drain in the pelvis after rectal cancer surgery reduces the risk of serious infections like leaks or abscesses. About 500 patients were randomly assigned to receive a drain or not. The main goal was to see if drainage lowered pelvic s…

This study tested a new drug called TJ004309, either alone or combined with another drug called Toripalimab, in 225 adults with advanced solid tumors that had stopped responding to standard treatments. The goal was to find the safest dose and see early signs of effectiveness. The…

This registry followed 500 adults with colorectal cancer that spread to the liver. All were treated with a microwave ablation device that uses heat to destroy tumors. The goal was to see how well the device controls tumors locally over 12 months and to track any side effects. The…

This early-phase study tested a daily combination of two oral drugs, axitinib and everolimus, in 19 people with advanced solid tumors, particularly kidney cancer. The main goal was to find the safest dose by monitoring side effects in the first month. Researchers also tracked how…

This phase 3 trial tested whether adding two months of Folfirinox chemotherapy before standard radiation and chemo could help more patients with early-stage rectal cancer avoid major surgery. 218 adults with small, low-lying tumors were enrolled. The goal was to see if more patie…

This study tested a new oral drug called HMPL-453 tartrate, either alone or combined with chemotherapy or an immunotherapy (toripalimab), in 190 people with advanced solid tumors that had stopped responding to standard treatments. The main goals were to check safety and see if th…

This early-phase trial tested a combination of two drugs (MEK162 and mFOLFIRI) in 25 adults with advanced RAS-positive colorectal cancer that had stopped responding to standard treatment. The main goal was to find the safest dose and check for side effects. Researchers also looke…

This early-stage study tested two drugs, cabozantinib and pamiparib, together in 44 people with advanced solid tumors that had stopped responding to standard treatments. The goal was to find the safest dose and understand side effects. The drugs work by blocking certain enzymes t…

This early-phase study tested a new drug called CCT3833 in 31 adults with advanced solid tumours, including melanoma. The main goal was to find a safe dose and check for side effects. Researchers measured how the drug moves through the body and looked for the best dose to use in …

This early-phase trial tested a new drug called PM14 in 126 people with advanced solid tumors that had no standard cure. The main goals were to find a safe dose and check for early signs of tumor shrinkage. The drug was given by IV infusion on different schedules. This is a first…

This early-phase study tested an experimental drug called COM902, alone or with other drugs, in 94 people with advanced cancers like ovarian, lung, and colon cancer. The main goal was to check safety and find the right dose. Researchers also looked for early signs that the drug m…

This early-stage study tested a new antibody drug (similar to cetuximab) in 18 people with advanced colorectal cancer that had stopped responding to standard treatments. The main goal was to check safety and how the drug moves through the body. Participants received one of two do…

This study tested an experimental drug called CBX-12 in 69 adults with advanced solid tumors (like ovarian, lung, breast, or colon cancer) that had stopped responding to standard therapies. The main goals were to check the drug's safety, find the best dose, and see if it could sh…

This early-stage study tested a custom-made yeast vaccine designed to train the immune system to recognize and attack leftover cancer cells. Five adults with various cancers (like colorectal, breast, or lung) who had completed initial treatment received the vaccine. The goal was …

This study tested a treatment plan for locally advanced rectal cancer that uses a short course of radiation followed by chemotherapy, aiming to avoid surgery. 39 patients were enrolled. The goal was to see if the cancer could be completely controlled without an operation, using a…

This early-stage study tested a new drug called BI 765049, alone or combined with another drug (ezabenlimab), in 21 Asian adults with advanced solid tumors (stomach, colorectal, pancreatic, liver, head and neck, or lung cancer) that have a specific marker called B7-H6. The main g…

This study tested whether a new drug called A140 works as well as the standard drug Erbitux for people with a certain type of advanced colorectal cancer (RAS wild-type). Both drugs were given together with chemotherapy. The trial involved 688 adults and measured how many patients…

This early-phase trial tested a new drug called KL340399, which is injected directly into tumors to activate the immune system. It involved 6 adults with advanced solid tumors who had no other treatment options. The main goals were to check safety, find the right dose, and see if…

This study looked at the long-term safety of the cancer drug vismodegib in 19 patients with ovarian cancer, basal cell carcinoma, or metastatic colorectal cancer. All participants had previously taken vismodegib in an earlier Genentech trial and were expected to benefit from cont…

This early-phase trial tested a new drug called KL340399 in 21 adults with advanced solid tumors that had stopped responding to standard treatments. The drug works by activating the STING pathway to help the immune system fight cancer. The main goals were to check safety, find th…

This study tested a DNA-based vaccine called VGX-3100 in 44 HIV-positive adults with high-grade anal precancer caused by HPV types 16 or 18. The vaccine was given with a mild electric pulse (electroporation) to help cells absorb it and boost the immune system's attack on the abno…

This study tested whether adding an immunotherapy drug called APX005M to standard treatment helps people with advanced rectal cancer achieve a complete response (no cancer left after treatment). 58 adults with stage II or III rectal cancer at high risk took part. The goal was to …

This study tested a new way to reconnect the colon after removing a cancerous section using a robot. The technique uses a special double purse-string stitch and a single stapler. Thirty-nine patients with sigmoid colon cancer were included, and the study looked at how well the te…

This study tested a combination of two drugs, lenvatinib and pembrolizumab, in 611 people with advanced cancers like breast, ovarian, stomach, colorectal, brain, bile duct, or pancreatic cancer that had stopped responding to standard treatments. The goal was to see if the combo c…

This phase 2 study tested the drug erdafitinib in 316 adults and children with advanced solid tumors that have specific FGFR gene mutations or fusions. The main goal was to see if the drug could shrink tumors. Participants took erdafitinib tablets daily. The study is now complete…

This study tested an experimental drug called CTX-009 in 49 adults with metastatic colorectal cancer that had worsened after two or three prior treatments. The goal was to see if the drug could shrink tumors or stop them from growing. Results will help determine if further testin…

This early-phase study tested a new drug, HBM1020, in 17 people with advanced solid tumors that had stopped responding to standard treatments. The main goal was to check safety and find the right dose. The drug was given by IV every three weeks. Because this is a Phase 1 trial, i…

This early-phase study tested the safety of combining the immunotherapy drug pembrolizumab with precise, high-dose radiation (SBRT) to the liver in 15 adults with colorectal cancer that had spread only to the liver. The goal was to see if this combination could prevent the cancer…

This study tested a device called Colovac+ in 27 adults having surgery for colorectal cancer. The device is placed inside the bowel to protect the surgical connection and keep stool away while it heals. The goal was to see if it is safe and effective, and whether it could help pa…

This study tested whether a short course of radiation followed by chemotherapy could eliminate the need for surgery in people with early-stage rectal cancer. 63 patients were enrolled, and the treatment aimed for a complete clinical response, meaning no tumor could be found on ex…

This study tested a new drug called PRL3-ZUMAB in 14 people with advanced solid tumors (like stomach or liver cancer) that stopped responding to standard treatments. The drug was given every two weeks to see if it could shrink tumors or stop them from growing. Researchers also lo…

This study tested a new two-drug combination (encorafenib and cetuximab) against standard treatments in 107 Chinese patients with a specific genetic mutation (BRAF V600E) that makes colorectal cancer harder to treat. The goal was to see if the new combo could slow cancer growth b…

This study tested a new oral drug called ensartinib (X-396) for the first time in humans. It involved 131 people with advanced solid tumors, including those with ALK-positive non-small cell lung cancer. The goal was to find the safest dose and see if the drug could shrink tumors.…

This study tested a new radioactive drug, 177Lu-NeoB, in 35 adults with advanced solid tumors that have a specific marker (GRPR). The goal was to check safety, find the best dose, and see if it shrinks tumors. It is an early-stage trial, so it focuses on safety and dosing, not a …

This study tested a treatment for people with colorectal cancer that spread to the liver and had not responded to at least two prior therapies. The treatment combined a strong chemotherapy cocktail delivered directly to the liver (FOLFOXIRI via hepatic arterial infusion) with an …

This early-phase trial tested a combination of two cancer drugs, bortezomib and clofarabine, in 28 adults with advanced solid tumors, lymphomas, or myelodysplastic syndromes that had stopped responding to standard therapy. The main goal was to find the safest dose and check for s…

This phase 3 trial tested whether combining sotorasib (a pill) and panitumumab (an infusion) can slow tumor growth better than standard chemotherapy in 160 adults with metastatic colorectal cancer that has a specific KRAS G12C mutation. Participants were randomly assigned to rece…

This early-phase trial tested a new drug called AZD8186 combined with the chemotherapy docetaxel in 23 patients with advanced solid tumors that have PTEN or PIK3CB gene mutations. The main goal was to find the safest dose and understand side effects. The study is complete, but re…

This phase 2 study tested the immunotherapy drug prolgolimab in 30 people with a specific type of colorectal cancer (MSI/dMMR) that had not spread. Participants received the drug for 6 months before planned surgery. The main goal was to see if the cancer completely disappeared in…

This early-stage trial tested an experimental drug called HH-101 in 12 people with advanced solid tumors that had not responded to standard treatments. The main goal was to check the drug's safety and find the right dose. Participants received HH-101 as an IV infusion every three…

This early-phase study tested a combination of two drugs, cabozantinib and TAS-102, in 15 people with advanced colorectal cancer that had spread and stopped responding to standard treatments. The main goal was to find the safest dose and identify side effects. The study is comple…

This study tested whether a 3-year physical activity program could help prevent colon cancer from coming back in 889 patients who had surgery and chemotherapy for high-risk stage II or stage III colon cancer. Participants were randomly assigned to either the exercise program plus…

This study tested a newer, less invasive surgery called ETAP (done through the anus) against standard laparoscopic surgery (done through the belly) for low rectal cancer. 226 adults took part. The goal was to see if ETAP is as good at removing all cancer while possibly leading to…

This phase II trial tested the immunotherapy drug nivolumab (Opdivo) in 35 adults with advanced colorectal cancer that has a specific marker (class II expression) and is microsatellite stable, a type that usually does not respond to immunotherapy. The goal was to see if the drug …

This completed phase I/IIb trial tested a personalized vaccine made from each patient's unique tumor mutations. Eight adults with advanced solid tumors or high recurrence risk received the vaccine alongside an immune booster and later checkpoint inhibitors. The goal was to see if…

This early-phase trial tested a combination of three drugs—vemurafenib, cetuximab, and irinotecan—in 47 people with advanced solid tumors that have a specific BRAF V600 mutation and could not be removed by surgery or had spread. The main goal was to find the safest dose and under…

This phase 2 trial tested the drug samotolisib in 18 children and young adults with advanced solid tumors, non-Hodgkin lymphoma, or histiocytic disorders that had spread, returned, or stopped responding to treatment. Only patients whose tumors had specific mutations in the TSC or…

This study tested a new drug called FF-10502-01 in 106 adults with advanced solid tumors or lymphomas that had stopped responding to standard treatments. The goal was to find the safest dose and see if the drug could shrink tumors or slow disease progression. While not a cure, th…

This study looked at whether removing small, early-stage anal cancers with local surgery alone is safe and effective for people with HIV. The goal was to see if this less invasive approach could avoid the need for stronger treatments like radiation or chemotherapy. Sixteen partic…

This early-phase trial tested a new drug called NOV140101 in 32 adults with advanced solid tumors that had spread or could not be removed by surgery. The main goals were to find the safest dose and check for side effects. The study is complete, but it was too small to determine i…

This study tested a drug called axitinib against a placebo in 52 people with advanced colorectal cancer that had spread to the liver and stopped responding to chemotherapy. The goal was to see if axitinib could help control the cancer and to test a special ultrasound technique th…

This study tested a new experimental treatment called HPVST cells in 32 people with HPV-related cancers that had returned or not responded to standard care. The cells are grown from the patient's own blood and trained to attack HPV-infected cancer cells. The goal was to find a sa…

This phase 2 trial tested an experimental drug called HX009 in 20 adults with advanced solid tumors that had stopped responding to standard treatments. HX009 is a bifunctional antibody designed to block two proteins (CD47 and PD-1) that help tumors hide from the immune system. Th…

This study compared two ways to close skin after colorectal cancer surgery: a tissue adhesive (skin bond) and traditional skin stapling. Researchers looked at wound infection rates within 30 days, pain, and cost in 304 patients. The goal was to see if skin bond leads to fewer inf…

This study tested a new drug called TAK-676, alone and with pembrolizumab, in 248 adults with advanced solid tumors that had no standard treatment options. The main goal was to check safety and find the highest dose that causes few side effects. The study also looked at how well …

This study tested giving chemotherapy before a less invasive surgery for early rectal cancer. The goal was to see if this approach could allow patients to keep their rectum instead of needing major surgery. 58 people took part, and the treatment was considered successful if at le…

This study looked at 180 people with rectal cancer that had spread to lymph nodes in the pelvis. One group received a three-drug chemotherapy regimen (FOLFOXIRI) followed by surgery to remove the affected lymph nodes. The other group got standard chemoradiotherapy before surgery.…

This phase 3 trial tested whether a surgical procedure called laparotomy plus heated chemotherapy (HIPEC) could improve outcomes for colorectal cancer patients at high risk of cancer spreading in the abdomen. 150 patients who had already undergone surgery and chemotherapy were ra…

This early-phase trial tested whether combining the experimental drug relatlimab with other immunotherapies (nivolumab plus either BMS-986205 or ipilimumab) is safe and can shrink tumors in people with advanced solid cancers. A total of 229 participants with various incurable, ad…

This study tested an experimental drug called BMS-986016 (anti-LAG-3) alone or combined with nivolumab in people with advanced solid tumors that had spread or couldn't be removed by surgery. It included several cancer types like lung, stomach, liver, kidney, bladder, head and nec…

This phase 2 trial tests the drug utidelone in 126 people with advanced solid tumors (excluding breast, lung, and colorectal cancers) that have not responded to standard treatments. The study aims to see if the drug can shrink tumors and how safe it is. Participants receive utide…

This study tested whether a device that uses light to monitor blood flow (photoplethysmography) could help doctors manage fluids better during colorectal surgery. The goal was to reduce complications after surgery. 160 adults having colorectal surgery took part. The approach is n…

This study tested combinations of three immunotherapy drugs—tislelizumab, surzebiclimab, and alcestobart—in 147 adults with advanced solid tumors that had not responded to prior treatments. The goal was to find safe doses and see if the drugs could shrink tumors. The trial is now…

This early-phase study tested a new drug called gevokizumab alongside standard cancer treatments in 167 adults with advanced colorectal, stomach, or kidney cancer that had spread. The goal was to find a safe and active dose and see if the combination could help control the diseas…

This early-phase trial tested the safety of combining pioglitazone (a diabetes drug) with carboplatin (a chemotherapy) in 14 people with advanced solid tumors that could not be cured with standard treatments. The goal was to find the best dose and see if the combination is safe. …

This early-phase study tested a new drug called BAT4706 in 28 adults with advanced solid tumors or melanoma who had no other good treatment options. The main goal was to find a safe dose and check for side effects. This was not a cure study; it aimed to gather safety information …

This early-phase trial tested an experimental drug called BAT8010 in 23 people with advanced or metastatic solid tumors who had no other standard treatment options. The main goals were to check safety, find the best dose, and see if the drug shows any sign of shrinking tumors. Pa…

This study tested a new method called underwater endoscopic submucosal dissection (UESD) for removing large colon growths. Instead of using gas to inflate the colon, the doctor fills it with saline (salt water) to improve visibility and make the procedure easier. The trial involv…

This study looked at whether a high-protein drink with added arginine can reduce problems like infections and slow bowel movement after colorectal surgery. It included 44 adults who were malnourished or at risk of malnutrition before their operation. Participants received either …

This completed Phase 2 trial tested whether a special DNA-based test could predict how well patients with stomach or rectal cancer respond to immunotherapy (tislelizumab) combined with chemotherapy and/or radiation. 189 adults with advanced cancer participated. The goal was to se…

This study tested a new cancer drug called brigimadlin (BI 907828) in 266 adults with advanced solid tumors that had spread or stopped responding to standard treatments. The goal was to find a safe dose and see if the drug could shrink tumors. Brigimadlin is an MDM2 inhibitor tak…

This early-phase study tested a personalized immunotherapy (iNeo-Vac-P01) in 6 patients with stage III colorectal or non-small cell lung cancer who had already completed surgery and standard adjuvant therapy. The vaccine was designed to target unique neoantigens from each patient…

This study looked at whether adding metformin, a common diabetes medicine, to standard chemo and radiation therapy could help people with locally advanced rectal cancer. 60 adults with stage T3 or T4 rectal cancer took part. The main goal was to see if the combination led to a co…

This study checked if a generic version of the cancer drug trifluridine/tipiracil works the same as the brand-name drug Lonsurf in 76 patients with solid tumors. Participants took the drug under fasting and fed conditions to compare how the body absorbs it. The goal was to show t…

This study tested a new cancer drug called ERAS-007, given by mouth, together with other targeted therapies in 101 people with advanced colorectal or pancreatic cancers that have certain gene changes. The main goals were to check safety, find the best dose, and see how the drugs …

This early-stage study tested a new drug called DF6215, alone or with another drug (pembrolizumab), in 35 adults with advanced solid tumors that could not be removed by surgery or had spread. The main goals were to find the safest dose and check for side effects. The study is com…

This early-stage study tested a new drug called cabotamig in 33 adults with advanced cancers of the digestive system (like colon, pancreas, or liver) that had stopped responding to standard treatments. The goal was to see if the drug is safe and how it affects the body and tumors…

This early-phase study tested a new drug called ZN-c3 (Azenosertib) in 274 adults with various solid tumors. The main goals were to find a safe dose and check for side effects. Researchers also looked for signs that the drug could shrink tumors. This is a first step to see if the…

This early-phase trial tested an experimental drug called DF6002, either alone or combined with the approved immunotherapy nivolumab (Opdivo), in 170 people with advanced solid tumors that had stopped responding to standard treatments. The main goals were to check safety, find th…

This study tested a new drug called DF1001 in 270 adults with advanced solid tumors that have spread or cannot be removed. The drug works by helping the body's immune cells attack cancer cells. The trial first found the safest dose, then tested it alone or with other cancer drugs…

This study tested a new drug called BI 3706674 in 47 adults with advanced stomach or esophageal cancer that had not responded to prior treatment. The drug is a tablet that blocks growth signals in cancer cells. The main goals were to find a safe dose and see if the drug could shr…

This early-phase trial tested a new drug called RS-0139 in 16 people with advanced solid tumors that had stopped responding to standard treatments. The drug is designed to target tumors specifically, and the main goals were to find a safe dose and understand how the body processe…

This study tested a drug called TAS-102 (Lonsurf) combined with a precise type of radiation (SBRT) in 52 people whose colorectal cancer had spread to the liver. The goal was to find the safest dose and see if the combination could control the liver tumors. The trial is complete, …

This study tested a combination of two drugs, palbociclib and cetuximab, in 24 people with a specific type of advanced colon cancer that had spread. The goal was to see if the combo could shrink tumors or stop them from growing. Participants took palbociclib pills and received ce…

This study tested a combination of two drugs—NT-I7 (efineptakin alfa) and pembrolizumab (Keytruda)—in 215 people with advanced solid tumors that had stopped responding to treatment. The goal was to check safety, find the right dose, and see if the combo could shrink tumors. The t…

This trial tested a new therapy for cancers caused by HPV-16, such as cervical, anal, and throat cancers. Researchers took patients' white blood cells, genetically engineered them to recognize a protein called E7 found in HPV cancer cells, and infused them back. Patients also rec…

This early-stage trial tested a modified virus called TILT-123 in 32 people with advanced solid tumors that had not responded to standard treatments. The virus is designed to infect and kill cancer cells while releasing immune-boosting proteins. The main goal was to check safety …

This early-phase study tested the safety of combining two drugs—AZD1775 (a pill) and durvalumab (an IV infusion)—in 56 adults with advanced solid tumours that had stopped responding to standard treatments. The goal was to find safe doses and watch for side effects. While not a cu…

This completed Phase 2 trial tested whether combining an immunotherapy drug (durvalumab) with an epigenetic drug (tazemetostat) can control advanced solid tumors like pancreatic, colorectal, and soft-tissue sarcoma. The study enrolled 164 adults and measured how well the combo sh…

This phase 2 trial tested a three-part treatment for people with colorectal cancer that spread to the liver and stopped responding to standard treatments. The approach combines two minimally invasive procedures (TACE and HAIC) with the targeted drug regorafenib. The goal was to s…

This study tested a combination of two experimental drugs, AK112 and AK117, with or without chemotherapy, in 154 people with advanced solid tumors. The goal was to see if the combo could shrink tumors and control the disease. The trial has finished, and researchers are now lookin…

This study tested a two-step approach for people with metastatic colorectal cancer that doesn't respond well to standard treatments. First, patients received a drug called temozolomide to make their tumors more genetically unstable. Then, they received the immunotherapy drug pemb…

This early-stage trial tested a new drug called PN20 in 24 adults with lymphoma or solid tumors who were getting chemotherapy. The goal was to see if a single injection before chemo could safely prevent a drop in platelets, which can cause bleeding. Researchers checked safety and…

This study tested a traditional Chinese medicine formula called modified Si Ni San in 32 adults who had colorectal polyps removed. The goal was to see if the herbal treatment could improve gut bacteria balance and reduce inflammation better than standard probiotics. Results may h…

This study tested a combination of two treatments (regorafenib and FOLFIRINOX) in 13 people with a type of advanced colorectal cancer that has a specific gene change (RAS mutation). The main goal was to see if the combination was safe and tolerable. The study also looked at how l…

This study tested a new oral drug called RLY-4008 in 490 adults with advanced bile duct cancer or other solid tumors that have specific FGFR2 gene changes. The drug is designed to block the FGFR2 protein, which can drive cancer growth. The trial aimed to find the safest dose and …

This study tested an experimental drug (BMS-986253) combined with standard immunotherapy drugs (nivolumab with or without ipilimumab) in 281 people with advanced cancers like melanoma. The main goals were to check safety and see if tumors shrank. This is a disease-control approac…

This trial tested a new approach for people with advanced gastrointestinal cancers that had stopped responding to standard treatments. Doctors removed immune cells from patients' tumors, used CRISPR gene editing to disable a gene called CISH, and then infused the modified cells b…

This early-stage trial tested the safety and tolerability of a chemotherapy drug called raltitrexed when given as a heated solution directly into the abdomen (HIPEC) in 30 patients with colorectal cancer. The goal was to find the highest safe dose and understand how the drug beha…

This early-phase trial tested a new drug called BGB-10188, alone or combined with other cancer drugs (zanubrutinib for blood cancers, tislelizumab for solid tumors), in 97 patients whose cancers had returned or stopped responding to treatment. The main goals were to find safe dos…

This study tested two or three drugs together in adults with advanced solid tumors (cancers that have spread). The main goal was to find the safest dose and see if the combination can shrink tumors. Participants took brigimadlin pills and received ezabenlimab infusions every 3 we…

This early-phase study tested an oral drug called AG-881 in 95 adults with advanced solid tumors, including brain tumors (gliomas), that have specific IDH gene mutations. The main goals were to check safety, find the best dose, and see how the drug works in the body. While not a …

This pilot study tested a newer, more precise form of proton radiation called pencil beam scanning, given alongside standard chemotherapy drugs (5-FU and mitomycin-C), for people with anal cancer. The goal was to see if this combination is practical and might cause fewer skin sid…

This early-phase study tested a new drug called AMG 305 in 37 adults with advanced solid tumors that had stopped responding to standard treatments. The main goals were to check the drug's safety and find the best dose for future studies. Participants received the drug and were mo…

This study tested a drug called romiplostim in 165 adults with gastrointestinal, pancreatic, or colorectal cancer who were receiving chemotherapy. The goal was to see if romiplostim could prevent low platelet counts (thrombocytopenia) that often force doctors to delay or reduce c…

This early-phase study tested a new drug called CUDC-907 in 26 children and young adults (ages 1-21) with cancers that had come back or stopped responding to treatment, including solid tumors, brain tumors, and lymphoma. The main goal was to find a safe dose and check for side ef…

This phase 2 trial tested whether adding the immunotherapy drug nivolumab to standard chemotherapy could help people with a specific type of metastatic colorectal cancer (MSS/pMMR). Eighty participants received either the combination or chemotherapy alone. The main goal was to se…

This study tested the drug tislelizumab given before surgery in 33 people with early-stage colorectal cancer that has specific genetic changes (MSI-H or dMMR). The goal was to see if the drug could shrink or eliminate tumors before surgical removal. The trial has completed, and r…

This early-phase study tested a combination of two drugs, regorafenib and nivolumab, in 52 people with advanced colorectal cancer that had stopped responding to other treatments. The goal was to find the safest dose and see if the combination could help control the cancer. The st…

This phase II trial tested a combination of three drugs—TAS-102, irinotecan, and bevacizumab—in 42 people with advanced colorectal cancer that had spread or couldn't be removed. The goal was to see if this mix could slow tumor growth better than standard treatments. Participants …

This study looked at whether taking daily aspirin and vitamin D, along with exercise and a low-fat diet, could help prevent colorectal cancer from returning in 16 patients who had no visible cancer but still had signs of cancer DNA in their blood. The goal was to see if these lif…

This early-phase trial tested two experimental drugs, FdCyd and THU, taken by mouth for advanced solid tumors that had not responded to standard treatments. Fifty-nine adults received the drugs in 21-day cycles to see if they were safe and tolerable. The goal was to find a dose f…

This phase II trial tested two different drug combinations in 240 people with advanced HER2-positive colorectal cancer that had spread and could not be removed by surgery. One group received the antibodies trastuzumab and pertuzumab, while the other received cetuximab (an antibod…

This phase 2 trial tested whether combining two drugs, sorafenib and irinotecan, works better than either drug alone in people with advanced colorectal cancer that has a KRAS mutation and has stopped responding to all standard treatments. The study enrolled 173 participants acros…

This study tested a combination of the targeted drug cetuximab with a strong chemotherapy cocktail (FOLFIRINOX) as a first treatment for people whose colorectal cancer had spread and could not be removed by surgery. The goal was to see if this mix could shrink tumors better than …

This study tested whether a Medtronic pump and Codman catheter can safely deliver chemotherapy directly to the liver in 35 people with colorectal cancer or bile duct cancer that spread to the liver. The main goal was to check safety, including liver side effects and need for sten…

This early-phase study tested a new drug called SHR-A1811 in 101 people with advanced stomach or colorectal cancers that have a specific protein called HER2. The main goals were to check the drug's safety, find the best dose, and see early signs of tumor shrinkage. Participants h…

This study tested a combination of two drugs, sorafenib and irinotecan, in 64 adults with metastatic colorectal cancer that has a K-RAS mutation and has progressed after prior treatment. The goal was to see if the combination could control the disease and to check for side effect…

This study tested a new pill called larotrectinib in 75 adults with advanced cancers that have a specific gene change (NTRK fusion). The main goals were to check the drug's safety, find the best dose, and see how the body processes it. Participants had no other good treatment opt…

This study tested a combination of two drugs, lenvatinib and pembrolizumab, against the usual treatments for people with advanced colorectal cancer that had spread and stopped responding to prior therapy. About 563 adults took part. The goal was to see if the new combo helped peo…

This study tested whether more intense chemotherapy combinations could shrink liver tumors in people with colorectal cancer that cannot be fully removed by surgery. 124 participants received either standard two-drug chemo or one of three stronger regimens. The goal was to see if …

This early-stage trial tested a new oral drug, MSP008-22, in 7 adults with advanced solid tumors (breast, ovarian, prostate, head and neck cancers) that had spread or could not be removed. The main goal was to find a safe dose and check for side effects. This is a first step to s…

This study looked at whether the drug dexmedetomidine, given during laparoscopic surgery for rectal or sigmoid colon cancer, can protect the lungs of patients aged 60 and older. The trial included 64 participants and measured oxygen levels and other breathing indicators. The goal…

This early-phase study tests two experimental drugs, BI 765049 and ezabenlimab, in adults with advanced solid tumors like colorectal, lung, and pancreatic cancer. The main goal is to find the highest safe dose of BI 765049 alone and in combination with ezabenlimab. Participants r…

This study looked at whether a special care plan led by a geriatrician and a nurse could improve survival and quality of life for older adults (70+) with advanced cancer. 792 patients with breast, colorectal, lung, prostate, bladder, ovarian cancer, or lymphoma took part. The app…

This study tested a new robotic surgery method called natural orifice specimen extraction surgery (NOSES) for middle rectal cancer. In this approach, the removed tumor is taken out through the anus instead of a large abdominal cut. The study involved 150 patients and compared NOS…

This early-phase trial tested a new immunotherapy drug called BI 754091 in 110 people with advanced solid tumours that had spread or could not be removed surgically. The main goals were to find the safest dose and check for side effects. Researchers also looked for early signs th…

This early-phase trial tested a new drug called SNB-101 in 21 people with advanced solid tumors (like colorectal, breast, and lung cancers) that had stopped responding to standard treatments. SNB-101 is a nanoparticle version of SN-38, the active part of a common chemotherapy dru…

This early-stage trial tested an experimental drug called CyPep-1, injected directly into tumors, either alone or with the immunotherapy pembrolizumab. The study involved 60 adults with advanced solid cancers that had stopped responding to standard treatments. The main goals were…

This phase 1 trial tested a combination of regorafenib (a targeted therapy) plus two immunotherapy drugs (nivolumab and ipilimumab) in 39 patients with advanced colorectal cancer that had spread and stopped responding to chemotherapy. The goal was to find the safest dose and chec…

This early-phase trial tested an experimental drug called VS-6766, given alone or with everolimus, in 104 adults with advanced solid tumors or multiple myeloma that had stopped responding to standard treatments. The goal was to find a safe, tolerable dosing schedule and measure h…

This early-stage study tested the drug revumenib in 42 adults with colorectal cancer or other solid tumors that had spread or come back after at least one prior treatment. The goal was to see if the drug is safe and can slow tumor growth. Researchers measured side effects, how th…

This study tested a new immunotherapy drug, ezabenlimab, combined with other cancer medicines in 211 adults with advanced solid tumors that had spread. The goal was to see if the tumors shrank or disappeared. Participants received different drug combinations, and doctors monitore…

This study tested two experimental drugs (BI 754111 and BI 754091) that help the immune system attack cancer. It included 172 adults with advanced solid tumors, including non-small cell lung cancer that had returned after prior treatment. The first part found the safest dose, and…

This early-phase study tested a combination therapy in 15 people with colon cancer who had completed standard treatment but still had tiny amounts of cancer DNA in their blood (called minimal residual disease). The treatment used specially activated immune cells from donated umbi…

This study tested whether a special ultrasound technique (D-CEUS) can predict how well rectal cancer responds to chemotherapy and radiation. The goal is to identify good responders who might avoid major surgery and instead have a less invasive procedure. Only 2 people took part, …

This early study tested a radioactive imaging agent called [99mTc]Tc(CO)3-(HE)3-Ec1 in 10 adults with solid tumors. The agent is designed to attach to EpCAM receptors on cancer cells, making them visible on SPECT scans. Researchers aimed to see where the agent goes in the body, m…

This study tests whether a software called ColoMaia II can help doctors find abnormal growths (polyps) in the colon during a routine colonoscopy. About 600 adults aged 40 to 80 having a screening or diagnostic colonoscopy will be randomly assigned to have the procedure with or wi…

This study tests a special SPECT imaging agent that seeks out a protein called LRRC15, found on many aggressive cancers like pancreatic, breast, lung, and brain tumors. The goal is to see if this scan can help doctors diagnose and stage these cancers more accurately. Healthy volu…

This study tested whether a special light technology (enhanced white light endoscopy) helps doctors find more precancerous growths in the colon compared to standard colonoscopy. Over 800 adults aged 45 to 85 undergoing colonoscopy took part. The goal was to see if the enhanced li…

This early-phase trial tested a radioactive tracer called 68Ga-NODAGA-SNA009 in 12 people with colorectal cancer. The tracer targets a protein (GPA33) found on cancer cells and is used with PET scans to see where the cancer is in the body. The main goals were to check safety and …

This study tested whether an artificial intelligence system called CAD EYE can accurately predict if colon polyps are cancerous during a screening colonoscopy. Researchers compared the AI's predictions to the doctor's judgment and the final lab results. The goal is to see if AI c…

This study tested whether specially trained dogs can identify breast, lung, prostate, or colorectal cancer by sniffing breath samples collected on masks. Over 1,300 people provided breath samples before their regular cancer screening or biopsy. The dogs' results were compared to …

This pilot study compared two stool-based tests—Cologuard and the fecal immunochemical test (FIT)—for colorectal cancer screening in adults aged 45-49. Researchers mailed the tests to eligible participants and tracked how many completed screening, had abnormal results, and follow…

This study tested a new digital scope called LUMENEYE to see if it can better measure how much a rectal tumor has shrunk after chemotherapy and radiation. 82 patients who were good candidates for organ preservation were included. The goal was to see if the scope could help doctor…

This study tested a simple blood test to screen for anal dysplasia, a precancerous condition linked to HPV. Researchers enrolled 104 people with past or current anal HPV, plus some healthy controls. The goal was to see if the blood test could detect and classify anal dysplasia wi…

This study tested whether using artificial intelligence (AI) during colonoscopy helps find more polyps in people with Lynch syndrome, a genetic condition that raises colon cancer risk. One hundred participants each had two colonoscopies back-to-back, with the second using either …

This study tested an artificial intelligence (AI) tool that helps doctors diagnose colorectal polyps during a colonoscopy. The AI analyzes images from a special high-magnification endoscope to predict whether a polyp is cancerous or not. The goal is to improve accuracy and reduce…

This study looked at a new test called OSNA to find free cancer cells in the belly fluid of 108 people with stomach or colon cancer who had no visible spread. The goal was to see if OSNA could detect cancer cells better than the usual lab method. If successful, this could help do…

This pilot study tested whether ultrasound can detect nerve damage caused by the chemotherapy drug oxaliplatin in people with gastrointestinal cancer. Twenty participants who had or were receiving oxaliplatin and had symptoms of nerve damage underwent nerve ultrasounds, skin biop…

This completed trial tested whether a 3D imaging device helps doctors more accurately classify colon polyps and adenomas during colonoscopy compared to standard 2D imaging. 460 adults with colorectal polyps were randomly assigned to either 3D or 2D imaging before polyp removal. T…

This study looked at three screening methods—colonoscopy, colon capsule endoscopy, and a fecal immunochemical test (FIT)—to detect colorectal cancer or advanced growths in people aged 45 and older who have a first-degree relative with colorectal cancer. The goal was to see if the…

This study tested whether an AI tool (GI Genius) helps doctors find more polyps during colonoscopy in people aged 50-74 who had a previous polyp. Over 1,100 participants were randomly assigned to either AI-assisted or standard colonoscopy. The main goal was to see if AI increases…

This study looked at whether offering a blood test for colorectal cancer screening would be accepted by average-risk patients in Appalachian outpatient clinics. Over 200 participants were given the option of a standard screening method or a blood-based test called Shield. The goa…

This study tests whether the drug SENS-401 can prevent hearing loss caused by cisplatin, a common chemotherapy. Adults with cancer who are scheduled to receive cisplatin take SENS-401 before, during, and after treatment. Hearing is measured with a standard test to see if the drug…

This study tests whether giving general practitioners a list of patients who have not completed colorectal cancer screening encourages those patients to get screened. Over 48,000 patients aged 50-74 are involved, and their doctors either receive the list or do not. The goal is to…

This study tested whether a taurolidine-citrate solution (TauroLock) placed in the catheter between treatments can prevent bloodstream infections in adults with solid tumors receiving IV anti-cancer therapy. 162 patients were randomly assigned to get either the TauroLock solution…

This study tested whether personalized reminders (like texts or emails) could encourage more people to return their at-home stool test kits for colon cancer screening. Over 2,100 adults aged 45 to 75 who had not yet returned their kit took part. The goal was to see if these gentl…

This study looked at whether a Mediterranean diet, weight loss, or both could lower colorectal cancer risk in 180 obese African Americans aged 45-75. Participants followed one of four plans for six months, and researchers measured changes in bile acids, gut bacteria, and cell act…

This study looked at whether mailing free stool tests (FIT kits) to people's homes could increase colorectal cancer screening rates. Over 4,300 adults aged 45-75 who were at average risk took part. The goal was to make screening easier for those who might otherwise skip it, espec…

This study looked at whether giving extra help and information to spouses of colorectal cancer patients could get them to complete a simple at-home screening test (FIT). About 60 people took part. The goal was to find out what stops them from screening and if a tailored approach …

This study looked at whether taking omeprazole (a heartburn drug) and low-dose aspirin together could help prevent colorectal polyps in people at high risk. Twenty-one adults with a history of multiple polyps took both pills daily for 25-45 days. Researchers collected tissue samp…

This phase 3 trial compared colonoscopy with annual fecal occult blood tests for colorectal cancer screening in nearly 5,000 healthy adults aged 50-69. The goal was to see which method finds more early tumors and has a better balance of benefits and harms. Participants were rando…

This study tested a community-based program to encourage colorectal cancer screening in rural China. Over 20,000 adults aged 45-70 took part. The goal was to increase the number of people who complete a colonoscopy after initial risk assessment and stool tests, since early detect…

This study tested whether taking magnesium supplements could reduce the risk of colorectal cancer in people with a specific genetic makeup. Researchers gave 250 participants either magnesium or a placebo for 12 weeks and measured changes in colon tissue markers linked to cancer d…

This trial compares two approaches to a nerve block (TAP block) for pain after colorectal cancer surgery. One group receives the standard numbing drug bupivacaine, while the other gets bupivacaine plus dexmedetomidine, a drug that may extend pain relief. The study measures pain s…

This study tests whether acupuncture using tiny, semi-permanent needles can prevent diarrhea caused by the chemotherapy drug irinotecan in children with solid tumors. About 22 children will receive the acupuncture during their second round of chemo, and researchers will measure p…

This study looked at whether adding the drug nefopam to standard pain relief (morphine and paracetamol) can reduce the amount of morphine needed after major colon surgery. 80 adults having planned surgery for colon cancer or diverticulosis took part. The main goal was to measure …

This study tested whether using warm, humidified carbon dioxide gas during low-pressure laparoscopic colorectal surgery reduces pain 24 hours after the procedure. 148 adults having surgery for colon or rectal tumors (benign or malignant) took part. One group received warm, moist …

This study tested a drug called M701, given directly into the belly, combined with standard cancer therapy, for people with malignant ascites (fluid buildup) from stomach, colon, or ovarian cancer. The goal was to see if M701 could delay the need for fluid drainage and improve su…

This study looked at whether placing a bridge device during loop ileostomy creation reduces complications like infections or stoma problems. 166 adults having elective colorectal surgery took part. The goal was to see if the device improves outcomes or just adds difficulty to car…

This study tested whether professional socio-aesthetics (specialized beauty and well-being care) can improve quality of life, reduce pain, and ease anxiety in adults undergoing chemotherapy for lung, breast, colon, or prostate cancer. 400 participants were randomly assigned to re…

Many colorectal cancer survivors lose muscle mass and strength after chemotherapy. This study tested whether adding creatine supplements to a 10-week resistance training program could help. Twenty-seven survivors participated, comparing those who took creatine with those who only…

This study tested a web app called PrehabPal designed to help frail adults aged 65 and older prepare for colon cancer surgery. The app creates a personalized prehabilitation program and offers coaching. Researchers compared it to standard written instructions in 132 participants …

This study tested a small, disposable device that gently stimulates nerves in the ear to see if it could reduce the amount of strong painkillers (opioids) needed after open abdominal or pelvic surgery. 286 adults who had surgery for cancer or a liver transplant took part. The goa…

This study tested whether a self-regulation hypnotic intervention could help reduce pain and anxiety during brachytherapy for rectal cancer. Fifty-two adults were randomly assigned to receive either hypnosis training or standard care with pain and anxiety medication. Researchers …

This study tested whether the drug benralizumab can safely reduce skin rashes caused by cancer treatments like checkpoint inhibitors. The goal was to lower the number of high-grade rashes to milder ones, which could improve quality of life and help patients stay on their cancer t…

This study tested an investigational drug called ponsegromab in 187 adults with lung, pancreatic, or colorectal cancer who also had cachexia—a condition causing severe weight loss, loss of appetite, and fatigue. The goal was to see if ponsegromab could help patients gain weight a…

This study tested whether silkworm pupa tablets can improve nutrition and reduce frailty in people who had surgery for stomach, colorectal, esophageal, or pancreatic cancer. 120 participants took the tablets for 3 months. Researchers measured weight, frailty, muscle mass, and qua…

This study looked at 2,000 adults with solid tumors to find the best dose of olanzapine for preventing nausea and vomiting caused by strong chemotherapy. Researchers compared 2.5 mg, 5 mg, and 10 mg doses to see which works best with the fewest side effects like daytime sleepines…

This study tested whether the Paula Method of muscle exercises can help people who have bowel control problems after rectal cancer surgery. 62 adults who had surgery and still had symptoms took part. The exercises aim to strengthen muscles naturally without drugs or surgery.

This study tested whether psyllium husk, a type of fiber supplement, can reduce bowel symptoms and improve quality of life in people who had rectal cancer surgery. 24 participants who had ongoing bowel issues after surgery took psyllium husk. The goal was to see if it helps with …

This study tested a special pain coping skills program for people with advanced solid tumor cancer who have pain that interferes with daily activities. 211 patients were randomly assigned to either the program or standard care. The program taught ways to manage pain and find mean…

This study tested a 12-week online mind-body program for adults with chronic conditions like heart failure, cancer, and liver disease. The program included mindful movement, meditation, breathwork, and coping skills. Researchers measured changes in anxiety, depression, fatigue, a…

This study tested whether a temporary stent placed inside the bowel could replace a traditional ileostomy (a bag outside the body) after rectal cancer surgery. 570 patients at high risk for leaks were randomly assigned to either the stent or ileostomy. The goal was to see if the …

This study looked at whether doing special exercises before colorectal cancer surgery (called prehabilitation) helps patients recover better compared to standard care. Over 700 adults scheduled for surgery took part. The main goal was to see if the exercise group had better physi…

This study tested whether two nurse phone calls during the first three cycles of chemotherapy could improve the emotional state and quality of life of patients with breast, colon, or rectal cancer. 274 patients were randomly assigned to receive either standard care or standard ca…

This study tested a web-based support program for people with colorectal cancer undergoing treatment. The program provided information and tips on physical, emotional, and daily-life challenges. Researchers measured whether it helped reduce symptoms and improve quality of life co…

This study tested whether an education and support program can help family caregivers of cancer patients feel more confident and less anxious. About 484 caregivers and patients took part. Researchers compared different types of support to see which worked best.

This study looked at whether mindfulness exercises can lower stress and improve communication between patients with liver disease and their doctors. 56 adults took part, answering surveys about their stress, anxiety, and how well they felt they could share decisions with their he…

This Phase 2 trial tested paltusotine, an oral drug, in 36 adults with carcinoid syndrome. The study looked at safety and how the body processes the drug at different doses. Participants were randomly assigned to 40 mg or 80 mg daily, with dose adjustments allowed. The goal is to…

This study looked at whether chewing gum after colorectal surgery can help reduce nausea, vomiting, and get the bowels working again sooner. 84 adults who had laparoscopic colorectal surgery took part. The idea is that chewing tricks the body into thinking it's eating, which may …

This study looked at two oral chemotherapy drugs, Xeloda and UFT with folinic acid, in 89 people with advanced or metastatic colorectal cancer. The main goal was to see which treatment patients preferred after trying both. The study also checked how safe each drug was. Results he…

This study tested an online educational program for cancer patients receiving chemotherapy. The program included video sessions, peer discussions, and digital materials to help with symptom management and emotional coping. Researchers compared 212 patients who used the program to…

This phase II trial tested a concentrated plant dietary supplement (made from foods like taro, rice, and carrots) in 30 people with gastrointestinal cancers who had diarrhea from chemotherapy. Participants received the supplement alongside standard anti-diarrheal treatment. The g…

This study tested a stepped-care telehealth program for cancer survivors living in rural areas who experience anxiety, depression, or sleep problems. Participants received either low-intensity check-ins or high-intensity phone therapy with a licensed therapist, depending on sympt…

This study tested a personalized rehabilitation program for 150 adults who finished treatment for colorectal cancer. The program connects patients with specialists like physiotherapists, dietitians, and psychologists based on their individual needs. The goal was to improve qualit…

This study tested whether group-based cancer rehabilitation could work when done virtually instead of in person for people with advanced breast or colorectal cancer. 111 participants were offered either in-person or online sessions to see which was more practical and acceptable. …

This pilot study tested whether offering free, personalized legal services to people with advanced colorectal cancer could help reduce stress, financial worries, and improve quality of life. Twenty participants received help from a nonprofit legal organization for six months. Res…

This study tested whether taking N-Acetylcysteine before chemotherapy could reduce nerve damage in colorectal cancer patients receiving oxaliplatin. 46 participants received either N-Acetylcysteine or a placebo before each chemo session. The goal was to see if the supplement coul…

This completed trial tested a web-based remote monitoring platform called CONTINUUM+ CONNECT in 411 adults with metastatic breast, lung, colorectal, or prostate cancer. Patients used the platform to report symptoms and receive alerts, aiming to improve their physical health and q…

This study tested a bladder training method called ICCAUT in 400 people who had rectal cancer surgery. The training involves clamping the urinary tube and practicing urinating before the tube is removed. The goal was to see if this reduces the need for a new catheter or incomplet…

This study tested whether an oral iron pill (ferric maltol) can improve anemia in 40 adults after colorectal cancer surgery, compared to standard care. The main goal was to see if a larger study is possible, while also checking blood iron levels. The approach is simple and aims t…

This study compared two ways to manage pain during and after colorectal surgery: a TAP block (an injection into the abdominal wall) versus epidural anesthesia (an injection near the spine). About 200 adults having elective colon or rectal surgery for cancer or diverticulitis took…

This phase 2 trial looked at whether adding acupuncture and acupressure to oral cryotherapy (sucking on ice chips) can reduce nerve pain caused by oxaliplatin chemotherapy in people with gastrointestinal cancers. 78 patients were split into two groups: one got cryotherapy alone, …

This study tested whether sending personalized text messages could help colorectal cancer survivors eat more whole grains and less refined grains. Forty-six survivors who had finished active treatment received text messages and nutrition materials. The main goal was to see if peo…

This study investigates whether women who have completed breast cancer treatment have a higher chance of developing colorectal polyps or colon cancer. Researchers will perform screening colonoscopies in 216 asymptomatic breast cancer survivors and check for abnormal growths. The …

This study looked at whether having a special consultation with a radiotherapy technician (called a manipulator) helps cancer patients feel more informed about their treatment. Researchers enrolled 308 adults with various cancers who were getting radiation therapy. They compared …

This study examined how Mexican-American families discuss their risk for diabetes, heart disease, breast cancer, and colon cancer. Researchers interviewed 498 adults from Mexican-American households in Houston to understand how culture and family history influence health communic…

This study looked at whether using a physical activity screener, along with exercise coaching and self-monitoring, could help breast and colon cancer survivors become more active and spend less time sitting. Twenty survivors who had finished their main cancer treatment at least t…

This study tested whether a weekly electronic survey could help identify cancer treatment delays and racial differences. About 100 adults with newly diagnosed breast or colorectal cancer who hadn't started treatment yet filled out a short survey each week for 8 weeks. The goal wa…

This study investigates whether having an empty bladder reduces movement of the mesorectum (tissue around the rectum) during radiotherapy for rectal cancer. About 50 adults with rectal cancer receive planning CT scans and weekly CBCT scans under both empty and full bladder condit…

This study looks at the DNA of 100 children (and young adults up to age 17) who have cancer, along with the DNA of their healthy parents. The goal is to find genetic changes that may have caused the cancer. By comparing the child's DNA to both parents', researchers hope to discov…

This study looks at whether a narrowed inferior mesenteric artery (IMA) — seen on routine CT scans — is linked to a higher chance of anastomotic leakage after rectal cancer surgery. Anastomotic leakage is a serious complication where the surgical connection leaks. The study will …

This study tested whether letting patients move freely between the injection of a radioactive tracer and the PET scan affects image quality. Normally, patients must rest for an hour to avoid muscle uptake that can blur results. The trial involved 284 adults with cancer or needing…

This study looks at whether it's possible for people diagnosed with solid tumors to have a follow-up visit with their general practitioner within 15 days of learning their diagnosis. Researchers will track how many patients actually attend this visit and why some might not. The g…

This study investigates how differences in cell membrane voltage, caused by varying physical pressures inside a tumor, help colorectal cancer resist chemotherapy and evade the immune system. Using advanced lab models and tissue samples from 11 patients, researchers found that cel…

This study observed 255 cancer patients receiving immunotherapy to understand why some develop skin side effects. Researchers measured immune markers and lipids in the skin and blood. The goal is to identify patterns that could predict or explain these reactions.

This study followed 110 people with anal cancer to see if PET/CT scans can help doctors monitor the disease after initial treatment. Researchers tracked how long patients stayed cancer-free and measured metabolic activity in tumors. The goal is to find better ways to detect relap…

This study aimed to create a detailed map of the cells in the human appendix and understand their genetic activity. Researchers analyzed appendix tissue from 5 patients undergoing colon cancer surgery. The goal was to learn more about the appendix's role in the immune system and …

This completed study took small tissue samples from the colons of 40 people during routine colonoscopies. Using advanced genetic techniques, researchers created a detailed map of the different cell types and their gene activity. The goal is to better understand how colon diseases…

This study looked at whether a new blood test called EPISPOT can predict how well chemotherapy works in people with metastatic colorectal cancer. Researchers measured circulating tumor cells in 168 patients before and during treatment. The goal was to see if early changes in thes…

This study looked at medical records of 938 adults with solid tumors who received immunotherapy. Researchers compared how well the treatment worked when cancer had spread to different organs like the liver, brain, lung, or bone. The goal is to understand why some metastatic sites…

This pilot study tested whether it's possible to adjust proton radiation plans each day while the patient is on the treatment table. Ten adults with solid tumors took part. The goal was to see if this approach is safe and practical enough to study in a larger trial.

This study surveyed 231 adults with Lynch syndrome, an inherited condition that raises bowel cancer risk. Researchers wanted to find out how many people follow the UK recommendation of a colonoscopy every two years, and what makes it harder or easier to keep up with these check-u…

This study looked at the safety of Bevacizumab-Pfizer Biosimilar, a drug used to treat colorectal cancer, by analyzing medical records from 1,000 patients in Japan. Researchers focused on side effects like bleeding, high blood pressure, and kidney problems. The goal was to unders…

This study tested whether a theory-based chatbot could increase colorectal cancer screening rates. 500 adults aged 50-75 in Hong Kong were randomly assigned to receive either standard text reminders or a chatbot that provided personalized risk information and screening guidance. …

This completed study looked at how nerve damage from the chemotherapy drug oxaliplatin affects hand function, grip strength, and quality of life in 103 colorectal cancer patients. Researchers measured hand and finger strength, dexterity, and daily living abilities using standard …

This study looked at whether combining detailed MRI scans with whole genome sequencing can help doctors choose the best treatment for people with liver cancer. Researchers studied 200 adults who were scheduled for liver surgery. The goal was to see if these advanced tests provide…

This study tested whether machine learning can detect cancer pain by analyzing facial expressions, voice, and speech. 83 people with cancer recorded videos at clinic visits and at home over 3 months. The goal was to see if this technology could classify pain levels in a diverse g…

This study looked at whether a nerve block called the erector spinae plane block can protect kidney function during laparoscopic colorectal cancer surgery. Sixty adults having this surgery were divided into two groups: one received the nerve block plus standard anesthesia, the ot…

This study looked at 30 colorectal cancer patients to see if tumor deposits (small clusters of cancer cells found near the main tumor) can help predict survival and whether the cancer spreads to other organs. Researchers tracked overall survival and the appearance of new metastas…

This study looked at the best ways to encourage childhood cancer survivors who are at high risk for colorectal cancer to get screened at the recommended age. Researchers tested different methods to see which helped more people complete a colonoscopy or stool-based test. The goal …

This completed registry followed nearly 8,000 adults with solid tumors who had next-generation sequencing (NGS) genetic testing. The goal was to collect real-world data linking test results, treatments, and survival. No new drug or intervention was tested; instead, the registry a…

This study looked for leftover cancer DNA in the blood of over 2,000 people who had surgery for stage II or III colorectal cancer. Participants did not receive any new treatment—they just gave blood samples over about 21 months. The goal was to find patients who might be eligible…

This study tested a physical activity program called PACE for African American colorectal cancer survivors. Researchers wanted to see if the program was practical and could increase steps and exercise. Twenty-one participants used Fitbits and watched videos to track their activit…

This study looked at 590 colorectal cancer patients to develop a risk tool that predicts postoperative delirium—a common complication causing confusion and slower recovery. Researchers combined blood test results (including the TyG index) with patient subtypes to create a scoring…

This study created and tested an educational website to help Black and African American cancer patients learn about personalized cancer treatments and clinical trials. Researchers interviewed 48 patients and caregivers, then tested the website with 33 patients. The goal was to se…

This study looked at whether being more physically active, measured by daily steps, helps rectal cancer patients respond better to chemotherapy and radiation before surgery. About 120 participants wore smartwatches to track their steps, heart rate, and sleep. The goal was to see …

This study looked at whether an AI computer program could suggest cancer treatments that match what experts recommend. Researchers reviewed medical records of 30 people with stomach, colon, or pancreatic cancer. They entered key details into the AI and compared its suggestions to…

This study followed 159 people with metastatic colorectal, pancreatic, biliary, or esophageal cancers who were starting a new line of therapy. Researchers collected blood samples (tumor markers and liquid biopsies) and patient-reported quality-of-life data to see if these could p…

This study looked at 140 patients who had colon cancer surgery and chemotherapy at Rouen University Hospital. The goal was to see if living farther from the hospital caused a longer wait to start chemotherapy after surgery. The findings could help improve care for patients who li…

This completed study looked at how well young and middle-aged colorectal cancer survivors can identify and describe their specific emotions—a skill called emotional granularity—and whether that helps them build resilience. Researchers surveyed 242 survivors online and interviewed…

This study tested whether a family history app can help doctors collect and use information about patients' family health risks. Over 600 adults aged 30-69 took part. The goal was to see if the app leads to better screening and genetic referrals for conditions like cancer, heart …

This study looked at 150 colorectal cancer patients to see if counting tumor buds in biopsy samples could predict whether cancer has spread to lymph nodes or other organs. Researchers used a special stain to find tumor buds and counted them in the densest area. They then used a c…

This study involved 132 adults with colorectal cancer who had standard surgery (low anterior resection) and a temporary ileostomy (a stoma to divert waste). The goal was to measure major complications after surgery and create a single safety endpoint. This will help doctors compa…

This study tested a new classification system for people whose colorectal cancer has spread only to the liver. Researchers looked at survival rates and compared different patient groups to see if the system helps predict outcomes. The goal is to better identify which patients mig…

This completed study looked at how often joint pain occurs in 71 people with ovarian, colorectal, or lung cancer who were taking the drug bevacizumab. Participants filled out a questionnaire about their joint pain over 6 months. The goal was to better understand this side effect.

This completed study looked back at medical records of 500 patients aged 50 or younger diagnosed with colorectal cancer or precancerous growths at a hospital in Shenzhen, China. Researchers compared those with early-stage disease to those with later-stage disease to identify fact…

This study looked at 26 adults having colorectal (bowel) cancer surgery while placed in a steep head-down position with legs raised in stirrups. Researchers measured blood flow and oxygen in the calf muscles during the operation to understand how a rare but serious leg injury cal…

This study looked at how cancer treatment changes patients' ability to stick with a Mediterranean diet. Researchers followed 116 patients starting chemotherapy or immunotherapy, checking their diet adherence and sensory changes (taste and smell) at the start and after 9 weeks. Th…

This study looked at 57 patients with rectal cancer to compare surgical outcomes from three different treatment approaches: the RAPIDO protocol (short-course radiation plus chemotherapy), standard long-course radiation with chemotherapy, and surgery alone. Researchers measured th…

This study looked at 200 older adults (65+) having planned surgery for colorectal cancer. Researchers used a frailty test before surgery to see if it could predict complications like infections or longer hospital stays. The goal is to help doctors better plan care and reduce risk…

This study tested whether a flexible, personalized exercise program is practical for cancer patients receiving chemotherapy. Twenty-one adults with breast, ovarian, or colorectal cancer took part. The main goal was to see if patients would join, attend, and stick with the exercis…

This study looked at how prostate and colorectal cancer affect mitochondria—the energy factories in cells—and whether a 4-week home exercise program could improve them. Fifteen men awaiting surgery did either resistance or high-intensity interval training at home. Researchers mea…

This study followed 516 HIV-positive men who have sex with men over two years to track anal HPV infection and related lesions. Researchers used exams and anoscopy to see how often high-grade lesions appear or go away on their own. The goal is to gather evidence to better prevent …

This study looked at whether analyzing the DNA of a patient's tumor can help doctors pick a targeted therapy for advanced or metastatic cancer. Researchers enrolled 550 adults with various solid tumors that had spread. They took biopsy or blood samples to search for genetic chang…

This study tested whether using an artificial intelligence system (ENDOAID) together with a small attachment on the colonoscope (Endocuff) helps doctors find more precancerous polyps (adenomas) than using AI alone. Over 1,700 adults aged 45-85 undergoing colonoscopy for screening…

This study looked at how the drug tuvusertib is absorbed, broken down, and removed from the body in 12 people with advanced solid tumors. Participants received a tiny radioactive tracer to track the drug. The main goal was to understand the drug's path in the body, not to treat t…

This study looked at whether adding walnuts to your diet can change the bacteria in your gut and reduce signs of colon cancer risk. About 140 people at higher risk for colorectal cancer ate walnuts for a month. Researchers measured changes in gut bacteria, blood markers, and colo…

This study looked at whether using a standardized set of measurements, including patient-reported outcomes, can improve care for people with colorectal cancer. Researchers followed 133 patients over time, collecting data on their health and quality of life. The goal was to see if…

This study tested a tool built into electronic health records that prompts doctors to discuss heart health with cancer survivors during routine visits. Researchers enrolled 645 survivors of breast, prostate, colorectal, endometrial, and lymphoma cancers across 12 clinics. The goa…

This study followed 150 people with solid tumors who were starting immunotherapy (immune checkpoint inhibitors) as part of their regular care. Researchers collected data on side effects and asked patients to fill out questionnaires before each treatment. The goal was to better un…

This study looked at 74 people with metastatic colorectal cancer starting their first chemotherapy. Researchers took blood samples early in treatment to measure three markers: CEA, circulating tumor DNA, and total cell-free DNA. The goal was to see if early changes in these marke…

This study followed 56 patients who had surgery for non-metastatic colon cancer to see if the number and type of immune cells in their tumors could predict whether the cancer would come back. Researchers analyzed both blood samples and tumor tissue for various immune markers. The…

This study looked at whether a genetic test called QMPSF can help predict if stage II or III colon cancer will come back after surgery. Researchers analyzed tumor tissue from 401 patients for specific DNA changes. The goal was to see if these genetic markers are linked to cancer …

This study looks at whether certain combinations of genetic variations, rather than a single gene, can increase the risk of colorectal cancer. Researchers will compare the DNA of 700 patients with strong family histories of the disease against 350 healthy controls. The goal is to…

This study looked at 846 people who had a positive stool test for colorectal cancer and needed a follow-up colonoscopy. Researchers wanted to understand how involved patients felt in making decisions about their care and how satisfied they were with the entire screening and treat…

This completed study tested whether a new biomarker called 'mass response' can predict how well a cancer therapy will work. Researchers collected tumor cells from 72 patients with various cancers through fluid drainage or biopsies. The goal was to see if this biomarker could guid…

This study looked back at the medical records of 500 people with colorectal cancer from two regions in China. Researchers collected information on patients' backgrounds, lifestyle, and treatments to find patterns that affect survival. The goal was to understand regional differenc…

This completed study looked at 29 patients with a hard-to-treat form of advanced colorectal cancer. The goal was to find new ways to group these patients based on the biology of their tumors. This could help doctors choose more effective treatments in the future. The study did no…

This study looked at 76 adults with advanced colorectal cancer to find genetic markers that might predict how well a combination of chemotherapy (FOLFOX) and the drug bevacizumab works. The goal was to understand which patients benefit most, not to test a new cure. Participants h…

This study explored how teenagers and their parents react emotionally and mentally when they learn about genetic risks for conditions like hereditary breast cancer, Lynch syndrome, or high cholesterol. Researchers surveyed 162 participants using questionnaires and interviews to m…

This study tested whether starting a colonoscopy with the patient lying on their back (supine) or on their left side (left-lateral) makes a difference. Researchers measured how long it took to complete the procedure, how much pain patients felt, and how difficult the procedure wa…

This completed study looked at 300 cancer patients treated with immune checkpoint inhibitors to see if measuring troponin levels could help detect serious heart problems early. The goal was to prevent major cardiovascular events like heart attack or stroke without unnecessarily s…

This study looked at how immune checkpoint inhibitors, a type of cancer drug, might affect blood vessels and increase heart risks. Researchers measured blood vessel function and checked for related markers in 39 cancer patients before and after starting treatment. The goal was to…

This study looks at whether the drug T-DXd works better than standard treatments for people with several types of HER2-positive solid tumors. Researchers will compare data from previous T-DXd trials with real-world medical records of patients who received standard care. The goal …

This study looked at whether cancer survivors living in rural areas can create their own survivorship care plans and learn from telehealth education. 261 survivors of breast, colorectal, lung, lymphoma, or prostate cancer took part. The goal was to see if this approach improves t…

This study looked at how two different diets affect gut bacteria and markers linked to colon cancer risk in 15 African American adults at higher risk. Participants ate a high-fat, animal-based diet and a low-fat, plant-based diet for three weeks each. Researchers measured changes…

This completed study from West China Hospital examined tumor tissue from 100 colorectal cancer patients who had already received immunotherapy. Researchers measured levels of a protein called PHGDH to see if it was linked to how well the patients responded to treatment and how lo…

This study looked for the most effective and practical way to screen for anal high-grade lesions (a precancerous condition) in Thai men who have sex with men and transgender women. Researchers tested different screening methods in 950 participants to see which approach finds the …

This study gave educational materials about colorectal cancer and screening to 188 adults aged 45-75 in the Tampa Bay area. Researchers used surveys to measure changes in knowledge and screening intentions. The goal was to see if education encourages people to talk to their docto…

This study looked at whether using a special balloon-assisted scope (G-Eye) together with artificial intelligence (CAD-Eye) finds more polyps than a standard colonoscopy with AI alone. About 300 people aged 50-74 who had a positive stool test took part. The goal was to see if the…

This completed study tested whether an online self-guided program could effectively return genetic test results for hereditary breast and ovarian cancer to African American women. Over 900 women from the Black Women's Health Study were offered their results online or by printed m…

This study tested whether having a clinical pharmacist review medications for cancer patients before they start treatment could prevent drug-related problems. Researchers observed 440 adults with solid tumors who were about to receive chemotherapy, immunotherapy, or oral targeted…

This study looked at nearly 1,000 cancer survivors to find out which follow-up care model works best for their quality of life and satisfaction. Participants were breast, prostate, or colorectal cancer survivors who had finished active treatment. Researchers compared different ca…

This completed study looked at 101 adults having laparoscopic colorectal surgery under general anesthesia. Researchers tested different levels of positive end-expiratory pressure (PEEP) after a lung recruitment maneuver to see how long the benefits lasted and how it affected hear…

This study tested whether a lung protective ventilation strategy (a gentler way of breathing during surgery) affects inflammation around tumors and certain blood markers in 60 colorectal cancer patients. Half received standard ventilation, half received the protective method. Res…

This study looked at 70 adults with colorectal cancer to see how common muscle loss (sarcopenia) is before surgery and whether it leads to more complications or longer hospital stays. Researchers measured muscle strength, mass, and physical performance. The goal is to find patien…

This study looked at 460 people with HIV to see what types of cancer they have and why some choose to join cancer clinical trials. Researchers tracked cancers like Kaposi sarcoma, lymphoma, and HPV-related tumors. They also used surveys to learn how HIV and cancer treatments affe…

This study followed 107 adults newly diagnosed with rectal cancer to see how their symptoms, balance, and quality of life changed over time. Researchers used questionnaires to track bowel issues, emotional distress, and balance problems. The goal was to better understand these ch…

This study tested how different social media messages influence people's plans to get screened for colorectal cancer. Over 2,000 participants completed a 15-minute survey after seeing one of several message types. The goal was to see which messages made people more likely to foll…

This study looked at 100 adults having laparoscopic surgery for colon cancer to see if the amount of oxygen delivered to tissues during the procedure affects the risk of a leak where the bowel is reconnected. Researchers measured oxygen delivery using a non-invasive monitor. The …

This study looked at how people feel and function after a two-step surgery for rectal cancer. Researchers followed 65 patients to measure bowel symptoms and their impact on quality of life one year after the final reconstruction. The goal is to identify which patients may have wo…

This pilot study looked at whether repeated FDG-PET/CT scans can help select patients and evaluate how well a special chemotherapy (PIPAC) works for cancer that has spread to the lining of the abdomen. 34 patients with various abdominal cancers were included. The goal was to see …

This study looked at how often a muscle enzyme called CPK increases in people with solid tumors who are taking a type of targeted therapy called tyrosine kinase inhibitors (TKIs). Researchers measured CPK levels in routine blood tests from 154 patients and checked if high levels …

This study looked at how common frailty is in people aged 70 and older with solid tumors who visited a cancer center. Researchers used a short questionnaire called VES-13 to screen patients before their doctor visit. They also compared the test results with the doctor's own judgm…

This completed study tested a blood test that looks for tiny cancer leftovers after surgery in 175 people with stage II or III colorectal cancer. The goal was to see if the test could identify who really needs chemotherapy. If it works, it could help personalize treatment and avo…

This study compared anxiety, depression, and quality of life between 125 cancer patients who joined clinical trials and those who received standard treatment. Researchers used questionnaires to measure stress and emotional well-being. The goal was to understand how trial particip…

This study followed 704 adults with metastatic colorectal cancer who received regorafenib through a French compassionate-use program. Researchers measured how long patients lived after starting the drug and collected data on tumor characteristics and prior treatments. The goal wa…

This study looked at 598 people who had surgery to remove colorectal cancer with the goal of curing it. Researchers wanted to understand how often the cancer comes back after five years and where it returns. The goal is to use this information to create better follow-up care plan…

This study looked at whether a special website or coaching phone calls could help more people with a personal or family history of certain cancers get genetic testing. Over 800 participants were randomly assigned to one of these two methods or to standard care. The goal was to se…

This study looked at 42 adults with advanced solid tumors who were already on or about to start checkpoint inhibitor immunotherapy and also needed palliative radiotherapy for symptom relief. Researchers wanted to see if the combination was safe (less than 30% severe side effects)…

This completed phase 2 study tested whether a new type of PET scan (FAPI-PET/CT) can accurately predict if rectal cancer has completely disappeared after a combination of short-course radiation, immunotherapy, and chemotherapy. Fifty-two patients with locally advanced rectal canc…

This study tested a digital chatbot (called CATALYST) to help cancer survivors learn about genetic testing for inherited cancer risk. Fifty adults who had certain cancers (like breast, ovarian, or prostate) used the chatbot or received usual care. The goal was to see if the chatb…

This study looked at 298 patients who had surgery for rectal cancer that came back in the same area. The goal was to find out how often the cancer returns again and what factors increase that risk. Researchers tracked long-term survival and identified key risk factors to help gui…

This study looks at data from 121 people with metastatic colorectal cancer who received two approved treatments—regorafenib and TAS (with or without bevacizumab)—in different orders. Researchers want to see which sequence works better and how long patients live. Since this is an …

This study reviewed the medical records of 255 adults who had colorectal polyps removed during a colonoscopy. The goal was to find out which factors, such as how the polyp was removed or its tissue type, make it more likely to come back. Researchers also tracked any complications…

This study tested an 11-step community program to help African Americans get screened for colorectal cancer. The program included education, risk assessment, and help with barriers like cost, transportation, and scheduling. 163 participants joined, and the study measured whether …

This pilot study tested whether training primary care doctors in shared decision-making could increase colorectal cancer screening rates. Doctors in quality circles received evidence summaries, decision aids, and stool test kits to help patients choose between colonoscopy and FIT…

This study looked at 143 people in China who had a second surgery after rectal cancer treatment because of a leak or tumor return. Researchers wanted to find out what factors help the surgery succeed and whether patients can regain the ability to poop normally. The goal is to bet…

This study looked at whether using a special dye (indocyanine green) during laparoscopic surgery for colon or rectal cancer can help surgeons see blood flow in real time and reduce the risk of a dangerous leak where the bowel is reconnected. Researchers compared 115 patients who …

This study watched 225 people with solid tumors who got a drug called G-CSF during chemotherapy. G-CSF can cause bone pain. Researchers measured pain levels and tracked what treatments (like pain relievers or other methods) helped. They also checked quality of life, fatigue, mood…

This completed study with 297 participants examined if offering a blood-based screening test (Guardant Shield) encourages people who previously avoided stool tests or colonoscopy to get screened for colorectal cancer. Participants were adults aged 45-75 at average risk who had no…

This study looked at whether two simple frailty questionnaires (G8 and VES-13) can predict serious side effects from chemotherapy in people 65 and older with gastrointestinal cancers. Researchers followed 72 patients receiving standard chemotherapy and checked their frailty, nutr…

This study looked at how a genetic test that checks 25 genes linked to hereditary cancers is used in clinics. Over 1,500 people with a personal or family history of cancer took part. Researchers collected blood samples and had participants fill out questionnaires over five years …

This study tested how well people understand genetic risk when shown different visual aids. Over 1,000 participants viewed either a single side-by-side chart or a step-by-step narrative with pictures. They then estimated their risk and answered questions about how they felt and w…

This study looked at 690 rectal cancer patients to see if the size of a specific artery (the middle rectal artery) on MRI scans could help predict whether cancer has spread to nearby lymph nodes. The goal was to create a tool that helps doctors decide if more extensive surgery is…

This study tested whether a program that uses computer algorithms to identify people who are overdue for colorectal cancer screening, combined with a patient navigator to help them schedule and complete the test, could increase screening rates. The study included 385 adults livin…

This study looked at 227 people with colorectal cancer that had spread to the lining of the belly. Researchers wanted to see if waiting longer between chemotherapy and surgery affected how long patients lived without the cancer coming back. The goal is to find the best timing for…

This study tested whether checking the removed tissue during surgery (frozen section) helps ensure all cancer is removed in people with mid or low rectal cancer who had radiation therapy. 99 patients were split into two groups: one had the extra check, the other had standard surg…

This study looked at how a digital care planning tool (eHNA) can help personalize care for people with colorectal cancer. Researchers interviewed 76 patients and clinicians to understand what works and what doesn't. The goal was to identify best practices for using digital tools …

This study looked at 3000 cancer patients to see which treatments work best for preventing dangerously low white blood cell counts after chemotherapy. It compared different approaches to see how well they prevent infections and improve quality of life. The goal is to give doctors…

This study tested whether a blood test can find tumor cells or substances released by intestinal polyps. Researchers compared blood samples from 120 people with and without polyps during a colonoscopy. The goal is to see if these markers could help predict or monitor cancer sprea…

This study looked at leftover tumor tissue and blood samples from 141 adults with glioblastoma or other solid tumors who were having surgery. The goal was to measure cell counts and viability to help scientists design better treatments for brain cancer and other solid tumors in t…

This study looked at 80 adults aged 40-60 to see if sitting for long periods slows down gut transit time and changes gut bacteria in ways that could lead to colon polyps. Participants wore activity monitors, ate blue muffins to track digestion time, and provided stool samples. Th…

This completed study analyzed tumor and blood samples from 160 people with esophageal or rectal cancer. Researchers looked for genetic markers in the EGFR signaling pathway that might predict how well a patient responds to chemoradiotherapy given before surgery. The goal is to be…

This study looked at whether eating certain fats (polyunsaturated fatty acids) is linked to colorectal cancer risk. Researchers measured fatty acids in fat tissue and blood samples from 551 people with and without colorectal cancer. The goal was to find reliable biomarkers that c…

This study tested whether a short training video on 'blink features' (visual clues like redness or ulcers) could help medical students and non-gastroenterology trainees better detect cancer in images of colon polyps. 65 participants completed an online survey before and after wat…

This study compared two types of laparoscopic surgery for early-stage colon cancer: conventional colectomy and complete mesocolic excision (CME). Researchers looked at 150 patients in Upper Egypt to see which surgery removed more lymph nodes and caused fewer complications. The go…

This study tested whether offering a simple blood test instead of a colonoscopy or stool test would encourage more people to get screened for colorectal cancer. Researchers enrolled 297 adults aged 45-75 who had previously skipped or refused traditional screening. The goal was to…

This study looked at whether a nurse practitioner can safely monitor people with colorectal cancer who are getting intravenous chemotherapy, compared to a doctor. About 207 adults took part. The goal was to see if the number of serious side effects and quality of life were simila…

This study tested a step-by-step plan for patients who had high C-reactive protein (CRP) levels after surgery for colorectal cancer. High CRP can signal a serious complication called an anastomotic leak, where the surgical connection leaks. The goal was to see if a proactive mana…

This study looked at whether proteins in the blood can help screen for colorectal cancer. Researchers tested blood samples from 350 people aged 50 and older who were already scheduled for a colonoscopy. The goal was to see if certain protein markers could reliably detect advanced…

This study looked at how bevacizumab, a drug used to treat advanced colorectal cancer, affects the stiffness of arteries. Researchers measured artery stiffness in 13 patients before and after 4 months of treatment. The goal was to better understand the drug's cardiovascular side …

This study looked at 236 adults with breast, colorectal, or pancreatic cancer who sought a second opinion at the University of Colorado. Researchers reviewed medical records to see if patients stayed for treatment or went elsewhere. The goal was to understand what factors influen…

This study tested an educational program to help people in rural areas learn more about colorectal cancer screening. 205 adults aged 45-74 from specific counties in New Hampshire and Vermont took part. Researchers measured changes in knowledge and intentions to get screened befor…

This completed study analyzed data from 1,500 colon cancer patients to see if a new way of classifying lymph node involvement—based on both the number and location of affected nodes and tumor deposits—can better predict survival than the current standard system. Researchers colle…

This completed study collected blood and tumor tissue from 64 patients with advanced cancers (like melanoma, breast, lung, and kidney cancer) to study genetic changes and treatment resistance. The samples are stored for future research, including genomic analysis. No new treatmen…

This study looks at how two common drugs—rifampicin (an antibiotic) and itraconazole (an antifungal)—affect the levels of a new cancer drug called BI 907828 in the blood. It involves 33 adults with advanced solid tumors who have not responded to previous treatments. Participants …

This study tested whether a deeper self-collected swab (5 cm) collects better cell samples from the anal canal compared to a shallower one (3 cm). Fifty adults at higher risk for anal cancer participated. The goal was to see which depth gives a more useful sample for screening, w…

This completed study followed over 3,600 people with stage I to III colon cancer who had surgery. The goal was to learn how far cancer spreads to lymph nodes and how much bowel and tissue should be removed for the best outcome. The results could help guide surgeons in the future,…

This completed trial tested an interactive survivorship program for adolescent and young adult cancer survivors. The program included a mobile app, telehealth support, and printed materials to help survivors access healthcare resources, improve self-management skills, and reduce …

This study tested whether an educational session at a church could help Latino adults learn more about colorectal cancer and feel more willing to join cancer clinical trials. Sixty Spanish-speaking participants watched videos and completed surveys. The goal was to understand barr…